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1. 发明授权

US5451573A Substituted cyclohexane derivatives for the treatment of diseases 失效
标题翻译：用于治疗疾病的取代的环己烷衍生物
公开(公告)号：US5451573A
公开(公告)日：1995-09-19
申请号：US116564
申请日：1993-09-07
申请人： Horst Hemmerle , Peter Schindler , Roland Utz , Robert Rippel , Andreas Herling
发明人： Horst Hemmerle , Peter Schindler , Roland Utz , Robert Rippel , Andreas Herling
IPC分类号： A61K31/185 , A61K31/16 , A61K31/19 , A61K31/215 , A61K31/235 , A61K31/255 , A61K31/36 , A61K31/38 , A61K31/381 , A61K31/415 , A61K31/44 , A61K31/66 , A61K31/67 , A61K31/675 , A61P3/08 , A61P3/10 , A61P11/00 , A61P43/00 , C07C49/04 , C07C49/20 , C07C61/08 , C07C69/013 , C07C69/03 , C07C69/533 , C07C69/612 , C07C69/63 , C07C69/65 , C07C69/67 , C07C69/73 , C07C69/732 , C07C69/734 , C07C205/56 , C07C235/36 , C07C327/06 , C07C327/10 , C07D213/55 , C07D333/24 , C07D333/32 , C07F9/38 , C07F9/40 , A61K31/435
CPC分类号： C07C205/56 , C07C235/36 , C07C69/013 , C07C69/732 , C07C69/734 , C07D213/55 , C07D333/24 , C07F9/383 , C07F9/4018 , C07C2101/16 , Y10S514/866
摘要： Substituted cyclohexane derivatives for the treatment of diseases Esters of cyclohexane derivatives of the formula I ##STR1## in which A--B, R.sup.3, R.sup.4, R.sup.5, Y and Z have the meanings indicated, for use as inhibitors of the glucose-6-phosphatase system of the liver in mammals are described. The compounds are suitable for the production of pharmaceutical preparations.
摘要翻译：用于治疗疾病的取代的环己烷衍生物式其中AB，R3，R4，R5，Y和Z具有所指义义的式I的环己烷衍生物的酯用作葡萄糖-6-磷酸酶系统的抑制剂描述了哺乳动物的肝脏。该化合物适用于制备药物制剂。

2. 发明授权

US5463062A Substituted cyclohexane derivatives, processes for their preparation and the use of the compounds for treating diseases 失效
标题翻译：取代的环己烷衍生物，其制备方法和用于治疗疾病的化合物的用途
公开(公告)号：US5463062A
公开(公告)日：1995-10-31
申请号：US116563
申请日：1993-09-07
申请人： Horst Hemmerle , Peter Schindler , Andreas Herling
发明人： Horst Hemmerle , Peter Schindler , Andreas Herling
IPC分类号： A61K31/185 , A61K31/19 , A61K31/215 , A61K31/22 , A61K31/28 , A61K31/357 , A61K31/37 , A61K31/38 , A61K31/381 , A61K31/395 , A61K31/40 , A61K31/403 , A61K31/404 , A61K31/41 , A61K31/415 , A61K31/4184 , A61K31/433 , A61K31/435 , A61K31/44 , A61K31/4402 , A61K31/4406 , A61K31/4409 , A61K31/4418 , A61K31/47 , A61P3/08 , A61P3/10 , C07C59/205 , C07C59/80 , C07C62/10 , C07C69/65 , C07C69/708 , C07C69/732 , C07C69/734 , C07C69/738 , C07C69/74 , C07C69/75 , C07C69/753 , C07C69/757 , C07C69/76 , C07C235/40 , C07C235/54 , C07C255/31 , C07C309/02 , C07C309/64 , C07C311/02 , C07D207/16 , C07D209/18 , C07D209/42 , C07D213/02 , C07D213/55 , C07D213/79 , C07D215/48 , C07D215/54 , C07D233/54 , C07D235/06 , C07D235/08 , C07D239/26 , C07D239/34 , C07D257/04 , C07D285/06 , C07D307/85 , C07D311/06 , C07D317/72 , C07D333/02 , C07D333/16 , C07D333/24 , C07D333/28 , C07D333/38 , C07D333/68 , C07D493/04 , C07D493/10 , C07D495/00 , C07D495/04 , C07D495/14 , C07D521/00 , C07D225/04 , C07D401/08 , C07D403/08
CPC分类号： C07D213/79 , C07C69/757 , C07D207/16 , C07D209/42 , C07D213/55 , C07D215/48 , C07D231/12 , C07D233/56 , C07D235/06 , C07D239/26 , C07D249/08 , C07D285/06 , C07D307/85 , C07D333/16 , C07D333/24 , C07D333/28 , C07D333/38 , C07D333/68 , C07D493/10 , C07D495/14 , Y02P20/55
摘要： Cyclohexane derivatives of the formula I ##STR1## in which the radicals R.sup.1 to R.sup.6, X, Y and Z have the stated meanings, and processes for the preparation of these compounds are described. The compounds have valuable pharmacological properties and can therefore be used as pharmaceuticals.
摘要翻译：描述了其中基团R 1至R 6，X，Y和Z具有所述含义的式I的环己烷衍生物及其制备方法。这些化合物具有有价值的药理学性质，因此可以用作药物。

