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1. 发明授权

US08409821B2 Detection of hypertension using glucuronidated metabolic products 有权
标题翻译：使用葡萄糖醛酸化代谢产物检测高血压
公开(公告)号：US08409821B2
公开(公告)日：2013-04-02
申请号：US12716570
申请日：2010-03-03
申请人： Hyesook Kim , Jorge H. Capdevila , Raymond F. Novak , Deanna Kroetz
发明人： Hyesook Kim , Jorge H. Capdevila , Raymond F. Novak , Deanna Kroetz
IPC分类号： G01N33/53 , G01N33/531 , G01N33/532 , C12Q1/48 , C07K16/00
CPC分类号： G01N33/88 , G01N2800/321
摘要： A method of assessing arachidonic acid (AA) metabolites-dependent hypertension by measuring glucuronidated dihydroxyeicosatrienoic acids (DHETs) and DHET metabolites in a biological sample which contains the epitopes unique to DHET (using any methods including GC/MS, LC/MS or ELISA). An example of the glucuronidated DHET metabolite is DHET-alcohols such as omega or omega-1 oxidated DHET and DHET esterified glycerol. The method further includes determining the amount of glucuronidated molecules containing a DHET-specific epitope which is immunoreactive with antibodies produced against DHETs.
摘要翻译：通过测量包含DHET特有的表位的生物样品中的葡糖苷酸化二羟基二十碳三烯酸（DHET）和DHET代谢物来评估花生四烯酸（AA）代谢物依赖性高血压的方法（使用任何方法，包括GC / MS，LC / MS或ELISA）。葡萄糖醛酸化的DHET代谢物的实例是DHET-醇，例如ω或ω-1氧化的DHET和DHET酯化甘油。该方法还包括确定含有针对DHET产生的抗体具有免疫反应性的DHET特异性表位的葡糖醛酸化分子的量。

2. 发明申请

US20100159481A1 DETECTION OF HYPERTENSION USING GLUCURONIDATED METABOLIC PRODUCTS 有权
标题翻译：使用GLUCURONIDATED代谢产物检测高血压
公开(公告)号：US20100159481A1
公开(公告)日：2010-06-24
申请号：US12716570
申请日：2010-03-03
申请人： Hyesook Kim , Jorge H. Capdevila , Raymond F. Novak , Deanna Kroetz
发明人： Hyesook Kim , Jorge H. Capdevila , Raymond F. Novak , Deanna Kroetz
IPC分类号： G01N33/573 , C12Q1/34
CPC分类号： G01N33/88 , G01N2800/321
摘要： A method of assessing arachidonic acid (AA) metabolites-dependent hypertension by measuring glucuronidated dihydroxyeicosatrienoic acids (DHETs) and DHET metabolites in a biological sample which contains the epitopes unique to DHET (using any methods including GC/MS, LC/MS or ELISA). An example of the glucuronidated DHET metabolite is DHET-alcohols such as omega or omega-1 oxidated DHET and DHET esterified glycerol. The method further includes determining the amount of glucuronidated molecules containing a DHET-specific epitope which is immunoreactive with antibodies produced against DHETs.
摘要翻译：通过测量包含DHET特有的表位的生物样品中的葡糖醛酸二羟基二十碳三烯酸（DHET）和DHET代谢物来评估花生四烯酸（AA）代谢物依赖性高血压的方法（使用任何方法，包括GC / MS，LC / MS或ELISA）。葡萄糖醛酸化的DHET代谢物的一个实例是DHET-醇如ω或ω-1氧化的DHET和DHET酯化甘油。该方法还包括确定含有针对DHET产生的抗体具有免疫反应性的DHET特异性表位的葡糖醛酸化分子的量。

