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1. 发明授权

US4664105A Absorbing wound dressing and method for making the same 失效
标题翻译：吸收伤口敷料及其制作方法
公开(公告)号：US4664105A
公开(公告)日：1987-05-12
申请号：US731480
申请日：1985-05-07
申请人： Horst Dautzenberg , Fritz Loth , Bodo Borrmeister , Dieter Bertram , Herbert Lettau , Jiri Stamberg , PesJan
发明人： Horst Dautzenberg , Fritz Loth , Bodo Borrmeister , Dieter Bertram , Herbert Lettau , Jiri Stamberg , PesJan
IPC分类号： A61F13/00 , A61L15/22 , C08J9/00 , C08L1/24 , A61K31/74
CPC分类号： A61L15/225
摘要： The absorbing wound dressing which is atoxic, tissue compatible and very well adjusted to the shape of the wound, it is easily removable, protecting from infections or reduces infections in that it absorbs, in addition to the wound excudate, bacteria, fungi, toxins, proteins and inflammation mediators and which is therefore suitable for covering and cleaning of strongly wetting, infected wounds, as well as effected areas in skin and tissue diseases, consists of potentially macroporous particulate mixtures of regenerated cellulose and a carboxylate groups containing polysaccharide derivative. For making it, viscose solutions, which contain the polysaccharide derivative are thermically coagulated, purified and dried, after the deformation.
摘要翻译：吸收伤口敷料是有毒的，组织相容的，并且很好地适应伤口的形状，它易于移除，防止感染或减少感染，除了伤口排泄物外，细菌，真菌，毒素，蛋白质和炎症介质，因此适用于覆盖和清洁强烈润湿，感染的伤口以及皮肤和组织疾病中的受影响区域，由再生纤维素和含多糖衍生物的羧酸盐基团的潜在大孔颗粒混合物组成。为了制造它，含有多糖衍生物的粘胶溶液在变形后热凝固，纯化和干燥。

2. 发明授权

US4599209A Method of producing absorbing wound dressing 失效
标题翻译：生产吸收伤口敷料的方法
公开(公告)号：US4599209A
公开(公告)日：1986-07-08
申请号：US627485
申请日：1984-07-05
申请人： Horst Dautzenberg , Fritz Loth , Bodo Borrmeister , Dieter Bertram , Herbert Lettau , Jiri Stamberg , Jan Peska
发明人： Horst Dautzenberg , Fritz Loth , Bodo Borrmeister , Dieter Bertram , Herbert Lettau , Jiri Stamberg , Jan Peska
IPC分类号： A61F13/00 , A61L15/22 , C08J9/00 , C08L1/24 , B29B9/00
CPC分类号： A61L15/225
摘要： A process of making a wound dressing is suggested, in which a technical conventional viscose solution is mixed with a polysaccharide derivative; the mixture is treated at increased temperatures such that it is thermally coagulated; the coagulate is wetted with a polyalkylene glycol and dried, whereby a particulate structure of the wound dressing is produced.
摘要翻译：建议制造伤口敷料的方法，其中将技术常规粘胶溶液与多糖衍生物混合; 混合物在升高的温度下进行处理，使其热凝固; 用聚亚烷基二醇润湿凝结物并干燥，由此制备伤口敷料的颗粒结构。

3. 发明授权

US4536217A Absorbing cover for wounds and the method for manufacturing thereof 失效
标题翻译：用于伤口的吸收罩及其制造方法
公开(公告)号：US4536217A
公开(公告)日：1985-08-20
申请号：US537151
申请日：1983-09-28
申请人： Fritz Loth , Horst Dautzenberg , Jiri Stamberg , Jan Peska , Dieter Bertram , Herbert Lettau
发明人： Fritz Loth , Horst Dautzenberg , Jiri Stamberg , Jan Peska , Dieter Bertram , Herbert Lettau
IPC分类号： A61L26/00 , C08B1/00
CPC分类号： A61L26/0023
摘要： The invention pertains to the absorbing dressing for wounds, which consists of spherical particles of regenerated cellulose of the size 0.05-0.5 mm (preferably 0.05-0.3 mm) and a macroporous structure characterized by the cyclohexane regain of the dry material at least 0.2 ml/g. The dressing is prepared from the regenerated cellulose swollen with water by replacement with organic solvents and the subsequent drying of the product swollen with the said solvent. The porous structure of the dressing warrants that it can absorb excretions of the wound in the amount 1.5 to 5 g water per g of solids; the grainy macrostructure remains preserved during the absorption so that the material applied on the wound in the form of a powder in the layer 2-5 mm thick, in particular 2-3 mm thick, can be without difficulties and almost without pain rinsed away with water.
摘要翻译：本发明涉及用于伤口的吸收敷料，其由尺寸为0.05-0.5mm（优选0.05-0.3mm）的再生纤维素的球形颗粒组成，其特征在于干燥材料的环己烷回收率为至少0.2ml / G。敷料由用有机溶剂置换的再生纤维素溶液制备，随后用所述溶剂干燥产物溶胀。敷料的多孔结构保证其可以吸收每克固体量为1.5至5g水的伤口排泄物; 颗粒状宏观结构在吸收期间保持保留，使得以2-5mm厚，特别是2-3mm厚的层施加在粉末形式的伤口上的材料可以是没有困难的，几乎没有疼痛被冲洗掉水。

