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1. 发明授权

US08688386B2 Analyte testing method and device for calculating basal insulin therapy 有权
标题翻译：基础胰岛素治疗的分析物检测方法及装置
公开(公告)号：US08688386B2
公开(公告)日：2014-04-01
申请号：US12826670
申请日：2010-06-30
申请人： Ian Shadforth , David Price , Zara Sieh , Brenda Montgomery , Eric David Bergman
发明人： Ian Shadforth , David Price , Zara Sieh , Brenda Montgomery , Eric David Bergman
IPC分类号： G01N33/48 , G01N31/00 , G06G7/48 , G06G7/58
CPC分类号： A61B5/1486 , A61B5/14532 , A61B5/4833 , G01N33/48785
摘要： Described herein are various methods to ensure safety and the compliance of therapeutic diabetes protocols. The method can be achieved by performing safeguards against hypoglycemia of the user prior to any change in basal insulin dosage based on the plurality of data.
摘要翻译：本文描述了确保治疗糖尿病方案的安全性和依从性的各种方法。在基于多个数据的基础胰岛素剂量的任何改变之前，可以通过执行防止使用者低血糖的保护措施来实现该方法。

2. 发明申请

US20120004637A1 DRUG DELIVERY MANAGEMENT SYSTEMS AND METHODS 有权
标题翻译：药物递送管理系统和方法
公开(公告)号：US20120004637A1
公开(公告)日：2012-01-05
申请号：US13203697
申请日：2010-01-27
申请人： Peter Krulevitch , Robert Wilk , Ulrich Kraft , Donna Savage , Nick Foley , James Glencross , David Shepherd , Zara Sieh , David Price
发明人： Peter Krulevitch , Robert Wilk , Ulrich Kraft , Donna Savage , Nick Foley , James Glencross , David Shepherd , Zara Sieh , David Price
IPC分类号： A61M5/31 , A61M5/315
CPC分类号： A61M5/315 , A61B5/002 , A61B5/14532 , A61M5/24 , A61M5/3129 , A61M5/3146 , A61M5/31525 , A61M5/31551 , A61M2005/3126 , A61M2005/3142 , A61M2205/14 , A61M2205/18 , A61M2205/215 , A61M2205/3317 , A61M2205/3553 , A61M2205/3561 , A61M2205/3569 , A61M2205/3584 , A61M2205/3592 , A61M2205/52 , A61M2205/581 , A61M2205/583 , A61M2205/584 , A61M2205/6054 , A61M2205/6081 , A61M2205/8212 , A61M2209/04 , G01D5/1655 , G06F19/00 , G06F19/3468
摘要： Various embodiments of a “smart” drug delivery system are provided which includes an add-on module and a reusable or disposable drug pen in conjunction with a data management unit(s) DMU. Upon attachment to the pen, the add-on module may: determine dosage selected, injection of selected dosage, duration of injection, time of injection, whether the pen has been primed or shaken to thoroughly mix up insulin mixtures, transmit information relating to insulin dosage and injection to a data management unit, provide reminders, error warning or messages on improper usage or reuse of needles, track amount of drug remaining on board the pen or duration of usage of pen with respect to expiry of the drug on board, or provide an audible alarm for locating misplaced pen and module. Methods of using the drug delivery system are also described.
摘要翻译：提供了“智能”药物递送系统的各种实施例，其包括与数据管理单元DMU结合的附加模块和可重复使用或一次性药物笔。附加模块可以：确定所选择的剂量，所选剂量的注射，注射持续时间，注射时间，笔是否被引发或摇动以充分混合胰岛素混合物，传送与胰岛素相关的信息剂量和注射到数据管理单元，提供提醒，错误警告或关于针的不正确使用或重复使用的信息，笔上留下的药物的轨迹量或笔的使用持续时间，关于药物到期的时间，或提供用于定位放错的笔和模块的声音报警器。还描述了使用药物递送系统的方法。