3. 发明授权

US5771302A Subwoofer--loudspeaker box 失效
标题翻译：超低音扬声器盒
公开(公告)号：US5771302A
公开(公告)日：1998-06-23
申请号：US852261
申请日：1997-05-06
申请人： Peter Schindler
发明人： Peter Schindler
IPC分类号： H04R1/02 , H04R1/28 , H04R31/00 , H04R25/00
CPC分类号： H04R31/00 , H04R1/2842
摘要： The invention presents a subwoofer-loudspeaker box which is essentially built in one piece. This one-piece housing is completed with a separation wall (20) which can be inserted through an installation opening (12). An insertion frame (16) is installed on the inside wall (15) of the box housing (10) to establish the necessary seal between the volumes (28.1, 28.2) which are divided by the separation wall (20). A seal (29) is also provided for the peripheral edge (27) of the separation wall (20). The separation wall (20) is furthermore equipped with a cover plate (21) which closes the installation opening (12) as soon as the separation wall (20) reaches its final position in the box housing (10).
摘要翻译：本发明提出了一种基本上内置于一体的低音扬声器盒。这个整体式的外壳完成了一个分隔壁（20），可以通过安装开口（12）插入。插入框架（16）安装在盒壳体（10）的内壁（15）上，以便在由分隔壁（20）分隔的容积（28.1,28.2）之间建立必要的密封。还为分隔壁（20）的周缘（27）提供密封件（29）。隔离壁（20）还具有盖板（21），一旦分隔壁（20）到达箱体（10）中的最终位置，该盖板封闭安装开口（12）。

4. 发明授权

US4529545A Isolation of chemically unstable antibiotics from fermentation solutions 失效
标题翻译：从发酵溶液中分离化学不稳定的抗生素
公开(公告)号：US4529545A
公开(公告)日：1985-07-16
申请号：US443130
申请日：1982-11-19
申请人： Gerhard Huber , Peter Schindler
发明人： Gerhard Huber , Peter Schindler
IPC分类号： C12P17/10 , C07D477/00 , C12P17/18 , C07D487/04 , A61K31/40
CPC分类号： C12P17/184
摘要： A method for isolating a chemically unstable carbapenem antibiotic from a fermentation solution by adsorbing the antibiotic on an ion exchanger resin at the maximum of product formation, thus converting it to a stabilized form, and then separating the resin from the fermentation solution.
摘要翻译：一种通过在最大产物形成下将抗生素吸附在离子交换树脂上从发酵溶液中分离化学不稳定的碳青霉烯抗生素的方法，从而将其转化为稳定的形式，然后将树脂与发酵液分离。

5. 发明授权

US4353824A Chromophoric cephalosporins 失效
标题翻译：发色头孢菌素
公开(公告)号：US4353824A
公开(公告)日：1982-10-12
申请号：US142767
申请日：1980-04-22
申请人： Peter Schindler , Gerhard Huber
发明人： Peter Schindler , Gerhard Huber
IPC分类号： A61K49/04 , C07D501/16 , C07D501/18 , C07D501/38 , C07D501/42 , C07D501/44 , C07D501/46 , C07D519/06 , C12Q1/04 , C12Q1/34
CPC分类号： C12Q1/34 , C12Q2334/00 , G01N2333/986 , G01N2415/00 , Y10S435/805
摘要： What are disclosed are cephalosporins of the formula ##STR1## processes for the manufacture of said cephalosporins, preparations containing same for the detection of .beta.-lactamases, a process for making said preparations, and the use of said cephalosporins for the detection of .beta.-lactamases.
摘要翻译：所公开的是用于制备所述头孢菌素的式（IMAGE）方法的头孢菌素，含有用于检测β-内酰胺酶的制剂，制备所述制剂的方法和使用所述头孢菌素检测β-内酰胺酶。

