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1. 发明授权

US06458934B1 Humanized antibody specific for human 4-1BB 失效
标题翻译：对人4-1BB特异的人源化抗体
公开(公告)号：US06458934B1
公开(公告)日：2002-10-01
申请号：US09438954
申请日：1999-11-12
申请人： Hyo Jeong Hong , Sung Sup Park , Young Jun Kang , Chang-Yuil Kang , Sung Kwan Yoon
发明人： Hyo Jeong Hong , Sung Sup Park , Young Jun Kang , Chang-Yuil Kang , Sung Kwan Yoon
IPC分类号： C07K1618
CPC分类号： C07K16/2878 , A61K2039/505 , C07K2317/24 , C07K2319/00
摘要： The present invention is directed to humanized antibodies that specifically bind the protein 4-1BB. The antibodies can be made by grafting of the complementarity determining regions (CDR's) of mouse monoclonal antibody to human 4-1BB to the remaining portions of a human antibody and by making further amino acid replacements. In addition, a pharmaceutical composition that includes the humanized antibody can be made and can be used to treat autoimmune diseases to suppress an immune response. The humanized antibody of the invention has high affinity for human 4-1BB, and exhibits sequence similarity to human antibody. As a result, the pharmaceutical composition of the present invention can be used to treat autoimmune disease and act as an immunosuppressant in humans without much side-effect.
摘要翻译：本发明涉及特异性结合蛋白4-1BB的人源化抗体。可以通过将小鼠单克隆抗体的互补决定区（CDR）与人4-1BB接枝到人抗体的其余部分并进一步进行氨基酸替换来制备抗体。此外，可以制备包含人源化抗体的药物组合物，并且可以用于治疗自身免疫疾病以抑制免疫应答。本发明的人源化抗体对人4-1BB具有高亲和力，与人抗体具有序列相似性。结果，本发明的药物组合物可以用于治疗自身免疫性疾病，并且在人体中作为免疫抑制剂没有太多的副作用。

2. 发明申请

US20110223140A1 METHOD FOR DIFFERENTIATION INTO RETINAL CELLS FROM STEM CELLS 有权
标题翻译：从干细胞分化成细胞的方法
公开(公告)号：US20110223140A1
公开(公告)日：2011-09-15
申请号：US13055709
申请日：2010-10-06
申请人： Sung Sup Park , Ji Yeon Kim
发明人： Sung Sup Park , Ji Yeon Kim
IPC分类号： A61K35/44 , C12N5/07 , C12Q1/02 , C12Q1/68 , A61P27/02
CPC分类号： C12N5/0621 , C12N2501/105 , C12N2501/155 , C12N2501/998 , C12N2506/02 , C12N2506/45
摘要： Disclosed is a method for inducing stem cells to differentiate into retinal cells at high yield within a short period of time, without gene implantation and co-culture with retinal tissues, by implementing a differentiation process similar to the in vivo embryonic development in chemically defined conditions. Also, retinal cells including the photoreceptor cells and their progenitor cells, and various types of other retinal cells, generated according to the method, are disclosed. A composition comprising the retinal cells and a method are provided for treating retinal degeneration-related diseases. The differentiated photoreceptor cells, when transplanted into degenerated or injured retinas, can be engrafted and fused within the retinas to prevent or cure retinal degeneration.
摘要翻译：公开了一种诱导干细胞在短时间内以高产率分化成视网膜细胞的方法，通过实施类似于在化学定义的条件下的体内胚胎发育的分化过程，而不进行基因植入和与视网膜组织的共培养。此外，还公开了根据该方法产生的包括感光细胞及其祖细胞的视网膜细胞和各种类型的其它视网膜细胞。提供了包含视网膜细胞的组合物和一种治疗视网膜变性相关疾病的方法。分化的感光细胞，当移植到退化或损伤的视网膜时，可以植入并融合在视网膜内，以预防或治愈视网膜变性。

3. 发明授权

US09359592B2 Method for differentiation into retinal cells from stem cells 有权
标题翻译：从干细胞分化成视网膜细胞的方法
公开(公告)号：US09359592B2
公开(公告)日：2016-06-07
申请号：US13055709
申请日：2010-10-06
申请人： Sung Sup Park , Ji Yeon Kim
发明人： Sung Sup Park , Ji Yeon Kim
IPC分类号： C12N5/07 , A61P27/02 , C12Q1/02 , A61K35/44 , C12N5/079
CPC分类号： C12N5/0621 , C12N2501/105 , C12N2501/155 , C12N2501/998 , C12N2506/02 , C12N2506/45
摘要： Disclosed is a method for inducing stem cells to differentiate into retinal cells at high yield within a short period of time, without gene implantation and co-culture with retinal tissues, by implementing a differentiation process similar to the in vivo embryonic development in chemically defined conditions. Also, retinal cells including the photoreceptor cells and their progenitor cells, and various types of other retinal cells, generated according to the method, are disclosed. A composition comprising the retinal cells and a method are provided for treating retinal degeneration-related diseases. The differentiated photoreceptor cells, when transplanted into degenerated or injured retinas, can be engrafted and fused within the retinas to prevent or cure retinal degeneration.
摘要翻译：公开了一种诱导干细胞在短时间内以高产率分化成视网膜细胞的方法，通过实施类似于在化学定义的条件下的体内胚胎发育的分化过程，而不进行基因植入和与视网膜组织的共培养。此外，还公开了根据该方法产生的包括感光细胞及其祖细胞的视网膜细胞和各种类型的其它视网膜细胞。提供了包含视网膜细胞的组合物和一种治疗视网膜变性相关疾病的方法。分化的感光细胞，当移植到退化或损伤的视网膜时，可以植入并融合在视网膜内，以预防或治愈视网膜变性。