3. 发明授权

US08556867B2 Drug delivery management systems and methods 有权
标题翻译：药物输送管理系统和方法
公开(公告)号：US08556867B2
公开(公告)日：2013-10-15
申请号：US13203697
申请日：2010-01-27
申请人： Peter Krulevitch , Robert Wilk , Ulrich Kraft , Donna Savage , Nick Foley , James Glencross , David Shepherd , Zara Sieh , David Price
发明人： Peter Krulevitch , Robert Wilk , Ulrich Kraft , Donna Savage , Nick Foley , James Glencross , David Shepherd , Zara Sieh , David Price
IPC分类号： A61M5/315 , A61M5/178 , A61M5/00
CPC分类号： A61M5/315 , A61B5/002 , A61B5/14532 , A61M5/24 , A61M5/3129 , A61M5/3146 , A61M5/31525 , A61M5/31551 , A61M2005/3126 , A61M2005/3142 , A61M2205/14 , A61M2205/18 , A61M2205/215 , A61M2205/3317 , A61M2205/3553 , A61M2205/3561 , A61M2205/3569 , A61M2205/3584 , A61M2205/3592 , A61M2205/52 , A61M2205/581 , A61M2205/583 , A61M2205/584 , A61M2205/6054 , A61M2205/6081 , A61M2205/8212 , A61M2209/04 , G01D5/1655 , G06F19/00 , G06F19/3468
摘要： Various embodiments of a “smart” drug delivery system are provided which includes an add-on module and a reusable or disposable drug pen in conjunction with a data management unit(s) DMU. Upon attachment to the pen, the add-on module may: determine dosage selected, injection of selected dosage, duration of injection, time of injection, whether the pen has been primed or shaken to thoroughly mix up insulin mixtures, transmit information relating to insulin dosage and injection to a data management unit, provide reminders, error warning or messages on improper usage or reuse of needles, track amount of drug remaining on board the pen or duration of usage of pen with respect to expiry of the drug on board, or provide an audible alarm for locating misplaced pen and module. Methods of using the drug delivery system are also described.
摘要翻译：提供了“智能”药物递送系统的各种实施例，其包括与数据管理单元DMU结合的附加模块和可重复使用或一次性药物笔。附加模块可以：确定所选择的剂量，所选剂量的注射，注射持续时间，注射时间，笔是否被引发或摇动以充分混合胰岛素混合物，传送与胰岛素相关的信息剂量和注射到数据管理单元，提供提醒，错误警告或关于针的不正确使用或重复使用的信息，笔上留下的药物的轨迹量或笔的使用持续时间，关于药物到期的时间，或提供用于定位放错的笔和模块的声音报警器。还描述了使用药物递送系统的方法。

4. 发明申请

US20100256047A1 Analyte Measurement and Management Device and Associated Methods 审中-公开
标题翻译：分析物测量和管理装置及相关方法
公开(公告)号：US20100256047A1
公开(公告)日：2010-10-07
申请号：US12417875
申请日：2009-04-03
申请人： Zara Sieh , David Horwitz , David Price , Peter Krulevitch , Donna Savage , Robert Shartle
发明人： Zara Sieh , David Horwitz , David Price , Peter Krulevitch , Donna Savage , Robert Shartle
IPC分类号： A61K38/28 , A61P3/10 , G06F19/00
CPC分类号： G06F19/3456
摘要： A method for measuring and managing an analyte (e.g., blood glucose) in a bodily fluid includes storing a therapeutic administration protocol in a memory module of an analyte measurement and management device and measuring the analyte in the bodily fluid sample using an analyte measurement module of the device. The method also includes calculating, with a processor module of the device, a recommended therapeutic agent dosage (for example, an insulin dosage) and a recommended administration time for user-activated delivery of the dosage by employing the therapeutic administration protocol. The method further includes displaying the recommended therapeutic agent dosage and administration time to a user on a visual display of the device, delivering a therapeutic agent dosage to the user via a user-activated therapeutic agent delivery device, and detecting the user-activated administration of the therapeutic agent using a delivery device communication module of the device. In addition, the method includes communicating the aforementioned detection to the processor module and/or memory module using the delivery device communication module. The method employs analyte measurement, memory, processor, and delivery device modules, as well as a visual display, and user interface that are integrated as a single hand-held unit.
摘要翻译：用于测量和管理体液中的分析物（例如，血糖）的方法包括将分析物测量和管理装置的存储器模块中的治疗性给药方案存储在体液样品中，并使用分析物测量模块装置。该方法还包括利用该设备的处理器模块，通过使用治疗性给药方案来计算推荐的治疗剂剂量（例如，胰岛素剂量）和用户激活的剂量递送的推荐给药时间。该方法还包括在设备的视觉显示上向用户显示推荐的治疗剂剂量和给药时间，经由用户激活的治疗剂递送装置向用户递送治疗剂剂量，以及检测用户激活的给药时间所述治疗剂使用所述装置的递送装置通信模块。此外，该方法包括使用传送设备通信模块将上述检测传送到处理器模块和/或存储器模块。该方法采用分析物测量，存储器，处理器和传送设备模块，以及作为单个手持单元集成的可视显示器和用户界面。

