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1. 发明申请

US20080051399A1 HYDROXYLATED AND METHOXYLATED PYRIMIDYL CYCLOPENTANES AS AKT PROTEIN KINASE INHIBITORS 有权
标题翻译：羟基和甲氧基吡咯烷酮作为AKT蛋白激酶抑制剂
公开(公告)号：US20080051399A1
公开(公告)日：2008-02-28
申请号：US11773949
申请日：2007-07-05
申请人： Ian Mitchell , James Blake , Rui Xu , Nicholas Kallan , Dengming Xiao , Keith Spencer , Josef Bencsik , Eli Wallace , Stephen Schlachter , Anna Banka , Jun Liang , Brian Safina , Birong Zhang , Christine Chabot , Steven Do
发明人： Ian Mitchell , James Blake , Rui Xu , Nicholas Kallan , Dengming Xiao , Keith Spencer , Josef Bencsik , Eli Wallace , Stephen Schlachter , Anna Banka , Jun Liang , Brian Safina , Birong Zhang , Christine Chabot , Steven Do
IPC分类号： A61K31/519 , A61K31/535 , A61P29/00 , C07D239/00 , C07D413/00
CPC分类号： A61K31/517 , C07D239/70 , C07D401/12 , C07D403/12 , C07D405/12 , C07D407/12 , C07D409/12 , C07D409/14 , C07D413/12
摘要： The present invention provides compounds, including resolved enantiomers, resolved diastereomers, solvates and pharmaceutically acceptable salts thereof, comprising the Formula I: Also provided are methods of using the compounds of this invention as AKT protein kinase inhibitors and for the treatment of hyperproliferative diseases such as cancer.
摘要翻译：本发明提供了包含分解的对映异构体，分解的非对映异构体，溶剂合物和其药学上可接受的盐的化合物，其包含式I：还提供了使用本发明化合物作为AKT蛋白激酶抑制剂和用于治疗过度增殖性疾病癌症。

2. 发明申请

US20080058327A1 PYRIMIDYL CYCLOPENTANES AS AKT PROTEIN KINASE INHIBITORS 有权
标题翻译：作为AKT蛋白激酶抑制剂的PYRIMIDYL CYCLOPENTANES
公开(公告)号：US20080058327A1
公开(公告)日：2008-03-06
申请号：US11773946
申请日：2007-07-05
申请人： Ian Mitchell , James Blake , Rui Xu , Nicholas Kallan , Dengming Xiao , Keith Spencer , Josef Bencsik , Eli Wallace , Stephen Schlachter , Anna Banka , Jun Liang , Brian Safina , Jun Li , Christine Chabot
发明人： Ian Mitchell , James Blake , Rui Xu , Nicholas Kallan , Dengming Xiao , Keith Spencer , Josef Bencsik , Eli Wallace , Stephen Schlachter , Anna Banka , Jun Liang , Brian Safina , Jun Li , Christine Chabot
IPC分类号： A61K31/517 , A61K31/535 , A61P43/00 , C07D211/00 , C07D239/70
CPC分类号： C07D409/14 , A61K31/517 , A61K31/5377 , A61K45/06 , C07D239/70 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D403/14 , C07D405/12 , C07D409/12
摘要： The present invention provides compounds of Formula I, including tautomers, resolved enantiomers, diastereomers, solvates, metabolites, salts and pharmaceutically acceptable prodrugs thereof. Also provided are methods of using the compounds of this invention as AKT protein kinase inhibitors and for the treatment of hyperproliferative diseases such as cancer.
摘要翻译：本发明提供了式I化合物，包括互变异构体，拆分的对映异构体，非对映异构体，溶剂合物，代谢物，盐和药学上可接受的前药。还提供了使用本发明化合物作为AKT蛋白激酶抑制剂和治疗过度增殖性疾病如癌症的方法。

