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1. 发明授权

US07456289B2 Anti-tumor compounds 有权
标题翻译：抗肿瘤化合物
公开(公告)号：US07456289B2
公开(公告)日：2008-11-25
申请号：US11300873
申请日：2005-12-15
申请人： Hsing-Pang Hsieh , Yu-Sheng Chao , Jing-Ping Liou , Jang-Yang Chang , Yen-Shih Tung
发明人： Hsing-Pang Hsieh , Yu-Sheng Chao , Jing-Ping Liou , Jang-Yang Chang , Yen-Shih Tung
IPC分类号： C07D401/00
CPC分类号： C07D471/04 , A61K31/498 , A61K31/503 , A61K31/519 , A61K31/52 , A61K31/53 , C07D231/56 , C07D307/80 , C07D333/56 , C07D487/04
摘要： Compounds of the following formula: wherein A, D, Q, T, U, V, W, X, Y, Z, R1, and are as defined herein. This invention also relates to a method of inhibiting tubulin polymerization, or treating cancer or an angiogenesis-related disorder with one of these compounds.
摘要翻译：下式的化合物：其中A，D，Q，T，U，V，W，X，Y，Z，R 1和如本文所定义。本发明还涉及一种抑制微管蛋白聚合或用这些化合物之一治疗癌症或血管发生相关病症的方法。

2. 发明申请

US20060148801A1 Anti-tumor compounds 有权
标题翻译：抗肿瘤化合物
公开(公告)号：US20060148801A1
公开(公告)日：2006-07-06
申请号：US11300873
申请日：2005-12-15
申请人： Hsing-Pang Hsieh , Yu-Sheng Chao , Jing-Ping Liou , Jang-Yang Chang , Yen-Shih Tung
发明人： Hsing-Pang Hsieh , Yu-Sheng Chao , Jing-Ping Liou , Jang-Yang Chang , Yen-Shih Tung
IPC分类号： A61K31/519 , A61K31/53 , A61K31/503 , A61K31/52 , A61K31/498
CPC分类号： C07D471/04 , A61K31/498 , A61K31/503 , A61K31/519 , A61K31/52 , A61K31/53 , C07D231/56 , C07D307/80 , C07D333/56 , C07D487/04
摘要： Compounds of the following formula: wherein A, D, Q, T, U, V, W, X, Y, Z, R1, and ---- are as defined herein. This invention also relates to a method of inhibiting tubulin polymerization, or treating cancer or an angiogenesis-related disorder with one of these compounds.
摘要翻译：下式的化合物：其中A，D，Q，T，U，V，W，X，Y，Z，R 1，和

3. 发明授权

US07528165B2 Indole compounds 有权
标题翻译：吲哚化合物
公开(公告)号：US07528165B2
公开(公告)日：2009-05-05
申请号：US11195531
申请日：2005-08-01
申请人： Hsing-Pang Hsieh , Jing-Ping Liou , Jang-Yang Chang , Chun-Wei Chang
发明人： Hsing-Pang Hsieh , Jing-Ping Liou , Jang-Yang Chang , Chun-Wei Chang
IPC分类号： A61K31/40
CPC分类号： A61K31/405 , C07D209/08 , C07D209/12 , C07D209/14 , C07D209/30 , C07D401/06 , C07D405/06 , C07D491/04
摘要： This invention relates to methods of inhibiting tubulin polymerization and treating cancer and other angiogenesis-related disorders with indole compounds of the formula: wherein L1, L2, R1, R2, Ra, Rb, Rc, Rd, and Re are defined herein.
摘要翻译：本发明涉及抑制微管蛋白聚合和用下式的吲哚化合物治疗癌症和其它血管发生相关病症的方法：其中L1，L2，R1，R2，Ra，Rb，Rc，Rd和Re在本文中定义。

