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1. 发明申请

US20090192155A1 Identification of Compounds Suitable for Treating Ad 审中-公开
标题翻译：鉴定适用于治疗广告的化合物
公开(公告)号：US20090192155A1
公开(公告)日：2009-07-30
申请号：US12223360
申请日：2007-01-30
申请人： Ian Churcher , Peter Hunt , Carmel Nanthakumar , Peter Simpson
发明人： Ian Churcher , Peter Hunt , Carmel Nanthakumar , Peter Simpson
IPC分类号： A61K31/5377 , C12Q1/48 , A61K31/496 , A61P25/28
CPC分类号： G01N33/6896 , A61K31/40 , C12Q1/485 , G01N2500/00 , G01N2800/2821
摘要： The invention provides a method of screening for compounds which inhibit the hyperphosphorylation of tau, and hence are suitable for treating AD and related conditions.
摘要翻译：本发明提供一种筛选抑制tau高度磷酸化的化合物的方法，因此适用于治疗AD和相关病症。

2. 发明申请

US20090247504A1 Indazole Derivatives for Treatment of Alzheimer's Disease 审中-公开
标题翻译：用于治疗阿尔茨海默病的吲唑衍生物
公开(公告)号：US20090247504A1
公开(公告)日：2009-10-01
申请号：US12223415
申请日：2007-02-02
申请人： Ian Churcher , Hedaythul Choudhury , Neil Wilkie , Peter Hunt , Richard Jelley , Alan Nadin , Carmel Nanthakumar , Peter Simpson
发明人： Ian Churcher , Hedaythul Choudhury , Neil Wilkie , Peter Hunt , Richard Jelley , Alan Nadin , Carmel Nanthakumar , Peter Simpson
IPC分类号： A61K31/416 , A61K31/5377 , A61K31/397 , C07D231/56 , C07D413/14 , A61P25/28
CPC分类号： A61K31/416 , A61K31/4439 , A61K31/454 , A61K31/5377 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D487/04 , C07D487/10
摘要： Compounds of formula (IA) and (IB) are inhibitors of MARK, and hence are suitable for treatment of Alzheimer's disease.
摘要翻译：式（IA）和（IB）的化合物是MARK的抑制剂，因此适用于治疗阿尔茨海默氏病。

3. 发明授权

US09579053B2 Dual electrode system for a continuous analyte sensor 有权
标题翻译：用于连续分析物传感器的双电极系统
公开(公告)号：US09579053B2
公开(公告)日：2017-02-28
申请号：US12748024
申请日：2010-03-26
申请人： Mark Brister , James R. Petisce , Peter Simpson
发明人： Mark Brister , James R. Petisce , Peter Simpson
IPC分类号： A61B5/05 , A61B5/1495 , A61B5/145 , A61B5/1486 , A61B5/00
CPC分类号： A61B5/14865 , A61B5/14532 , A61B5/1495 , A61B5/7203 , A61B5/742 , A61B2560/0223 , B33Y70/00 , B33Y80/00
摘要： Disclosed herein are systems and methods for a continuous analyte sensor, such as a continuous glucose sensor. One such system utilizes first and second working electrodes to measure additional analyte or non-analyte related signal. Such measurements may provide a background and/or sensitivity measurement(s) for use in processing sensor data and may be used to trigger events such as digital filtering of data or suspending display of data.
摘要翻译：本文公开了用于连续分析物传感器（例如连续葡萄糖传感器）的系统和方法。一个这样的系统利用第一和第二工作电极来测量附加分析物或非分析物相关信号。这样的测量可以提供用于处理传感器数据的背景和/或灵敏度测量，并且可以用于触发诸如数据的数字滤波或暂停显示数据的事件。

4. 发明授权

US08968281B2 Handholdable laser device featuring sensor for eye safe activation 有权
标题翻译：可手持激光装置，具有用于眼睛安全激活的传感器
公开(公告)号：US08968281B2
公开(公告)日：2015-03-03
申请号：US13413747
申请日：2012-03-07
申请人： Srinivasan Krishnan , Peter Simpson , Thomas Gerard Parent , Xiaomin Yan
发明人： Srinivasan Krishnan , Peter Simpson , Thomas Gerard Parent , Xiaomin Yan
IPC分类号： A61B18/20 , A61N5/06 , A61B17/00 , A61B18/00 , A61B19/00 , A61N5/067
CPC分类号： A61N5/0616 , A61B18/203 , A61B2017/00734 , A61B2018/00684 , A61B2018/00875 , A61B2018/202 , A61B2090/065 , A61N2005/0633 , A61N2005/0644 , A61N2005/0659 , A61N2005/067
摘要： A laser device for treating skin is provided which includes a handholdable housing; a laser member arranged within the housing emitting an output beam; a capacitance sensor arranged at the first end of the housing which includes a plate surrounding and defining a window through which the output beam exits, the plate having at least three segments with each flexibly movable in and out of a common plane, each of the segments being connected to an electrode, the electrodes operating to determine dielectric constants of a skin surface; a signal and control storage device communicating with the sensor comparing input signals of measured dielectric constant values to a stored standard dielectric constant value, and wherein emission of the output beam is activated to fire only when all of the at least three segments align in a plane and sense the stored standard dielectric constant value.
摘要翻译：提供一种用于治疗皮肤的激光装置，其包括可手持的外壳; 布置在所述壳体内的发射输出光束的激光部件; 布置在壳体的第一端处的电容传感器，其包括围绕并限定输出光束离开的窗口的板，该板具有至少三个段，每个段可柔性地移入和移出公共平面，每个段连接到电极，所述电极用于确定皮肤表面的介电常数; 与所述传感器通信的信号和控制存储装置，将测量的介电常数值的输入信号与存储的标准介电常数值进行比较，并且其中，当所有所述至少三个片段在平面中对齐时，所述输出光束的发射被激活并感测存储的标准介电常数值。