3. 发明申请

US20050130954A1 AKT protein kinase inhibitors 审中-公开
标题翻译： AKT蛋白激酶抑制剂
公开(公告)号：US20050130954A1
公开(公告)日：2005-06-16
申请号：US10993173
申请日：2004-11-19
申请人： Ian Mitchell , Keith Spencer , Peter Stengel , Yongxin Han , Nicholas Kallan , Mark Munson , Guy Vigers , James Blake , Anthony Piscopio , John Josey , Scott Miller , Dengming Xiao , Riu Xu , Chang Rao , Bin Wang , April Bernacki
发明人： Ian Mitchell , Keith Spencer , Peter Stengel , Yongxin Han , Nicholas Kallan , Mark Munson , Guy Vigers , James Blake , Anthony Piscopio , John Josey , Scott Miller , Dengming Xiao , Riu Xu , Chang Rao , Bin Wang , April Bernacki
IPC分类号： A61K20060101 , A61K31/496 , A61K31/519 , A61K31/53
CPC分类号： C07D239/94 , B41M3/008 , B44F1/10 , C07D231/56 , C07D237/28 , C07D239/42 , C07D239/47 , C07D239/48 , C07D401/04 , C07D401/12 , C07D403/04 , C07D403/12 , C07D409/04 , C07D409/12 , C07D471/04 , C07D487/04 , C07D491/048 , C07D495/04 , G09F13/16 , Y10T428/24802 , Y10T428/24851 , Y10T428/25 , Y10T428/31507 , Y10T428/31551 , Y10T428/31786 , Y10T428/31855
摘要： The present invention provides compounds, including resolved enantiomers, diastereomers, solvates and pharmaceutically acceptable salts thereof, comprising the Formula: A-L-CR where CR is a cyclical core group, L is a linking group and A is as defined herein. Also provided are methods of using the compounds of this invention as AKT protein kinase inhibitors and for the treatment of hyperproliferative diseases such as cancer.
摘要翻译：本发明提供包括拆分的对映异构体，非对映异构体，溶剂合物和药学上可接受的盐的化合物，其包含式：<？在线公式描述=“在线公式”end =“lead”→> AL-CR < in-line-formula description =“In-line Formulas”end =“tail”？>其中CR是循环核心组，L是连接组，A如本文所定义。还提供了使用本发明化合物作为AKT蛋白激酶抑制剂和治疗过度增殖性疾病如癌症的方法。

4. 发明授权

US08039616B2 Benzodiazepine derivatives for treating hepatitis C infection 失效
公开(公告)号：US08039616B2
公开(公告)日：2011-10-18
申请号：US12067318
申请日：2005-09-19
申请人： Helena Dennison , Justin Warne , Keith Spencer , George Cockerill , James Lumley
发明人： Helena Dennison , Justin Warne , Keith Spencer , George Cockerill , James Lumley
IPC分类号： C07D243/12 , A61K31/55
CPC分类号： C07D243/24 , A61K31/5513
摘要： Use of a benzodiazepine of formula (I), or a pharmaceutically acceptable salt thereof, in the manufacture of a medicament for use in treating or preventing a hepatitis C infection, wherein: —R1 represents C1-6 alkyl, aryl or heteroaryl; —R2 represents hydrogen or C1-6 alkyl; —each R3 is the same or different and represents halogen, hydroxy, C1-6 alkyl, C1-6 alkoxy, C1-6 alkylthio, C1-6 haloalkyl, C1-6 haloalkoxy, amino, mono(C1-6 alkyl)amino, di(C1-6 alkyl)amino, nitro, cyano, —CO2R′, —CONR′R″, —NH—CO—R′, —S(O)R′, —S(O)2R′, —NH—S(O)2R′, —S(O)NR′R″ or —S(O)2NR′R″, wherein each R′ and R″ is the same or different and represents hydrogen or C1-6 alkyl; —n is from 0 to 3; —R4 represents hydrogen or C1-6 alkyl; —R5 represents C1-6alkyl, aryl, heteroaryl, carbocyclyl, heterocyclyl, aryl-(C1-6 alkyl)-, heteroaryl-(C1-6 alkyl)-, carbocyclyl-(C1-6 alkyl)-, heterocyclyl-(C1-6 alkyl)-, aryl-(C1-6 hydroxyalkyl)-, heteroaryl-(C1-6hydroxyalkyl)-, carbocyclyl-(C1-6 hydroxyalkyl)-, heterocyclyl-(C1-6hydroxyalkyl)-, aryl-C(O)—C(O)—, heteroaryl-C(O)—C(O)—, carbocyclyl-C(O)—C(O)—, heterocyclyl-C(O)—C(O)— or —XR6; —X represents —CO—, —S(O)— or —S(O)2—; and —R6 represents C1-6 alkyl, hydroxy, C1-6 alkoxy, C1-6 alkylthio, aryl, heteroaryl, carbocyclyl, heterocyclyl, aryl-(C1-6 alkyl)-, heteroaryl-(C1-6 alkyl)-, carbocyclyl-(C1-6 alkyl)-, heterocyclyl-(C1-6 alkyl)-, aryl-(C1-6 alkyl)-O—, heteroaryl-(C1-6 alkyl)-O—, carbocyclyl-(C1-6 alkyl)-O—, heterocyclyl-(C1-6 alkyl)-O— or —NR′R″ wherein each R′ and R″ is the same or different and represents hydrogen, C1-6 alkyl, carbocyclyl, heterocyclyl, aryl, heteroaryl, aryl-(C1-6 alkyl)-, heteroaryl-(C1-6 alkyl)-, carbocyclyl-(C1-6 alkyl)- or heterocyclyl-(C1-6 alkyl)-.