5. 发明申请

US20100016700A1 ANALYTE MEASUREMENT AND MANAGEMENT DEVICE AND ASSOCIATED METHODS 审中-公开
标题翻译：分析测量和管理设备及相关方法
公开(公告)号：US20100016700A1
公开(公告)日：2010-01-21
申请号：US12505007
申请日：2009-07-17
申请人： Zara Sieh , David Horwitz , David Price , Peter Krulevitch , Donna Savage , Robert Shartle
发明人： Zara Sieh , David Horwitz , David Price , Peter Krulevitch , Donna Savage , Robert Shartle
IPC分类号： A61B5/00 , G06F3/048 , H04L9/32 , G08B1/08 , G06F15/16 , G06N5/02
CPC分类号： A61B5/4839 , A61B5/14532 , G06F19/3418 , G06F19/3468 , G16H40/63
摘要： Various embodiments of a diabetes management system are provided. One exemplary system may include an analyte measurement device and a therapeutic agent delivery device. The measurement device includes a measurement unit, display, and first wireless module. The therapeutic agent delivery device has a delivery device housing, delivery mechanism disposed in the housing that delivers a dosage of the agent to the user upon actuation by the user or health care provider, and a second wireless module. The second module, automatically, without prompting from a user or any active input or action by the user, transmits a signal to the first wireless module indicative of: (a) type of therapeutic agent delivered; and (b) amount of therapeutic agent delivered to the user; or (c) type of therapeutic agent device from which the therapeutic agent was administered. Also described are diabetes management devices and methods.
摘要翻译：提供了糖尿病管理系统的各种实施例。一个示例性系统可以包括分析物测量装置和治疗剂递送装置。测量装置包括测量单元，显示器和第一无线模块。治疗剂递送装置具有输送装置壳体，设置在壳体中的输送机构，其在用户或医疗保健提供者致动时将剂量的剂量递送给使用者，以及第二无线模块。自动地，第二模块在不提示用户或用户的任何有效输入或动作的情况下，向第一无线模块发送指示：（a）递送的治疗剂的类型; 和（b）递送给使用者的治疗剂量; 或（c）施用治疗剂的治疗剂装置的类型。还描述了糖尿病管理装置和方法。

6. 发明授权

US08974387B2 Analyte testing method and device for diabetes management 有权
标题翻译：糖尿病管理分析物检测方法及装置
公开(公告)号：US08974387B2
公开(公告)日：2015-03-10
申请号：US12826674
申请日：2010-06-30
申请人： Ian Shadforth , David Price , Gretchen Anderson , Lorraine Comstock , Mary McEvoy , Douglas Graham , Alexander Strachan , Alistair Longmuir , Robert Cavaye , Gillian Teft
发明人： Ian Shadforth , David Price , Gretchen Anderson , Lorraine Comstock , Mary McEvoy , Douglas Graham , Alexander Strachan , Alistair Longmuir , Robert Cavaye , Gillian Teft
IPC分类号： A61B5/00 , A61B5/145 , G06F19/00
CPC分类号： A61M5/1723 , A61B5/14532 , A61B5/4839 , A61B5/486 , A61B5/4866 , A61B5/7282 , G06F19/00 , G06F19/3418 , G06F19/3456 , H04L67/12
摘要： Various embodiments are described and illustrated to calculate an insulin bolus, recommend such bolus, and provide reminder messages for performing an additional glucose test.
摘要翻译：描述和说明了各种实施方案以计算胰岛素推注，推荐这种推注，并提供用于进行额外葡萄糖测试的提醒消息。