5. 发明授权

US08532730B2 Analyte sensor 有权
标题翻译：分析物传感器
公开(公告)号：US08532730B2
公开(公告)日：2013-09-10
申请号：US11543404
申请日：2006-10-04
申请人： Mark Brister , Peter Simpson
发明人： Mark Brister , Peter Simpson
IPC分类号： A61B5/05
CPC分类号： A61B5/14532 , A61B5/14542 , A61B5/14546 , A61B5/1473 , A61B5/14865 , A61B5/1495 , A61B5/412 , A61B5/6848 , A61B5/6849 , A61B2560/0223 , A61M5/14 , A61M5/16804 , A61M5/1723 , A61M2230/201
摘要： Systems and methods of use for continuous analyte measurement of a host's vascular system are provided. In some embodiments, a continuous glucose measurement system includes a vascular access device, a sensor and sensor electronics, the system being configured for insertion into a host's peripheral vein or artery.
摘要翻译：提供了用于宿主血管系统的连续分析物测量的系统和方法。在一些实施例中，连续葡萄糖测量系统包括血管通路装置，传感器和传感器电子装置，所述系统被配置为插入宿主的外周静脉或动脉。

6. 发明申请

US20090188361A1 CUTTING TOOLS 有权
标题翻译：切割工具
公开(公告)号：US20090188361A1
公开(公告)日：2009-07-30
申请号：US12042438
申请日：2008-03-05
申请人： Peter Simpson , Rainer Glauning
发明人： Peter Simpson , Rainer Glauning
IPC分类号： B26D5/00
CPC分类号： A01G3/053 , A01D34/135 , A01D34/30 , A01D34/37 , A01D34/408 , A01G2003/0461 , Y10T83/525 , Y10T83/536
摘要： The present invention relates to cutting tools, in particular, to control systems for cutters such as vegetation cutters, especially hedge cutters or trimmers (10). Hedge cutters (10) frequently suffer in use from a problem of blocked cutting blades when they encounter a twig or branch whose size or density exceeds the capacity of the blades. We describe a vegetation cutting apparatus (10) having a plurality of cutting blades (11,12), at least one of which blades (11,12) is drivable by means of an electric motor. At least one driven blade (11,12) is movable between two predefined points of maximum travel. The apparatus (10) comprises a control means which causes a change of direction in the movement of the at least one movable blade at a point intermediate the points of maximum travel in response to an event sensed by the control means.
摘要翻译：技术领域本发明涉及切割工具，特别涉及用于诸如植被切割器，特别是树篱刀或修剪器（10）的切割器的控制系统。冲锋刀（10）经常遭受使用中的切割刀片的问题，当它们遇到尺寸或密度超过刀片容量的枝条或枝条时。我们描述具有多个切割刀片（11,12）的植被切割设备（10），其中至少一个刀片（11,12）可以通过电动机驱动。至少一个从动叶片（11,12）可在两个预定的最大行程点之间移动。装置（10）包括控制装置，其响应于由控制装置感测到的事件，使至少一个可动刀片在最大行程点之间的点处的移动方向发生变化。

7. 发明授权

US07467003B2 Dual electrode system for a continuous analyte sensor 有权
公开(公告)号：US07467003B2
公开(公告)日：2008-12-16
申请号：US11543539
申请日：2006-10-04
申请人： Mark Brister , James R. Petisce , Peter Simpson
发明人： Mark Brister , James R. Petisce , Peter Simpson
IPC分类号： A61B5/00
CPC分类号： A61B5/14865 , A61B5/14532 , A61B5/6848
摘要： Disclosed herein are systems and methods for a continuous analyte sensor, such as a continuous glucose sensor. One such system utilizes first and second working electrodes to measure additional analyte or non-analyte related signal. Such measurements may provide a background and/or sensitivity measurement(s) for use in processing sensor data and may be used to trigger events such as digital filtering of data or suspending display of data.