4. 发明授权

US09200252B2 Compositions for inducing differentiation into retinal cells from retinal progenitor cells or inducing proliferation of retinal cells comprising Wnt signaling pathway activators 有权
标题翻译：用于诱导从视网膜祖细胞分化成视网膜细胞或诱导包含Wnt信号通路激活剂的视网膜细胞增殖的组合物
公开(公告)号：US09200252B2
公开(公告)日：2015-12-01
申请号：US13055708
申请日：2010-10-06
申请人： Sung Sup Park , Ji Yeon Kim
发明人： Sung Sup Park , Ji Yeon Kim
IPC分类号： C12N5/071 , C12N5/07 , C12N5/0793 , A61K35/12
CPC分类号： C12N5/062 , A61K35/12 , C12N2500/44 , C12N2501/105 , C12N2501/115 , C12N2501/155 , C12N2501/385 , C12N2501/41 , C12N2501/415 , C12N2506/02 , C12N2506/45
摘要： Disclosed is a composition for inducing the proliferation of retinal cells or the differentiation of retinal progenitor cells into retinal cells. The composition, similar to in vivo conditions for development during embryogenesis, induces stem cells to differentiate into a multitude of photoreceptor cells at high yield within a short period of time, without an additional gene transfer. In addition, the differentiated photoreceptor cells are useful in cellular therapy because they, when transplanted into degenerated or injured retinas, can be engrafted and fused within the retinas to prevent or cure retinal degeneration.
摘要翻译：公开了用于诱导视网膜细胞增殖或将视网膜祖细胞分化成视网膜细胞的组合物。与胚胎发生期间的体内发育条件类似的组合物诱导干细胞在短时间内以高产率分化成多种感光细胞细胞，而不需要额外的基因转移。此外，分化的感光细胞可用于细胞治疗，因为它们在移植到退化或损伤的视网膜中时可以被植入并融合在视网膜内以预防或治愈视网膜变性。

5. 发明申请

US20110223660A1 COMPOSITIONS FOR INDUCING DIFFERENTIATION INTO RETINAL CELLS FROM RETINAL PROGENITOR CELLS OR INDUCING PROLIFERATION OF RETINAL CELLS COMPRISING WNT SIGNALING PATHWAY ACTIVATORS 有权
标题翻译：用于诱导来自末端原核细胞的细胞分化或诱导包含WNT信号途径激活剂的细胞增殖的组合物
公开(公告)号：US20110223660A1
公开(公告)日：2011-09-15
申请号：US13055708
申请日：2010-10-06
申请人： Sung Sup Park , Ji Yeon Kim
发明人： Sung Sup Park , Ji Yeon Kim
IPC分类号： C12N5/071 , C12N5/07
CPC分类号： C12N5/062 , A61K35/12 , C12N2500/44 , C12N2501/105 , C12N2501/115 , C12N2501/155 , C12N2501/385 , C12N2501/41 , C12N2501/415 , C12N2506/02 , C12N2506/45
摘要： Disclosed is a composition for inducing the proliferation of retinal cells or the differentiation of retinal progenitor cells into retinal cells. The composition, similar to in vivo conditions for development during embryogenesis, induces stem cells to differentiate into a multitude of photoreceptor cells at high yield within a short period of time, without an additional gene transfer. In addition, the differentiated photoreceptor cells are useful in cellular therapy because they, when transplanted into degenerated or injured retinas, can be engrafted and fused within the retinas to prevent or cure retinal degeneration.
摘要翻译：公开了用于诱导视网膜细胞增殖或将视网膜祖细胞分化成视网膜细胞的组合物。与胚胎发生期间的体内发育条件类似的组合物诱导干细胞在短时间内以高产率分化成多种感光细胞细胞，而不需要额外的基因转移。此外，分化的感光细胞可用于细胞治疗，因为它们在移植到退化或损伤的视网膜中时可以被植入并融合在视网膜内以预防或治愈视网膜变性。

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