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1. 发明申请

US20170319868A1 PHOSPHORS AND SCINTILLATORS FOR LIGHT STIMULATION WITHIN A MEDIUM 审中-公开
公开(公告)号：US20170319868A1
公开(公告)日：2017-11-09
申请号：US15649917
申请日：2017-07-14
申请人： IMMUNOLIGHT, LLC. , DUKE UNIVERSITY
发明人： Frederic A. Bourke, JR. , Harold Walder , Zakaryae Fathi , Michael J. Therien , Mark W. Dewhirst , Ian N. Stanton , Jennifer Ann Ayres , Diane Renee Fels , Joseph A. Herbert
IPC分类号： A61N5/06 , A61N5/10 , A61K41/00
CPC分类号： A61N5/062 , A61K41/0085 , A61N5/0622 , A61N5/1077 , A61N2005/0661 , A61N2005/1091 , A61N2005/1098
摘要： A system and method for light stimulation within a medium. The system has a reduced-voltage x-ray source configured to generate x-rays from a peak applied cathode voltage at or below 105 kVp, and a plurality of energy-emitting particles in the medium which, upon radiation from the x-ray source, radiate at a first lower energy than the x-ray source to interact with at least one photoactivatable agent in the medium. The method introduces the plurality of energy-emitting particles into the medium, radiates the energy-emitting particles in the medium with x-rays generated from a peak applied cathode voltage at or below 105 kVp; and emits a lower energy than the x-ray source to interact with the medium or with at least one photoactivatable agent in the medium.

2. 发明授权

US10232190B2 Phosphors and scintillators for light stimulation within a medium 有权
公开(公告)号：US10232190B2
公开(公告)日：2019-03-19
申请号：US15649917
申请日：2017-07-14
申请人： IMMUNOLIGHT, LLC. , DUKE UNIVERSITY
发明人： Frederic A. Bourke, Jr. , Harold Walder , Zakaryae Fathi , Michael J. Therien , Mark W. Dewhirst , Ian N. Stanton , Jennifer Ann Ayres , Diane Renee Fels , Joseph A. Herbert
IPC分类号： A61N5/06 , A61K41/00 , A61N5/10
摘要： A system and method for light stimulation within a medium. The system has a reduced-voltage x-ray source configured to generate x-rays from a peak applied cathode voltage at or below 105 kVp, and a plurality of energy-emitting particles in the medium which, upon radiation from the x-ray source, radiate at a first lower energy than the x-ray source to interact with at least one photoactivatable agent in the medium. The method introduces the plurality of energy-emitting particles into the medium, radiates the energy-emitting particles in the medium with x-rays generated from a peak applied cathode voltage at or below 105 kVp; and emits a lower energy than the x-ray source to interact with the medium or with at least one photoactivatable agent in the medium.

3. 发明申请

US20190168015A1 PHOSPHORS AND SCINTILLATORS FOR LIGHT STIMULATION WITHIN A MEDIUM 审中-公开
公开(公告)号：US20190168015A1
公开(公告)日：2019-06-06
申请号：US16251973
申请日：2019-01-18
申请人： IMMUNOLIGHT, LLC. , DUKE UNIVERSITY
发明人： Frederic A. BOURKE, JR. , Harold Walder , Zakaryae Fathi , Michael J. Therien , Mark W. Dewhirst , Ian N. Stanton , Jennifer Ann Ayres , Diane Renee Fels , Joseph A. Herbert
IPC分类号： A61N5/06 , A61N5/10 , A61K41/00
CPC分类号： A61N5/062 , A61K41/0085 , A61N5/0622 , A61N5/1077 , A61N2005/0661 , A61N2005/1091 , A61N2005/1098
摘要： A system and method for light stimulation within a medium. The system has a reduced-voltage x-ray source configured to generate x-rays from a peak applied cathode voltage at or below 105 kVp, and a plurality of energy-emitting particles in the medium which, upon radiation from the x-ray source, radiate at a first lower energy than the x-ray source to interact witht least one photoactivatable agent in the medium. The method introduces the plurality of energy-emitting particles into the medium, radiates the energy-emitting particles in the medium with x-rays generated from a peak applied cathode voltage at or below 105 kVp; and emits a lower energy than the x-ray source to interact with the medium or with at least one photoactivatable agent in the medium.

