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1. 发明授权

US07812879B2 Self-triggering CMOS image sensor 有权
标题翻译：自触发CMOS图像传感器
公开(公告)号：US07812879B2
公开(公告)日：2010-10-12
申请号：US11928285
申请日：2007-10-30
申请人： Xinqiao Liu , Hung Do
发明人： Xinqiao Liu , Hung Do
IPC分类号： H04N3/14 , H04N5/335
CPC分类号： H04N5/32 , H04N5/343
摘要： An image sensor and method for using the image sensor to capture an image are disclosed. The image sensor includes an imaging array, a first block amplifier and a controller. A first plurality of pixels in the imaging array includes pixels having a photodiode connected to a first node by a gate transistor, a reset transistor connected between the first node and a reset node, a pixel amplifier having an input connected to the first node and an output, and an output gate for connecting the pixel amplifier output to an output bus. The sensor has a monitoring mode and an image capture mode. In the monitoring mode the reset node is connected to the first block amplifier whose output is monitored and used to trigger the image capture mode when the output exceeds a predetermined threshold.
摘要翻译：公开了一种使用图像传感器拍摄图像的图像传感器和方法。图像传感器包括成像阵列，第一块放大器和控制器。成像阵列中的第一多个像素包括具有通过栅晶体管连接到第一节点的光电二极管的像素，连接在第一节点和复位节点之间的复位晶体管，具有连接到第一节点的输入的像素放大器和输出，以及用于将像素放大器输出连接到输出总线的输出门。传感器具有监控模式和图像捕捉模式。在监视模式下，复位节点连接到第一块放大器，其输出被监视并用于当输出超过预定阈值时触发图像捕获模式。

2. 发明申请

US20130344054A1 VARIANT, RECOMBINANT BETA-GLUCOCEREBROSIDASE PROTEINS WITH INCREASED STABILITY AND INCREASED RETAINED CATALYTIC ACTIVITY 有权
标题翻译：变体，具有增加的稳定性和增加的保留催化活性的重组型β-GLUCOCEREBROSIDASE蛋白
公开(公告)号：US20130344054A1
公开(公告)日：2013-12-26
申请号：US13884126
申请日：2011-11-08
申请人： Hung Do
发明人： Hung Do
IPC分类号： C12N9/24
CPC分类号： A61K38/47 , A61K31/445 , C12N9/2402 , C12Y302/01045
摘要： Described herein are variant, recombinant β-glucocerebrosidase proteins characterized as having increased stability relative to recombinant wild-type β-glucocerebrosidase. Also provided herein are variant, recombinant β-glucocerebrosidase proteins characterized as retaining more catalytic activity relative to recombinant wild-type β-glucocerebrosidase. Further described herein are variant, recombinant β-glucocerebrosidase proteins that can have amino acid variations at one or more of the following positions: 316, 317, 321 and 145. Methods of making the variant, recombinant β-glucocerebrosidase proteins are also described as well as methods of treating patients having lysosomal storage diseases.
摘要翻译：本文描述的是重组β-葡糖脑苷脂酶蛋白，其特征在于相对于重组野生型β-葡糖脑苷脂酶具有增加的稳定性。本文还提供了相对于重组野生型β-葡糖脑苷脂酶具有更多催化活性的变体，重组β-葡糖脑苷脂酶蛋白质。本文进一步描述的是可以在以下一个或多个位置具有氨基酸变异的变体，重组β-葡糖脑苷脂酶蛋白：316,317,321和145.还描述了制备变体，重组β-葡糖脑苷脂酶蛋白的方法作为治疗患有溶酶体贮积病的患者的方法。

3. 发明申请

US20090109313A1 Self-Triggering CMOS Image Sensor 有权
标题翻译：自动触发CMOS图像传感器
公开(公告)号：US20090109313A1
公开(公告)日：2009-04-30
申请号：US11928285
申请日：2007-10-30
申请人： Xinqiao Liu , Hung Do
发明人： Xinqiao Liu , Hung Do
IPC分类号： H04N5/335
CPC分类号： H04N5/32 , H04N5/343
摘要： An image sensor and method for using the image sensor to capture an image are disclosed. The image sensor includes an imaging array, a first block amplifier and a controller. A first plurality of pixels in the imaging array includes pixels having a photodiode connected to a first node by a gate transistor, a reset transistor connected between the first node and a reset node, a pixel amplifier having an input connected to the first node and an output, and an output gate for connecting the pixel amplifier output to an output bus. The sensor has a monitoring mode and an image capture mode. In the monitoring mode the reset node is connected to the first block amplifier whose output is monitored and used to trigger the image capture mode when the output exceeds a predetermined threshold.
摘要翻译：公开了一种使用图像传感器拍摄图像的图像传感器和方法。图像传感器包括成像阵列，第一块放大器和控制器。成像阵列中的第一多个像素包括具有通过栅晶体管连接到第一节点的光电二极管的像素，连接在第一节点和复位节点之间的复位晶体管，具有连接到第一节点的输入的像素放大器和输出，以及用于将像素放大器输出连接到输出总线的输出门。传感器具有监控模式和图像捕获模式。在监视模式下，复位节点连接到第一块放大器，其输出被监视并用于当输出超过预定阈值时触发图像捕获模式。

