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1. 发明授权

US07592807B2 Maximum likelihood estimator in the presence of non-identically distributed noise for decomposition of chemical species in MRI 有权
标题翻译：在存在不均匀分布的噪声用于MRI中化学物质分解的情况下的最大似然估计量
公开(公告)号：US07592807B2
公开(公告)日：2009-09-22
申请号：US11738343
申请日：2007-04-20
申请人： Angel R. Pineda , Charles A. McKenzie , Huanzhou Yu , Scott B. Reeder
发明人： Angel R. Pineda , Charles A. McKenzie , Huanzhou Yu , Scott B. Reeder
IPC分类号： G01V3/00
CPC分类号： G01R33/5611 , G01R33/4828 , G01R33/5608 , G01R33/5615
摘要： A method of separating signals from at least two species in a body using echo-coherent time magnetic resonance imaging is provided. A plurality of echo signals is acquired at acquisition times optimized based on the noise properties of images with different variance with possibly correlated noise resulting in possibly asymmetrically positioned images with respect to an echo time. The plurality of echo signals is combined iteratively by using a maximum likelihood decomposition algorithm for non-identically distributed noise.
摘要翻译：提供了使用回波相干时间磁共振成像从身体中的至少两个物种分离信号的方法。在基于具有不同方差的图像的噪声属性优化的采集时间获取多个回波信号，可能的相关噪声导致相对于回波时间可能不对称地定位的图像。通过使用用于非相同分布的噪声的最大似然分解算法来迭代地组合多个回波信号。

2. 发明授权

US07468605B2 Simultaneous chemical species separation and T2* measurement using MRI 有权
标题翻译：使用MRI同时进行化学物质分离和T2 *测量
公开(公告)号：US07468605B2
公开(公告)日：2008-12-23
申请号：US11738350
申请日：2007-04-20
申请人： Huanzhou Yu , Scott B. Reeder , Charles A. McKenzie , Angel R. Pineda
发明人： Huanzhou Yu , Scott B. Reeder , Charles A. McKenzie , Angel R. Pineda
IPC分类号： G01V3/00
CPC分类号： G01N24/08 , G01R33/4828 , G01R33/50
摘要： A method for generating a magnetic resonance image is provided. A magnetic resonance imaging excitation is applied for a plurality of cycles at a cycle rate. A plurality of magnetic resonance image echoes is acquired for each cycle. A decay map is estimated from the plurality of magnetic resonance image echoes for each cycle. The estimated decay map is used to generate an image for at least two different species.
摘要翻译：提供了一种用于产生磁共振图像的方法。磁共振成像激励以循环速率施加多个周期。对于每个周期获取多个磁共振图像回波。对于每个周期，从多个磁共振图像回波估计衰减图。估计的衰减图用于生成至少两种不同物种的图像。

3. 发明授权

US07508211B2 Regularized species separation 有权
标题翻译：正规物种分离
公开(公告)号：US07508211B2
公开(公告)日：2009-03-24
申请号：US11738345
申请日：2007-04-20
申请人： Zhifei Wen , Angel R. Pineda , Huanzhou Yu , Scott B. Reeder , Norbert J. Pelc
发明人： Zhifei Wen , Angel R. Pineda , Huanzhou Yu , Scott B. Reeder , Norbert J. Pelc
IPC分类号： G01V3/00
CPC分类号： G01R33/4828 , G01R33/5608
摘要： A method for generating a magnetic resonance images is provided. A magnetic resonance imaging excitation is applied. A plurality of magnetic resonance image signals is acquired. The plurality of image signals is combined iteratively by using a regularized decomposition algorithm. An image created from combining the plurality of image signals iteratively is displayed.
摘要翻译：提供了一种用于产生磁共振图像的方法。应用磁共振成像激励。获得多个磁共振图像信号。多个图像信号通过使用正则化分解算法迭代地组合。显示通过迭代地组合多个图像信号而创建的图像。

4. 发明授权

US07486073B2 Sliding window reconstruction and phase/field map updating for dynamic chemical shift imaging 有权
标题翻译：动态化学位移成像的滑动窗口重建和相位/场地图更新
公开(公告)号：US07486073B2
公开(公告)日：2009-02-03
申请号：US11738347
申请日：2007-04-20
申请人： Huanzhou Yu , Charles A. McKenzie , Jean H. Brittain , Norbert J. Pelc , Scott B. Reeder
发明人： Huanzhou Yu , Charles A. McKenzie , Jean H. Brittain , Norbert J. Pelc , Scott B. Reeder
IPC分类号： G01V3/00
CPC分类号： G01R33/5617 , G01R33/4828
摘要： A method for generating dynamic magnetic resonance images is provided. A cyclical magnetic resonance imaging excitation is applied for a plurality of cycles at a cycle rate. A plurality of magnetic resonance image echoes is acquired for each cycle. A plurality of frames of images is generated from the acquired plurality of magnetic resonance echoes at a frame rate that is at least twice the cycle rate, wherein each frame of the plurality of frames is generated from a plurality of echoes and wherein some of the plurality of frames are generated from magnetic resonance image echoes of adjacent cycles.
摘要翻译：提供了一种用于产生动态磁共振图像的方法。周期磁共振成像激励以循环速率施加多个周期。对于每个周期获取多个磁共振图像回波。从所获取的多个磁共振回波以至少为循环速率的两倍的帧速率产生多个图像帧，其中，多个帧中的每个帧由多个回波生成，并且其中多个帧中的一些的帧由相邻周期的磁共振图像回波产生。