6. 发明授权

US08592017B2 Stretch blow molded articles comprising a blend of HDPE/LDPE 有权
标题翻译：包括HDPE / LDPE共混物的拉伸吹塑制品
公开(公告)号：US08592017B2
公开(公告)日：2013-11-26
申请号：US13500042
申请日：2010-09-27
申请人： Rodolfo Salmang , Peter Schindler , Marc A. Mangnus
发明人： Rodolfo Salmang , Peter Schindler , Marc A. Mangnus
IPC分类号： B29D22/00
CPC分类号： B65D1/0207 , B29C49/0005 , B29C49/08
摘要： Stretch blow molded articles, e.g., thin wall containers, are made from a polymer blend comprising at least 70 percent by weight HDPE and at least 10 percent by weight LDPE based upon the total weight of the polymer blend. The HDPE/LDPE blends used in the practice of this invention provide increased melt strength resulting in a wider processing window.
摘要翻译：拉伸吹塑制品例如薄壁容器由包含至少70重量％HDPE和至少10重量％LDPE的聚合物共混物制成，基于聚合物共混物的总重量。在本发明实践中使用的HDPE / LDPE共混物提供了增加的熔体强度，导致更宽的加工窗口。

7. 发明授权

US5302582A Enkastins: new glycopeptides which act to inhibit enkephlinase, processes for their preparation, and their use as pharmaceutical products 失效
标题翻译：恩卡斯汀：用于抑制肠胃蛋白酶的新糖肽，其制备方法及其作为药物的用途
公开(公告)号：US5302582A
公开(公告)日：1994-04-12
申请号：US727388
申请日：1991-07-05
申请人： Laszlo Vertesy , Peter Schindler , Herbert Kogler , Hans-Wolfram Fehlhaber , Francoise Delevallee
发明人： Laszlo Vertesy , Peter Schindler , Herbert Kogler , Hans-Wolfram Fehlhaber , Francoise Delevallee
IPC分类号： C12P21/02 , A61K31/70 , A61K31/7028 , A61K38/00 , A61K38/55 , A61P25/04 , C07H7/02 , C07H15/12 , C07K1/113 , C07K5/06 , C07K9/00 , C07K14/195 , C07K14/41 , C07K14/81 , C07K17/00 , C12N1/14 , C12N1/20 , C12N9/99 , C12P19/26 , C12P19/28 , C12R1/47
CPC分类号： C12R1/47 , C07K9/001 , C07K9/003 , C12N1/14 , A61K38/00
摘要： The invention relates to new biologically active glycopeptides of the general formulaSacch--A--B--Rin which Sacch represents a monosaccharide residue with, where appropriate, the OH groups being partially or completely substituted,A represents the residue of a neutral L- or D-amino acid or --if B is absent--represents the residue of a neutral D-amino acid,B is absent or represents the residue of a neutral L- or D-amino acid or of an optionally .omega.-substituted bi-functional acidic or basic L- or D-amino acid, and R represents hydroxyl, (C.sub.1 -C.sub.8)-alkoxy, an amino radical which is optionally substituted by one or two identical or different radicals from the series comprising (C.sub.1 -C.sub.8)-alkyl, (C.sub.5 -C.sub.8)-cycloalkyl, (C.sub.5 -C.sub.8)-heteroalkyl or (C.sub.5 -C.sub.8)-heteroaryl, or another acid derivative. These compounds have enkephalinase-inhibiting properties and can thus be used, for example, as analgesics in human and veterinary medicine. The isolation of these compounds from Streptomyces albus ATCC 21838, and further processes for their preparation, are also described.
摘要翻译：本发明涉及通式为Sacch-ABR的新的生物活性糖肽，其中Sacch代表单糖残基，在适当的情况下OH基部分或完全被取代，A代表中性L-或D-氨基酸的残基或 - 如果B不存在 - 表示中性D-氨基酸的残基，B不存在或表示中性L-或D-氨基酸或任选（ω） - 取代的双官能酸性或碱性的残基 L-或D-氨基酸，R代表羟基，（C1-C8） - 烷氧基，任选被一个或两个相同或不同的基团取代的氨基，所述基团包括（C 1 -C 8） - 烷基， -C 8） - 环烷基，（C 5 -C 8） - 杂烷基或（C 5 -C 8） - 杂芳基或其它酸衍生物。这些化合物具有脑啡肽酶抑制性质，因此可用于例如人和兽医学中的镇痛药。这些化合物从Streptomyces albus ATCC 21838的分离以及其制备方法也被描述。

