专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US06831097B2 2,3-diaryl-pyrazolo[1,5-B]pyridazines derivatives, their preparation and their use as cyclooxygenase 2 (COX-2) inhibitors 失效
标题翻译： 2,3-二芳基 - 吡唑并[1,5-B]哒嗪衍生物，它们的制备及其作为环加氧酶2（COX-2）抑制剂的用途
公开(公告)号：US06831097B2
公开(公告)日：2004-12-14
申请号：US10212514
申请日：2002-08-05
申请人： Paul John Beswick , Ian Baxter Campbell , Neil Mathews , Alan Naylor
发明人： Paul John Beswick , Ian Baxter Campbell , Neil Mathews , Alan Naylor
IPC分类号： A61K315025
CPC分类号： C07D487/04 , A61K31/50 , Y02P20/55
摘要： The invention provides the compounds of formula (I) and pharmaceutically acceptable derivatives thereof in which: R0 is halogen, C1-6alkyl, C1-6alkoxy, C1-6alkoxy substituted by one or more fluorine atoms, or O(CH2)nNR4R5; R1 and R2 are independently selected from H, C1-6alkyl, C1-6alkyl substituted by one or more fluorine atoms, C1-6alkoxy, C1-6hydroxyalkyl, SC1-6alkyl, C(O)H, C(O)C1-6alkyl, C1-6alkylsulphonyl, C1-6alkoxy substituted by one or more fluorine atoms, O(CH2)nCO2C1-6alkyl, O(CH2)nSC1-6alkyl, (CH2)nNR4R5, (CH2)nSC1-6alkyl or C(O)NR4R5; with the proviso that when R0 is at the 4-position and is halogen, at least one of R1 and R2 is C1-6alkylsulphonyl, C1-6alkoxy substituted by one or more fluorine atoms, O(CH2)nCO2C1-6alkyl, O(CH2)nSC1-6alkyl, (CH2)nNR4R5 or (CH2)nSC1-6alkyl, C(O)NR4R5; R3 is C1-6alkyl or NH2; R4 and R5 are independently selected from H, or C1-6alkyl or, together with the nitrogen atom to which they are attached, form a 4-8 membered saturated ring; and n is 1-4. Compounds of formula (I) are potent and selective inhibitors of COX-2 and are of use in the treatment of the pain, fever, inflammation of a variety of conditions and diseases.
摘要翻译：本发明提供式（I）化合物及其药学上可接受的衍生物，其中：R 0是卤素，C 1-6烷基，C 1-6烷氧基，被一个或多个氟原子取代的C 1-6烷氧基或O（CH 2）n NR R 5和R 2独立地选自H，C 1-6烷基，被一个或多个氟原子取代的C 1-6烷基，C 1-6烷氧基，C 1-6羟烷基，SC 1-6烷基， C（O）H，C（O）C 1-6烷基，C 1-6烷基磺酰基，被一个或多个氟原子取代的C 1-6烷氧基，O（CH 2）n CO 2 C 1-6烷基，O（CH 2）nSC 1-6烷基，（CH 2）n NR R 5，（CH 2）nSC 1-6烷基或C（O）NR 4 R 5; 条件是当R 0在4-位且是卤素时，R 1和R 2中的至少一个是C 1-6烷基磺酰基，被一个或多个氟原子取代的C 1-6烷氧基，O（ O（CH 2）n C 1-6烷基，（CH 2）n NR 4 R 5或（CH 2）nSC 1-6烷基，C（O）NR 4 R 5; R 3，是C 1-6烷基或NH 2; R 4和R 5独立地选自H或C 1-6烷基，或与它们所连接的氮原子一起形成4-8元饱和环; 而且是1-4.式（I）的化合物是COX-2的有效和选择性抑制剂，并且可用于治疗疼痛，发热，各种病症和疾病的炎症。

