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    • 5. 发明申请
    • Process for the Preparation of 11-(4-[2-(2-Hydroxyethoxy)Ethyl]-I-Piperazinyl)Dibenzo[b,f][I,4]Thiazepine
    • 制备11-(4- [2-(2-羟基乙氧基)乙基] -1-哌嗪基)二苯并[b,f] [I,4]噻吩
    • US20070225494A1
    • 2007-09-27
    • US11571116
    • 2005-06-17
    • Byong KwakSang LeeHee HwangJong Lim
    • Byong KwakSang LeeHee HwangJong Lim
    • C07D281/12
    • C07D281/16
    • Disclosed is a process for the preparation of 11-(4-[2-(2-hydroxyethoxy)ethyl]-1-piperazinyl)-dibenzo[b,f][1,4]thiazepine. In the process, low-priced 2,2′-dithiosalicylic acid as starting material is subjected to bond formation reaction with 1-chloro-2-nitrobenzene in a basic aqueous solution, a nitro group reduction reaction is conducted, cyclization and chlorination reactions are simultaneously carried out in the presence of a equivalent amount of halogenating agent, a reaction with piperazine is continuously conducted without separation, and a reaction with 2-haloethoxyethanol is conducted, thereby it is possible to economically producing Quetiapine, that is, 11-(4-[2-(2-hydroxyethoxy)ethyl]-1-piperazinyl)-dibenzo[b,f][1,4]thiazepine, in an environmentally friendly manner. Particularly, the process is advantageous in that economic efficiency is assured because of use of the low-priced starting material, use of an organic solvent is minimized because a reaction is conducted in an aqueous solution, and it is possible to achieve the environmentally friendly and economical process having high commercial usefulness because the number of reaction steps of the process is reduced and because generation of acidic waste is minimized.
    • 公开了制备11-(4- [2-(2-羟基乙氧基)乙基] -1-哌嗪基) - 二苯并[b,f] [1,4]硫杂吖庚因的方法。 在此过程中,作为起始原料的低价2,2'-二硫代水杨酸与碱性水溶液中的1-氯-2-硝基苯进行结合形成反应,进行硝基还原反应,环化反应和氯化反应 在等量的卤化剂的存在下同时进行,与哌嗪的反应在不分离的情况下连续进行,与2-卤代乙氧基乙醇进行反应,从而可以经济地制备喹硫平,即11-(4 - [2-(2-羟基乙氧基)乙基] -1-哌嗪基) - 二苯并[b,f] [1,4]硫杂吖庚因。 特别地,该方法的优点在于,由于使用低价起始材料来确保经济效率,因此在水溶液中进行反应而使有机溶剂的使用最小化,并且可以实现环境友好和 经济的方法具有很高的商业用途,因为该方法的反应步骤的数量减少并且由于酸性废物的产生被最小化。
    • 6. 发明申请
    • Communication terminal
    • 通讯终端
    • US20070103457A1
    • 2007-05-10
    • US11546352
    • 2006-10-12
    • Sang AhnJong Lim
    • Sang AhnJong Lim
    • G09G5/00
    • H04M1/0295H04M1/0214H04M1/0235
    • A communication terminal equipped with a sliding-type flat display module includes a main body and a flat display which slides between retracted and extended positions along a first axis relative to the main body and which rotates to a tilted position along a second axis when in the extended position. The first axis may be substantially perpendicular to the second axis. In the retracted position, the flat display is unable to rotate to the tilted position along the second axis. Also, in this position, the display is partially visible to allow information to be read by a user while at the same time being protected within a receiving part of the terminal.
    • 具有滑动型平板显示模块的通信终端包括主体和平面显示器,其在相对于主体的第一轴线的缩回位置和延伸位置之间滑动,并且当在第二轴线处于第二轴线时旋转到倾斜位置 延长位置 第一轴线可以基本上垂直于第二轴线。 在缩回位置,平面显示器不能沿着第二轴线旋转到倾斜位置。 此外,在该位置,显示器是部分可见的,以允许用户读取信息,同时在终端的接收部分内受到保护。