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    • 4. 发明申请
    • Protease susceptibility II
    • 蛋白酶敏感性II
    • US20080058261A1
    • 2008-03-06
    • US11801120
    • 2007-05-08
    • Anthony Weiss
    • Anthony Weiss
    • A61K38/00A61P43/00C07K14/00C07K7/00
    • C07K7/02A61K38/00C07K14/78
    • The manipulation of the amino acid sequence of tropoelastin, particularly human tropoelastin, to modify its protease susceptibility is described. The modified tropoelastins include tropoelastin derivatives having modified protease susceptibility, peptidomimetic molecules which contain amino acid sequences which correspond to or incorporate the protease susceptible sequences of tropoelastin. Uses of these tropoelastin derivatives and peptidomimetic molecules are provided. Also provided are nucleic acid molecules and genetic constructs encoding the amino acid sequences of the derivatives and peptidomimetic molecules of the invention.
    • 描述了针刺弹性蛋白(特别是人类原弹性蛋白)的氨基酸序列的操纵以改变其蛋白酶敏感性。 改性的原油弹性蛋白包括具有修饰的蛋白酶敏感性的前驱弹性蛋白衍生物,含有对应于或掺入蛋白酶敏感序列的托普拉斯汀的氨基酸序列的拟肽分子。 提供这些托普弹力素衍生物和拟肽分子的用途。 还提供了编码本发明的衍生物和拟肽分子的氨基酸序列的核酸分子和遗传构建体。
    • 5. 发明申请
    • Tropoelastin-based protoelastin biomaterials
    • 基于原始弹力蛋白的原弹性蛋白生物材料
    • US20080107708A1
    • 2008-05-08
    • US11864006
    • 2007-09-28
    • Martin NgAnthony WeissSteven Wise
    • Martin NgAnthony WeissSteven Wise
    • A61K9/00A61K38/39
    • A61K38/39A61L27/227A61L27/26A61L27/34A61L31/047A61L31/10
    • Biocompatible materials suitable for use in vascular applications have been engineered, combining human recombinant tropoelastin with other synthetic or natural biomaterials to form protoelastin. The materials can be in the form of elastin films on metal, bone, ceramic or polymer substrates, laminates of alternating polymer and elastin, blends of polymer and elastin, or elastin crosslinked with or tethered to polymer. The flexibility in engineering and design makes protoelastin biomaterials suited not only to the production of conduits but any number of other vascular applications that require blood contacting surfaces. Tropoelastin and the subsequently engineered biomaterial protoelastin provide the opportunity to satisfy a large unmet need for a biocompatible material adaptable enough to meet a range of diverse vascular uses. These are mechanically stable, elastic, strong and biocompatible (i.e., not thrombogenic and promoting adhesion of cells, especially human endothelial cells.
    • 已经设计了适用于血管应用的生物相容性材料,将人重组托拉斯特蛋白与其他合成或天然生物材料组合以形成原胶原蛋白。 材料可以是金属,骨,陶瓷或聚合物基底上的弹性蛋白膜,交替聚合物和弹性蛋白的叠层,聚合物和弹性蛋白的共混物,或与聚合物交联或连接的弹性蛋白。 工程和设计的灵活性使得原胶原生物材料不仅适用于导管的生产,而且也适用于需要接触血液的表面的任何数量的其他血管应用。 托罗弹性蛋白和随后改良的生物材料原弹性蛋白提供了满足大量未满足的生物相容性材料需求的机会,其适应性足以满足多种血管用途的范围。 这些是机械稳定的,弹性的,强的和生物相容的(即,不是血栓形成和促进细胞,特别是人内皮细胞的粘附。
    • 6. 发明申请
    • Tropoelastin derivatives
    • 托普拉斯汀衍生物
    • US20050204408A1
    • 2005-09-15
    • US11053710
    • 2005-02-08
    • Anthony Weiss
    • Anthony Weiss
    • A01K67/00C07H21/04C12N9/66C12N15/09C12Q1/68
    • C07H21/04
    • The invention relates to derivatives of tropoelastin and variants of those derivatives. The invention further provides expression products and hybrid molecules of the derivatives and variants of the invention. The invention further provides methods for the production of the derivatives, variants, expression products and hybrid molecules. Further provided are formulations, cross-linked structures and implants comprising the derivatives, variants, expression products and hybrid molecules of the invention. Further provided are uses of the derivatives, variants, expression products and hybrid molecules of the invention.
    • 本发明涉及托普拉斯汀的衍生物和那些衍生物的变体。 本发明还提供了本发明的衍生物和变体的表达产物和杂合分子。 本发明进一步提供了衍生物,变体,表达产物和杂合分子的制备方法。 还提供了包含本发明的衍生物,变体,表达产物和杂合分子的制剂,交联结构和植入物。 进一步提供本发明的衍生物,变体,表达产物和杂合分子的用途。