2. 发明授权

US06498166B1 Pyrazolopyridines 失效
标题翻译：吡唑并吡啶类
公开(公告)号：US06498166B1
公开(公告)日：2002-12-24
申请号：US09890925
申请日：2001-08-30
申请人： Ian Baxter Campbell , Paul Francis Lambeth , Alan Naylor , Neil Anthony Pegg
发明人： Ian Baxter Campbell , Paul Francis Lambeth , Alan Naylor , Neil Anthony Pegg
IPC分类号： A61K31437
CPC分类号： C07D471/04
摘要： The invention provides the compounds of formula (I) wherein: R0 and R1 are independently selected from H, halogen, C1-6alkyl, C1-6alkoxy, or C1-6alkoxy substituted by one or more fluorine atoms; R2 is halogen, CN, CONR4R5, CO2H, CO2C1-6alkyl, or NHSO2R4; R3 is C1-6alkyl or NH2; and R4 and R5 are independently selected from H, C1-6alkyl, phenyl, phenyl substituted by one or more atoms or groups (selected from halogen, C1-6alkyl, C1-6alkoxy, or C1-6alkoxy substituted by one or more fluorine atoms), or together with the nitrogen atom to which they are attached form a saturated 4 to 8 membered ring; and pharmaceutically acceptable derivatives thereof. Compounds of formula (I) are potent and selective inhibitors of COX-2 and are of use in the treatment of the pain, fever, inflammation of a variety of conditions and diseases.
摘要翻译：本发明提供式（I）化合物，其中：R 0和R 1独立地选自H，卤素，C 1-6烷基，C 1-6烷氧基或被一个或多个氟原子取代的C 1-6烷氧基; R 2是卤素，CN，CONR 4 R 5 ，CO 2 H，CO 2 C 1-6烷基或NHSO 2 R 4; R 3是C 1-6烷基或NH 2; R 4和R 5独立地选自H，C 1-6烷基，苯基，被一个或多个原子或基团取代的苯基（选自卤素，C 1-6烷基，C 1-6烷氧基或被一个或多个氟原子取代的C 1-6烷氧基），或与它们所连接的氮原子一起形成饱和的4至8元环; 其药学上可接受的衍生物。式（I）化合物是COX-2的有效和选择性抑制剂，可用于治疗疼痛，发热，多种病症和疾病的炎症。

3. 发明授权

US06451794B1 2,3-Diaryl-pyrazolo[1,5-b]pyridazines derivatives, their preparation and their use as cyclooxygenase 2(COX-2) inhibitors 失效
标题翻译： 2,3-二芳基 - 吡唑并[1,5-b]哒嗪衍生物，其制备及其作为环氧合酶2（COX-2）抑制剂的用途
公开(公告)号：US06451794B1
公开(公告)日：2002-09-17
申请号：US09508029
申请日：2000-06-13
申请人： Paul John Beswick , Ian Baxter Campbell , Neil Mathews , Alan Naylor
发明人： Paul John Beswick , Ian Baxter Campbell , Neil Mathews , Alan Naylor
IPC分类号： A61K314985
CPC分类号： C07D487/04 , A61K31/50 , Y02P20/55
摘要： The invention provides the compounds of formula (I) and pharmaceutically acceptable derivatives thereof in which: R0 is halogen, C1-6alkyl, C1-6alkoxy, C1-6alkoxy substituted by one or more fluorine atoms, or O(CH2)nNR4R5; R1 and R2 are independently selected from H, C1-6alkyl, C1-6alkyl, substituted by one or more fluorine atoms, C1-6alkoxy, C1-6hydroxyalkyl, SC1-6alkyl, C(O)H, C(O)C1-6alkyl, C1-6alkylsulphonyl, C1-6alkoxy substituted by one or more fluorine atoms, O(CH2)nCO2C1-6alkyl, O(CH2)nSC1-6alkyl, (CH2)nNR4R5, (CH2)nSC1-6alkyl or C(O)NR4R5; with the proviso that when R0 is at the 4-position and is halogen, at least one of R1 and R2 is C1-6alkylsulphonyl, C1-6alkoxy substituted by one or more fluorine atoms, O(CH2)nCO2C1-6alkyl, O(CH2)nSC1-6alkyl, (CH2)nNR4R5 or (CH2)nSC1-6alkyl, C(O)NR4R5; R3 is C1-6alkyl or NH2; R4 and R5 are independently selected from H, or C1-6alkyl or, together with the nitrogen atom to which they are attached, form a 4-8 membered saturated ring; and n is 1-4. Compounds of formula (I) are potent and selective inhibitors of COX-2 and are of use in the treatment of the pain, fever, inflammation of a variety of conditions and diseases.
摘要翻译：本发明提供式（I）化合物及其药学上可接受的衍生物，其中：R 0是卤素，C 1-6烷基，C 1-6烷氧基，被一个或多个氟原子取代的C 1-6烷氧基或O（CH 2）n NR 4 R 5; R 1和R 2独立地选自被一个或多个氟原子取代的H，C 1-6烷基，C 1-6烷基，C 1-6烷氧基，C 1-6羟烷基，SC 1-6烷基，C（O）H，C（O）C 1-6烷基（C 1-6烷基磺酰基），被一个或多个氟原子取代的C 1-6烷氧基，O（CH 2）n CO 2 C 1-6烷基，O（CH 2）nSC 1-6烷基，（CH 2）n NR 4 R 5，（CH 2）nSC 1-6烷基或C（O）NR 4 R 5; 条件是当R 0在4-位且是卤素时，R 1和R 2中的至少一个是C 1-6烷基磺酰基，被一个或多个氟原子取代的C 1-6烷氧基，O（CH 2）n CO 2 C 1-6烷基，O（CH 2））nSC1-6烷基，（CH2）nNR4R5或（CH2）nSC1-6烷基，C（O）NR4R5; R3是C1-6烷基或NH2; R 4和R 5独立地选自H或C 1-6烷基，或与它们所连接的氮原子一起形成4-8元饱和环; n为1-4。式（I）化合物是COX-2的有效和选择性抑制剂，可用于治疗疼痛，发热，各种病症和疾病的炎症。