4. 发明申请

US20060115357A1 Runner for francis type hydraulic turbine 审中-公开
标题翻译：弗兰西斯型水轮机轮毂
公开(公告)号：US20060115357A1
公开(公告)日：2006-06-01
申请号：US11260434
申请日：2005-10-28
申请人： Stuart Coulson , Hung Do
发明人： Stuart Coulson , Hung Do
IPC分类号： F01D1/02
CPC分类号： F03B3/125 , F05B2240/242 , F05B2240/301 , Y02E10/223
摘要： There is disclosed a runner for a Francis-type hydraulic turbine where each runner blade has a outlet edge comprising a deflected edge portion. The deflected edge portion is located adjacent to the junction or attachment point of the outlet edge to the band of the runner to define a stress reducing tip extension portion of the blade adjacent the band. This tip extension portion reduces stress concentration adjacent where the outlet edge joins the runner band.
摘要翻译：公开了一种用于弗朗西斯型水轮机的转轮，其中每个转轮叶片具有包括偏转边缘部分的出口边缘。偏转的边缘部分位于与出口边缘的连接点或连接点相邻的流道的带上，以限定与带相邻的叶片的应力减小尖端延伸部分。该尖端延伸部分减少出口边缘连接转轮带附近的应力集中。

5. 发明授权

US09545450B2 Methods for coupling targeting peptides onto recombinant lysosomal enzymes for improved treatments of lysosomal storage diseases 有权
标题翻译：将靶向肽结合到重组溶酶体酶上以改进溶酶体贮积病治疗的方法
公开(公告)号：US09545450B2
公开(公告)日：2017-01-17
申请号：US14122858
申请日：2012-05-25
申请人： Hung Do
发明人： Hung Do
IPC分类号： C12N9/96 , A61K38/47 , A61K47/48 , C07K14/65 , C12N9/16 , C12N9/24
CPC分类号： A61K47/6847 , A61K38/47 , A61K47/642 , C07K14/65 , C07K2319/00 , C07K2319/21 , C07K2319/50 , C12N9/16 , C12N9/2402 , C12N9/96
摘要： Described herein are methods of making targeting peptides conjugated to recombinant lysosomal enzymes by modifying the amino (N)-terminus and one or more lysine residues on recombinant human lysosomal enzymes using a first crosslinking agent to give rise to first crosslinking agent modified recombinant human lysosomal enzymes, modifying the first amino acid within a short linker at the amino (N)-terminus on a variant IGF-2 peptide using a second crosslinking agent to give rise to a second crosslinking agent modified variant IGF-2 peptide, and then conjugating the first crosslinking agent modified recombinant human lysosomal enzyme to the second crosslinking agent modified variant IGF-2 peptide containing a short linker. Also described herein are conjugates synthesized characterized as having higher affinities for the IGF2/CI-MPR receptor and cellular uptake using the methods disclosed herein. Also described herein are treatment methods using the disclosed conjugates.
摘要翻译：本文描述的是通过使用第一交联剂修饰重组人溶酶体酶上的氨基（N）末端和一个或多个赖氨酸残基以产生第一交联剂修饰的重组人溶酶体酶来制备与重组溶酶体酶缀合的靶向肽的方法使用第二交联剂在变体IGF-2肽上在氨基（N）末端修饰短接头内的第一个氨基酸，以产生第二交联剂修饰的变体IGF-2肽，然后将第一个交联剂修饰的重组人溶酶体酶至含有短接头的第二交联剂修饰变体IGF-2肽。本文还描述了使用本文公开的方法合成的缀合物，其特征在于对IGF2 / CI-MPR受体具有较高的亲和力和细胞摄取。本文还描述了使用所公开的缀合物的治疗方法。

