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1. 发明申请

US20120277629A1 SYSTEMS AND METHODS FOR COLLECTION AND/OR MANIPULATION OF BLOOD SPOTS OR OTHER BODILY FLUIDS 审中-公开
标题翻译：用于收集和/或处理血液或其他体液的系统和方法
公开(公告)号：US20120277629A1
公开(公告)日：2012-11-01
申请号：US13456546
申请日：2012-04-26
申请人： Howard Bernstein , Donald E. Chickering, III , Shawn Davis , Ping Gong , Kristin Horton , Scott James
发明人： Howard Bernstein , Donald E. Chickering, III , Shawn Davis , Ping Gong , Kristin Horton , Scott James
IPC分类号： A61B5/153
CPC分类号： A61B5/150099 , A61B5/1411 , A61B5/1438 , A61B5/14514 , A61B5/14532 , A61B5/14539 , A61B5/14546 , A61B5/1455 , A61B5/1486 , A61B5/150022 , A61B5/150213 , A61B5/150221 , A61B5/150229 , A61B5/150343 , A61B5/150358 , A61B5/150412 , A61B5/150419 , A61B5/150503 , A61B5/150755 , A61B5/150969 , A61B5/150984 , A61B5/151 , A61B5/15105 , A61B5/15142 , A61B5/154 , A61B10/0045 , A61B2562/0295 , A61M1/34 , A61M1/3486 , A61M1/3687 , A61M2202/0415 , A61M2205/3334 , B01L3/502753 , B01L2300/0672 , B01L2300/0681 , B01L2300/0816 , B01L2300/087 , B01L2300/0874 , B01L2400/049 , B01L2400/0655 , B01L2400/0688 , G01N33/18 , G01N33/1826
摘要： The present invention generally relates to systems and methods for receiving blood (or other bodily fluids) from a subject, e.g., from or beneath the skin of a subject. In some cases, the blood (or other bodily fluids) may be deposited on a membrane or other substrate. For example, blood may be absorbed in a substrate, and dried in some cases to produce a dried blood spot. In one aspect, the present invention is generally directed to devices and methods for receiving blood from a subject, e.g., from the skin, using devices including a substance transfer component (which may contain, for example, one or more microneedles), and directing the blood on a substrate, e.g., for absorbing blood. The substrate, in some embodiments, may comprise filter paper or cotton-based paper. After absorption of some blood onto the substrate, the substrate may be removed from the device and shipped or analyzed.
摘要翻译：本发明一般涉及从受试者（例如从受试者的皮肤或皮下）接收血液（或其它体液）的系统和方法。在某些情况下，血液（或其他体液）可以沉积在膜或其他底物上。例如，血液可以被吸收在基质中，并且在一些情况下干燥以产生干血斑。一方面，本发明一般涉及用于从受试者接收血液的装置和方法，例如使用包括物质转移组分（其可以包含例如一个或多个微针）的装置，并指导基底上的血液，例如用于吸收血液。在一些实施例中，基底可以包括滤纸或基于棉的纸。在将一些血液吸收到基底上之后，基底可以从装置中移出并运输或分析。