4. 发明申请

US20080058386A1 Indoline-sulfonamides compounds 失效
标题翻译：二氢吲哚磺酰胺化合物
公开(公告)号：US20080058386A1
公开(公告)日：2008-03-06
申请号：US11798079
申请日：2007-05-10
申请人： Jing-Ping Liou , Jang-Yang Chang , Hsing-Pang Hsieh
发明人： Jing-Ping Liou , Jang-Yang Chang , Hsing-Pang Hsieh
IPC分类号： A61K31/404 , A61K31/44 , A61P35/00 , C07D209/04 , C07D401/02 , C07D405/00
CPC分类号： C07D401/12 , C07D209/08 , C07D405/12 , C07D409/12
摘要： A series of indoline-sulfonamide compounds is disclosed. The formula of indoline-sulfonamide compounds is shown as formula (I). In formula (I), R1 is H or halogen; R2 is Ar, Ar—C(O)—, Ar—CH2—, Ar—SO2—, Ar—O—C(O), or R″—C(O)—, and Ar is a substituted or unsubstituted C5-C20 aryl, cyclyl, heterocyclyl, or heteroaryl, R′ and R″ independently is C1-C10 alkyl, or C1-C10 alkoxyl; and R3 is C5-C15 aryl or C1-C10 alkyl. The indoline-sulfonamide compounds disclosed in the present invention are characterized in inhibiting tubulin polymerization, and treating cancers and other tubulin polymerization-related disorders with a suitable pharmaceutical acceptable carrier.
摘要翻译：公开了一系列二氢吲哚磺酰胺化合物。二氢吲哚磺酰胺化合物的配方如式（I）所示。在式（I）中，R 1是H或卤素; R 2是Ar，Ar-C（O） - ，Ar-CH 2 - ，Ar-SO 2 - ，Ar-OC（ O）或R“C（O） - ，Ar是取代或未取代的C 5 -C 20芳基，环基，杂环基或杂芳基，R'和R”独立地是C 1 -C 10烷基或C 1 -C 10 烷氧基 R 3是C 5 -C 15芳基或C 1 -C 10烷基。本发明中公开的二氢吲哚磺酰胺化合物的特征在于抑制微管蛋白聚合，并用合适的药学上可接受的载体处理癌症和其它微管蛋白聚合相关疾病。

5. 发明授权

US07632955B2 Indole compounds 有权
标题翻译：吲哚化合物
公开(公告)号：US07632955B2
公开(公告)日：2009-12-15
申请号：US11195524
申请日：2005-08-01
申请人： Hsing-Pang Hsieh , Jing-Ping Liou , Jang-Yang Chang , Chun-Wei Chang
发明人： Hsing-Pang Hsieh , Jing-Ping Liou , Jang-Yang Chang , Chun-Wei Chang
IPC分类号： C07D209/04 , C07D209/12
CPC分类号： C07D401/06 , A61K31/405 , C07D209/08 , C07D209/12 , C07D209/14 , C07D209/30 , C07D405/06 , C07D491/04
摘要： Indole compounds of the formula: wherein L1, L2, R1, R2, Ra, Rb, Rc, Rd, and Re are defined herein. Also disclosed are methods of using of the indole compounds in inhibiting tubulin polymerization and treating cancer and other angiogenesis-related disorders.
摘要翻译：下式定义的吲哚化合物：其中L1，L2，R1，R2，Ra，Rb，Rc，Rd和Re在本文中定义。还公开了使用吲哚化合物抑制微管蛋白聚合和治疗癌症和其它血管发生相关疾病的方法。

