专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

US20080108701A1 Diagnostic Agent for Tumor 有权
标题翻译：肿瘤诊断剂
公开(公告)号：US20080108701A1
公开(公告)日：2008-05-08
申请号：US11664065
申请日：2005-09-22
申请人： Ichiro Okura , Toshiaki Kamachi , Shunichiro Ogura , Masahiro Ishizuka , Tohru Tanaka
发明人： Ichiro Okura , Toshiaki Kamachi , Shunichiro Ogura , Masahiro Ishizuka , Tohru Tanaka
IPC分类号： A61K31/197 , A61P43/00 , C07C229/22
CPC分类号： C07C229/22 , A61K49/0021 , G01N33/574
摘要： According to the present invention, a tumor diagnostic agent which carries out early stage detection, monitoring of therapeutic effect and prognostic diagnosis of all tumors The tumor diagnostic agent of the present invention is a tumor diagnostic agent comprising δ-aminolevulinic acid represented by formula (I), a derivative thereof and a salt thereof: R2R1NCH2COCH2CH2COR3 (I) wherein R1 and R2 each independently represents hydrogen, alkyl, acyl, alkoxycarbonyl, aryl or aralkyl; and R3 represents hydroxy, alkoxy, acyloxy, alkoxycarbonyloxy, aryloxy, aralkyloxy or amino, which is used for diagnoses by measuring porphyrins in a sample collected from the inside or outside of the body after its administration.
摘要翻译：根据本发明，进行早期检测，所有肿瘤的治疗效果和预后诊断的肿瘤诊断剂本发明的肿瘤诊断剂是包含由式（I）表示的δ-氨基乙酰丙酸的肿瘤诊断剂），其衍生物及其盐：<？in-line-formula description =“In-line formula”end =“lead”？> R＆lt; 2＆lt; 1＆gt; NCH 2 COCH 2 CH 2 2（3）（I）<？in-line-formula description =“In 其中R 1和R 2各自独立地表示氢，烷基，酰基，烷氧基羰基，芳基或芳烷基; R 3表示羟基，烷氧基，酰氧基，烷氧基羰基氧基，芳氧基，芳烷氧基或氨基，其用于通过测量在其施用后从身体内部或外部收集的样品中的卟啉进行诊断。

2. 发明授权

US09340490B2 Diagnostic agent for tumor 有权
标题翻译：肿瘤诊断剂
公开(公告)号：US09340490B2
公开(公告)日：2016-05-17
申请号：US11664065
申请日：2005-09-22
申请人： Ichiro Okura , Toshiaki Kamachi , Shunichiro Ogura , Masahiro Ishizuka , Tohru Tanaka
发明人： Ichiro Okura , Toshiaki Kamachi , Shunichiro Ogura , Masahiro Ishizuka , Tohru Tanaka
IPC分类号： A61K31/197 , A61P43/00 , C07C229/22 , A61K49/00 , G01N33/574
CPC分类号： C07C229/22 , A61K49/0021 , G01N33/574
摘要： According to the present invention, a tumor diagnostic agent which carries out early stage detection, monitoring of therapeutic effect and prognostic diagnosis of all tumors The tumor diagnostic agent of the present invention is a tumor diagnostic agent comprising δ-aminolevulinic acid represented by formula (I), a derivative thereof and a salt thereof: R2R1NCH2COCH2CH2COR3 (I) wherein R1 and R2 each independently represents hydrogen, alkyl, acyl, alkoxycarbonyl, aryl or aralkyl; and R3 represents hydroxy, alkoxy, acyloxy, alkoxycarbonyloxy, aryloxy, aralkyloxy or amino, which is used for diagnoses by measuring porphyrins in a sample collected from the inside or outside of the body after its administration.
摘要翻译：根据本发明，进行早期检测，所有肿瘤的治疗效果和预后诊断的肿瘤诊断剂本发明的肿瘤诊断剂是包含由式（I）表示的δ-氨基乙酰丙酸的肿瘤诊断剂），其衍生物及其盐：R2R1NCH2COCH2CH2COR3（I）其中R1和R2各自独立地表示氢，烷基，酰基，烷氧基羰基，芳基或芳烷基; R3表示羟基，烷氧基，酰氧基，烷氧基羰基氧基，芳氧基，芳烷氧基或氨基，其用于通过在给药后从身体内部或外部收集的样品中的卟啉测量来诊断。