5. 发明申请

US20090318427A1 BENZODIAZEPINE DERIVATIVES FOR TREATING HEPATITIS C INFECTION 失效
公开(公告)号：US20090318427A1
公开(公告)日：2009-12-24
申请号：US12067318
申请日：2005-09-19
申请人： Helena Dennison , Justin Warne , Keith Spencer , George Cockerill , James Lumley
发明人： Helena Dennison , Justin Warne , Keith Spencer , George Cockerill , James Lumley
IPC分类号： A61K31/5513 , A61P31/12 , C07D243/24
CPC分类号： C07D243/24 , A61K31/5513
摘要： Use of a benzodiazepine of formula (I), or a pharmaceutically acceptable salt thereof, in the manufacture of a medicament for use in treating or preventing a hepatitis C infection, wherein: —R1 represents C1-6 alkyl, aryl or heteroaryl; —R2 represents hydrogen or C1-6 alkyl; —each R3 is the same or different and represents halogen, hydroxy, C1-6 alkyl, C1-6 alkoxy, C1-6 alkylthio, C1-6 haloalkyl, C1-6 haloalkoxy, amino, mono(C1-6 alkyl)amino, di(C1-6 alkyl)amino, nitro, cyano, —CO2R′, —CONR′R″, —NH—C0-R′, —S(O)R′, —S(O)2R′, —NH—S(O)2R′, —S(O)NR′R″ or —S(O)2NR′R″, wherein each R′ and R″ is the same or different and represents hydrogen or C1-6 alkyl; —n is from 0 to 3; —R4 represents hydrogen or C1-6 alkyl; —R5 represents C1-6alkyl, aryl, heteroaryl, carbocyclyl, heterocyclyl, aryl-(C1-6 alkyl)-, heteroaryl-(C1-6 alkyl)-, carbocyclyl-(C1-6 alkyl)-, heterocyclyl-(C1-6 alkyl)-, aryl-(C1-6 hydroxyalkyl)-, heteroaryl-(C1-6hydroxyalkyl)-, carbocyclyl-(C1-6 hydroxyalkyl)-, heterocyclyl-(C1-6hydroxyalkyl)-, aryl-C(O)—C(O)—, heteroaryl-C(O)—C(O)—, carbocyclyl-C(O)—C(O)—, heterocyclyl-C(O)—C(O)— or —XR6; —X represents —CO—, —S(O)— or —S(O)2—; and —R6 represents C1-6 alkyl, hydroxy, C1-6 alkoxy, C1-6 alkylthio, aryl, heteroaryl, carbocyclyl, heterocyclyl, aryl-(C1-6 alkyl)-, heteroaryl-(C1-6 alkyl)-, carbocyclyl-(C1-6 alkyl)-, heterocyclyl-(C1-6 alkyl)-, aryl-(C1-6 alkyl)-O—, heteroaryl-(C1-6 alkyl)-O—, carbocyclyl-(C1-6 alkyl)-O—, heterocyclyl-(C1-6 alkyl)-O— or —NR′R″ wherein each R′ and R″ is the same or different and represents hydrogen, C1-6 alkyl, carbocyclyl, heterocyclyl, aryl, heteroaryl, aryl-(C1-6 alkyl)-, heteroaryl-(C1-6 alkyl)-, carbocyclyl-(C1-6 alkyl)- or heterocyclyl-(C1-6 alkyl)-.