4. 发明授权

US4615880A Dressing for wounds and the method for manufacturing thereof 失效
标题翻译：伤口敷料及其制造方法
公开(公告)号：US4615880A
公开(公告)日：1986-10-07
申请号：US599637
申请日：1984-04-12
申请人： Frith Loth , Horst Dautzenberg , Jiri Stamberg , Jan Peska , Dieter Bertram , Herbert Lettau
发明人： Frith Loth , Horst Dautzenberg , Jiri Stamberg , Jan Peska , Dieter Bertram , Herbert Lettau
IPC分类号： A61L26/00 , A61K9/16 , A61K9/18 , A61L15/03
CPC分类号： A61L26/0023
摘要： An absorbing dressing for wounds consists of spherical particles of regenerated cellulose of the size 0.05-0.5 mm and a macroporous structure characterized by the cyclohexane regain of the dry material at least 0.2 ml/g. The dressing is prepared from the regenerated cellulose swollen with water by replacement with organic solvents and the subsequent drying of the product swollen with the said solvent and impregnated with a therapeutically active compound.
摘要翻译：用于伤口的吸收性敷料由尺寸为0.05-0.5mm的再生纤维素的球形颗粒组成，其特征在于干物质的环己烷重吸收率至少为0.2ml / g。该敷料由用有机溶剂置换的再生纤维素溶液制备，随后用所述溶剂干燥产物并用治疗活性化合物浸渍。

5. 发明授权

US4613502A Proteolytic, dry biopolymeric composition for treatment of wounds, and method of using same 失效
标题翻译：用于治疗伤口的蛋白水解，干生物聚合物组合物及其使用方法
公开(公告)号：US4613502A
公开(公告)日：1986-09-23
申请号：US679118
申请日：1984-12-06
申请人： Jaroslava Turkova , Jiri Stamberg
发明人： Jaroslava Turkova , Jiri Stamberg
IPC分类号： A61K38/48 , A61L26/00 , C12N11/10 , A61K37/48 , A61K37/547
CPC分类号： C12N11/10 , A61K38/48 , A61K38/4826 , A61L26/0023 , A61L26/0057 , A61L26/0066 , A61L2300/254
摘要： The invention pertains to a cover of wounds in the form of a powder or a dry powdery fluid and is useful in covering and treating of ulcerous and necrotic wounds. It consists of animal or fungous chitin and chitosan in a powdered form of particle size 0.01 to 0.3 mm or of crosslinked dextran in the form of spheric particles of diameter 0.05 to 0.5 mm and of an immobilized protease. Enzymes are chemically bonded to the structure of the biopolymeric carrier and provide cleaning of the wound by dissolution of undesirable protein material, in particular fibrin, necrotic tissues, components of pus, and the like. In addition the adsorption and regeneration effects of powder act to provide suction of exudate and purulent matter infected with bacteria into interstitial capillary space. The cover according to the invention acts by fast cleaning of necrotic defects and speeds up the granulation and healing of the wound. The invention can be utilized in pharmaceutical production.
摘要翻译：本发明涉及粉末或干燥粉末状流体的伤口覆盖物，可用于覆盖和治疗溃疡性坏死性伤口。它由动物或真菌的壳多糖和粒径为0.01至0.3mm的粉末形式的壳聚糖或直径为0.05至0.5mm的球形颗粒形式的交联的葡聚糖和固定的蛋白酶组成。酶化学键合到生物聚合物载体的结构，并通过溶解不期望的蛋白质材料，特别是纤维蛋白，坏死组织，脓液组分等来提供对伤口的清洁。此外，粉末的吸附和再生作用可以将渗出物和感染细菌的化脓物吸引到间质毛细管空间。根据本发明的盖子通过快速清洁坏死缺陷起作用并加速伤口的造粒和愈合。本发明可用于制药生产。