6. 发明授权

US07741495B2 Indoline-sulfonamides compounds 失效
标题翻译：二氢吲哚磺酰胺化合物
公开(公告)号：US07741495B2
公开(公告)日：2010-06-22
申请号：US11798079
申请日：2007-05-10
申请人： Jing-Ping Liou , Jang-Yang Chang , Hsing-Pang Hsieh
发明人： Jing-Ping Liou , Jang-Yang Chang , Hsing-Pang Hsieh
IPC分类号： C07D209/44 , A61K31/41
CPC分类号： C07D401/12 , C07D209/08 , C07D405/12 , C07D409/12
摘要： A series of indoline-sulfonamide compounds is disclosed. The formula of indoline-sulfonamide compounds is shown as formula (I). In formula (I), R1 is H or halogen; R2 is Ar, Ar—C(O)—, Ar—CH2—, Ar—SO2—, Ar—O—C(O), or R″—C(O)—, and Ar is a substituted or unsubstituted C5-C20 aryl, cyclyl, heterocyclyl, or heteroaryl, R′ and R″ independently is C1-C10 alkyl, or C1-C10 alkoxyl; and R3 is C5-C15 aryl or C1-C10 alkyl. The indoline-sulfonamide compounds disclosed in the present invention are characterized in inhibiting tubulin polymerization, and treating cancers and other tubulin polymerization-related disorders with a suitable pharmaceutical acceptable carrier.
摘要翻译：公开了一系列二氢吲哚磺酰胺化合物。二氢吲哚磺酰胺化合物的配方如式（I）所示。在式（I）中，R 1为H或卤素; R2是Ar，Ar-C（O） - ，Ar-CH2-，Ar-SO2-，Ar-O-C（O）或R“-C（O） - ，Ar是取代或未取代的C5- C20芳基，环基，杂环基或杂芳基，R'和R“独立地为C 1 -C 10烷基或C 1 -C 10烷氧基; 且R 3为C 5 -C 15芳基或C 1 -C 10烷基。本发明中公开的二氢吲哚磺酰胺化合物的特征在于抑制微管蛋白聚合，并用合适的药学上可接受的载体处理癌症和其它微管蛋白聚合相关疾病。

7. 发明申请

US20050267194A1 Indole compounds 有权
标题翻译：吲哚化合物
公开(公告)号：US20050267194A1
公开(公告)日：2005-12-01
申请号：US11195524
申请日：2005-08-01
申请人： Hsing-Pang Hsieh , Jing-Ping Liou , Jang-Yang Chang , Chun-Wei Chang
发明人： Hsing-Pang Hsieh , Jing-Ping Liou , Jang-Yang Chang , Chun-Wei Chang
IPC分类号： A61K31/405 , C07D209/08 , C07D209/12 , C07D209/14 , C07D209/30 , C07D401/06 , C07D405/06 , C07D491/04 , A61K31/404 , C07D209/04 , C07D49/02
CPC分类号： C07D401/06 , A61K31/405 , C07D209/08 , C07D209/12 , C07D209/14 , C07D209/30 , C07D405/06 , C07D491/04
摘要： Indole compounds of the formula: wherein L1, L2, R1, R2, Ra, Rb, Rc, Rd, and Re are defined herein. Also disclosed are methods of using of the indole compounds in inhibiting tubulin polymerization and treating cancer and other angiogenesis-related disorders.
摘要翻译：下式的吲哚化合物：其中L 1，L 2，R 1，R 2，R SUB 其中R a，R b，R c，R d和R e e在本文中定义。还公开了使用吲哚化合物抑制微管蛋白聚合和治疗癌症和其它血管发生相关疾病的方法。

8. 发明申请

US20050267108A1 Indole compounds 有权
标题翻译：吲哚化合物
公开(公告)号：US20050267108A1
公开(公告)日：2005-12-01
申请号：US11195531
申请日：2005-08-01
申请人： Hsing-Pang Hsieh , Jing-Ping Liou , Jang-Yang Chang , Chun-Wei Chang
发明人： Hsing-Pang Hsieh , Jing-Ping Liou , Jang-Yang Chang , Chun-Wei Chang
IPC分类号： A61K31/405 , C07D209/08 , C07D209/12 , C07D209/14 , C07D209/30 , C07D401/06 , C07D405/06 , C07D491/04 , A61K31/5377 , A61K31/404 , A61K31/4439 , A61K31/496
CPC分类号： A61K31/405 , C07D209/08 , C07D209/12 , C07D209/14 , C07D209/30 , C07D401/06 , C07D405/06 , C07D491/04
摘要： This invention relates to methods of inhibiting tubulin polymerization and treating cancer and other angiogenesis-related disorders with indole compounds of the formula: wherein L1, L2, R1, R2, Ra, Rb, Rc, Rd, and Re are defined herein.
摘要翻译：本发明涉及抑制微管蛋白聚合并用下式的吲哚化合物治疗癌症和其它血管生成相关病症的方法：其中L 1，L 2，R 2， R 1，R 2，R a，R b，R c，R b，本文定义了本发明的化合物。