2. 发明申请

US20120010529A1 SAMPLING DEVICES AND METHODS INVOLVING RELATIVELY LITTLE PAIN 有权
标题翻译：采用相关的轻度疼痛的装置和方法
公开(公告)号：US20120010529A1
公开(公告)日：2012-01-12
申请号：US13166451
申请日：2011-06-22
申请人： Donald E. Chickering, III , Howard Bernstein , Shawn Davis , Ramin Haghgooie , Douglas A. Levinson , Mark Michelman , Ping Gong
发明人： Donald E. Chickering, III , Howard Bernstein , Shawn Davis , Ramin Haghgooie , Douglas A. Levinson , Mark Michelman , Ping Gong
IPC分类号： A61M5/42 , A61M5/32 , A61M5/178 , A61B5/151 , A61B5/15
CPC分类号： A61B5/150984 , A61B5/1411 , A61B5/14514 , A61B5/14546 , A61B5/1455 , A61B5/1468 , A61B5/150022 , A61B5/150091 , A61B5/150099 , A61B5/150106 , A61B5/150129 , A61B5/150145 , A61B5/15016 , A61B5/150229 , A61B5/150389 , A61B5/150412 , A61B5/150442 , A61B5/150969 , A61B5/15105 , A61B5/15113 , A61B5/15117 , A61B5/15119 , A61B5/15125 , A61B5/15134 , A61B5/15136 , A61B5/1514 , A61B5/15186 , A61B5/1519 , A61B5/15194 , A61B5/154 , A61B5/157 , A61B17/00234 , A61B2010/0225 , A61B2562/0238 , A61M37/0015 , A61M2037/0023 , A61M2037/003 , A61M2037/0046
摘要： The present invention generally relates to systems and methods for delivering and/or receiving a substance or substances such as blood, from subjects, e.g., to the skin and/or from the skin. In one aspect, the present invention is generally directed to devices and methods for receiving blood from a subject, e.g., from the skin, using devices including a substance transfer component (which may contain, for example, one or more microneedles), and a storage chamber having an internal pressure less than atmospheric pressure prior to receiving blood. In certain embodiments, substances may be received from and/or delivered to the subject with relatively little pain. The pain may be assessed, to for example, using pain scales such as the Wong-Baker FACES Pain Scale. In some cases, the device may be self-contained, and in certain instances, the device can be applied to the skin, and activated to receive blood from the subject. The device, or a portion thereof, may then be processed to determine the blood and/or an analyte within the blood, alone or with an external apparatus. For example, blood may be received from the device, and/or the device may contain sensors or agents able to determine the blood and/or an analyte suspected of being contained in the blood. Other aspects of the present invention are directed at other devices for receiving blood (or other bodily fluids, e.g., interstitial fluid), kits involving such devices, methods of making such devices, methods of using such devices, and the like.
摘要翻译：本发明一般涉及用于递送和/或接受诸如血液的物质或物质从受试者例如皮肤和/或从皮肤接收的系统和方法。一方面，本发明一般涉及使用包括物质转移组分（其可以包含例如一个或多个微针）的装置从例如皮肤接收血液的装置和方法，以及存储室在接收血液之前具有小于大气压的内部压力。在某些实施方案中，可以相对较少的疼痛从受试者接受和/或递送物质。可以评估疼痛，例如使用诸如Wong-Baker FACES Pain Scale的疼痛量表。在一些情况下，该装置可以是独立的，并且在某些情况下，可以将该装置应用于皮肤并被激活以从受试者接收血液。然后可以处理装置或其一部分，以单独或与外部装置一起确定血液和/或血液内的分析物。例如，可以从装置接收血液，和/或装置可以包含能够确定血液和/或怀疑包含在血液中的分析物的传感器或试剂。本发明的其它方面涉及用于接收血液（或其他体液，例如间质液）的其他装置，涉及这种装置的试剂盒，制造这种装置的方法，使用这种装置的方法等。