4. 发明授权

US07223772B1 Pyrazolopyridine derivatives as selective cox-2 inhibitors 失效
标题翻译：吡唑并吡啶衍生物作为选择性cox-2抑制剂
公开(公告)号：US07223772B1
公开(公告)日：2007-05-29
申请号：US09830836
申请日：1999-11-01
申请人： Ian Baxter Campbell , Alan Naylor
发明人： Ian Baxter Campbell , Alan Naylor
IPC分类号： A61K31/415 , A61K31/44 , C07D231/56 , C07D471/02
CPC分类号： C07D471/04
摘要： The invention provides the compounds of formula (I) and pharmaceutically acceptable derivatives thereof wherein: R0 and R1 are independently selected from the group consisting of H, halogen, C1-6alkyl, C1-6alkoxy, and C1-6alkoxy substituted by one or more fluorine atoms; R2 is selected from the group consisting of H, C1-6alkyl, C1-6alkyl substituted by one or more fluorine atoms, C1-6alkoxy, C1-6hydroxyalkyl, SC1-6alkyl, C(O)H, C(O)C1-6alkyl, C1-6alkylsulphonyl, and C1-6alkoxy substituted by one or more fluorine atoms; and R3 is C1-6alkyl or NH2. Compounds of formula (I) are potent and selective inhibitors of COX-2 and are of use in the treatment of the pain, fever, inflammation of a variety of conditions and diseases.
摘要翻译：本发明提供式（I）化合物及其药学上可接受的衍生物，其中：R 0和R 1独立地选自H，卤素， C 1-6烷基，C 1-6烷氧基和被一个或多个氟原子取代的C 1-6烷氧基; R 2选自H，C 1-6烷基，被一个或多个氟原子取代的C 1-6烷基，C 1-6烷氧基，C 1-6 1-6烷基，C 1-6烷基，C（O）H，C（O） C 1-6烷基，C 1-6烷基磺酰基和被一个或多个氟原子取代的C 1-6烷氧基; R 3是C 1-6烷基或NH 2。式（I）化合物是COX-2的有效和选择性抑制剂，可用于治疗疼痛，发热，各种病症和疾病的炎症。

