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1. 发明申请

US20170151295A1 USE OF CHI-JU-DI-HUANG-WAN IN TREATING RETINAL ISCHEMIA OR A DISEASE, CONDITION, OR DISORDER ASSOCIATED WITH RETINAL ISCHEMIA 有权
公开(公告)号：US20170151295A1
公开(公告)日：2017-06-01
申请号：US14953026
申请日：2015-11-27
申请人： Hsiao-Ming Chao , Chih-Chiang Hsieh
发明人： Hsiao-Ming Chao
IPC分类号： A61K36/076 , A61K9/00 , A61K36/8945 , A61K36/64 , A61K36/884 , A61K36/287 , A61K36/815 , A61K36/40 , A61K35/644 , A61K36/65
CPC分类号： A61K36/076 , A61K9/0053 , A61K35/644 , A61K36/287 , A61K36/40 , A61K36/64 , A61K36/65 , A61K36/815 , A61K36/884 , A61K36/8945 , A61K2300/00
摘要： The present invention relates to a method for treating retinal ischemia, or a disease, condition, or disorder associated with retinal ischemia, in a subject in need thereof, comprising administering to said subject a therapeutically effective amount of a composition comprising Chi-Ju-Di-Huang-Wan, wherein the Chi-Ju-Di-Huang-Wan consists of Rehmanniae Radix Preparata, Corni Fructus, Rhizoma Diocoreae, Poria, Cortex Moutan Redicis, Alismatis Rhizome, Fructus Lycii, and Chrysanthemi Flos.

2. 发明授权

US09839658B2 Use of chi-ju-di-huang-wan in treating retinal ischemia or a disease, condition, or disorder associated with retinal ischemia 有权
公开(公告)号：US09839658B2
公开(公告)日：2017-12-12
申请号：US14953026
申请日：2015-11-27
申请人： Hsiao-Ming Chao , Chih-Chiang Hsieh
发明人： Hsiao-Ming Chao
IPC分类号： A61K36/076 , A61K9/00 , A61K35/644 , A61K36/287 , A61K36/40 , A61K36/64 , A61K36/65 , A61K36/815 , A61K36/884 , A61K36/8945
CPC分类号： A61K36/076 , A61K9/0053 , A61K35/644 , A61K36/287 , A61K36/40 , A61K36/64 , A61K36/65 , A61K36/815 , A61K36/884 , A61K36/8945 , A61K2300/00
摘要： The present invention relates to a method for treating retinal ischemia, or a disease, condition, or disorder associated with retinal ischemia, in a subject in need thereof, comprising administering to said subject a therapeutically effective amount of a composition comprising Chi-Ju-Di-Huang-Wan, wherein the Chi-Ju-Di-Huang-Wan consists of Rehmanniae Radix Preparata, Corni Fructus, Rhizoma Dioscoreae, Poria, Cortex Moutan Radicis, Alismatis Rhizome, Fructus Lycii, and Chrysanthemi Flos.

3. 发明申请

US20210393547A1 USE OF EMODIN IN TREATING RETINAL ISCHEMIA OR A DISEASE, CONDITION, OR DISORDER ASSOCIATED WITH RETINAL ISCHEMIA 有权
公开(公告)号：US20210393547A1
公开(公告)日：2021-12-23
申请号：US16907310
申请日：2020-06-22
申请人： Hsiao-Ming Chao
发明人： Hsiao-Ming Chao
IPC分类号： A61K31/122 , A61P27/02
摘要： A method for treating a subject suffering from retinal ischemia, or a disease, condition, or disorder associated with retinal ischemia, comprising administering to the subject a therapeutically effective amount of emodin or a composition comprising emodin.

4. 发明申请

US20090239875A1 Protection of ferulic acid and/or tetramethylpyrazine against retinal ischaemia, glaucoma and siderosis oculi 审中-公开
标题翻译：保护阿魏酸和/或四甲基吡嗪对视网膜缺血，青光眼和铁皮质毒性
公开(公告)号：US20090239875A1
公开(公告)日：2009-09-24
申请号：US12053425
申请日：2008-03-21
申请人： Hsiao-Ming Chao
发明人： Hsiao-Ming Chao
IPC分类号： A61K31/4965 , A61K31/192 , A61P25/28
CPC分类号： A61K31/192 , A61K31/4965
摘要： A method for preventing and/or treating ischaemic and/or iron-related retinal or brain disorders comprising administering an effective amount of ferulic acid (FA), tetramethylpyrazine (TMP) or their pharmaceutically acceptable salt, ester, solvate, hydrate, analogs, metabolite, enantiomer, isomer, tautomer, amide, derivative or prodrug to a subject. The former diseases comprise retinal ischemia, glaucoma as well as brain ischaemia (i.e. stroke, infarction typed). The latter ones comprise age-related macular degeneration, intraocular hemorrhage, siderosis oculi (due to retained intraocular iron), oxidative stress of the retina as well as brain hemorrhage (stroke, hemorrhagic type) or Alzheimer disease. Clinically, FA alone or in combination of TMP can be administered systemically, orally, intravitreously, topically (in form of eyedrops), as well as other routes such as periocular, subconjunctival, and intracamera.
摘要翻译：一种用于预防和/或治疗缺血性和/或铁相关的视网膜或脑疾病的方法，包括给予有效量的阿魏酸（FA），四甲基吡嗪（TMP）或其药学上可接受的盐，酯，溶剂合物，水合物，类似物，代谢物，对映体，异构体，互变异构体，酰胺，衍生物或前药。前者的疾病包括视网膜缺血，青光眼以及脑局部缺血（即中风，梗死型）。后者包括年龄相关性黄斑变性，眼内出血，眼球内注射（由于保留的眼内铁），视网膜的氧化应激以及脑出血（中风，出血类型）或阿尔茨海默病。临床上，单独使用FA或TMP组合可以全身，口服，玻璃体内，局部（以眼药水的形式）以及其他途径例如眼周，结膜下和门静脉内给药。