3. 发明申请

US20080058215A1 Chip Production, Hybridization and Data Interpretation for Antibody and Protein Microarrays 有权
标题翻译：芯片生产，抗体和蛋白质微阵列的杂交和数据解释
公开(公告)号：US20080058215A1
公开(公告)日：2008-03-06
申请号：US10593412
申请日：2005-03-18
申请人： Hyesook Kim , Alan A. Dombkowski , Raymond F. Novak , Brian B. Haab
发明人： Hyesook Kim , Alan A. Dombkowski , Raymond F. Novak , Brian B. Haab
IPC分类号： C40B30/04 , C40B40/10 , C40B50/06
CPC分类号： G01N33/54366 , G01N33/54306 , G01N33/573 , G01N2333/90245
摘要： An antibody microarray screen including a substrate, monoclonal and polyclonal antibodies that are purified immunoglobins, wherein the antibodies are spotted on predetermined positions on the substrate, and fluids unprocessed for immunoglobulin isolation (e.g., anti-sera, ascites fluids, or hybridoma culture media), wherein the unprocessed fluids are spotted on the predetermined positions on the substrate. Production of drug-metabolizing enzyme antibody microarrays containing closely related cytochromes P450 is disclosed. Methods of manufacturing an antibody microarray, an internal control molecule for use in an antibody microarray, a method of determining optimal spotting concentrations of IgG and a method to increase a detectable signal with microarray analysis are disclosed.
摘要翻译：一种包含底物，纯化免疫球蛋白的单克隆抗体和多克隆抗体的抗体微阵列筛选，其中所述抗体被点在基底上的预定位置，以及未加工用于免疫球蛋白分离的流体（例如抗血清，腹水或杂交瘤培养基），其中未处理的流体被点在基板上的预定位置上。公开了含有密切相关的细胞色素P450的药物代谢酶抗体微阵列的生产。公开了制造抗体微阵列的方法，用于抗体微阵列的内部对照分子，确定IgG的最佳点样浓度的方法以及通过微阵列分析增加可检测信号的方法。

4. 发明授权

US08765641B2 Chip production, hybridization and data interpretation for antibody and protein microarrays 有权
标题翻译：针对抗体和蛋白质微阵列的芯片生产，杂交和数据解释
公开(公告)号：US08765641B2
公开(公告)日：2014-07-01
申请号：US10593412
申请日：2005-03-18
申请人： Hyesook Kim , Alan A. Dombkowski , Raymond F. Novak , Brian B. Haab
发明人： Hyesook Kim , Alan A. Dombkowski , Raymond F. Novak , Brian B. Haab
IPC分类号： C40B30/04 , G01N33/563
CPC分类号： G01N33/54366 , G01N33/54306 , G01N33/573 , G01N2333/90245
摘要： An antibody microarray screen including a substrate, monoclonal and polyclonal antibodies that are purified immunoglobins, wherein the antibodies are spotted on predetermined positions on the substrate, and fluids unprocessed for immunoglobulin isolation (e.g., anti-sera, ascites fluids, or hybridoma culture media), wherein the unprocessed fluids are spotted on the predetermined positions on the substrate. Production of drug-metabolizing enzyme antibody microarrays containing closely related cytochromes P450 is disclosed. Methods of manufacturing an antibody microarray, an internal control molecule for use in an antibody microarray, a method of determining optimal spotting concentrations of IgG and a method to increase a detectable signal with microarray analysis are disclosed.
摘要翻译：一种包含底物，纯化免疫球蛋白的单克隆抗体和多克隆抗体的抗体微阵列筛选，其中所述抗体被点在基底上的预定位置，以及未加工用于免疫球蛋白分离的流体（例如抗血清，腹水或杂交瘤培养基），其中未处理的流体被点在基板上的预定位置上。公开了含有密切相关的细胞色素P450的药物代谢酶抗体微阵列的生产。公开了制造抗体微阵列的方法，用于抗体微阵列的内部对照分子，确定IgG的最佳点样浓度的方法以及通过微阵列分析增加可检测信号的方法。

