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1. 发明授权

US09681844B2 Biopotential signal acquisition system and method 有权
公开(公告)号：US09681844B2
公开(公告)日：2017-06-20
申请号：US14315520
申请日：2014-06-26
申请人： IMEC VZW , Stichting IMEC Nederland
发明人： Jiawei Xu , Refet Firat Yazicioglu
IPC分类号： A61B5/00 , A61B5/04 , A61B5/0402 , A61B5/0428 , A61B5/0476 , A61B5/0488 , A61B5/0496 , A61B5/0408 , A61B5/0478 , A61B5/0492
CPC分类号： A61B5/7207 , A61B5/04004 , A61B5/0402 , A61B5/0408 , A61B5/0428 , A61B5/0476 , A61B5/0478 , A61B5/0488 , A61B5/0492 , A61B5/0496 , A61B2562/0209
摘要： A biopotential signal acquisition system, comprising: a first active electrode including an integrated pre-amplifier and an analogue to digital converter; a second active electrode including an integrated pre-amplifier and an analogue to digital converter, wherein the second active electrode has variable gain; a test signal generator for generating a test signal at a test frequency and coupling the test signal to the first and/or second active electrodes; and a digital signal processor configured to: process the digital outputs of the first and second active electrodes to derive a gain control signal based on a difference between the first and second active electrode outputs at the test frequency, and apply the gain control signal to the second active electrode. The disclosure also relates to an electronic circuit or device and a biopotential signal acquisition method.

2. 发明申请

US20150005585A1 Biopotential Signal Acquisition System and Method 有权
标题翻译：生物电位信号采集系统及方法
公开(公告)号：US20150005585A1
公开(公告)日：2015-01-01
申请号：US14315520
申请日：2014-06-26
申请人： IMEC VZW , Stichting IMEC Nederland
发明人： Jiawei Xu , Refet Firat Yazicioglu
IPC分类号： A61B5/00 , A61B5/0476 , A61B5/04 , A61B5/0496 , A61B5/0428 , A61B5/0402 , A61B5/0488
CPC分类号： A61B5/7207 , A61B5/04004 , A61B5/0402 , A61B5/0408 , A61B5/0428 , A61B5/0476 , A61B5/0478 , A61B5/0488 , A61B5/0492 , A61B5/0496 , A61B2562/0209
摘要： A biopotential signal acquisition system, comprising: a first active electrode including an integrated pre-amplifier and an analogue to digital converter; a second active electrode including an integrated pre-amplifier and an analogue to digital converter, wherein the second active electrode has variable gain; a test signal generator for generating a test signal at a test frequency and coupling the test signal to the first and/or second active electrodes; and a digital signal processor configured to: process the digital outputs of the first and second active electrodes to derive a gain control signal based on a difference between the first and second active electrode outputs at the test frequency, and apply the gain control signal to the second active electrode. The disclosure also relates to an electronic circuit or device and a biopotential signal acquisition method.
摘要翻译：一种生物电势信号采集系统，包括：第一有源电极，包括集成前置放大器和模数转换器; 包括集成前置放大器和模数转换器的第二有源电极，其中所述第二有源电极具有可变增益; 测试信号发生器，用于产生测试频率的测试信号，并将测试信号耦合到第一和/或第二有源电极; 以及数字信号处理器，被配置为：处理第一和第二有源电极的数字输出，以基于在测试频率处的第一和第二有源电极输出之间的差异导出增益控制信号，并将增益控制信号施加到第二活性电极。本公开还涉及电子电路或装置以及生物电势信号采集方法。

3. 发明申请

US20150119747A1 System and Method for Acquisition of Biopotential Signals With Electrode-Tissue Impedance Measurement 审中-公开
标题翻译：用电极组织阻抗测量获取生物电位信号的系统和方法
公开(公告)号：US20150119747A1
公开(公告)日：2015-04-30
申请号：US14528931
申请日：2014-10-30
申请人： IMEC VZW
发明人： Tom Torfs , Refet Firat Yazicioglu
IPC分类号： A61B5/053 , A61B5/00
CPC分类号： A61B5/053 , A61B5/04004 , A61B5/04012 , A61B5/04284 , A61B5/7207 , A61B5/7278
摘要： A system for the acquisition of biopotential signals, comprising at least a first electrode configured for detecting a biopotential signal within a signal bandwidth of interest and being connected to an impedance detection module that provides a first electrode voltage. The impedance detection module comprises a current generation circuit connected in parallel to an amplifier. The current generation circuit comprises an AC current generator configured to generate a first current signal through the first electrode. The first current signal has a frequency outside of the signal bandwidth of interest. The current generation circuit also comprising a capacitor connected between the input of the amplifier and the AC current generator so as to isolate the AC current generator from the amplifier input at the signal bandwidth of interest. The system also including a signal processor configured to calculate a component value of a first and a second electrode-tissue impedance based on a difference between the first electrode voltage and a second electrode voltage.
摘要翻译：一种用于获取生物电位信号的系统，包括至少第一电极，其被配置用于检测感兴趣的信号带宽内的生物电位信号，并连接到提供第一电极电压的阻抗检测模块。阻抗检测模块包括与放大器并联连接的电流产生电路。电流产生电路包括配置成通过第一电极产生第一电流信号的AC电流发生器。第一电流信号具有在感兴趣的信号带宽以外的频率。电流产生电路还包括连接在放大器的输入端和交流电流发生器之间的电容器，以便在感兴趣的信号带宽上将交流电流发生器与放大器输入隔离。该系统还包括被配置为基于第一电极电压和第二电极电压之间的差来计算第一和第二电极组织阻抗的分量值的信号处理器。