6. 发明授权

US4439588A Polymers of pivaloyloxyalkyl methacrylates, method for their preparation and modification 失效
标题翻译：聚甲基丙烯酸新戊酰氧基烷基酯的聚合物，其制备和改性方法
公开(公告)号：US4439588A
公开(公告)日：1984-03-27
申请号：US204615
申请日：1980-11-06
申请人： Stanislav Sevcik , Jiri Trekoval , Jan Holata , Jiri Stamberg
发明人： Stanislav Sevcik , Jiri Trekoval , Jan Holata , Jiri Stamberg
IPC分类号： C08F8/00 , C08F8/12 , C08F20/00 , C08F20/26 , C08F20/28 , C08F290/00 , C08F297/02 , C08F299/00
CPC分类号： C08F297/026 , C08F20/28 , C08F8/44
摘要： The invention relates to polymers and copolymers of pivaloyloxyalkyl methacrylates which contain structural units of the general formula ##STR1## where R.sup.1 is (CH.sub.2).sub.n.sbsb.1 --O (n.sub.1 =2 to 10) or (CH.sub.2 CH.sub.2 --O).sub.n.sbsb.2 (n.sub.2 =1 to 4) and to the method of their preparation and modification. The polymerization and copolymerization can be initiated by free-radical initiators of the peroxy type or by anionic initiators, e.g., alkali metal alkoxides or butyllithium, and carried out in a solution, bulk or suspension process in the presence of a crosslinking agent or without it. Anionic polymerization may result in stereoregular polymers or may be used for preparation of block copolymers by the "living" polymer technique. The polymers and copolymers can be modified by the partial or total conversion of the pivaloyloxyalkyl methacrylate units into hydroxyalkyl methacrylate units by selective hydrolysis, alcoholysis or other reaction.
摘要翻译：本发明涉及甲基丙烯酸新戊酰氧基烷基酯的聚合物和共聚物，其含有通式为“IMAGE”的结构单元，其中R1是（CH2）n1-O（n1 = 2〜10）或（CH2CH2-O）n2（n2 = 1〜4））及其制备和修改方法。聚合和共聚可以由过氧型的自由基引发剂或阴离子引发剂例如碱金属醇盐或丁基锂引发，并且在溶剂，本体或悬浮方法中，在交联剂或不存在下进行。阴离子聚合可能导致有规立构聚合物，或者可以通过“活性”聚合物技术制备嵌段共聚物。聚合物和共聚物可以通过选择性水解，醇解或其它反应将甲基丙烯酸新戊酰氧基烷基酯单元部分或全部转化成甲基丙烯酸羟烷基酯单元来进行改性。

7. 发明授权

US4067825A Method for preparation of amphoteric ion-exchangers by substitution of hydrophilic polymers 失效
标题翻译：通过亲水性聚合物取代制备两性离子交换剂的方法
公开(公告)号：US4067825A
公开(公告)日：1978-01-10
申请号：US689963
申请日：1976-05-26
申请人： Jiri Hradil , Jiri Stamberg , Jiri Coupek
发明人： Jiri Hradil , Jiri Stamberg , Jiri Coupek
IPC分类号： B01J43/00 , C08F8/00 , C08F8/40 , C08L23/32 , C08L23/34 , C08L23/36
CPC分类号： B01J43/00 , C08F8/14 , C08F8/34 , C08F8/44 , C08F2222/1013 , C08F2800/20 , C08F2810/30
摘要： The invention relates to a method for preparation of cationactive and amphoteric ion-exchangers from non-ionogenic crosslinked copolymers containing hydroxyl groups by their reaction with mineral acids, addition products of sulfur trioxide, sulfuric acid or chlorosulfuric acid with alcohols or pyridine, unsaturated compounds, as acrylonitrile, methacrylonitrile or sodium vinylsulfonate in a strongly alkaline medium, or with halogenoalkylammonium compounds. The starting copolymer containing hydroxyl groups is prepared by the suspension copolymerization of monomers, selected from the group which comprises hydroxyalkyl methacrylates and acrylates and oligoglycol acrylates and methacrylates, with crosslinking divinyl monomers, e.g. divinylbenzene, ethylene dimethacrylate, butylenediol dimethacrylate or diacrylate, and advantageously has the macroporous structure. The products are suitable for application in column process thanks to their favorable mechanical properties, namely for chromatographic separation of hydrophilic compounds, e.g. biological materials as aminoacids. The hydrophilicity of the product may be varied by selection of monomers for the starting copolymer, by the type of ionactive substitution and by the degree of transformation.
摘要翻译：本发明涉及一种通过与无机酸反应而含有羟基的非离子型交联共聚物，三氧化硫，硫酸或氯磺酸与醇或吡啶的不饱和化合物的加成反应产生的阳离子和两性离子交换剂的制备方法，作为丙烯腈，甲基丙烯腈或乙烯基磺酸钠在强碱性介质中，或与卤代烷基铵化合物。包含羟基的起始共聚物是通过悬浮共聚单体制备的，所述单体选自包括甲基丙烯酸羟烷基酯和丙烯酸酯和低聚丙烯酸酯和甲基丙烯酸酯的基团，与交联二乙烯基单体例如。二乙烯基苯，乙烯二甲基丙烯酸酯，丁二烯二醇二甲基丙烯酸酯或二丙烯酸酯，并且有利地具有大孔结构。由于它们有利的机械性能，即用于亲水化合物的色谱分离，例如，生物材料作为氨基酸。产物的亲水性可以通过选择起始共聚物的单体，离子取代的类型和转化程度来改变。