6. 发明申请

US20140045216A1 NOVEL SIGNAL SEQUENCES TO IMPROVE PROTEIN EXPRESSIONS AND SECRETION OF RECOMBINANT ENZYMES AND OTHER PROTEINS 有权
标题翻译：提高蛋白质表达和重组酶及其他蛋白质分泌的新信号序列
公开(公告)号：US20140045216A1
公开(公告)日：2014-02-13
申请号：US13988946
申请日：2011-11-22
申请人： Hung Do
发明人： Hung Do
IPC分类号： C07K14/47 , C12N9/24
CPC分类号： C07K14/47 , C07K2319/036 , C12N9/0002 , C12N9/2402 , C12N9/2434 , C12N15/85
摘要： Polypeptide signal sequences of modified fragments of human immunoglobulin heavy chain binding protein (Bip) are disclosed. Also disclosed are fusion proteins comprising a modified fragment of human immunoglobulin heavy chain binding protein (Bip) operably linked to a heterologous polypeptide. Also disclosed are protein expression vectors comprising a promoter operably linked to a first DNA sequence encoding a signal sequence comprising a modified fragment of human immunoglobulin heavy chain binding protein (Bip) and a second DNA sequence encoding a heterologous polypeptide fused in frame to the first DNA sequence. Further disclosed are methods of producing a polypeptide comprising expressing a fusion protein comprising a polypeptide signal sequences of modified fragments of human immunoglobulin heavy chain binding protein (Bip) operably linked to a heterologous polypeptide and recovering the heterologous polypeptide.
摘要翻译：公开了人免疫球蛋白重链结合蛋白（Bip）的修饰片段的多肽信号序列。还公开了包含可操作地连接到异源多肽的人免疫球蛋白重链结合蛋白（Bip）的修饰片段的融合蛋白。还公开了包含可操作地连接到编码包含人免疫球蛋白重链结合蛋白（Bip）的修饰片段的信号序列的第一DNA序列的启动子的蛋白质表达载体和编码与第一DNA融合的异源多肽的第二DNA序列序列。还公开了生产多肽的方法，其包括表达融合蛋白，其包含可操作地连接到异源多肽的人免疫球蛋白重链结合蛋白（Bip）的修饰片段的多肽信号序列，并回收异源多肽。

7. 发明授权

US5226804A Propeller blade configuration 失效
标题翻译：螺旋桨叶片配置
公开(公告)号：US5226804A
公开(公告)日：1993-07-13
申请号：US713227
申请日：1991-06-11
申请人： Hung Do
发明人： Hung Do
IPC分类号： F03B3/12
CPC分类号： F03B3/121 , F03B3/126 , Y02E10/223 , Y10S416/04
摘要： A propeller type runner is described in which the leading edge of each blade "leans" forward from the root in the direction of rotation to reduce cavitation and increase efficiency. The "lean" provided to each blade of a five blade design is such that the leading edge of each blade obscures a large portion of the trailing edge of the preceding blade.
摘要翻译：描述了一种螺旋桨型流道，其中每个叶片的前缘沿着旋转方向从根部向前倾斜以减少空化并提高效率。提供给五叶片设计的每个叶片的“瘦”使得每个叶片的前缘遮挡前一叶片的后缘的大部分。

8. 发明授权

US09279007B2 Signal sequences to improve protein expressions and secretion of recombinant enzymes and other proteins 有权
标题翻译：用于改善重组酶和其他蛋白质的蛋白质表达和分泌的信号序列
公开(公告)号：US09279007B2
公开(公告)日：2016-03-08
申请号：US13988946
申请日：2011-11-22
申请人： Hung Do
发明人： Hung Do
IPC分类号： C07K14/47 , C12N9/00 , C12N9/24 , C12N9/42 , C12N15/85
CPC分类号： C07K14/47 , C07K2319/036 , C12N9/0002 , C12N9/2402 , C12N9/2434 , C12N15/85
摘要： Polypeptide signal sequences of modified fragments of human immunoglobulin heavy chain binding protein (Bip) are disclosed. Also disclosed are fusion proteins comprising a modified fragment of human immunoglobulin heavy chain binding protein (Bip) operably linked to a heterologous polypeptide. Also disclosed are protein expression vectors comprising a promoter operably linked to a first DNA sequence encoding a signal sequence comprising a modified fragment of human immunoglobulin heavy chain binding protein (Bip) and a second DNA sequence encoding a heterologous polypeptide fused in frame to the first DNA sequence. Further disclosed are methods of producing a polypeptide comprising expressing a fusion protein comprising a polypeptide signal sequences of modified fragments of human immunoglobulin heavy chain binding protein (Bip) operably linked to a heterologous polypeptide and recovering the heterologous polypeptide.
摘要翻译：公开了人免疫球蛋白重链结合蛋白（Bip）的修饰片段的多肽信号序列。还公开了包含可操作地连接到异源多肽的人免疫球蛋白重链结合蛋白（Bip）的修饰片段的融合蛋白。还公开了包含可操作地连接于编码包含人免疫球蛋白重链结合蛋白（Bip）的修饰片段的信号序列的第一DNA序列的启动子的蛋白质表达载体和编码与第一DNA融合的异源多肽的第二DNA序列序列。还公开了生产多肽的方法，其包括表达融合蛋白，其包含可操作地连接到异源多肽的人免疫球蛋白重链结合蛋白（Bip）的修饰片段的多肽信号序列，并回收异源多肽。