5. 发明授权

US06861429B2 2,3-diaryl-pyrazolo[1,5-b]pyridazines derivatives, their preparation and their use as cyclooxygenase 2 (COX-2) inhibitors 失效
标题翻译： 2,3-二芳基 - 吡唑并[1,5-b]哒嗪衍生物，其制备及其作为环加氧酶2（COX-2）抑制剂的用途
公开(公告)号：US06861429B2
公开(公告)日：2005-03-01
申请号：US10212513
申请日：2002-08-05
申请人： Paul John Beswick , Charanjit Bountra , Ian Baxter Campbell , Neil Matthews , Alan Naylor
发明人： Paul John Beswick , Charanjit Bountra , Ian Baxter Campbell , Neil Matthews , Alan Naylor
IPC分类号： A61K31/00 , A61K31/50 , A61K31/5025 , A61P1/04 , A61P3/10 , A61P7/06 , A61P9/00 , A61P11/00 , A61P11/06 , A61P17/00 , A61P17/02 , A61P19/02 , A61P19/06 , A61P25/06 , A61P25/16 , A61P25/28 , A61P27/02 , A61P27/16 , A61P29/00 , A61P35/00 , C07D487/04 , A61K31/4985
CPC分类号： C07D487/04 , A61K31/50 , Y02P20/55
摘要： The invention provides a pharmaceutical composition comprising a compound of formula (I) or a pharmaceutically acceptable salt, solvate, ester or salt or solvate of such ester, of a compound of formula (I) in which: R0 is halogen, C1-6alkyl, C1-6alkoxy, C1-6alkoxy substituted by one or more fluorine atoms, or O(CH2)nNR4R5; R1 and R2 are independently selected from H, C1-6alkyl, C1-6alkyl substituted by one or more fluorine atoms, C1-6alkoxy, C1-6hydroxyalkyl, SC1-6alkyl, C(O)H, C(O)C1-6alkyl, C1-6alkylsulphonyl, C1-6alkoxy substituted by one or more fluorine atoms, O(CH2)nCO2C1-6alkyl, O(CH2)nSC1-6alkyl, (CH2)nNR4R5, (CH2)nSC1-6alkyl or C(O)NR4R5; with the proviso that when R0 is at the 4-position and is halogen, at least one of R1 and R2 is C1-6alkylsulphonyl, C1-6alkoxy substituted by one or more fluorine atoms, O(CH2)nCO2C1-6alkyl, O(CH2)nSC1-6alkyl, (CH2)nNR4R5 or (CH2)nSC1-6alkyl, C(O)NR4R5; R3 is C1-6alkyl or NH2; R4 and R5 are independently selected from H and C1-6alkyl or, together with the nitrogen atom to which they are attached, form a 4-8 membered saturated ring; and n is 1-4; and a sodium channel inhibitor.
摘要翻译：本发明提供包含式（I）化合物或其药学上可接受的盐，溶剂化物，酯或盐或溶剂合物的药物组合物，其中：R 0是卤素，C1 1-6烷基，C 1-6烷氧基，被一个或多个氟原子取代的C 1-6烷氧基，或O（CH 2）n NR 4 R 5; R 1和R 2独立地选自H，C 1-6烷基被一个或多个氟原子取代的C 1-6烷基，C 1-6烷氧基，C 1-6羟烷基，SC 1-6烷基，C（O）H，C（O）C 1-6烷基，C 1-6烷基磺酰基，被一个或多个氟原子，O（CH 2）n CO 2 C 1-6烷基，O（CH 2）nSC 1-6烷基，（CH 2）n NR 4 R 5，（CH 2）nSC 1-6烷基或C（O）NR 4 R 5 ; 条件是当R 0在4-位且是卤素时，R 1和R 2中的至少一个是C 1-6烷基磺酰基，被一个或多个氟原子取代的C 1-6烷氧基，O（ O（CH 2）n C 1-6烷基，（CH 2）n NR 4 R 5或（CH 2）nSC 1-6烷基，C（O）NR 4 R 5; R 3，是C 1-6烷基或NH 2; R 4和R 5独立地选自H和C 1-6烷基，或与它们所连接的氮原子一起形成4-8元饱和环; 和n为1-4;和钠通道抑制剂。