5. 发明授权

US07486074B2 Self-calibration methods for parallel imaging and multipoint water-fat separation methods 有权
标题翻译：用于平行成像和多点水脂分离方法的自校准方法
公开(公告)号：US07486074B2
公开(公告)日：2009-02-03
申请号：US11738340
申请日：2007-04-20
申请人： Charles A. McKenzie , Anja Brau , Huanzhou Yu , Scott B. Reeder , Jean H. Brittain , Ann Shimakawa
发明人： Charles A. McKenzie , Anja Brau , Huanzhou Yu , Scott B. Reeder , Jean H. Brittain , Ann Shimakawa
IPC分类号： G01V3/00
CPC分类号： G01R33/5611 , G01R33/4828 , G01R33/5607
摘要： A method for generating a self-calibrating parallel multiecho magnetic resonance image is provided. A magnetic resonance imaging excitation is applied. A first echo at a first echo time in a first pattern is acquired. A second echo at a second echo time different from the first echo phase in a second pattern different from the first pattern is acquired. The acquired first echo and acquired second echo are used to generate an image in an image pattern, wherein none of the acquired echoes for generating the image have the same pattern as the image pattern.
摘要翻译：提供了一种用于产生自校准并联多环磁共振图像的方法。应用磁共振成像激励。获取第一模式中的第一回波时间的第一回波。在与第一图案不同的第二图案中与第一回波相位不同的第二回波时间获得第二回波。获取的第一回波和获取的第二回波用于产生图像图案中的图像，其中用于生成图像的所获取的回波都不具有与图像图案相同的图案。

6. 发明授权

US07176683B2 Iterative decomposition of water and fat with echo asymmetry and least square estimation 有权
标题翻译：水和脂肪的迭代分解与回波不对称和最小二乘估计
公开(公告)号：US07176683B2
公开(公告)日：2007-02-13
申请号：US11124041
申请日：2005-05-06
申请人： Scott B. Reeder , Angel R. Pineda
发明人： Scott B. Reeder , Angel R. Pineda
IPC分类号： G01V3/00
CPC分类号： G01R33/4828 , G01R33/5608
摘要： A method of separating signals from water and lipid in a body using spin-echo magnetic resonance imaging comprising steps of acquiring image signals at three acquisition times asymmetrically positioned with respect to a spin-echo time, the three acquisition times being separated by 2π/3 and the middle signal acquisition is centered at π/2+πk where k is an integer, and combining the plurality of image signals iterative using a least squares decomposition method.
摘要翻译：一种使用自旋回波磁共振成像从身体中的水和脂质分离信号的方法，包括以相对于自旋回波时间为非对称定位的三个采集时间获取图像信号的步骤，三次采集时间被分离2pi / 3 并且中间信号采集以pi / 2 + pik为中心，其中k是整数，并且使用最小二乘法分解方法组合多个图像信号迭代。

7. 发明申请

US20110254547A1 METHOD FOR SEPARATING MAGNETIC RESONANCE IMAGING SIGNALS USING SPECTRAL DISTINCTION OF SPECIES 有权
标题翻译：使用光谱分析物种分离磁共振成像信号的方法
公开(公告)号：US20110254547A1
公开(公告)日：2011-10-20
申请号：US12761231
申请日：2010-04-15
申请人： Scott B. Reeder , Huanzhou Yu
发明人： Scott B. Reeder , Huanzhou Yu
IPC分类号： G01R33/48
CPC分类号： G01R33/4828 , G01R33/5615 , G01R33/56563
摘要： A method for producing an image of a subject with a magnetic resonance imaging (MRI) system in which a signal contribution of a chemical species is depicted and a signal contribution of another chemical species is substantially separated is provided. For example, the provided method is applicable for water-fat separation. Spectral differences between at least two different chemical species are exploited to produce a weighting map that depicts the likelihood that one chemical species being depicted as another. A weighting map that characterizes the smoothness of a field map variation is also produced. These weighting maps are utilized to produce a correct field map estimate, such that a robust separation of the signal contributions of the at least two chemical species can be performed.
摘要翻译：提供了一种利用其中描绘了化学物质的信号贡献并且另一种化学物质的信号贡献基本上分离的磁共振成像（MRI）系统来产生受试者的图像的方法。例如，所提供的方法适用于水脂分离。利用至少两种不同化学物质之间的光谱差异来产生加权图，其描绘了一种化学物种被描绘为另一种的可能性。还产生了表征场映射变化的平滑度的权重映射。这些加权图用于产生正确的场映射估计，使得可以执行至少两种化学物质的信号贡献的鲁棒分离。