8. 发明授权

US4535156A Chromogenic cephalosporin compound 失效
标题翻译：显色头孢菌素化合物
公开(公告)号：US4535156A
公开(公告)日：1985-08-13
申请号：US565847
申请日：1983-12-29
申请人： Jurgen Blumbach , Peter Schindler
发明人： Jurgen Blumbach , Peter Schindler
IPC分类号： C07D501/18 , C07D501/36 , C12Q1/34 , A61K31/545
CPC分类号： C12Q1/34 , C12Q2334/00 , G01N2333/986 , G01N2415/00
摘要： What are disclosed are cephalosporin derivatives of the formula ##STR1## formulations containing such cephem derivatives suitable for the detection of .beta.-lactamases, process for the manufacture of the cephem derivatives and the formulations, and use of the cephem derivatives for the detection of .beta.-lactamases and .beta.-lactamase inhibitors.
摘要翻译：所公开的是含有适用于检测β-内酰胺酶的头孢衍生物，用于制备头孢烯衍生物和制剂的方法，以及头孢烯衍生物用于检测β-内酰胺酶的配方的头孢菌素衍生物，内酰胺酶和β-内酰胺酶抑制剂。

9. 发明授权

US08486323B2 Rotational molded articles, and method of making the same 有权
标题翻译：旋转成形品及其制造方法
公开(公告)号：US08486323B2
公开(公告)日：2013-07-16
申请号：US13387772
申请日：2010-08-23
申请人： Mark B. Davis , Mridula Kapur , William J. Michie, Jr. , Peter Schindler , Nathan J. Wiker , Debra R. Wilson
发明人： Mark B. Davis , Mridula Kapur , William J. Michie, Jr. , Peter Schindler , Nathan J. Wiker , Debra R. Wilson
IPC分类号： C08F210/16 , B28B1/20
CPC分类号： B29C41/04 , B29C2945/7605 , B29K2023/06 , B29K2995/0088 , C08F4/65912 , C08F4/65925 , C08F210/16 , C08L2205/06 , C08L2314/06 , C08F4/65916 , C08F210/14 , C08F2500/12 , C08F2500/13 , C08F2500/03
摘要： The instant invention provides rotational molded articles, and method of making the same. The rotational molded articles according to the present invention comprise a polyethylene composition comprising: (a) at least 85 percent by weight of the units derived from ethylene; and (b) less than 15 percent by weight of units derived from one or more α-olefin comonomers; wherein the polyethylene composition has a density in the range of 0.930 to 0.945 g/cm3, a molecular weight distribution (Mw/Mn) in the range of 1.70 to 3.50, a melt index (I2) in the range of 0.5 to 20 g/10 minutes, a molecular weight distribution (Mz/Mw) in the range of less than 2.5, vinyl unsaturation of less than 0.06 vinyls per one thousand carbon atoms present in the backbone of the polyethylene composition.
摘要翻译：本发明提供旋转成型制品及其制造方法。根据本发明的旋转模塑制品包括聚乙烯组合物，其包含：（a）至少85重量％的衍生自乙烯的单元; 和（b）少于15重量％的衍生自一种或多种α-烯烃共聚单体的单元; 其中，所述聚乙烯组合物的密度为0.930〜0.945g / cm 3，分子量分布（Mw / Mn）为1.70〜3.50，熔体指数（I2）为0.5〜20g / 10分钟内，存在于聚乙烯组合物的主链中的每千个碳原子的分子量分布（Mz / Mw）小于2.5的乙烯基不饱和度小于0.06个乙烯基。

10. 发明申请

US20120193266A1 Stretch Blow Molded Articles Comprising a Blend of HDPE/LDPE 有权
标题翻译：包含HDPE / LDPE混合物的拉伸吹塑制品
公开(公告)号：US20120193266A1
公开(公告)日：2012-08-02
申请号：US13500042
申请日：2010-09-27
申请人： Rodolfo Salmang , Peter Schindler , Marc A. Mangnus
发明人： Rodolfo Salmang , Peter Schindler , Marc A. Mangnus
IPC分类号： B65D85/00
CPC分类号： B65D1/0207 , B29C49/0005 , B29C49/08
摘要： Stretch blow molded articles, e.g., thin wall containers, are made from a polymer blend comprising at least 70 percent by weight HDPE and at least 10 percent by weight LDPE based upon the total weight of the polymer blend. The HDPE/LDPE blends used in the practice of this invention provide increased melt strength resulting in a wider processing window.
摘要翻译：拉伸吹塑制品例如薄壁容器由包含至少70重量％HDPE和至少10重量％LDPE的聚合物共混物制成，基于聚合物共混物的总重量。在本发明实践中使用的HDPE / LDPE共混物提供了增加的熔体强度，导致更宽的加工窗口。

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