7. 发明授权

US09522972B2 Star polymers and compositions thereof 有权
标题翻译：星形聚合物及其组合物
公开(公告)号：US09522972B2
公开(公告)日：2016-12-20
申请号：US11738572
申请日：2007-04-23
申请人： Daniel C. Visger , Mark Davies , David Price , Marina Baum , Barton J. Schober , John R. Johnson
发明人： Daniel C. Visger , Mark Davies , David Price , Marina Baum , Barton J. Schober , John R. Johnson
IPC分类号： B01D19/04 , C08F293/00 , C10M145/14
CPC分类号： C08F293/005 , C08F293/00 , C08F2438/01 , C08F2438/03 , C08F2500/04 , C08G83/005 , C10M145/14 , C10M2205/04 , C10M2209/084 , C10M2217/024 , C10M2217/028 , C10N2220/021 , C10N2220/022 , C10N2220/029 , C10N2230/02 , C10N2230/68 , C10N2240/042
摘要： The invention provides a composition comprising: (a) a star polymer comprising: (i) a core portion comprising a polyvalent (meth)acrylic monomer, oligomer or polymer thereof or a polyvalent divinyl non-acrylic monomer, oligomer or polymer thereof; and (ii) at least two arms of polymerized alkyl(meth)acrylate ester; and (b) an oil of lubricating viscosity, wherein the core portion further comprises a functional group of formula (I): —CH2—C(R1)(C(═O)A)-Y— (I) wherein R1 is hydrogen, a linear or branched alkyl group containing 1 to 5 carbon atoms; A is nitrogen or oxygen; and Y is a free radical leaving group selected from the group consisting of one or more atoms or groups of atoms which may be transferred by a radical mechanism under the polymerization conditions, a halogen, an —O—N═ group and an —S—C(═S)— group. The invention further provides the use of the composition in an oil of lubricating viscosity as a dispersant, a viscosity modifier or a precursor to a dispersant viscosity modifier.
摘要翻译：其中R1是氢，含1至5个碳原子的直链或支链烷基; A是氮或氧; 并且Y是选自一个或多个原子或原子基团的自由基离去基团，其可以在聚合条件下通过自由基机理转移，卤素，-O-N =基团和-S- C（= S） - 组。本发明还提供了组合物在润滑粘度油中作为分散剂，粘度调节剂或分散剂粘度调节剂前体的用途。

8. 发明授权

US09241631B2 Continuous analyte monitor data recording device operable in a blinded mode 有权
标题翻译：连续分析物监测数据记录装置可在盲模式下操作
公开(公告)号：US09241631B2
公开(公告)日：2016-01-26
申请号：US13282182
申请日：2011-10-26
申请人： Jorge Valdes , David Price , Leif N. Bowman , Kristin Cote
发明人： Jorge Valdes , David Price , Leif N. Bowman , Kristin Cote
IPC分类号： A61B5/00 , A61B5/15 , A61B5/155 , A61B5/145 , A61B5/151 , A61B5/157 , A61B5/1486 , A61B5/1473 , A61B5/1495
CPC分类号： A61B5/0004 , A61B5/0022 , A61B5/0024 , A61B5/1411 , A61B5/1427 , A61B5/14532 , A61B5/14546 , A61B5/14735 , A61B5/14865 , A61B5/1495 , A61B5/150022 , A61B5/150267 , A61B5/150358 , A61B5/150854 , A61B5/150862 , A61B5/15087 , A61B5/150877 , A61B5/150969 , A61B5/15105 , A61B5/155 , A61B5/157 , A61B5/7282 , A61B5/742 , A61B5/746 , A61B2562/0295 , G06F19/00 , G16H40/67
摘要： A system is provided including a continuous analyte sensor that produces a data stream indicative of a host's analyte concentration and a device that receives and records data from the data stream from the continuous analyte sensor. The data received from the continuous analyte sensor may be used to provide alarms to the user when the analyte concentration and/or the rate of change of analyte concentration, as measured by the continuous analyte sensor, is above or below a predetermined range. Data received from the continuous analyte sensor may also be used to prompt the diabetic or caregiver to take certain actions, such as to perform another single point blood glucose measurement. The device may provide for toggling between modes that allow or prevent the display of glucose concentration values associated with the continuous glucose sensor.
摘要翻译：提供了一种系统，其包括产生指示宿主分析物浓度的数据流的连续分析物传感器，以及从连续分析物传感器接收并记录来自数据流的数据的设备。当通过连续分析物传感器测量的分析物浓度和/或分析物浓度的变化速率高于或低于预定范围时，从连续分析物传感器接收的数据可用于向用户提供警报。从连续分析物传感器接收的数据也可用于促使糖尿病患者或护理者采取某些措施，例如进行另一单点血糖测量。该装置可以提供在允许或防止显示与连续葡萄糖传感器相关联的葡萄糖浓度值的模式之间切换。