6. 发明申请

US20110245310A1 Novel Compounds 失效
标题翻译：新型化合物
公开(公告)号：US20110245310A1
公开(公告)日：2011-10-06
申请号：US13133738
申请日：2009-12-16
申请人： Ian Baxter Campbell , Simon Peace , John Martin Pritchard , Daniel Tape , Robert Charles Wheeler
发明人： Ian Baxter Campbell , Simon Peace , John Martin Pritchard , Daniel Tape , Robert Charles Wheeler
IPC分类号： A61K31/4184 , C07D235/02 , C07D235/08 , A61P37/08 , A61P11/06 , A61P11/02
CPC分类号： C07D235/02
摘要： The present invention relates to compounds of formula (I): or pharmaceutically acceptable salts or solvates thereof, processes for their preparation, pharmaceutical compositions containing these compounds, and their use in the treatment of allergic disorders, such as allergic rhinitis and asthma.
摘要翻译：本发明涉及式（I）化合物或其药学上可接受的盐或溶剂合物，其制备方法，含有这些化合物的药物组合物及其在治疗过敏性疾病如过敏性鼻炎和哮喘中的用途。

7. 发明授权

US08399444B2 Bicyclic imidazole as DP1 receptor antagonists 失效
标题翻译：双环咪唑作为DP1受体拮抗剂
公开(公告)号：US08399444B2
公开(公告)日：2013-03-19
申请号：US13133738
申请日：2009-12-16
申请人： Ian Baxter Campbell , Simon Peace , John Martin Pritchard , Daniel Tape , Robert Charles Wheeler
发明人： Ian Baxter Campbell , Simon Peace , John Martin Pritchard , Daniel Tape , Robert Charles Wheeler
IPC分类号： A01N43/00 , A61K31/33
CPC分类号： C07D235/02
摘要： The present invention relates to compounds of formula (I): or pharmaceutically acceptable salts or solvates thereof, processes for their preparation, pharmaceutical compositions containing these compounds, and their use in the treatment of allergic disorders, such as allergic rhinitis and asthma.
摘要翻译：本发明涉及式（I）化合物或其药学上可接受的盐或溶剂合物，其制备方法，含有这些化合物的药物组合物及其在治疗过敏性疾病如过敏性鼻炎和哮喘中的用途。

8. 发明授权

US08247377B2 Non-steroidal glucocorticoid inhibitors and their use in treating inflammation, allergy and auto-immune conditions 有权
标题翻译：非类固醇糖皮质激素抑制剂及其在治疗炎症，过敏和自身免疫条件方面的应用
公开(公告)号：US08247377B2
公开(公告)日：2012-08-21
申请号：US12303791
申请日：2007-06-11
申请人： Heather Anne Barnett , Ian Baxter Campbell , Diane Mary Coe , Anthony William James Cooper , Graham George Adam Inglis , Haydn Terence Jones , Steven Philip Keeling , Simon John Fawcett MacDonald , Iain McFarlane McLay , Philip Alan Skone , Gordon Gad Weingarten , James Michael Woolven
发明人： Heather Anne Barnett , Ian Baxter Campbell , Diane Mary Coe , Anthony William James Cooper , Graham George Adam Inglis , Haydn Terence Jones , Steven Philip Keeling , Simon John Fawcett MacDonald , Iain McFarlane McLay , Philip Alan Skone , Gordon Gad Weingarten , James Michael Woolven
IPC分类号： A61K31/44 , A61K31/40 , A61P23/00
CPC分类号： C07D231/38
摘要： The present invention provides compounds of formula (I): a process for their preparation, to pharmaceutical compositions comprising the compounds and the preparation of said compositions, to intermediates and to use of the compounds for the manufacture of a medicament for therapeutic treatment, particularly for the treatment of inflammation, allergy and/or autoimmune conditions.
摘要翻译：本发明提供式（I）化合物：其制备方法，包含所述化合物的药物组合物和所述组合物的制备，中间体和用于制备用于治疗性治疗的药物的用途，特别是治疗炎症，过敏和/或自身免疫病症。