3. 发明授权

US08927532B2 Therapeutic agent and diagnostic agent for mitochondrial dysfunction brain diseases 有权
标题翻译：线粒体功能障碍脑疾病的治疗剂和诊断剂
公开(公告)号：US08927532B2
公开(公告)日：2015-01-06
申请号：US13613565
申请日：2012-09-13
申请人： Toshihiko Kuroiwa , Yoshinaga Kajimoto , Takahiro Masubuchi , Masahiro Ishizuka , Tohru Tanaka
发明人： Toshihiko Kuroiwa , Yoshinaga Kajimoto , Takahiro Masubuchi , Masahiro Ishizuka , Tohru Tanaka
IPC分类号： A61K31/555 , A61K31/195 , A61K31/295 , A61K31/197 , A61K31/198 , A61K33/26 , A61K45/06 , A61K49/00
CPC分类号： A61K31/295 , A61K31/197 , A61K31/198 , A61K33/26 , A61K45/06 , A61K49/0008 , A61K2300/00
摘要： To provide a therapeutic agent and a diagnostic agent for mitochondrial dysfunction brain diseases including cerebral infarction as a representative.A therapeutic agent for a mitochondrial dysfunction brain disease, which comprises (A) δ-aminolevulinic acid represented by the formula (1), a derivative thereof, or a salt thereof and (B) an iron compound in combination. R2R1NCH2COCH2CH2COR3 (1) wherein R1 and R2 each independently represents a hydrogen atom, an alkyl group, an acyl group, an alkoxycarbonyl group, an aryl group, or an aralkyl group; and R3 represents a hydroxy group, an alkoxy group, an acyloxy group, an alkoxycarbonyloxy group, an aryloxy group, an aralkyloxy group, or an amino group.
摘要翻译：提供治疗剂和用于线粒体功能障碍脑疾病（包括脑梗死代表）的诊断剂。线粒体功能障碍性脑病的治疗剂，其包含（A）由式（1）表示的δ-氨基乙酰丙酸，其衍生物或其盐和（B）铁化合物的组合。 R2R1NCH2COCH2CH2COR3（1）其中R1和R2各自独立地表示氢原子，烷基，酰基，烷氧基羰基，芳基或芳烷基; R3表示羟基，烷氧基，酰氧基，烷氧基羰基氧基，芳氧基，芳烷氧基或氨基。

4. 发明授权

US08790712B2 Constitutional function-improving agents 有权
标题翻译：宪法功能改善剂
公开(公告)号：US08790712B2
公开(公告)日：2014-07-29
申请号：US11661688
申请日：2005-08-26
申请人： Masao Kondo , Naomi Aiba , Setsuko Miyanari , Tohru Tanaka , Takaya Suzuki , Masahiro Ishizuka
发明人： Masao Kondo , Naomi Aiba , Setsuko Miyanari , Tohru Tanaka , Takaya Suzuki , Masahiro Ishizuka
IPC分类号： A61K33/34
CPC分类号： A61K31/197 , A23K20/142 , A23K20/24 , A23K20/30 , A23L33/16 , A23L33/175 , A61K33/26 , A61K33/34 , A61K45/06 , A61K2300/00
摘要： The present invention is drawn to a method of inducing thymocyte proliferation in a vertebrate animal with an impaired immune system comprising administering δ-aminolevulinic acid or a salt thereof every day in succession. The method further comprises administering at least one mineral.
摘要翻译：本发明涉及在具有受损免疫系统的脊椎动物中诱导胸腺细胞增殖的方法，包括每天连续施用δ-氨基乙酰丙酸或其盐。该方法还包括施用至少一种矿物质。

5. 发明授权

US08309493B2 Polyphenol-content-increasing agent for plant 有权
标题翻译：植物多酚含量增加剂
公开(公告)号：US08309493B2
公开(公告)日：2012-11-13
申请号：US12376865
申请日：2007-07-18
申请人： Masao Kondo , Naomi Aiba , Setsuko Miyanari , Masahiro Ishizuka , Tohru Tanaka
发明人： Masao Kondo , Naomi Aiba , Setsuko Miyanari , Masahiro Ishizuka , Tohru Tanaka
IPC分类号： A01N47/10 , A01N47/24 , A01N47/20 , A01N47/06 , A01N37/00 , A01N37/44 , A01N33/00 , A01N37/18
CPC分类号： A01N37/44
摘要： To provide a polyphenol-content-increasing agent which increases the content of polyphenol in a plant.A polyphenol-content-increasing agent for plant, containing, as an active ingredient, a 5-aminolevulinic acid or a derivative thereof represented by the following formula (1):(Chem 1) R2R1NCH2COCH2CH2COR3 (1) wherein R1 and R2 each independently represents a hydrogen atom, an alkyl group, an acyl group, an alkoxycarbonyl group, an aryl group, or an aralkyl group; R3 represents a hydroxyl group, an alkoxy group which may have a substituent, an acyloxy group, an alkoxycarbonyloxy group, an aryloxy group, an aralkyloxy group, or an amino group, or a salt thereof.
摘要翻译：提供增加植物中多酚含量的多酚含量增加剂。含有下述式（1）所示的5-氨基乙酰丙酸或其衍生物作为活性成分的植物多酚含量增加剂：（化学式1）R2R1NCH2COCH2CH2COR3（1）其中R1和R2各自独立地表示氢原子，烷基，酰基，烷氧基羰基，芳基或芳烷基; R3表示羟基，可以具有取代基的烷氧基，酰氧基，烷氧基羰基氧基，芳氧基，芳烷氧基或氨基，或其盐。