5. 发明授权

US10493044B1 Method for treating developmental retinal vascular disorder 有权
公开(公告)号：US10493044B1
公开(公告)日：2019-12-03
申请号：US15992126
申请日：2018-05-29
申请人： Hsiao-Ming Chao
发明人： Hsiao-Ming Chao
IPC分类号： A61K31/09 , A61P27/02 , C07K16/22 , A61K9/00 , A61K36/00 , A61K31/05
CPC分类号： A61K31/09 , A61P27/02 , A61K9/0048 , A61K31/05 , A61K36/00 , C07K16/22
摘要： A method for treating a subject suffering from a developmental retinal vascular disorder by administering to the subject a composition which has a therapeutically effective amount of a dendrobium nobile lindley (DNL).

6. 发明授权

US09844577B1 Medicinal composition for prevention or treatment retinal ischemia 有权
公开(公告)号：US09844577B1
公开(公告)日：2017-12-19
申请号：US15490863
申请日：2017-04-18
申请人： Hsiao-Ming Chao
发明人： Hsiao-Ming Chao
IPC分类号： A61K36/00 , A61K36/752 , A61K36/232 , A61K36/233 , A61K36/286 , A61K36/21 , A61K36/484 , A61K36/23 , A61K36/65 , A61K36/346 , A61K36/736 , A61K36/64
CPC分类号： A61K36/752 , A61K36/21 , A61K36/23 , A61K36/232 , A61K36/233 , A61K36/286 , A61K36/346 , A61K36/484 , A61K36/64 , A61K36/65 , A61K36/736 , A61K2300/00
摘要： This invention relates to a use of producing a medicinal composition for preventing or treating a disease, disorder or condition induced by retina ischemia, wherein the medicinal composition comprising 4.5 units by weight of Radix Angelicae Sinensis (Dang Gui), 4.5 units by weight of Radix Rehmanniae glutinosae (Di Huang), 3 units by weight of Radix Paeoniae Rubra (Chi Shao), from 2.25 to 2.3 units by weight of Rhizoma Ligustici Chuanxiong (Chuan Xiong), 6 units by weight of Semen Pruni Persicae (Táo Rén), 4.5 units by weight of Flos Carthami Tinctorii (Hong Hua), 1.5 units by weight of Radix Glycyrrhizae Uralensis (Gan Cao), 3 units by weight of Fructus Aurantii (Zhi Qiao), 1.5 units by weight of Radix Bupleuri Chinense (Chai Hu), 4.5 units by weight of Radix Achyranthis Bidentatae (Niu Xi), and from 2.25 to 2.3 units by weight of Radix Platycodi Grandiflori (Jie Geng).

7. 发明申请

US20130079411A1 METHOD FOR PREVENTING OR TREATING A DISEASE, DISORDER OR CONDITION INDUCED BY RETINA ISCHEMIA 有权
标题翻译：用于预防或治疗由RETINA ISCHEMIA引起的疾病，疾病或病症的方法
公开(公告)号：US20130079411A1
公开(公告)日：2013-03-28
申请号：US13246057
申请日：2011-09-27
申请人： Hsiao-Ming Chao
发明人： Hsiao-Ming Chao
IPC分类号： A61K31/198 , A61P27/02 , A61P7/00 , A61P3/10
CPC分类号： A61K31/198
摘要： The present invention provides a method for preventing or treating a disease, disorder or condition induced by retina ischemia, comprising administering to a subject in need thereof a S-allyl-L-cysteine in a therapeutically effective amount.
摘要翻译：本发明提供了一种预防或治疗由视网膜缺血引起的疾病，病症或病症的方法，其包括向有需要的受试者施用治疗有效量的S-烯丙基-L-半胱氨酸。

8. 发明申请

US20180296626A1 Medicinal composition for prevention or treatment retinal ischemia 审中-公开
公开(公告)号：US20180296626A1
公开(公告)日：2018-10-18
申请号：US15810150
申请日：2017-11-13
申请人： Hsiao-Ming Chao
发明人： Hsiao-Ming Chao
IPC分类号： A61K36/752 , A61K36/64 , A61K36/736 , A61K36/346 , A61K36/65 , A61K36/23 , A61K36/21 , A61K36/286 , A61K36/233 , A61K36/232 , A61K36/484
摘要： This invention relates to a method of preventing or treating a disease, disorder or condition induced by retina ischemia comprising administrating a subject a therapeutically effective amount of a RBP2 inhibitor for preventing or treating a disease, disorder or condition induced by retina ischemia.

9. 发明授权

US08569372B2 Method for preventing or treating a disease, disorder or condition induced by retina ischemia 有权
标题翻译：用于预防或治疗由视网膜缺血引起的疾病，障碍或病症的方法
公开(公告)号：US08569372B2
公开(公告)日：2013-10-29
申请号：US13246057
申请日：2011-09-27
申请人： Hsiao-Ming Chao
发明人： Hsiao-Ming Chao
IPC分类号： A61K31/19
CPC分类号： A61K31/198
摘要： The present invention provides a method for preventing or treating a disease, disorder or condition induced by retina ischemia, comprising administering to a subject in need thereof a S-allyl-L-cysteine in a therapeutically effective amount.
摘要翻译：本发明提供了一种预防或治疗由视网膜缺血引起的疾病，病症或病症的方法，其包括向有需要的受试者施用治疗有效量的S-烯丙基-L-半胱氨酸。

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