4. 发明授权

US11571587B2 Method for treating a disease, disorder, or condition using inhalation to administer an activatable pharmaceutical agent, an energy modulation agent, or both 有权
公开(公告)号：US11571587B2
公开(公告)日：2023-02-07
申请号：US16860623
申请日：2020-04-28
申请人： IMMUNOLIGHT, LLC , DUKE UNIVERSITY
发明人： Frederic A. Bourke, Jr. , Harold Walder , Zakaryae Fathi , Michael J. Therien , Mark W. Dewhirst , Ian N. Stanton , Jennifer Ann Ayres , Diane Renee Fels , Joseph A. Herbert
IPC分类号： A61N5/06 , A61K41/00 , A61N5/10
摘要： A method for treating a disease, disorder, or condition in a subject in need thereof, by administering either or both of (i) at least one photoactivatable pharmaceutical agent, or (ii) a first plurality of energy-emitting particles, into the subject in a region of the disease, disorder, or condition, whereby the administering is performed through inhalation; and applying an applied electromagnetic energy to the subject, wherein the applied electromagnetic energy directly or indirectly activates the at least one photoactivatable pharmaceutical agent, when present, and wherein when the first plurality of energy-emitting particles is present, the first plurality of energy-emitting particles absorbs the applied energy and emits an emitted electromagnetic energy, wherein the emitted electromagnetic energy interacts directly with the region of the disease, disorder, or condition or activates the at least one photoactivatable pharmaceutical agent.

5. 发明授权

US10709900B2 Phosphors and scintillators for light stimulation within a medium 有权
公开(公告)号：US10709900B2
公开(公告)日：2020-07-14
申请号：US16251973
申请日：2019-01-18
申请人： IMMUNOLIGHT, LLC , DUKE UNIVERSITY
发明人： Frederic A. Bourke, Jr. , Harold Walder , Zakaryae Fathi , Michael J. Therien , Mark W. Dewhirst , Ian N. Stanton , Jennifer Ann Ayres , Diane Renee Fels , Joseph A. Herbert
IPC分类号： A61K41/00 , A61N5/06 , A61N5/10
摘要： A system and method for light stimulation within a medium. The system has a reduced-voltage x-ray source configured to generate x-rays from a peak applied cathode voltage at or below 105 kVp, and a plurality of energy-emitting particles in the medium which, upon radiation from the x-ray source, radiate at a first lower energy than the x-ray source to interact with least one photoactivatable agent in the medium. The method introduces the plurality of energy-emitting particles into the medium, radiates the energy-emitting particles in the medium with x-rays generated from a peak applied cathode voltage at or below 105 kVp; and emits a lower energy than the x-ray source to interact with the medium or with at least one photoactivatable agent in the medium.

6. 发明授权

US09618632B2 Linear-response nanocrystal scintillators and methods of using the same 有权
公开(公告)号：US09618632B2
公开(公告)日：2017-04-11
申请号：US14387103
申请日：2013-03-14
申请人： DUKE UNIVERSITY
发明人： Ian N. Stanton , Terry T. Yoshizumi , Michael J. Therien
IPC分类号： G01T1/20 , G01T1/202
CPC分类号： G01T1/202 , G01T1/20 , G01T1/2018
摘要： Systems and devices incorporating radiation detection, and techniques and materials for improved radiation detection are provided that involve a nano-scintillator exhibiting a linear luminescent emission response to stimulating electromagnetic radiation. The nano-scintillator can include at least one nanocrystal comprising a rare earth element, a lanthanide dopant, and a spectator dopant, wherein the nanocrystal exhibits a linear luminescent emission response to stimulating electromagnetic radiation of wavelengths less than 100 nm. As one example, the nanocrystal is [Y2-x03; Eux, Liy], where x is 0.05 to 0.1 and y is 0.1 to 0.16, and has an average nanoparticle size of 40 to 70 nm. These nanocrystals can be fabricated through a glycine combustion method.

7. 发明授权

US11000702B2 Systems and methods for the verification of source placement for brachytherapy radiation procedures using real time radiation detectors 有权
公开(公告)号：US11000702B2
公开(公告)日：2021-05-11
申请号：US15517624
申请日：2015-10-09
申请人： Duke University
发明人： Matthew D. Belley , Michael J. Therien , Ian N. Stanton , Terry T. Yoshizumi , Brian W. Langloss , Oana I. Craciunescu , Junzo P. Chino
IPC分类号： A61N5/10
摘要： The present disclosure provides systems and methods for verifying radiation source delivery in brachytherapy by allowing for the radiation source location and dwell time to be determined via real-time measurement. In an embodiment, a radiation detector may be disposed proximate to a radiotherapy target. The radiation detector is configured to provide real-time information indicative of ionizing radiation emitted by a radiation source. A controller may perform operations including receiving, from the radiation detector, real-time information indicative of at least one of: a particle flux rate, an energy fluence, or an absorbed dose of ionizing radiation emitted from the radiation source. The operations may also include determining, based on the received information, at least one of: a location of the radiation source or a dwell time of the radiation source.