8. 发明授权

US07924003B2 Method for water-fat separation and T2* estimation in an MRI system employing multiple fat spectral peaks and fat spectrum self-calibration 有权
标题翻译：在使用多个脂肪光谱峰和脂肪谱自校准的MRI系统中进行水脂分离和T2 *估计的方法
公开(公告)号：US07924003B2
公开(公告)日：2011-04-12
申请号：US12104842
申请日：2008-04-17
申请人： Huanzhou Yu , Scott B. Reeder
发明人： Huanzhou Yu , Scott B. Reeder
IPC分类号： G01V3/00
CPC分类号： G01R33/4828 , G01R33/5607 , G01R33/56527
摘要： NMR signal contributions from water and fat are separated using a model of the fat resonant frequency spectrum that has multiple resonant peaks. The relative frequencies of the multiple fat spectrum peaks are known a priori and their relative amplitudes are determined using a self-calibration process. With the determined relative amplitudes of the fat spectrum peaks, acquired NMR signals are modeled. Using this model and NMR signal data acquired at a plurality of echo times (TE), the signal contribution from multiple fat spectrum peaks is separated from the acquired NMR signal data. A combined image is alternatively produced from weighted contributions of the separated water and fat images. Additionally, a more accurate estimation of the apparent relaxation time and rate (T*2 and R*2, respectively) is alternatively performed.
摘要翻译：使用具有多个共振峰的脂肪共振频谱的模型分离水和脂肪的NMR信号贡献。多个脂肪谱峰的相对频率是先验已知的，它们的相对幅度使用自校准过程来确定。利用确定的脂肪谱峰的相对幅度，对获得的NMR信号进行建模。使用在多个回波时间（TE）下获得的该模型和NMR信号数据，从所获取的NMR信号数据中分离来自多个脂肪谱峰的信号贡献。可以通过分离的水和脂肪图像的加权贡献来产生组合图像。此外，交替进行表观松弛时间和速率（分别为T * 2和R * 2）的更准确的估计。

9. 发明申请

US20090261823A1 METHOD FOR WATER-FAT SEPARATION AND T2* ESTIMATION IN AN MRI SYSTEM EMPLOYING MULTIPLE FAT SPECTRAL PEAKS AND FAT SPECTRUM SELF-CALIBRATION 有权
标题翻译：用于水分离和T2 *估计的方法在使用多个FAT谱峰和FAT谱自校准的MRI系统中
公开(公告)号：US20090261823A1
公开(公告)日：2009-10-22
申请号：US12104842
申请日：2008-04-17
申请人： Huanzhou Yu , Scott B. Reeder
发明人： Huanzhou Yu , Scott B. Reeder
IPC分类号： G01R33/48 , G01R33/54
CPC分类号： G01R33/4828 , G01R33/5607 , G01R33/56527
摘要： NMR signal contributions from water and fat are separated using a model of the fat resonant frequency spectrum that has multiple resonant peaks. The relative frequencies of the multiple fat spectrum peaks are known a priori and their relative amplitudes are determined using a self-calibration process. With the determined relative amplitudes of the fat spectrum peaks, acquired NMR signals are modeled. Using this model and NMR signal data acquired at a plurality of echo times (TE), the signal contribution from multiple fat spectrum peaks is separated from the acquired NMR signal data. A combined image is alternatively produced from weighted contributions of the separated water and fat images. Additionally, a more accurate estimation of the apparent relaxation time and rate (T2* and R2*, respectively) is alternatively performed.
摘要翻译：使用具有多个共振峰的脂肪共振频谱的模型分离水和脂肪的NMR信号贡献。多个脂肪谱峰的相对频率是先验已知的，它们的相对幅度使用自校准过程来确定。利用确定的脂肪谱峰的相对幅度，对获得的NMR信号进行建模。使用在多个回波时间（TE）下获得的该模型和NMR信号数据，从所获取的NMR信号数据中分离来自多个脂肪谱峰的信号贡献。可以通过分离的水和脂肪图像的加权贡献来产生组合图像。此外，替代地执行更明确地估计表观弛豫时间和速率（分别为T2 *和R2 *）。

10. 发明授权

US07741842B2 Calibration maps for parallel imaging free of chemical shift artifact 有权
标题翻译：没有化学位移假象的并行成像的校准图
公开(公告)号：US07741842B2
公开(公告)日：2010-06-22
申请号：US11738352
申请日：2007-04-20
申请人： Charles A. McKenzie , Scott B. Reeder , Ann Shimakawa
发明人： Charles A. McKenzie , Scott B. Reeder , Ann Shimakawa
IPC分类号： G01V3/00
CPC分类号： G01R33/5611 , G01R33/5616 , G01R33/5617 , G01R33/56527
摘要： A method for generating a calibrated parallel magnetic resonance image is provided in a manifestation of the invention. A magnetic resonance imaging excitation is applied. A plurality of echoes at different echo times (TE) is acquired. The acquired plurality of echoes from different echo times is used to create a chemical shift corrected calibration map.
摘要翻译：在本发明的表现中提供了用于产生校准的并联磁共振图像的方法。应用磁共振成像激励。获取不同回波时间（TE）的多个回波。使用从不同回波时间获取的多个回波来创建化学位移校正校准图。

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