9. 发明授权

US09181510B2 Lubricating composition containing a dispersant 有权
标题翻译：含有分散剂的润滑组合物
公开(公告)号：US09181510B2
公开(公告)日：2015-11-10
申请号：US13698293
申请日：2011-05-19
申请人： William R. S. Barton , David Price , Patrick E. Mosier
发明人： William R. S. Barton , David Price , Patrick E. Mosier
IPC分类号： C10M149/00 , C10M159/12 , C10M133/16 , C10M149/06 , C10M159/00
CPC分类号： C10M133/16 , C10M149/06 , C10M159/005 , C10M2205/022 , C10M2205/024 , C10M2205/026 , C10M2205/028 , C10M2207/028 , C10M2207/262 , C10M2209/084 , C10M2215/086 , C10M2215/28 , C10M2217/06 , C10M2219/046 , C10M2219/089 , C10N2220/022 , C10N2230/04 , C10N2230/45 , C10N2230/52 , C10N2240/10 , C10N2240/101 , C10N2240/102 , C10N2240/103 , C10N2240/104 , C10N2240/105 , C10M2209/086 , C10N2260/06 , C10N2260/09
摘要： The invention provides a lubricating composition containing a copolymer comprising units derived from monomers (i) α-olefin and (ii) an ethylenically unsaturated carboxylic acid or derivatives thereof esterified and amidated with an alcohol and an aromatic amine respectively, and an oil of lubricating viscosity. The invention further relates to the use of the lubricating composition in an internal combustion engine.
摘要翻译：本发明提供一种含有共聚物的润滑组合物，所述共聚物包含衍生自单体（i）α-烯烃的单体和（ii）分别与醇和芳族胺酯化和酰胺化的烯键式不饱和羧酸或其衍生物，以及润滑粘度。本发明还涉及润滑组合物在内燃机中的应用。

10. 发明授权

US09006159B2 Star polymer lubricating composition 有权
标题翻译：星形聚合物润滑组合物
公开(公告)号：US09006159B2
公开(公告)日：2015-04-14
申请号：US13557718
申请日：2012-07-25
申请人： Barton J. Schober , Mark C. Davies , Michael R. Sutton , Marina Baum , Daniel C. Visger , David Price , Brent R. Dohner , Mark F. Wilkes
发明人： Barton J. Schober , Mark C. Davies , Michael R. Sutton , Marina Baum , Daniel C. Visger , David Price , Brent R. Dohner , Mark F. Wilkes
IPC分类号： C10M145/14 , C10M169/04 , C10M167/00 , C10M161/00
CPC分类号： C10M167/00 , C10M161/00 , C10M2207/028 , C10M2207/26 , C10M2209/084 , C10M2215/064 , C10M2215/28 , C10M2217/00 , C10M2217/043 , C10M2219/022 , C10M2219/046 , C10M2223/045 , C10N2210/06 , C10N2220/021 , C10N2220/029 , C10N2230/52 , C10N2240/04 , C10N2240/08 , C10N2240/10
摘要： The invention provides a lubricating composition containing (a) 0.001 wt % to 15 wt % of a polymer with radial or star architecture; (b) an overbased detergent; (c) a dispersant; and (d) an oil of lubricating viscosity. The invention further provides a method for lubricating a mechanical device with the lubricating composition.
摘要翻译：本发明提供了含有（a）0.001重量％至15重量％的具有径向或星形结构的聚合物的润滑组合物; （b）高碱性洗涤剂; （c）分散剂; 和（d）润滑粘度的油。本发明还提供了一种用润滑组合物润滑机械装置的方法。

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