6. 发明申请

US20070297556A1 FULL FUNCTION PRECISION WELDING SYSTEM 审中-公开
标题翻译：全功能精密焊接系统
公开(公告)号：US20070297556A1
公开(公告)日：2007-12-27
申请号：US11752733
申请日：2007-05-23
申请人： Keith Spencer , Bradley Powell
发明人： Keith Spencer , Bradley Powell
IPC分类号： G21C17/00
CPC分类号： G21C17/017 , B23K9/0286 , B23K2101/06
摘要： A welding system for performing a welding process on a pipe in a confined space includes a motor housing, a weld head assembly and an insertion tube that extends between the motor housing and the weld head assembly with the weld head assembly remote from the motor housing. The motor housing is supported on a platform for rotational and translational movement of the weld head assembly and houses a motor for positioning the weld head assembly relative to the pipe. The weld head assembly includes a clamp assembly for attaching the weld head assembly to the pipe and a weld tool assembly mounted adjacent the clamp assembly for welding the pipe. An arc length gear and a travel gear adjust the distance between a torch assembly and the pipe and adjust the location of the torch assembly around the pipe when the weld head assembly is attached to the pipe.
摘要翻译：用于在密闭空间中的管子上执行焊接过程的焊接系统包括马达壳体，焊接头组件和插入管，其在马达壳体和焊接头组件之间延伸，焊头组件远离马达壳体。电动机壳体支撑在用于焊头组件的旋转和平移运动的平台上，并且容纳用于相对于管定位焊头组件的电动机。焊头组件包括用于将焊接头组件附接到管道的夹具组件和邻近夹具组件安装以焊接管道的焊接工具组件。电弧长度齿轮和行走齿轮调节焊枪组件和管道之间的距离，并且当焊头组件附接到管道时调整焊枪组件在管道周围的位置。

7. 发明申请

US20050070546A1 Tyrosine kinase inhibitors 失效
公开(公告)号：US20050070546A1
公开(公告)日：2005-03-31
申请号：US10489594
申请日：2002-09-10
申请人： Kenneth Arrington , Mark Fraley , Barbara Hanney , Yuntae Kim , Keith Spencer
发明人： Kenneth Arrington , Mark Fraley , Barbara Hanney , Yuntae Kim , Keith Spencer
IPC分类号： A61K31/519 , A61P9/10 , A61P35/00 , C07D401/14 , C07D403/04 , C07D403/14 , C07D471/04 , C07D487/02 , C07D487/04
CPC分类号： C07D401/14 , C07D401/04 , C07D403/04 , C07D403/14 , C07D471/04 , C07D487/04
摘要： The present invention relates to compounds which inhibit, regulate and/or modulate tyrosine kinase signal transduction, compositions which contain these compounds, and methods of using them to treat tyrosine kinase-dependent diseases and conditions, such as angiogenesis, cancer, tumor growth, atherosclerosis, age related macular degeneration, diabetic retinopathy, inflammatory diseases, and the like in mammals.

8. 发明申请

US20060036098A1 Carbonylamino-benzimidazole derivatives as androgen receptor modulators 失效
公开(公告)号：US20060036098A1
公开(公告)日：2006-02-16
申请号：US10533259
申请日：2003-10-28
申请人： Yuntae Kim , Barbara Hanney , Mark Duggan , Keith Spencer
发明人： Yuntae Kim , Barbara Hanney , Mark Duggan , Keith Spencer
IPC分类号： C07D403/02 , A61K31/4184
CPC分类号： C07D417/04 , C07D401/04 , C07D403/04 , C07D417/14
摘要： Compounds of structural formula (I) are modulators of the androgen receptor (AR) in a tissue selective manner. They are useful as agonists of the androgen receptor in bone and/or muscle tissue while antagonizing the AR in the prostate of a male patient or in the uterus of a female patient. These compounds are therefore useful in the enhancement of weakened muscle tone and the treatment of conditions caused by androgen deficiency or which can be ameliorated by androgen administration, including osteoporosis, osteopenia, glucocorticoid-induced osteoporosis, periodontal disease, bone fracture, bone damage following bone reconstructive surgery, sarcopenia, frailty, aging skin, male hypogonadism, postmenopausal symptoms in women, atherosclerosis, hypercholesterolemia, hyperlipidemia, obesity, aplastic anemia and other hematopoietic disorders, arthritic condition and joint repair, HIV-wasting, prostate cancer, cancer cachexia, Alzheimer s disease, muscular dystrophies, premature ovarian failure, and autoimmune disease, alone or in combination with other active agents.

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