9. 发明申请

US20140302001A1 METHODS FOR COUPLING TARGETING PEPTIDES ONTO RECOMBINANT LYSOSOMAL ENZYMES FOR IMPROVED TREATMENTS OF LYSOSOMAL STORAGE DISEASES 有权
标题翻译：将靶向肽连接到用于改善体液储存疾病治疗的重组体溶菌酶的方法
公开(公告)号：US20140302001A1
公开(公告)日：2014-10-09
申请号：US14122858
申请日：2012-05-25
申请人： Hung Do
发明人： Hung Do
IPC分类号： C12N9/96 , A61K38/47 , A61K47/48
CPC分类号： A61K47/6847 , A61K38/47 , A61K47/642 , C07K14/65 , C07K2319/00 , C07K2319/21 , C07K2319/50 , C12N9/16 , C12N9/2402 , C12N9/96
摘要： Described herein are methods of making targeting peptides conjugated to recombinant lysosomal enzymes by modifying the amino (N)-terminus and one or more lysine residues on recombinant human lysosomal enzymes using a first crosslinking agent to give rise to first crosslinking agent modified recombinant human lysosomal enzymes, modifying the first amino acid within a short linker at the amino (N)-terminus on a variant IGF-2 peptide using a second crosslinking agent to give rise to a second crosslinking agent modified variant IGF-2 peptide, and then conjugating the first crosslinking agent modified recombinant human lysosomal enzyme to the second crosslinking agent modified variant IGF-2 peptide containing a short linker. Also described herein are conjugates synthesized characterized as having higher affinities for the IGF2/CI-MPR receptor and cellular uptake using the methods disclosed herein. Also described herein are treatment methods using the disclosed conjugates.
摘要翻译：本文描述的是通过使用第一交联剂修饰重组人溶酶体酶上的氨基（N）末端和一个或多个赖氨酸残基以产生第一交联剂修饰的重组人溶酶体酶来制备与重组溶酶体酶缀合的靶向肽的方法使用第二交联剂在变体IGF-2肽上在氨基（N）末端修饰短接头内的第一个氨基酸，以产生第二交联剂修饰的变体IGF-2肽，然后将第一个交联剂修饰的重组人溶酶体酶至含有短接头的第二交联剂修饰变体IGF-2肽。本文还描述了使用本文公开的方法合成的缀合物，其特征在于对IGF2 / CI-MPR受体具有较高的亲和力和细胞摄取。本文还描述了使用所公开的缀合物的治疗方法。

10. 发明授权

US07268338B2 Imaging array having variable conversion gain 有权
公开(公告)号：US07268338B2
公开(公告)日：2007-09-11
申请号：US11175948
申请日：2005-07-06
申请人： Xinqiao (Chiao) Liu , Hung Do
发明人： Xinqiao (Chiao) Liu , Hung Do
IPC分类号： H03F3/08
CPC分类号： H04N5/378 , H04N5/243 , H04N5/355
摘要： A CCD imaging array and a charge measurement amplifier for use in such imaging arrays is disclosed. The array includes a plurality of pixels that accumulate charge when exposed to light, a readout amplifier having input and output ports. The readout amplifier has a variable gain that is set by a gain control signal. The readout amplifier also includes a reset path between the input and output ports, the path having an impedance controlled by a reset signal. A controller generates the gain control signal and the reset signal during a charge measurement cycle. Initially the gain is set to a first value after generating the reset signal. The gain is changed to a second value during the charge measurement cycle if the output signal exceeds a first threshold value. The readout amplifier can be constructed from an operational amplifier having a capacitive feedback loop.

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