5. 发明申请

US20080145858A1 DETECTION AND IDENTIFICATION OF TOXICANTS BY MEASUREMENT OF GENE EXPRESSION PROFILE 审中-公开
标题翻译：通过测量基因表达谱来检测和鉴定毒素
公开(公告)号：US20080145858A1
公开(公告)日：2008-06-19
申请号：US11964117
申请日：2007-12-26
申请人： Hyesook Kim , Mary Murray , Raymond F. Novak
发明人： Hyesook Kim , Mary Murray , Raymond F. Novak
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , A01K2227/50 , C12Q2600/142 , C12Q2600/158
摘要： A screen for detecting, identifying, and characterizing chemicals as toxicants is based on the affect of the chemical on gene expression in animal cleavage stage embryos. A microarray screen for detecting and measuring the affects of chemicals on gene expression in animal cleavage stage embryos. A screen for detecting, identifying and characterizing chemicals as toxicants based on the common or differential affects on gene expression in animal cleavage stage embryos and neurulation stage embryos. Markers of chemical exposure and teratogenesis identified using the screen disclosed herein. A treatment that enables the transfer of biotinylated PCR products or DNA to a membrane following gel electrophoresis by depurinating the PCR or DNA products and denaturing the PCR products or DNA.
摘要翻译：用于检测，鉴定和表征化学品作为有毒物质的屏幕是基于化学物质对动物切割阶段胚胎中基因表达的影响。一种用于检测和测量化学物质对动物切割期胚胎中基因表达的影响的微阵列筛选。基于对动物切割阶段胚胎和神经阶段胚胎中基因表达的共同或不同影响的用于检测，鉴定和表征化学品作为有毒物质的筛选。使用本文公开的屏幕鉴定化学暴露和致畸的标记。通过对PCR或DNA产物进行降解和变性PCR产物或DNA，可以在凝胶电泳后将生物素化的PCR产物或DNA转移到膜上进行处理。

6. 发明授权

US5525482A Method and cell line for testing cytotoxicity and mutagenicity of a chemical 失效
标题翻译：用于测试化学品的细胞毒性和致突变性的方法和细胞系
公开(公告)号：US5525482A
公开(公告)日：1996-06-11
申请号：US339658
申请日：1994-11-15
申请人： J. Christopher States , Ronald N. Hines , Raymond F. Novak
发明人： J. Christopher States , Ronald N. Hines , Raymond F. Novak
IPC分类号： C12N9/02 , G01N33/50 , C12Q1/18 , C12N5/10 , C12N15/09
CPC分类号： C12N9/0077 , G01N33/5017
摘要： A method of testing the cytotoxicity and mutagenicity of a chemical includes the steps of exposing test cells to the chemical in vitro, intracellularly metabolizing the chemical into a mutagenic or cytotoxic metabolite and then detecting gene/protein/cell damage in the test cells as an indication of the mutagenicity/cytotoxicity of the chemical.A cell line is provided for testing cytotoxicity and mutagenicity of the chemicals, the cell line consisting essentially of fibroblasts normally having no detectable cytochrome P450 mixed function oxidase enzyme activity. The fibroblasts are transformed with chimeric gene constructs containing cytochrome P450 coding sequences and have intracellular cytochrome P450 oxidative metabolizing activity.
摘要翻译：测试化学品的细胞毒性和致突变性的方法包括以下步骤：将测试细胞在体外暴露于化学物质，将细胞内代谢化学物质转化为诱变或细胞毒性代谢物，然后检测测试细胞中的基因/蛋白质/细胞损伤作为指示的化学物质的致突变性/细胞毒性。提供用于测试化学物质的细胞毒性和致突变性的细胞系，细胞系基本上由通常不具有可检测的细胞色素P450混合功能氧化酶活性的成纤维细胞组成。用含有细胞色素P450编码序列的嵌合基因构建体转化成纤维细胞，并具有细胞内细胞色素P450氧化代谢活性。

