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1. 发明授权

US5514602A Method of producing a metal sol reagent containing colloidal metal particles 失效
标题翻译：制备含有胶体金属颗粒的金属溶胶试剂的方法
公开(公告)号：US5514602A
公开(公告)日：1996-05-07
申请号：US22544
申请日：1993-02-25
申请人： Houston G. Brooks, Jr. , Chi-Deu Chang , Utpal R. Chakraborty , Henry A. Graham, Jr. , Lloyd L. Hollenbeck, Jr. , Sharon R. Lawler , Jennifer Nasser , Ernest G. Schutt , Albert Venturini
发明人： Houston G. Brooks, Jr. , Chi-Deu Chang , Utpal R. Chakraborty , Henry A. Graham, Jr. , Lloyd L. Hollenbeck, Jr. , Sharon R. Lawler , Jennifer Nasser , Ernest G. Schutt , Albert Venturini
IPC分类号： B01J13/00 , G01N33/543 , G01N33/558 , G01N33/58 , G01N33/74 , G01N33/553
CPC分类号： G01N33/587 , B01J13/0004 , B01J13/0043 , G01N33/54326 , G01N33/54386 , G01N33/558 , G01N33/74 , Y10S435/975
摘要： A method and test kit useful in a wide variety of immunoassay systems. A method of producing metal sol reagents containing metal sol particles of a preselected size is provided. A metal containing solution is reduced under optimized pH conditions to produce metal sol particles of a preselected size, the particles are coated with a coupling compound and then bound with at least one selected immunochemically reactive component. Particles having different immunochemical specificities are also mixed to produce reagents having multiple selected immunochemical specificities.
摘要翻译：用于各种免疫测定系统的方法和测试试剂盒。提供一种制备含有预选尺寸的金属溶胶颗粒的金属溶胶试剂的方法。在优化的pH条件下还原含金属溶液以制备预选尺寸的金属溶胶颗粒，用偶联化合物涂覆颗粒，然后与至少一种选择的免疫化学反应性组分结合。具有不同免疫化学特异性的颗粒也混合以产生具有多种选择的免疫化学特异性的试剂。

2. 发明授权

US5571726A Kit containing glutaraldehyde coated colloidal metal particles of a preselected size 失效
标题翻译：含有预选大小的含戊二醛涂层胶体金属颗粒的试剂盒
公开(公告)号：US5571726A
公开(公告)日：1996-11-05
申请号：US446533
申请日：1995-05-19
申请人： Houston G. Brooks, Jr. , Chi-Deu Chang , Utpal R. Chakraborty , Henry A. Graham, Jr. , Lloyd L. Hollenbeck, Jr. , Sharon R. Lawler , Jennifer Nasser , Ernest G. Schutt , Albert Venturini
发明人： Houston G. Brooks, Jr. , Chi-Deu Chang , Utpal R. Chakraborty , Henry A. Graham, Jr. , Lloyd L. Hollenbeck, Jr. , Sharon R. Lawler , Jennifer Nasser , Ernest G. Schutt , Albert Venturini
IPC分类号： B01J13/00 , G01N33/543 , G01N33/558 , G01N33/58 , G01N33/74 , G01N33/551 , G01N33/553
CPC分类号： G01N33/587 , B01J13/0004 , B01J13/0043 , G01N33/54326 , G01N33/54386 , G01N33/558 , G01N33/74 , Y10S435/975
摘要： A method and test kit useful in a wide variety of immunoassay systems. A method of producing metal sol reagents containing metal sol particles of a preselected size is provided. A metal containing solution is reduced under optimized pH conditions to produce metal sol particles of a preselected size, the particles are coated with a coupling compound and then bound with at least one selected immunochemically reactive component. Particles having different immunochemical specificities are also mixed to produce reagents having multiple selected immunochemical specificities.
摘要翻译：用于各种免疫测定系统的方法和测试试剂盒。提供一种制备含有预选尺寸的金属溶胶颗粒的金属溶胶试剂的方法。在优化的pH条件下还原含金属溶液以制备预选尺寸的金属溶胶颗粒，用偶联化合物涂覆颗粒，然后与至少一种选择的免疫化学反应性组分结合。具有不同免疫化学特异性的颗粒也混合以产生具有多种选择的免疫化学特异性的试剂。