4. 发明授权

US09375182B2 System and method for acquisition of biopotential signals with motion artifact reduction 有权
标题翻译：用于获取生物电位信号的运动神经减影的系统和方法
公开(公告)号：US09375182B2
公开(公告)日：2016-06-28
申请号：US14573714
申请日：2014-12-17
申请人： IMEC VZW
发明人： Hyejung Kim , Nick Van Helleputte , Refet Firat Yazicioglu
IPC分类号： A61B5/04 , A61B5/00 , A61B5/0428 , A61B5/0402
CPC分类号： A61B5/7207 , A61B5/04017 , A61B5/0402 , A61B5/0428 , A61B5/7214 , A61B5/7246
摘要： A biopotential signal acquisition system including an analog readout unit configured to receive an analog biopotential signal, which may be acquired from at least one electrode attached to a body; and to extract an analog measured biopotential signal and an analog reference signal. The system also includes an ADC unit configured to provide a digital version of the analog measured biopotential signal and the analog reference signal, a digital filter unit configured to calculate a digital motion artifact estimate based on the digital version of the measured biopotential signal and the reference signal. The system further comprises a reference signal processing unit configured to convert the reference signal into a new reference signal being provided to the digital filter unit based on the correlation between the measured biopotential signal and the reference signal.
摘要翻译：生物电位信号采集系统，包括被配置为接收模拟生物电位信号的模拟读出单元，模拟生物电位信号可以从附着于身体的至少一个电极获取; 并提取模拟测量的生物电位信号和模拟参考信号。该系统还包括被配置为提供模拟测量生物电位信号和模拟参考信号的数字版本的ADC单元，数字滤波器单元，被配置为基于测量的生物电位信号和参考的数字版本来计算数字运动伪影估计信号。该系统还包括参考信号处理单元，其被配置为基于所测量的生物电位信号和参考信号之间的相关性将参考信号转换为提供给数字滤波器单元的新参考信号。

5. 发明申请

US20150216481A1 System and Method for Acquisition of Biopotential Signals with Motion Artifact Reduction in Real Time Operation 有权
标题翻译：用于实时运算减少运动神经元的生物电位信号采集系统和方法
公开(公告)号：US20150216481A1
公开(公告)日：2015-08-06
申请号：US14615150
申请日：2015-02-05
申请人： IMEC VZW
发明人： Hyejung Kim , Nick Van Helleputte , Refet Firat Yazicioglu
IPC分类号： A61B5/00 , A61B5/0488 , A61B5/0476 , A61B5/0402 , A61B5/04
CPC分类号： A61B5/7207 , A61B5/04012 , A61B5/04017 , A61B5/0402 , A61B5/0476 , A61B5/0488 , A61B5/7214
摘要： A biopotential signal acquisition system comprising an analogue readout unit configured to receive an analogue biopotential signal and to extract an analogue measured biopotential signal and an analogue reference signal, and an ADC unit configured to provide a digital version of the analogue measured biopotential signal and the analogue reference signal. The system also includes a first digital filter unit comprising a cascaded integrator-comb filter configured to provide a first digital filtered version of the digital measured biopotential signal and the reference signal, and a second digital filter unit configured to calculate a digital motion artifact estimate based on the first digital filtered version signals.
摘要翻译：生物电位信号采集系统，包括模拟读出单元，其被配置为接收模拟生物电位信号并提取模拟测量的生物电位信号和模拟参考信号，以及ADC单元，被配置为提供所述模拟测量生物电位信号和模拟参考信号。该系统还包括第一数字滤波器单元，其包括级联的积分器梳状滤波器，其被配置为提供数字测量的生物电位信号和参考信号的第一数字滤波版本，以及第二数字滤波器单元，被配置为基于数字滤波器单元在第一个数字滤波版本信号上。