7. 发明授权

US4784308A Fastener driving tool 失效
标题翻译：紧固件驱动工具
公开(公告)号：US4784308A
公开(公告)日：1988-11-15
申请号：US847726
申请日：1986-04-03
申请人： Raymond F. Novak , Ernest F. Schaudek
发明人： Raymond F. Novak , Ernest F. Schaudek
IPC分类号： B25C1/00 , B25C1/04 , B25C5/16 , B25C5/13
CPC分类号： B25C5/1624 , B25C1/003 , B25C1/045
摘要： A pneumatic fastener driving tool includes a return system for efficiently and rapidly returning a drive piston to the static position and effecting a fastener feeding operation. A housing defines a pressure fluid reservoir connected by a pneumatic control system to a first side of a drive piston to move a driver blade through a drive track in a drive stroke. A pressure fluid actuated fastener feed assembly advances fasteners along a feed path to the drive track. Following a drive stroke, the return system connects the reservoir to the second side of the drive piston for moving the drive piston and driver blade in a return stroke. The return system also connects the reservoir to the fastener feeding assembly for feeding of a fastener. The return system includes two separate return valves operable at different flow capacities and fluid pressures for drive piston return and for fastener feeding.
摘要翻译：气动紧固件驱动工具包括用于有效且快速地将驱动活塞返回到静态位置并进行紧固件进给操作的返回系统。壳体限定通过气动控制系统连接到驱动活塞的第一侧的压力流体储存器，以在驱动行程中移动驱动器叶片通过驱动轨道。压力流体致动的紧固件进给组件沿着进给路径将紧固件推进到驱动轨道。在驱动行程之后，返回系统将储存器连接到驱动活塞的第二侧，用于在回程中移动驱动活塞和驱动器叶片。返回系统还将储存器连接到用于馈送紧固件的紧固件进给组件。返回系统包括两个单独的返回阀，可在不同的流量和流体压力下操作，用于驱动活塞返回和紧固件进给。

8. 发明授权

US4200215A Compression tacker 失效
标题翻译：压片机
公开(公告)号：US4200215A
公开(公告)日：1980-04-29
申请号：US921977
申请日：1978-07-05
申请人： Raymond F. Novak , Richard Doyle , Edmund Frank
发明人： Raymond F. Novak , Richard Doyle , Edmund Frank
IPC分类号： B25C5/06 , B25C5/10 , B25C5/00
CPC分类号： B25C5/10 , B25C5/06
摘要： A compression tacker for driving fasteners includes a frame defining a nose portion and a grip portion. A front jaw is pivotally and removably mounted on the nose portion to define a drive track. A plunger is reciprocated in the drive track. The front jaw includes a locking mechanism that upon actuation by the operator of the tool, unlocks the jaw from the frame and allows it to be pivoted relative to the frame to expose the drive track. A handle for actuating the plunger is mounted on the frame and includes a bearing about which a spring is mounted. A workpiece engaging jaw may be removably fastened to the nose portion. The workpiece jaw includes upper and lower surfaces for engaging different workpieces.
摘要翻译：用于驱动紧固件的压紧粘合剂包括限定鼻部和抓握部的框架。前颚枢转地和可拆卸地安装在鼻部上以限定驱动轨道。柱塞在驱动轨道中往复运动。前钳口包括锁定机构，该操作机构在操作者致动时，将卡爪从框架解锁，并允许其相对于框架枢转以露出驱动轨道。用于致动柱塞的把手安装在框架上，并且包括一个轴承，弹簧围绕该轴承安装。工件接合爪可以可拆卸地紧固到鼻部。工件夹爪包括用于接合不同工件的上表面和下表面。