6. 发明授权

US08173839B2 5-aminolevulinic acid salt, process for producing the same and use thereof 有权
标题翻译： 5-氨基乙酰丙酸盐，其制备方法及其用途
公开(公告)号：US08173839B2
公开(公告)日：2012-05-08
申请号：US10594923
申请日：2005-03-28
申请人： Naohisa Tachiya , Seiji Nishikawa , Mai Higo , Tohru Tanaka , Masahiro Ishizuka , Hideki Okada
发明人： Naohisa Tachiya , Seiji Nishikawa , Mai Higo , Tohru Tanaka , Masahiro Ishizuka , Hideki Okada
IPC分类号： C07C227/40 , C07C227/42 , C07C227/16 , C07C229/22
CPC分类号： A01N37/44 , A61K41/0061 , A61K49/0021 , C07C227/00 , C07C229/22 , C07C309/30 , C07F9/11
摘要： A 5-aminolevulinic acid salt which is useful in fields of microorganisms, fermentation, animals, medicaments, plants and the like; a process for producing the same; a medical composition comprising the same; and a plant activator composition comprising the same.
摘要翻译：可用于微生物，发酵，动物，药物，植物等领域的5-氨基乙酰丙酸盐; 其制造方法; 包含其的医药组合物; 以及包含该组合物的植物活化剂组合物。

7. 发明授权

US08999296B2 Method of detecting bladder cancer 有权
标题翻译：检测膀胱癌的方法
公开(公告)号：US08999296B2
公开(公告)日：2015-04-07
申请号：US12988621
申请日：2009-04-21
申请人： Keiji Inoue , Masahiro Ishizuka , Tohru Tanaka
发明人： Keiji Inoue , Masahiro Ishizuka , Tohru Tanaka
IPC分类号： A61K49/00 , A61K31/198 , A61K41/00
CPC分类号： A61K49/0021 , A61K41/0061 , Y10S514/814
摘要： Provided is a sensitizing detection agent of an oral or intravenous administration type which enables the detection of bladder cancer with a higher sensitivity without causing pain to the patient. A sensitizing detection agent for bladder cancer comprising 5-aminolevulinic acid (ALA), a derivative thereof, or a salt of these is orally or intravenously administered, and a video camera system is inserted via the urethra and a blue light at 380-440 nm is irradiated to observe the red fluorescent part. Further, VLD-M1 is inserted and a blue light at 405 nm is irradiated to observe fluorescence intensity (relative intensity) of the red light part. For oral administration, 20 mg/kg (maximum of 1 g) of ALA is dissolved in 50 mL of a 5% glucose solution prior to the administration.
摘要翻译：本发明提供口服或静脉内给药型敏化检测剂，其能够以更高的灵敏度检测膀胱癌，而不会对患者造成疼痛。通过口服或静脉内施用包含5-氨基乙酰丙酸（ALA），其衍生物或其盐的膀胱癌敏化检测剂，通过尿道插入摄像机系统，并将380-440nm的蓝光照射以观察红色荧光部分。此外，插入VLD-M1，照射405nm的蓝色光，以观察红色光部分的荧光强度（相对强度）。对于口服给药，在施用前将20mg / kg（最多1g）的ALA溶于50mL的5％葡萄糖溶液中。