6. 发明授权

US08914099B2 Biomedical acquisition system with motion artifact reduction 有权
标题翻译：具有运动神经减影的生物医学采集系统
公开(公告)号：US08914099B2
公开(公告)日：2014-12-16
申请号：US13671050
申请日：2012-11-07
申请人： IMEC
发明人： Refet Firat Yazicioglu , Sunyoung Kim
IPC分类号： A61B5/04 , A61B5/00 , A61B5/0402 , A61B5/053 , H01L27/08 , H03F1/56 , H03F3/45
CPC分类号： A61B5/7214 , A61B5/04017 , A61B5/0402 , A61B5/0531 , H01L27/0811 , H03F1/56 , H03F3/45475 , H03F2200/213 , H03F2200/261 , H03F2203/45538 , H03F2203/45544 , H03F2203/45548 , H03F2203/45576
摘要： A system for the analysis of ECG signals is disclosed. The system may comprise (i) at least one readout channel, configured to receive an analog ECG signal acquired from at least one electrode attached to a body, and to extract an analog measured ECG signal and analog electrode-skin impedance signals; (ii) at least one ADC, configured to convert those extracted analog signals at the readout channel into digital signals; (iii) a digital adaptive filter unit, configured to calculate a digital motion artifact estimate based on said digital versions of the measured ECG signal and the electrode-skin impedance signals; (iv) at least one DAC, configured to convert said digital motion artifact estimate into an analog signal; and (v) a feedback loop for sending said analog motion artifact estimate signal back to the readout channel configured to deduct said analog motion artifact estimate signal from said analog measured ECG signal.
摘要翻译：公开了一种用于分析ECG信号的系统。该系统可以包括（i）至少一个读出通道，其被配置为接收从附接到身体的至少一个电极获取的模拟ECG信号，并且提取模拟测量的ECG信号和模拟电极 - 皮肤阻抗信号; （ii）至少一个ADC，被配置为将读出信道中提取的模拟信号转换为数字信号; （iii）数字自适应滤波器单元，被配置为基于测量的ECG信号和电极 - 皮肤阻抗信号的所述数字版本来计算数字运动伪影估计; （iv）至少一个DAC，被配置为将所述数字运动假象估计转换为模拟信号; 以及（v）用于将所述模拟运动假象估计信号发送回所述读出通道的反馈回路，所述读出通道被配置为从所述模拟测量的ECG信号中扣除所述模拟运动伪像估计信号。

7. 发明授权

US10624547B2 Sensing device with array of microelectrodes 有权
公开(公告)号：US10624547B2
公开(公告)日：2020-04-21
申请号：US15197778
申请日：2016-06-30
申请人： IMEC VZW , Katholieke Universiteit Leuven, KU LEUVEN R&D
发明人： Bogdan Raducanu , Srinjoy Mitra , Refet Firat Yazicioglu
IPC分类号： A61B5/0478 , A61B5/04 , A61B5/00 , A61N1/05
CPC分类号： A61B5/04001 , A61B5/0478 , A61B5/6868 , A61B5/7225 , A61B5/4076 , A61B2562/043 , A61N1/0529 , A61N1/0551
摘要： Devices and systems described herein relate to a sensing device that includes an output area and an electrode area. The output area includes an output circuit comprising an integrator adapted to integrate a received current so as to generate an output voltage corresponding to the received current. The electrode area includes an electrode comprising an exposed, electrically conductive, surface area and electrode circuitry connected to the exposed surface area. The electrode circuitry comprises a voltage-to-current transducer adapted to produce a wire current corresponding to a voltage present at the exposed surface area. The sensing device also includes a connecting wire electrically connecting the electrode circuitry to the output circuit, wherein the current received by the output circuit is the wire current.