9. 发明授权

US4463888A Fastener driving tool 失效
标题翻译：紧固件驱动工具
公开(公告)号：US4463888A
公开(公告)日：1984-08-07
申请号：US256409
申请日：1981-04-22
申请人： Bernard W. Geist , Edmund Frank , Richard H. Doyle , Raymond F. Novak
发明人： Bernard W. Geist , Edmund Frank , Richard H. Doyle , Raymond F. Novak
IPC分类号： B25C1/00 , B25C1/04 , B25C7/00
CPC分类号： B25C1/005
摘要： A tool for driving uncollated nails includes a tool body with a nose portion defining a drive track wherein a driver blade moves in drive and return strokes. A magazine carried by the body supports a row of nails, and a pusher urges the nails along a feed path toward the drive track. The magazine is adjustable for tailoring the feed path width to the nail size. Individual nails are advanced from the magazine to a drive position in the drive track by an escapement mechanism operated in timed relationship with the driver blade, and an advanced nail is held in the drive position by a magnet assembly supported by the tool nose portion. Nails are positively advanced and are properly oriented by the escapement mechanism independently of the number of nails, the pusher force, or other conditions in the magazine. The tool magazine is quickly and conveniently loaded with nails supplied in an oriented condition from a loading chute. The loading operation is automatic in response to engagement of the magazine with the chute, and does not require awkward manipulation of the pusher. Coupling members on the magazine and on the chute are mated by means of ramp and guide structures. In the mated position, stops in the nail path are opened to permit nails to slide from the chute into the magazine.
摘要翻译：用于驱动未折叠钉子的工具包括具有限定驱动轨道的鼻部的工具主体，其中驱动器刀片在驱动和返回行程中移动。由身体携带的杂志支撑一排指甲，并且推动器沿着沿着驱动轨道的馈送路径推动指甲。这个杂志是可调整的，用于根据钉子尺寸调整进给路径宽度。单个指甲通过与驱动器刀片定时关系操作的擒纵机构从刀库前进到驱动轨道中的驱动位置，并且先进的钉子由由刀尖部分支撑的磁体组件保持在驱动位置。钉子是积极进取的，并且由擒纵机构适当地定向，独立于钉子的数量，推动力或杂志中的其他条件。工具箱快速方便地装载从装载滑槽以定向状态提供的指甲。响应于料仓与滑槽的接合，加载操作是自动的，并且不需要对推动器的笨拙的操纵。杂志和滑槽上的耦合元件通过斜坡和引导结构配合。在配合位置，指甲路上的停止位置打开，以便指甲从滑槽滑入料仓。

10. 发明授权

US4375867A Electric fastener driving tool 失效
标题翻译：电动紧固件驱动工具
公开(公告)号：US4375867A
公开(公告)日：1983-03-08
申请号：US148365
申请日：1980-05-09
申请人： Raymond F. Novak , Richard Doyle
发明人： Raymond F. Novak , Richard Doyle
IPC分类号： B25C1/00 , B25C1/06
CPC分类号： B25C1/008 , B25C1/005 , B25C1/06
摘要： An electric nailer includes a body and a fastener magazine pivotally connected thereto. The nailer also includes a switch for energizing the nailer that is engagable by a safety to prevent actuation. The safety is moved out of engagement with the switch upon pivoting of the magazine. The magazine includes a pusher assembly defined in part by portions of an elongated tube joined together to define a gap. A pusher is slideably mounted within the gap and biased to push fasteners toward the nose of the nailer. The magazine also includes a fastener track that includes a reduced portion and an enlarged portion to accommodate fasteners of different sizes. A shoe may be releasably attached to the bottom portion of the magazine and in one embodiment is V-shaped including a raised portion at one end. In another embodiment the shoe has a flat workpiece engagement portion.
摘要翻译：电动钉枪包括主体和枢轴连接的紧固件仓。钉子还包括用于通过安全性可接合以防止致动的打钉机的开启。当弹匣旋转时，安全性与开关脱离啮合。杂志包括推动器组件，该推动器组件被部分地限定为连接在一起以限定间隙的细长管的一部分。推动器可滑动地安装在间隙内并被偏压以朝向钉枪的鼻部推动紧固件。该杂志还包括一个紧固件轨道，其包括减小部分和扩大部分以适应不同尺寸的紧固件。鞋可以可释放地附接到钉仓的底部，并且在一个实施例中是V形，包括在一端的凸起部分。在另一个实施例中，鞋具有平坦的工件接合部分。

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