8. 发明授权

US4267287A Polymers of pivaloyloxyalkyl methacrylates, method for their preparation and modification 失效
标题翻译：聚甲基丙烯酸新戊酰氧基烷基酯的聚合物，其制备和改性方法
公开(公告)号：US4267287A
公开(公告)日：1981-05-12
申请号：US89628
申请日：1979-10-29
申请人： Stanislav Sevcik , Jiri Trekoval , Jan Holata , Jiri Stamberg
发明人： Stanislav Sevcik , Jiri Trekoval , Jan Holata , Jiri Stamberg
IPC分类号： C08F8/00 , C08F8/12 , C08F20/00 , C08F20/26 , C08F20/28 , C08F290/00 , C08F297/02 , C08F299/00 , C08F220/10
CPC分类号： C08F297/026 , C08F20/28 , C08F8/44
摘要： The invention relates to polymers and copolymers of pivaloyloxyalkyl methacrylates which contain structural units of the general formula ##STR1## where R.sup.1 is (CH.sub.2).sub.n.sbsb.1 --O (n.sub.1 =2 to 10) or (CH.sub.2 CH.sub.2 --O).sub.n.sbsb.2 (n.sub.2 =1 to 4) and to the method of their preparation and modification. The polymerization and copolymerization can be initiated by free-radical initiators of the peroxy type or by anionic initiators, e.g., alkali metal alkoxides or butyllithium, and carried out in a solution, bulk or suspension process in the presence of a crosslinking agent or without it. Anionic polymerization may result in stereoregular polymers or may be used for preparation of block copolymers by the "living" polymer technique. The polymers and copolymers can be modified by the partial or total conversion of the pivaloyloxyalkyl methacrylate units into hydroxyalkyl methacrylate units by selective hydrolysis, alcoholysis or other reaction.
摘要翻译：本发明涉及甲基丙烯酸新戊酰氧基烷基酯的聚合物和共聚物，其含有通式为“IMAGE”的结构单元，其中R1为（CH2）n1-O（n1 = 2〜10）或（CH2CH2-O）n2（n2 = 1〜4 ）及其制备和修改方法。聚合和共聚可以由过氧型的自由基引发剂或阴离子引发剂例如碱金属醇盐或丁基锂引发，并且在溶剂，本体或悬浮方法中，在交联剂或不存在下进行。阴离子聚合可能导致有规立构聚合物，或者可以通过“活性”聚合物技术制备嵌段共聚物。聚合物和共聚物可以通过选择性水解，醇解或其它反应将甲基丙烯酸新戊酰氧基烷基酯单元部分或全部转化成甲基丙烯酸羟烷基酯单元来进行改性。