9. 发明授权

US06177419B1 Bipyridine manganese complexes 失效
标题翻译：联吡啶锰络合物
公开(公告)号：US06177419B1
公开(公告)日：2001-01-23
申请号：US09376044
申请日：1999-08-17
申请人： Ian Baxter Campbell , Ann Louise Walker , Philip Charles Box , Gerard Martin Paul Giblin , George Edward Tranter
发明人： Ian Baxter Campbell , Ann Louise Walker , Philip Charles Box , Gerard Martin Paul Giblin , George Edward Tranter
IPC分类号： A61K3133
CPC分类号： C07D213/53 , A61K33/32 , C07F5/04 , C07F13/005
摘要： Compounds and methods of preparing compounds represented by structural formula (I): wherein X represents any suitable counter-anion; R1 and R2 independently represent hydrogen, C1-6 alkoxy or nitro; R3, R4, R5 and R6 each independently represents hydrogen, hydroxy, halo, C1-6 alkyl, C2-6 alkenyl or C1-6 alkoxy; and R7, R8, R9 and R10 each independently represents hydrogen, hydroxy, halo, C1-6 alkyl, C2-6 alkenyl or C1-6 alkoxy. Compounds represented by structural formula (I) are useful in treating or preventing free radical-associated diseases or conditions in mammals.
摘要翻译：制备由结构式（I）表示的化合物的化合物和方法：其中X表示任何合适的抗衡阴离子; R 1和R 2独立地表示氢，C 1-6烷氧基或硝基; R 3，R 4，R 5和R 6各自独立地表示氢，羟基，卤素，C 1-6烷基，C 2-6烯基或C 1-6烷氧基; 和R 7，R 8，R 9和R 10各自独立地表示氢，羟基，卤素，C 1-6烷基，C 2-6烯基或C 1-6烷氧基。结构式（I）表示的化合物可用于治疗或预防自由基相关疾病或哺乳动物的条件。

10. 发明申请

US20120277279A1 Non-Steroidal Glucocorticoid Inhibitors and Their Use in Treating Inflammation, Allergy and Auto-Immune Conditions 审中-公开
标题翻译：非甾类糖皮质激素抑制剂及其在治疗炎症，过敏和自身免疫病症中的应用
公开(公告)号：US20120277279A1
公开(公告)日：2012-11-01
申请号：US13548573
申请日：2012-07-13
申请人： Heather Anne BARNETT , Ian Baxter Campbell , Diane Mary Coe , Anthony William James Cooper , Graham George Adam Inglis , Haydn Terence Jones , Steven Philip Keeling , Simon John Fawcett MacDonald , Iain McFarlane McLay , Philip Alan Skone , Gordon Gad Weingarten , James Michael Woolven
发明人： Heather Anne BARNETT , Ian Baxter Campbell , Diane Mary Coe , Anthony William James Cooper , Graham George Adam Inglis , Haydn Terence Jones , Steven Philip Keeling , Simon John Fawcett MacDonald , Iain McFarlane McLay , Philip Alan Skone , Gordon Gad Weingarten , James Michael Woolven
IPC分类号： A61K31/415 , A61P37/08 , A61P11/10 , A61P25/00 , A61P29/00 , A61P17/00 , A61P25/28 , A61P35/00 , A61P31/06 , A61P37/06 , A61P17/06 , A61P17/04 , A61P11/06 , A61P19/04
CPC分类号： C07D231/38
摘要： The present invention provides compounds of formula (I): a process for their preparation, to pharmaceutical compositions comprising the compounds and the preparation of said compositions, to intermediates and to use of the compounds for the manufacture of a medicament for therapeutic treatment, particularly for the treatment of inflammation, allergy and/or auto-immune conditions.
摘要翻译：本发明提供式（I）化合物：其制备方法，包含所述化合物的药物组合物和所述组合物的制备，中间体和用于制备用于治疗性治疗的药物的用途，特别是治疗炎症，过敏和/或自身免疫状况。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式