3. 发明授权

US09033898B2 Sampling devices and methods involving relatively little pain 有权
标题翻译：抽样装置和方法相对较少疼痛
公开(公告)号：US09033898B2
公开(公告)日：2015-05-19
申请号：US13166451
申请日：2011-06-22
申请人： Donald E. Chickering, III , Howard Bernstein , Shawn Davis , Ramin Haghgooie , Douglas A. Levinson , Mark Michelman , Ping Gong
发明人： Donald E. Chickering, III , Howard Bernstein , Shawn Davis , Ramin Haghgooie , Douglas A. Levinson , Mark Michelman , Ping Gong
IPC分类号： A61B5/00 , A61B17/14 , A61B17/32 , A61M37/00 , A61B5/15 , A61B5/151 , A61B5/157 , A61B10/02 , A61B17/00 , A61B5/145 , A61B5/1455 , A61B5/1468 , A61B5/154
CPC分类号： A61B5/150984 , A61B5/1411 , A61B5/14514 , A61B5/14546 , A61B5/1455 , A61B5/1468 , A61B5/150022 , A61B5/150091 , A61B5/150099 , A61B5/150106 , A61B5/150129 , A61B5/150145 , A61B5/15016 , A61B5/150229 , A61B5/150389 , A61B5/150412 , A61B5/150442 , A61B5/150969 , A61B5/15105 , A61B5/15113 , A61B5/15117 , A61B5/15119 , A61B5/15125 , A61B5/15134 , A61B5/15136 , A61B5/1514 , A61B5/15186 , A61B5/1519 , A61B5/15194 , A61B5/154 , A61B5/157 , A61B17/00234 , A61B2010/0225 , A61B2562/0238 , A61M37/0015 , A61M2037/0023 , A61M2037/003 , A61M2037/0046
摘要： Systems and methods for delivering and/or receiving a substance or substances, such as blood, from subjects. In one embodiment, devices and methods for receiving blood from a subject employ devices including a substance transfer component (such as one or more microneedles), and a storage chamber having an internal pressure less than atmospheric pressure prior to receiving blood. In certain embodiments, substances may be received from and/or delivered to the subject with relatively little pain. The pain may be assessed, for example, using pain scales such as the WONG BAKER FACES Pain Scale. The device may be self-contained, applied to the skin, and activated to receive blood from the subject. The device, or a portion thereof, may be processed to determine the blood and/or an analyte within the blood using sensors or agents in the device or an external apparatus. Other aspects of the present invention are directed at other devices for receiving bodily fluids kits involving such devices, methods of making such devices, methods of using such devices, and the like.
摘要翻译：用于从受试者传送和/或接收物质或物质如血液的系统和方法。在一个实施例中，用于从受试者接收血液的装置和方法使用包括物质转移组分（例如一个或多个微针）的装置和在接收血液之前具有小于大气压的内部压力的储存室。在某些实施方案中，可以相对较少的疼痛从受试者接受和/或递送物质。可以评估疼痛，例如，使用诸如黄巴克面霜疼痛量表的疼痛量表。该装置可以是独立的，应用于皮肤，并被激活以从受试者接收血液。可以使用装置或外部装置中的传感器或试剂处理装置或其一部分，以确定血液和/或血液内的分析物。本发明的其它方面涉及用于接收涉及这种装置的体液套件的其他装置，制造这种装置的方法，使用这种装置的方法等。

4. 发明授权

US08263411B2 Capacitive morpholino diagnostics for analysis of nucleic acids 有权
标题翻译：用于分析核酸的电容性吗啉诊断
公开(公告)号：US08263411B2
公开(公告)日：2012-09-11
申请号：US12362071
申请日：2009-01-29
申请人： Rastislav Levicky , Napoleon Tercero , Kang Wang , Ping Gong , Kenneth Shepard
发明人： Rastislav Levicky , Napoleon Tercero , Kang Wang , Ping Gong , Kenneth Shepard
IPC分类号： G01N33/50
CPC分类号： C12Q1/6825 , Y10T436/143333 , C12Q2525/113
摘要： A method to monitor the progress of hybridization between nucleic acid strands in solution and Morpholino strands immobilized on a solid support such as a working electrode in-situ, in real-time, and using label-free electrochemical measurements sensitive to hybridization-induced changes in the near-surface dielectric constant and charge organization.
摘要翻译：监测溶液中核酸链之间杂交进程的方法和实时固定在固体支持物如工作电极上的Morpholino链，并使用对杂交诱导的变化敏感的无标记电化学测量近表面介电常数和电荷组织。

5. 发明申请

US20080249155A1 5-Hydroxyindole-3-Carboxylate Derivatives and Uses Thereof 失效
标题翻译： 5-羟基吲哚-3-羧酸酯衍生物及其用途
公开(公告)号：US20080249155A1
公开(公告)日：2008-10-09
申请号：US10592619
申请日：2005-03-11
申请人： Ping Gong , Yanfang Zhao
发明人： Ping Gong , Yanfang Zhao
IPC分类号： A61K31/404 , A61P31/16 , C07D209/04
CPC分类号： C07D209/42
摘要： The present invention relates to 5-hydroxy-indole-3-carboxylate derivatives of formula I, or racemic mixture or optical isomers or pharmaceutically acceptable salts and/or hydrates thereof, wherein: substituents R1, R2, Z, X and Y are as defined in the description. The compounds of formula I can be useful for preparation of medicament for treatment and/or prophylaxis of virus infections, especially for preparation of medicament for anti-HBV (Hepatitis B virus) and anti-HIV (Human immunodeficiency virus).
摘要翻译：本发明涉及式I的5-羟基 - 吲哚-3-羧酸酯衍生物，或外消旋混合物或光学异构体或其药学上可接受的盐和/或水合物，其中：取代基R 1， SUB 2，Z，X和Y如说明书中所定义。式I化合物可用于制备用于治疗和/或预防病毒感染的药物，特别是用于制备用于抗HBV（乙型肝炎病毒）和抗HIV（人类免疫缺陷病毒）的药物。