8. 发明申请

US20070027385A1 Dual electrode system for a continuous analyte sensor 有权
公开(公告)号：US20070027385A1
公开(公告)日：2007-02-01
申请号：US11543707
申请日：2006-10-04
申请人： Mark Brister , Sean Saint , James Petisce , Curtis Hanson , Peter Simpson , Jack Pryor
发明人： Mark Brister , Sean Saint , James Petisce , Curtis Hanson , Peter Simpson , Jack Pryor
IPC分类号： A61B5/00 , A61B5/05
CPC分类号： A61B5/14532 , A61B5/14865 , A61B5/1495 , A61B5/6848 , A61B5/7203 , A61B2560/0223
摘要： Disclosed herein are systems and methods for a continuous analyte sensor, such as a continuous glucose sensor. One such system utilizes first and second working electrodes to measure additional analyte or non-analyte related signal. Such measurements may provide a background and/or sensitivity measurement(s) for use in processing sensor data and may be used to trigger events such as digital filtering of data or suspending display of data.

9. 发明申请

US20060200019A1 Oxygen enhancing membrane systems for implantable devices 有权
标题翻译：用于可植入装置的氧增强膜系统
公开(公告)号：US20060200019A1
公开(公告)日：2006-09-07
申请号：US11410392
申请日：2006-04-25
申请人： James Petisce , Mark Tapsak , Peter Simpson , Victoria Carr-Brendel , James Brauker
发明人： James Petisce , Mark Tapsak , Peter Simpson , Victoria Carr-Brendel , James Brauker
IPC分类号： A61B5/05 , C12Q1/00 , G01N33/487
CPC分类号： A61B5/1473 , A61B5/145 , A61B5/14503 , A61B5/14532 , A61B5/14546 , A61B5/1468 , A61B5/14735 , A61B5/14865
摘要： The present invention relates generally to systems and methods for increasing oxygen availability to implantable devices. The preferred embodiments provide a membrane system configured to provide protection of the device from the biological environment and/or a catalyst for enabling an enzymatic reaction, wherein the membrane system includes a polymer formed from a high oxygen soluble material. The high oxygen soluble polymer material is disposed adjacent to an oxygen-utilizing source on the implantable device so as to dynamically retain high oxygen availability to the oxygen-utilizing source during oxygen deficits. Membrane systems of the preferred embodiments are useful for implantable devices with oxygen-utilizing sources and/or that function in low oxygen environments, such as enzyme-based electrochemical sensors and cell transplantation devices.
摘要翻译：本发明一般涉及用于增加可植入装置的氧气可用性的系统和方法。优选的实施方案提供了一种膜系统，其被配置为提供该装置与生物环境的保护和/或用于实现酶反应的催化剂，其中所述膜系统包括由高氧可溶性材料形成的聚合物。高氧可溶性聚合物材料与可植入装置上的氧气源相邻设置，以便在缺氧期间动态地保持氧利用源的高氧可利用性。优选实施方案的膜系统对于具有氧利用源的可植入装置和/或在低氧环境中起作用，例如基于酶的电化学传感器和细胞移植装置是有用的。

10. 发明申请

US20050115832A1 Electrode systems for electrochemical sensors 有权
标题翻译：电化学传感器用电极系统
公开(公告)号：US20050115832A1
公开(公告)日：2005-06-02
申请号：US10897312
申请日：2004-07-21
申请人： Peter Simpson , James Petisce , Victoria Carr-Brendel , James Brauker
发明人： Peter Simpson , James Petisce , Victoria Carr-Brendel , James Brauker
IPC分类号： G01N20060101 , G01N27/26 , G01N27/416
CPC分类号： G01N27/3274 , A61B5/14532 , A61B5/14865 , C12Q1/001
摘要： The present invention relates generally to systems and methods for improved electrochemical measurement of analytes. The preferred embodiments employ electrode systems including an analyte-measuring electrode for measuring the analyte or the product of an enzyme reaction with the analyte and an auxiliary electrode configured to generate oxygen and/or reduce electrochemical interferants. Oxygen generation by the auxiliary electrode advantageously improves oxygen availability to the enzyme and/or counter electrode; thereby enabling the electrochemical sensors of the preferred embodiments to function even during ischemic conditions. Interferant modification by the auxiliary electrode advantageously renders them substantially non-reactive at the analyte-measuring electrode, thereby reducing or eliminating inaccuracies in the analyte signal due to electrochemical interferants.
摘要翻译：本发明一般涉及用于改进分析物的电化学测量的系统和方法。优选实施例采用电极系统，包括用于测量被分析物的分析物测量电极或与分析物的酶反应的产物以及被配置为产生氧和/或减少电化学干扰剂的辅助电极。通过辅助电极产生氧气有利地提高了对酶和/或对电极的氧气可利用性; 从而使得优选实施例的电化学传感器能够在缺血状况下起作用。通过辅助电极的干扰修饰有利地使得它们在分析物 - 测量电极处基本上不反应，从而减少或消除由于电化学干扰剂引起的分析物信号的不准确性。

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