3. 发明授权

US08168223B1 Engineered particles and methods of use 有权
标题翻译：工程粒子和使用方法
公开(公告)号：US08168223B1
公开(公告)日：2012-05-01
申请号：US09886296
申请日：2001-06-21
申请人： Thomas E. Tarara , Jeffry G. Weers , Alexey Kabalnov , Ernest G. Schutt , Luis A. Dellamary
发明人： Thomas E. Tarara , Jeffry G. Weers , Alexey Kabalnov , Ernest G. Schutt , Luis A. Dellamary
IPC分类号： A61K9/14 , A61K9/127
CPC分类号： A61K9/008 , A61K9/0073 , A61K9/0075 , A61K9/0078 , A61K9/1611 , A61K9/1617 , A61K9/1635 , A61K9/1641 , A61K9/1652 , A61K9/1694 , A61K31/685 , Y02A50/41 , Y02A50/466 , Y02A50/472 , Y10S514/937 , Y10S977/904 , Y10S977/906 , Y10S977/926
摘要： Engineered particles are provided may be used for the delivery of a bioactive agent to the respiratory tract of a patient. The particles may be used in the form of dry powders or in the form of stabilized dispersions comprising a nonaqueous continuous phase. In particularly preferred embodiments the particles may be used in conjunction with an inhalation device such as a dry powder inhaler, metered dose inhaler or a nebulizer.
摘要翻译：提供的工程颗粒可用于将生物活性剂递送到患者的呼吸道。颗粒可以以干粉形式或以包含非水连续相的稳定分散体的形式使用。在特别优选的实施方案中，颗粒可以与吸入装置如干粉吸入器，计量剂量吸入器或喷雾器结合使用。

4. 发明授权

US07790145B2 Respiratory dispersion for metered dose inhalers 有权
标题翻译：计量吸入器的呼吸分散
公开(公告)号：US07790145B2
公开(公告)日：2010-09-07
申请号：US12012827
申请日：2008-02-05
申请人： Jeffry G. Weers , Ernest G. Schutt , Luis A. Dellamary , Thomas E. Tarara , Alexey Kabalnov
发明人： Jeffry G. Weers , Ernest G. Schutt , Luis A. Dellamary , Thomas E. Tarara , Alexey Kabalnov
IPC分类号： A61K9/00 , A61K9/10 , A61K9/12 , A61K9/14 , A61K38/00 , A61K38/02 , A61K47/42 , A61K31/56 , A61K31/565 , A61K31/567 , A61K31/568 , A61K31/569 , A61K31/57 , A61K31/573 , A61K31/575
CPC分类号： A61K9/008 , A61K9/0073 , A61K9/0075 , A61K9/0078 , A61K9/1611 , A61K9/1617 , A61K9/1635 , A61K9/1641 , A61K9/1652 , A61K9/1694 , A61K31/685 , Y10S514/937 , Y10S977/904 , Y10S977/906 , Y10S977/926
摘要： A respiratory dispersion is provided for the pulmonary delivery of at least two bioactive agents. The dispersion comprises a propellant suspension medium having dispersed therein a plurality of perforated microstructures, wherein the two bioactive agents are incorporated into individual perforated microstructures.
摘要翻译：为肺部递送至少两种生物活性剂提供呼吸分散体。分散体包括其中分散有多个穿孔微结构的推进剂悬浮介质，其中两种生物活性剂并入单独的穿孔微结构中。

5. 发明授权

US06309623B1 Stabilized preparations for use in metered dose inhalers 有权
公开(公告)号：US06309623B1
公开(公告)日：2001-10-30
申请号：US09218212
申请日：1998-12-22
申请人： Jeffry G. Weers , Ernest G. Schutt , Luis A. Dellamary , Thomas E. Tarara , Alexey Kabalnov
发明人： Jeffry G. Weers , Ernest G. Schutt , Luis A. Dellamary , Thomas E. Tarara , Alexey Kabalnov
IPC分类号： A61K912
CPC分类号： A61K9/008 , A61K9/0073 , A61K9/0075 , A61K9/0078 , A61K9/1611 , A61K9/1617 , A61K9/1635 , A61K9/1641 , A61K9/1652 , A61K9/1694 , A61K31/685 , Y10S514/937 , Y10S977/904 , Y10S977/906 , Y10S977/926
摘要： Stabilized dispersions are provided for the delivery of a bioactive agent to the respiratory tract of a patient. The dispersions preferably comprise a plurality of perforated microstructures dispersed in a suspension medium that typically comprises a hydrofluoroalkane propellant. As density variations between the suspended particles and suspension medium are minimized and attractive forces between microstructures are attenuated, the disclosed dispersions are particularly resistant to degradation, such as, by settling or flocculation. In particularly preferred embodiments, the stabilized dispersions may be administered to the lung of a patient using a metered dose inhaler.