6. 发明授权

US09049796B2 Client connection device for UPS system 有权
标题翻译： UPS系统的客户端连接装置
公开(公告)号：US09049796B2
公开(公告)日：2015-06-02
申请号：US13415301
申请日：2012-03-08
申请人： Hongjie Qiu , Ping Gong
发明人： Hongjie Qiu , Ping Gong
IPC分类号： H02B1/26 , H05K7/14
CPC分类号： H05K7/1457
摘要： A client connection device for a UPS system includes a frame on which a main input distribution unit, a bypass input distribution unit, a battery distribution unit, and an output distribution unit are provided, in which the main input distribution unit and the bypass input distribution unit are arranged on the frame with being opposite to each other up and down, the output distribution unit and the battery distribution unit are arranged on the frame on different sides of the main input distribution unit and the bypass input distribution unit, and the battery distribution unit is side placed near the main input distribution unit and the bypass input distribution unit. A client connection device for a UPS system is provided which can be of a compact structure, be space saving, and be convenient for space operation.
摘要翻译：用于UPS系统的客户端连接装置包括一个框架，主框架设有主输入分配单元，旁路输入分配单元，电池分配单元和输出分配单元，其中主输入分配单元和旁路输入分布单元布置在框架上彼此上下相对，输出分配单元和电池分配单元布置在主输入分配单元和旁路输入分配单元的不同侧上的框架上，并且电池分布单元侧面放置在主输入分配单元和旁路输入分配单元附近。提供一种用于UPS系统的客户端连接装置，其结构紧凑，节省空间，方便空间操作。

7. 发明申请

US20120250236A1 CLIENT CONNECTION DEVICE FOR UPS SYSTEM 有权
标题翻译：用于UPS系统的客户端连接装置
公开(公告)号：US20120250236A1
公开(公告)日：2012-10-04
申请号：US13415301
申请日：2012-03-08
申请人： Hongjie Qiu , Ping Gong
发明人： Hongjie Qiu , Ping Gong
IPC分类号： H05K7/00
CPC分类号： H05K7/1457
摘要： A client connection device for a UPS system includes a frame on which a main input distribution unit, a bypass input distribution unit, a battery distribution unit, and an output distribution unit are provided, in which the main input distribution unit and the bypass input distribution unit are arranged on the frame with being opposite to each other up and down, the output distribution unit and the battery distribution unit are arranged on the frame on different sides of the main input distribution unit and the bypass input distribution unit, and the battery distribution unit is side placed near the main input distribution unit and the bypass input distribution unit. A client connection device for a UPS system is provided which can be of a compact structure, be space saving, and be convenient for space operation.
摘要翻译：用于UPS系统的客户端连接装置包括一个框架，主框架设有主输入分配单元，旁路输入分配单元，电池分配单元和输出分配单元，其中主输入分配单元和旁路输入分布单元布置在框架上彼此上下相对，输出分配单元和电池分配单元布置在主输入分配单元和旁路输入分配单元的不同侧上的框架上，并且电池分布单元侧面放置在主输入分配单元和旁路输入分配单元附近。提供一种用于UPS系统的客户端连接装置，其结构紧凑，节省空间，方便空间操作。