8. 发明申请

US20130116588A1 System and Method for the Analysis of Electrocardiogram Signals 有权
标题翻译：心电图信号分析系统与方法
公开(公告)号：US20130116588A1
公开(公告)日：2013-05-09
申请号：US13666167
申请日：2012-11-01
申请人： IMEC
发明人： Refet Firat Yazicioglu , Tom Torfs , Sachin Shrestha
IPC分类号： A61B5/0456
CPC分类号： A61B5/726 , A61B5/04017 , A61B5/0456
摘要： A microprocessor configured to receive and process digitized signals derived from an analogue ECG signal is provided. An example microprocessor comprises a beat detection unit configured to receive the in-phase and quadrature phase band power signals, calculate a band power value and an adaptive threshold value, and compare said band power value with said adaptive threshold value to detect a QRS complex of the ECG signal indicative of a detected valid beat; and an R peak detection unit configured to receive the digital ECG signal and information about the detected valid beat, select a portion of the received ECG signal as a first time window around the detected valid beat; determine the location of a first R peak position; and perform a time domain search in a second time window around said first R peak position in order to refine the location of an R peak position.
摘要翻译：提供了被配置为接收和处理从模拟ECG信号导出的数字化信号的微处理器。示例性微处理器包括：拍摄检测单元，被配置为接收同相和正交相位带功率信号，计算频带功率值和自适应阈值，并将所述频带功率值与所述自适应阈值进行比较，以检测QRS波群所述ECG信号指示检测到的有效搏动; 以及R峰值检测单元，被配置为接收数字ECG信号和关于检测到的有效搏动的信息，将所接收的ECG信号的一部分选择为围绕检测到的有效搏动的第一时间窗; 确定第一个R峰位置的位置; 并且在围绕所述第一R峰位置的第二时间窗中执行时域搜索，以便改善R峰位置的位置。

9. 发明申请

US20170000368A1 Sensing Device With Array of Microelectrodes 审中-公开
标题翻译：具有微电极阵列的感应装置
公开(公告)号：US20170000368A1
公开(公告)日：2017-01-05
申请号：US15197778
申请日：2016-06-30
申请人： IMEC VZW , Katholieke Universiteit Leuven, KU LEUVEN R&D
发明人： Bogdan Raducanu , Srinjoy Mitra , Refet Firat Yazicioglu
IPC分类号： A61B5/0478 , A61B5/00 , A61B5/04
CPC分类号： A61B5/6868 , A61B5/04001 , A61B5/4076 , A61B5/7225 , A61B2562/043 , A61N1/0529 , A61N1/0551
摘要： Devices and systems described herein relate to a sensing device that includes an output area and an electrode area. The output area includes an output circuit comprising an integrator adapted to integrate a received current so as to generate an output voltage corresponding to the received current. The electrode area includes an electrode comprising an exposed, electrically conductive, surface area and electrode circuitry connected to the exposed surface area. The electrode circuitry comprises a voltage-to-current transducer adapted to produce a wire current corresponding to a voltage present at the exposed surface area. The sensing device also includes a connecting wire electrically connecting the electrode circuitry to the output circuit, wherein the current received by the output circuit is the wire current.
摘要翻译：本文所述的装置和系统涉及包括输出区域和电极区域的感测装置。输出区域包括输出电路，该输出电路包括积分器，该积分器适于积分接收的电流，以产生对应于所接收的电流的输出电压。电极区域包括包括暴露的导电表面区域和连接到暴露表面区域的电极电路的电极。电极电路包括适于产生对应于暴露表面区域处存在的电压的线电流的电压 - 电流换能器。感测装置还包括将电极电路电连接到输出电路的连接线，其中由输出电路接收的电流是线电流。

10. 发明授权

US09391456B2 Current generator 有权
标题翻译：电流发生器
公开(公告)号：US09391456B2
公开(公告)日：2016-07-12
申请号：US14107399
申请日：2013-12-16
申请人： IMEC
发明人： Sunyoung Kim , Refet Firat Yazicioglu
IPC分类号： H02J1/00 , H02J3/00 , G06F1/02 , G06F1/03
CPC分类号： H02J3/00 , G06F1/022 , G06F1/0321 , Y10T307/724
摘要： A current generator is disclosed. An example current generator includes a plurality of current cells connected in parallel, each current cell being connected to a switch. The current generator further includes a first summer configured to sum the output of each current cell of a first subset of the plurality of current cells and a second summer configured to sum the output of each current cell of a second subset of the plurality of current cells. The current generator also includes a combiner configured to combine the outputs of the first and second summers. Further, each switch is switchable according to a sequence to generate a summed output of the current cells at a plurality of quantization levels to generate positive and/or negative alternations of a pseudo-sinusoidal, alternating current.
摘要翻译：公开了一种电流发生器。示例性电流发生器包括并联连接的多个电流单元，每个电流单元连接到开关。电流发生器还包括第一加法器，其被配置为对多个当前单元的第一子集的每个当前单元的输出进行求和，第二加法器被配置为对多个当前单元的第二子集的每个当前单元的输出求和。电流发生器还包括组合器，其被配置为组合第一和第二加法器的输出。此外，每个开关可以根据序列切换，以产生多个量化级别的当前单元的相加输出，以产生伪正弦交流电流的正和/或负变化。

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