6. 发明授权

US06193952B1 Stabilized gas emulsions containing phospholipid for ultrasound contrast enhancement 失效
标题翻译：含有磷脂的稳定气体乳液用于超声对比度增强
公开(公告)号：US06193952B1
公开(公告)日：2001-02-27
申请号：US08973281
申请日：1998-02-09
申请人： Alexey Kabalnov , Ernest G. Schutt , Jeffry G. Weers
发明人： Alexey Kabalnov , Ernest G. Schutt , Jeffry G. Weers
IPC分类号： A61K800
CPC分类号： A61K49/223 , A61K49/1806 , A61K49/226 , Y10S514/937
摘要： A gas emulsion for ultrasound contrast enhancement comprising a plurality of gas bubbles in a liquid medium, the gas bubbles comprising at least one fluoroether selected from the group consisting of CF3OCF2OCF3, CF3(OCF2)2OCF3, CF3(OCF2)3OCF3, and CF3(OCF2)4OCF3.
摘要翻译：一种用于超声波对比度增强的气体乳液，包括在液体介质中的多个气泡，所述气泡包含至少一种选自CF 3 OCF 2 OCF 3，CF 3（OCF 2）2 OCF 3，CF 3（OCF 2）3 OCF 3和CF 3（OCF 2））4OCF3。

7. 发明授权

US5733527A Methods for harmonic imaging with ultrasound 失效
标题翻译：超声波谐波成像方法
公开(公告)号：US5733527A
公开(公告)日：1998-03-31
申请号：US688167
申请日：1996-07-29
申请人： Ernest G. Schutt
发明人： Ernest G. Schutt
IPC分类号： A61K9/00 , A61B8/00 , A61K49/00 , A61K49/22 , G01N29/00 , G01N29/02 , A61B8/13
CPC分类号： A61B8/481 , A61K49/223
摘要： A method for ultrasonic harmonic imaging is disclosed, which uses microbubbles particularly selected for their properties of reradiating ultrasound energy at frequencies other than the exciting frequency.
摘要翻译：公开了一种用于超声波谐波成像的方法，其使用特别选择用于在除了激励频率之外的频率再次辐射超声能量的性质的微泡。

8. 发明授权

US5639443A Stabilized microbubble compositions 失效
标题翻译：稳定的微泡组合物
公开(公告)号：US5639443A
公开(公告)日：1997-06-17
申请号：US405447
申请日：1995-03-16
申请人： Ernest G. Schutt , David P. Evitts , Rene Alta Kinner , Charles David Anderson , Jeffry G. Weers
发明人： Ernest G. Schutt , David P. Evitts , Rene Alta Kinner , Charles David Anderson , Jeffry G. Weers
IPC分类号： A61K49/00 , A61B8/00 , A61K49/22 , B01J13/02 , F21V8/00
CPC分类号： A61K49/227 , A61K49/223 , G02B6/0006
摘要： A microbubble preparation formed of a plurality of microbubbles comprising a first gas and a second gas surrounded by a membrane such as a surfactant, wherein the first gas and the second gas are present in a molar ratio of from about 1:100 to about 1000:1, and wherein the first gas has a vapor pressure of at least about (760-x) mm Hg at 37.degree. C., where x is the vapor pressure of the second gas at 37.degree. C., and wherein the vapor pressure of each of the first and second gases is greater than about 75 mm Hg at 37.degree. C.; also disclosed are methods for preparing microbubble compositions, including compositions that rapidly shrink from a first average diameter to a second average diameter less than about 75% of the first average diameter and are stabilized at the second average diameter; kits for preparing microbubbles; and methods for using such microbubbles as ultrasound contrast agents.
摘要翻译：一种由多个微泡形成的微泡制品，包括第一气体和被诸如表面活性剂的膜包围的第二气体，其中第一气体和第二气体以约1:100至约1000:1的摩尔比存在。 1，并且其中第一气体在37℃具有至少约（760-x）mm Hg的蒸汽压，其中x是第二气体在37℃的蒸汽压，并且其中蒸气压第一和第二气体中的每一种在37℃下大于约75mm Hg。还公开了制备微泡组合物的方法，包括从第一平均直径快速收缩至小于第一平均直径的约75％的第二平均直径的组合物，并且稳定在第二平均直径; 用于制备微泡的试剂盒以及使用这种微泡作为超声造影剂的方法。