8. 发明授权

US07960427B2 5-hydroxyindole-3-carboxylate derivatives and uses thereof 失效
标题翻译： 5-羟基吲哚-3-羧酸酯衍生物及其用途
公开(公告)号：US07960427B2
公开(公告)日：2011-06-14
申请号：US10592619
申请日：2005-03-11
申请人： Ping Gong , Yanfang Zhao
发明人： Ping Gong , Yanfang Zhao
IPC分类号： A61K31/40 , C07D209/42
CPC分类号： C07D209/42
摘要： The present invention relates to 5-hydroxy-indole-3-carboxylate derivatives of formula I, or racemic mixture or optical isomers or pharmaceutically acceptable salts and/or hydrates thereof, wherein: substituents R1, R2, Z, X and Y are as defined in the description. The compounds of formula I can be useful for preparation of medicament for treatment and/or prophylaxis of virus infections, especially for preparation of medicament for anti-HBV (Hepatitis B virus) and anti-HIV (Human immunodeficiency virus).
摘要翻译：本发明涉及式I的5-羟基 - 吲哚-3-羧酸酯衍生物或其外消旋混合物或光学异构体或其药学上可接受的盐和/或水合物，其中：取代基R 1，R 2，Z，X和Y如上所定义在说明中。式I化合物可用于制备用于治疗和/或预防病毒感染的药物，特别是用于制备用于抗HBV（乙型肝炎病毒）和抗HIV（人类免疫缺陷病毒）的药物。

9. 发明申请

US20100035248A1 SURFACE-BASED NUCLEIC ACID ASSAYS EMPLOYING MORPHOLINOS 审中-公开
标题翻译：基于表面的核酸测定使用莫比诺
公开(公告)号：US20100035248A1
公开(公告)日：2010-02-11
申请号：US12139477
申请日：2008-06-15
申请人： Rastislav Levicky , Napoleon Tercero , Ping Gong , Kenneth Shepard
发明人： Rastislav Levicky , Napoleon Tercero , Ping Gong , Kenneth Shepard
IPC分类号： C12Q1/68 , C12M1/34
CPC分类号： C12Q1/6834 , C12Q2525/113
摘要： The sequence determination, detection, and quantification of nucleic acid molecules through sequence-specific binding (hybridization) on a solid support, specifically when Morpholinos are used as the surface-immobilized probe species in surface-based nucleic acid assays, and the assays as disclosed herein.
摘要翻译：通过在固体支持物上的序列特异性结合（杂交），特别是当在基于表面的核酸测定中将Morpholinos用作表面固定化探针物质时，核酸分子的序列测定，检测和定量以及所公开的测定这里。

10. 发明授权

US08273578B2 Capacitive morpholino diagnostics for analysis of nucleic acids 有权
标题翻译：用于分析核酸的电容性吗啉诊断
公开(公告)号：US08273578B2
公开(公告)日：2012-09-25
申请号：US13423228
申请日：2012-03-18
申请人： Rastislav Levicky , Napoleon Tercero , Kang Wong , Ping Gong , Kenneth Shepard
发明人： Rastislav Levicky , Napoleon Tercero , Kang Wong , Ping Gong , Kenneth Shepard
IPC分类号： G01N33/50
CPC分类号： C12Q1/6825 , Y10T436/143333 , C12Q2525/113
摘要： Use of Morpholinos, a class of uncharged DNA analogues, for surface-hybridization applications. Monolayers of Morpholino probes on gold supports are fabricated with methods similar to those employed with DNA, and are used to hybridize efficiently and sequence-specifically with target strands. Hybridization-induced changes in the interfacial charge organization are analyzed with electrochemical methods and compared for Morpholino and DNA probe monolayers. Molecular mechanisms connecting surface hybridization state to the interfacial capacitance are identified and interpreted through comparison to numerical Poisson-Boltzmann calculations. Positive as well as negative capacitive responses (contrast inversion) to hybridization are possible, depending on surface populations of mobile ions as controlled by the applied potential. Quantitative comparison of surface capacitance with target coverage (targets/area) reveals a near-linear relationship, and demonstrates sensitivities (limits of quantification) in the pg mm−2 range.
摘要翻译：使用Morpholinos，一类不带电荷的DNA类似物，用于表面杂交应用。使用类似于DNA使用的方法制备金支持物上的Morpholino探针的单层，并且用于与靶链有效地和序列特异性地杂交。用电化学方法分析杂交诱导的界面电荷组织变化，并比较Morpholino和DNA探针单层。通过与数值泊松 - 玻尔兹曼计算进行比较，可以确定和解释连接表面杂交态与界面电容的分子机制。取决于由施加电位控制的移动离子的表面种群，对于杂交，阳性以及负电容反应（对比反转）是可能的。表面电容与目标覆盖（目标/面积）的定量比较显示近似线性关系，并显示pg mm-2范围内的灵敏度（定量限度）。

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