8. 发明申请

US20170304652A1 Systems and Methods for the Verification of Source Placement for Brachytherapy Radiation Procedures Using Real Time Radiation Detectors 审中-公开
公开(公告)号：US20170304652A1
公开(公告)日：2017-10-26
申请号：US15517624
申请日：2015-10-09
申请人： Duke University
发明人： Matthew D. Belley , Michael J. Therein , Ian N. Stanton , Terry T. Yoshizumi , Brian W. Langloss , Oana I. Craciunescu , Junzo P. Chino
IPC分类号： A61N5/10
CPC分类号： A61N5/1071 , A61N5/1001 , A61N5/1075 , A61N2005/1076
摘要： The present disclosure provides systems and methods for verifying radiation source delivery in brachytherapy by allowing for the radiation source location and dwell time to be determined via real-time measurement. In an embodiment, a radiation detector may be disposed proximate to a radiotherapy target. The radiation detector is configured to provide real-time information indicative of ionizing radiation emitted by a radiation source. A controller may perform operations including receiving, from the radiation detector, real-time information indicative of at least one of: a particle flux rate, an energy fluence, or an absorbed dose of ionizing radiation emitted from the radiation source. The operations may also include determining, based on the received information, at least one of: a location of the radiation source or a dwell time of the radiation source.

9. 发明申请

US20150083923A1 LINEAR-RESPONSE NANOCRYSTAL SCINTILLATORS AND METHODS OF USING THE SAME 有权
标题翻译：线性反应纳米晶体扫描仪及其使用方法
公开(公告)号：US20150083923A1
公开(公告)日：2015-03-26
申请号：US14387103
申请日：2013-03-14
申请人： DUKE UNIVERSITY
发明人： Ian N. Stanton , Terry T. Yoshizumi , Michael J. Therien
IPC分类号： G01T1/202 , G01T1/20
CPC分类号： G01T1/202 , G01T1/20 , G01T1/2018
摘要： Systems and devices incorporating radiation detection, and techniques and materials for improved radiation detection are provided that involve a nano-scintillator exhibiting a linear luminescent emission response to stimulating electromagnetic radiation. The nano-scintillator can include at least one nanocrystal comprising a rare earth element, a lanthanide dopant, and a spectator dopant, wherein the nanocrystal exhibits a linear luminescent emission response to stimulating electromagnetic radiation of wavelengths less than 100 nm. As one example, the nanocrystal is [Y2-x03; Eux, Liy], where x is 0.05 to 0.1 and y is 0.1 to 0.16, and has an average nanoparticle size of 40 to 70 nm. These nanocrystals can be fabricated through a glycine combustion method.
摘要翻译：提供了包含放射线检测的系统和装置，以及用于改进辐射检测的技术和材料，其涉及呈现线性发光响应以刺激电磁辐射的纳米闪烁体。纳米闪烁体可以包括至少一种包含稀土元素，镧系元素掺杂剂和观察剂掺杂剂的纳米晶体，其中纳米晶体表现出线性发光响应以刺激波长小于100nm的电磁辐射。作为一个例子，纳米晶体是[Y2-x03; Eux，Liy]，其中x为0.05〜0.1，y为0.1〜0.16，平均纳米粒子尺寸为40〜70nm。这些纳米晶体可以通过甘氨酸燃烧法制造。

10. 发明授权

US10061037B2 Linear-response nanocrystal scintillators and methods of using the same 有权
公开(公告)号：US10061037B2
公开(公告)日：2018-08-28
申请号：US15456208
申请日：2017-03-10
申请人： Duke University
发明人： Ian N. Stanton , Terry T. Yoshizumi , Michael J. Therien
IPC分类号： G01T1/20 , G01T1/202
CPC分类号： G01T1/202 , G01T1/20 , G01T1/2018
摘要： Systems and devices incorporating radiation detection, and techniques and materials for improved radiation detection are provided that involve a nano-scintillator exhibiting a linear luminescent emission response to stimulating electromagnetic radiation. The nano-scintillator can include at least one nanocrystal comprising a rare earth element, a lanthanide dopant, and a spectator dopant, wherein the nanocrystal exhibits a linear luminescent emission response to stimulating electromagnetic radiation of wavelengths less than 100 nm. As one example, the nanocrystal is [Y2−xO3; Eux, Liy], where x is 0.05 to 0.1 and y is 0.1 to 0.16, and has an average nanoparticle size of 40 to 70 nm. These nanocrystals can be fabricated through a glycine combustion method.

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