9. 发明授权

US06933316B2 Indole compounds 有权
公开(公告)号：US06933316B2
公开(公告)日：2005-08-23
申请号：US10318337
申请日：2002-12-12
申请人： Hsing-Pang Hsieh , Jing-Ping Liou , Jang-Yang Chang , Chun-Wei Chang
发明人： Hsing-Pang Hsieh , Jing-Ping Liou , Jang-Yang Chang , Chun-Wei Chang
IPC分类号： A61K31/405 , C07D209/08 , C07D209/12 , C07D209/14 , C07D209/30 , C07D401/06 , C07D405/06 , C07D491/04 , A61K31/404 , C07D209/04
CPC分类号： A61K31/405 , C07D209/08 , C07D209/12 , C07D209/14 , C07D209/30 , C07D401/06 , C07D405/06 , C07D491/04
摘要： Indole compounds of the formula: wherein L1 is CO; L2 is a bond; R1 is aryl or heteroaryl; R2 is H, aryl, heteroaryl, halogen, nitro, nitroso, cyano, azide, isothionitro, OR, OC(O)R, OC(O)OR, OC(O)NRR′, SO2R, SO3R, SO2NRR′, SR, NRR′, NRSO2NR′R″, NRSO2R′, NRSO3R′, NRC(O)R′, NRC(O)NR′R″, NRC(O)OR′, NRC(N)NR′R″, C(O)OR, or C(O)NRR′; each of Ra, Rb, Rc, and Rd, independently, is R, halogen, nitro, nitroso, cyano, azide, isothionitro, OR, OC(O)R, OC(O)OR, OC(O)NRR′, SO2R, SO3R, SO2NRR′, SR, NRR′, NRSO2NR′R″, NRSO2R′, NRSO3R′, NRC(O)R′, NRC(O)NR′R″, NRC(O)OR′, NRC(N)NR′R″, C(O)R, C(O)OR, C(O)NRR′, or Rb and Rc, Ra and Rb, or Rc and Rd taken together are O(CH2)nO; and Rc is H, alkyl, alkenyl, alkynyl, cyclyl, heterocyclyl, halogen, nitro, nitroso, cyano, azide, isothionitro, OR, OC(O)R, OC(O)OR, OC(O)NRR′, SO2R, SO3R, SO2NRR′, SR, NRR′, NRSO2NR′R″, NRSO2R′, NRSO3R′, NRC(O)R′, NRC(O)NR′R″, NRC(O)OR′, NRC(N)NR′R″, C(O)R, C(O)OR, or C(O)NRR′; in which each of R, R′, and R″, independently, is H, alkyl, alkenyl, alkynyl, aryl, heteroaryl, cyclyl, or heterocyclyl; and n is 1, 2, 3, 4, or 5.

10. 发明授权

US08058427B2 Coumarin compounds and their use for treating cancer 有权
标题翻译：香豆素化合物及其用于治疗癌症的用途
公开(公告)号：US08058427B2
公开(公告)日：2011-11-15
申请号：US12481783
申请日：2009-06-10
申请人： Hsing-Pang Hsieh , Jang-Yang Chang , Ching-Chuan Kuo , Yu-Sheng Chao
发明人： Hsing-Pang Hsieh , Jang-Yang Chang , Ching-Chuan Kuo , Yu-Sheng Chao
IPC分类号： C07D413/12 , C07D405/12 , C07D217/04 , C07D401/12 , C07D493/02
CPC分类号： C07D493/04 , C07D491/04 , C07D497/04
摘要： Coumarin compounds of formula (I): wherein R1, R2, R3, R4, R5, R6, and X are defined herein. Also disclosed is a method for treating cancer with coumarin compounds.
摘要翻译：式（I）的香豆素化合物：其中R1，R2，R3，R4，R5，R6和X如本文所定义。还公开了一种用香豆素化合物治疗癌症的方法。

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