8. 发明申请

US20110065787A1 THERAPEUTIC AGENT FOR MALE STERILITY 有权
标题翻译：用于男性不育的治疗剂
公开(公告)号：US20110065787A1
公开(公告)日：2011-03-17
申请号：US12736782
申请日：2009-05-13
申请人： Setsuko Miyanari , Masumi Takahashi , Masahiro Ishizuka , Tohru Tanaka
发明人： Setsuko Miyanari , Masumi Takahashi , Masahiro Ishizuka , Tohru Tanaka
IPC分类号： A61K31/295 , A61K31/197 , A61P15/08 , A61P15/10
CPC分类号： A61K31/197 , A23L33/10 , A23L33/16 , A61K33/26 , A61K2300/00
摘要： The present invention is intended to provide an agent for treating male infertility which is highly effective to male infertility, and having few side effects. To achieve the object, an agent for treating male infertility comprising δ-amino levulinic acid shown by general formula (1), its derivative or salt thereof: R2R1NCH2COCH2CH2COR3 (1) [wherein R1 and R2 independently represent a hydrogen atom, alkyl group, acyl group, alkoxycarbonyl group, aryl group, or aralkyl group; R3 represents a hydroxy group, alkoxy group, acyloxy group, alkoxycarbonyloxy group, aryloxy group, aralkyloxy group or amino group] can be used.
摘要翻译：本发明旨在提供一种治疗男性不育症的药剂，其对男性不育症具有高度有效性，并且副作用很少。为了达到上述目的，可以列举通式（1）所示的δ-氨基乙酰丙酸及其衍生物或其盐的治疗男性不育症的药剂：R2R1NCH2COCH2CH2COR3（1）[式中，R1和R2分别表示氢原子，烷基，酰基基团，烷氧基羰基，芳基或芳烷基; R3表示羟基，烷氧基，酰氧基，烷氧基羰基氧基，芳氧基，芳烷氧基或氨基]。

9. 发明申请

US20070203027A1 5-Aminolevulinic Acid Salt, Process For Producing The Same And Use Thereof 有权
标题翻译： 5-氨基乙酰丙酸盐，其生产方法和用途
公开(公告)号：US20070203027A1
公开(公告)日：2007-08-30
申请号：US10594923
申请日：2005-03-28
申请人： Naohisa Tachiya , Seiji Nishikawa , Mai Higo , Tohru Tanaka , Masahiro Ishizuka , Hideki Okada
发明人： Naohisa Tachiya , Seiji Nishikawa , Mai Higo , Tohru Tanaka , Masahiro Ishizuka , Hideki Okada
IPC分类号： A01N57/00 , A61K31/66 , C07F9/02
CPC分类号： A01N37/44 , A61K41/0061 , A61K49/0021 , C07C227/00 , C07C229/22 , C07C309/30 , C07F9/11
摘要： A 5-aminolevulinic acid salt which is useful in fields of microorganisms, fermentation, animals, medicaments, plants and the like; a process for producing the same; a medical composition comprising the same; and a plant activator composition comprising the same.
摘要翻译：可用于微生物，发酵，动物，药物，植物等领域的5-氨基乙酰丙酸盐; 其制造方法; 包含其的医药组合物; 和包含其的植物活化剂组合物。

10. 发明申请

US20100120916A1 THERAPEUTIC AGENT AND DIAGNOSTIC AGENT FOR MITOCHONDRIAL DYSFUNCTION BRAIN DISEASES 审中-公开
标题翻译：麻醉药物治疗药物和诊断药物用于麻醉性脑缺血性脑病
公开(公告)号：US20100120916A1
公开(公告)日：2010-05-13
申请号：US12594672
申请日：2008-03-27
申请人： Toshihiko Kuroiwa , Yoshinaga Kajimoto , Takahiro Masubuchi , Masahiro Ishizuka , Tohru Tanaka
发明人： Toshihiko Kuroiwa , Yoshinaga Kajimoto , Takahiro Masubuchi , Masahiro Ishizuka , Tohru Tanaka
IPC分类号： A61K31/197 , A61P25/00 , C07C229/22
CPC分类号： A61K31/295 , A61K31/197 , A61K31/198 , A61K33/26 , A61K45/06 , A61K49/0008 , A61K2300/00
摘要： To provide a therapeutic agent and a diagnostic agent for mitochondrial dysfunction brain diseases including cerebral infarction as a representative.A therapeutic agent for a mitochondrial dysfunction brain disease, which comprises (A) δ-aminolevulinic acid represented by the formula (1), a derivative thereof, or a salt thereof and (B) an iron compound in combination. R2R1NCH2COCH2CH2COR3 (1) wherein R1 and R2 each independently represents a hydrogen atom, an alkyl group, an acyl group, an alkoxycarbonyl group, an aryl group, or an aralkyl group; and R3 represents a hydroxy group, an alkoxy group, an acyloxy group, an alkoxycarbonyloxy group, an aryloxy group, an aralkyloxy group, or an amino group.
摘要翻译：提供治疗剂和用于线粒体功能障碍脑疾病（包括脑梗死代表）的诊断剂。线粒体功能障碍性脑病的治疗剂，其包含（A）由式（1）表示的δ-氨基乙酰丙酸，其衍生物或其盐和（B）铁化合物的组合。 R2R1NCH2COCH2CH2COR3（1）其中R1和R2各自独立地表示氢原子，烷基，酰基，烷氧基羰基，芳基或芳烷基; R3表示羟基，烷氧基，酰氧基，烷氧基羰基氧基，芳氧基，芳烷氧基或氨基。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式