9. 发明授权

US07442388B2 Phospholipid-based powders for drug delivery 有权
标题翻译：用于药物输送的基于磷脂的粉末
公开(公告)号：US07442388B2
公开(公告)日：2008-10-28
申请号：US09851226
申请日：2001-05-08
申请人： Jeffry G. Weers , Thomas E. Tarara , Luis A. Dellamary , Jean G. Riess , Ernest G. Schutt
发明人： Jeffry G. Weers , Thomas E. Tarara , Luis A. Dellamary , Jean G. Riess , Ernest G. Schutt
IPC分类号： A61K9/14 , A61K9/50
CPC分类号： A61K9/0075 , A61K9/008 , A61K9/0082 , A61K9/10 , A61K9/1611 , A61K9/1617 , A61K9/1694 , A61K38/29 , A61K47/02 , A61M15/0065 , A61M2205/3306
摘要： Phospholipid based powders for drug delivery applications are disclosed. The powders comprise a polyvalent cation in an amount effective to increase the gel-to-liquid crystal transition temperature of the particle compared to particles without the polyvalent cation. The powders are hollow and porous and are preferably administered via inhalation.
摘要翻译：公开了用于药物递送应用的基于磷脂的粉末。与没有多价阳离子的颗粒相比，粉末包含有效增加颗粒的凝胶 - 液晶的转变温度的多价阳离子。粉末是中空的和多孔的，并且优选通过吸入给药。

10. 发明授权

US06953569B2 Mixed gas microbubble compositions 失效
标题翻译：混合气体微泡组合物
公开(公告)号：US06953569B2
公开(公告)日：2005-10-11
申请号：US10029712
申请日：2001-12-19
申请人： Ernest G. Schutt , David P. Evitts , Rene Alta Kinner , Charles David Anderson , Jeffry G. Weers
发明人： Ernest G. Schutt , David P. Evitts , Rene Alta Kinner , Charles David Anderson , Jeffry G. Weers
IPC分类号： A61K49/00 , A61B8/00 , A61K49/22 , B01J13/02 , F21V8/00
CPC分类号： A61K49/227 , A61K49/223 , G02B6/0006
摘要： A microbubble preparation formed of a plurality of microbubbles comprising a first gas and a second gas surrounded by a membrane such as a surfactant, wherein the first gas and the second gas are present in a molar ratio of from about 1:100 to about 1000:1, and wherein the first gas has a vapor pressure of at least about (760−x) mm Hg at 37 C., where x is the vapor pressure of the second gas at 37 C., and wherein the vapor pressure of each of the first and second gases is greater than about 75 mm Hg at 37 C.; also disclosed are methods for preparing microbubble compositions, including compositions that rapidly shrink from a first average diameter to a second average diameter less than about 75% of the first average diameter and are stabilized at the second average diameter; kits for preparing microbubbles; and methods for using such microbubbles as ultrasound contrast agents.
摘要翻译：一种由多个微泡形成的微泡制品，包括第一气体和被诸如表面活性剂的膜包围的第二气体，其中第一气体和第二气体以约1:100至约1000:1的摩尔比存在。 1，并且其中第一气体在37℃下具有至少约（760-x）mm Hg的蒸汽压，其中x是第二气体在37℃的蒸汽压，并且其中每个第一和第二气体在37℃下大于约75mm Hg。还公开了制备微泡组合物的方法，包括从第一平均直径快速收缩至小于第一平均直径的约75％的第二平均直径的组合物，并且稳定在第二平均直径; 用于制备微泡的试剂盒以及使用这种微泡作为超声造影剂的方法。

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