9. 发明授权

US4218552A Polymers of pivaloyloxyalkyl methacrylates, method for their preparation and modification 失效
标题翻译：聚甲基丙烯酸新戊酰氧基烷基酯的聚合物，其制备和改性方法
公开(公告)号：US4218552A
公开(公告)日：1980-08-19
申请号：US944392
申请日：1978-09-21
申请人： Stanislav Sevcik , Jiri Trekoval , Jan Holata , Jiri Stamberg
发明人： Stanislav Sevcik , Jiri Trekoval , Jan Holata , Jiri Stamberg
IPC分类号： C08F8/12 , C08F20/28 , C08F297/02 , C08F22/10 , C08F4/32 , C08F4/34
CPC分类号： C08F297/026 , C08F20/28 , C08F8/44
摘要： The invention relates to polymers and copolymers of pivaloyloxyalkyl methacrylates which contain structural units of the general formula ##STR1## where R.sup.1 is (CH.sub.2).sub.n.sbsb.1 --O (n.sub.1 =2 to 10) or (CH.sub.2 CH.sub.2 --O).sub.n.sbsb.2 (n.sub.2 =1 to 4) and to the method of their preparation and modification. The polymerization and copolymerization can be initiated by free-radical initiators of the peroxy type or by anionic initiators, e.g., alkali metal alkoxides or butyllithium, and carried out in a solution, bulk or suspension process in the presence of a crosslinking agent or without it. Anionic polymerization may result in stereoregular polymers or may be used for preparation of block copolymers by the "living" polymer technique. The polymers and copolymers can be modified by the partial or total conversion of the pivaloyloxyalkyl methacrylate units into hydroxyalkyl methacrylate units by selective hydrolysis, alcoholysis or other reaction.
摘要翻译：本发明涉及甲基丙烯酸新戊酰氧基烷基酯的聚合物和共聚物，其含有通式为“IMAGE”的结构单元，其中R1是（CH2）n1-O（n1 = 2〜10）或（CH2CH2-O）n2（n2 = 1〜4））及其制备和修改方法。聚合和共聚可以由过氧型的自由基引发剂或阴离子引发剂例如碱金属醇盐或丁基锂引发，并且在溶剂，本体或悬浮方法中，在交联剂或不存在下进行。阴离子聚合可能导致有规立构聚合物，或者可以通过“活性”聚合物技术制备嵌段共聚物。聚合物和共聚物可以通过选择性水解，醇解或其它反应将甲基丙烯酸新戊酰氧基烷基酯单元部分或全部转化成甲基丙烯酸羟烷基酯单元来进行改性。

10. 发明授权

US4055510A Method for manufacturing of spherical cellulose particles 失效
标题翻译：球形纤维素颗粒的制造方法
公开(公告)号：US4055510A
公开(公告)日：1977-10-25
申请号：US579716
申请日：1975-05-21
申请人： Jan Peska , Jiri Stamberg , Zdenko Blace
发明人： Jan Peska , Jiri Stamberg , Zdenko Blace
IPC分类号： C08L1/00 , B01J2/00 , B01J13/00 , C08J3/12 , C08J3/14 , C08J3/16 , C08L7/00 , C08L21/00 , B01J37/00 , B01D3/00
CPC分类号： C08J3/16 , B01J13/0065 , B01J2/00 , C08K5/0025 , C08K5/15 , C08J2301/24
摘要： The invention relates to a method for manufacturing of spherical cellulose particles in bead form which enables to control the partial shape and porosity of the particles. Resulting cellulose sorbents are suitable carriers and materials for chromatography. The invented methods consists in heating a viscose (an aqueous solution of sodium cellulose xanthate) suspension in a water-immiscible liquid to 30.degree.-100.degree. C under stirring to form spherical droplets and solidify them and in the subsequent acidic decomposition of the solid xanthate globules either directly by addition of an acid soluble in the dispersion medium, or additionally after isolation and eventual washing of the particles to achieve the required wet volume. Liquids with the viscosity up to 100 cSt are advantageously used as dispersion medium and surfactants and/or modifying reagents (e.g. epichlorohydrine) may be added to the suspension.
摘要翻译：本发明涉及一种珠粒形球形纤维素颗粒的制造方法，其能够控制颗粒的部分形状和孔隙率。得到的纤维素吸附剂是适用于色谱的载体和材料。本发明的方法是在搅拌下将粘性纤维素（黄原酸钠纤维素钠水溶液）悬浮液加热至30〜-100℃，形成球形液滴并使其固化，随后固体黄原酸酸性分解直接通过加入可溶于分散介质中的酸，或另外分离并最终洗涤颗粒以达到所需的湿体积。粘度高达100cSt的液体有利地用作分散介质，并且可以向悬浮液中加入表面活性剂和/或改性试剂（例如表氯醇）。

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