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1. 发明授权

US06913832B2 Prototyping of patterned functional nanostructures 有权
标题翻译：图案化功能纳米结构的原型
公开(公告)号：US06913832B2
公开(公告)日：2005-07-05
申请号：US10163425
申请日：2002-06-07
申请人： Hongyou Fan , Gabriel P. Lopez , Charles Jeffrey Brinker , Yunfeng Lu
发明人： Hongyou Fan , Gabriel P. Lopez , Charles Jeffrey Brinker , Yunfeng Lu
IPC分类号： C09D183/04 , C09D4/00 , C09D5/00 , C09D183/02 , C09D183/08 , C09D183/14 , C30B7/00 , B32B25/20
CPC分类号： C08G77/04 , C09D4/00 , C09D183/02 , C09D183/08 , C30B7/00 , C30B7/005 , C30B29/605 , Y10T428/31663 , C08G77/28 , C08G77/26
摘要： The present invention provides a coating composition comprising: A coating composition comprising: TEOS; a surfactant; at least one organosilane; HCl; water; and ethanol. The present invention also provides films made from such a coating composition and a method for making such films.
摘要翻译：本发明提供一种涂料组合物，其包含：涂料组合物，其包含：TEOS; 表面活性剂; 至少一种有机硅烷; HCl; 水; 和乙醇。本发明还提供了由这种涂料组合物制成的薄膜和制造这种薄膜的方法。

2. 发明授权

US06471761B2 Prototyping of patterned functional nanostructures 有权
公开(公告)号：US06471761B2
公开(公告)日：2002-10-29
申请号：US09838153
申请日：2001-04-20
申请人： Hongyou Fan , Gabriel P. Lopez , Charles Jeffrey Brinker , Yunfeng Lu
发明人： Hongyou Fan , Gabriel P. Lopez , Charles Jeffrey Brinker , Yunfeng Lu
IPC分类号： C09D500
CPC分类号： C08G77/04 , C09D4/00 , C09D183/02 , C09D183/08 , C30B7/00 , C30B7/005 , C30B29/605 , Y10T428/31663 , C08G77/28 , C08G77/26
摘要： The present invention provides a coating composition comprising: A coating composition comprising: TEOS; a surfactant; at least one organosilane; HCl; water; and ethanol. The present invention also provides films made from such a coating composition and a method for making such films.

3. 发明授权

US06270846B1 Method for making surfactant-templated, high-porosity thin films 有权
标题翻译：制备表面活性剂模板，高孔隙率薄膜的方法
公开(公告)号：US06270846B1
公开(公告)日：2001-08-07
申请号：US09517689
申请日：2000-03-02
申请人： C. Jeffrey Brinker , Yunfeng Lu , Hongyou Fan
发明人： C. Jeffrey Brinker , Yunfeng Lu , Hongyou Fan
IPC分类号： B05B500
CPC分类号： B01F17/0028 , B01F17/0021 , B01F17/0042 , B01F17/0057 , B01F17/0064 , C03C17/007 , C03C17/009 , C03C2217/425 , Y10T428/21 , Y10T428/24331
摘要： An evaporation-induced self-assembly method to prepare a surfactant-templated thin film by mixing a silica sol, a surfactant, and a hydrophobic polymer and then evaporating a portion of the solvent during coating onto a substrate and then heating to form a liquid-phase, thin film material with a porosity greater than approximately 50 percent. The high porosity thin films can have dielectric constants less than 2 to be suitable for applications requiring low-dielectric constants. An interstitial compound can be added to the mixture, with the interstitial compound either covalently bonded to the pores or physically entrapped within the porous structure. The selection of the interstitial compound provides a means for developing thin films for applications including membranes, sensors, low dielectric constant films, photonic materials and optical hosts.
摘要翻译：蒸发诱导的自组装方法，通过混合二氧化硅溶胶，表面活性剂和疏水聚合物制备表面活性剂模板化薄膜，然后在涂布过程中将一部分溶剂蒸发到基底上，然后加热形成液体 - 孔隙率大于约50％的薄膜材料。高孔隙率薄膜可以具有小于2的介电常数，以适用于需要低介电常数的应用。间隙化合物可以加入到混合物中，间隙化合物共价键合到孔或物理地截留在多孔结构内。间隙化合物的选择提供了一种用于开发用于包括膜，传感器，低介电常数膜，光子材料和光学主体的薄膜的薄膜的方法。

4. 发明授权

US06387453B1 Method for making surfactant-templated thin films 有权
标题翻译：制备表面活性剂模板薄膜的方法
公开(公告)号：US06387453B1
公开(公告)日：2002-05-14
申请号：US09517873
申请日：2000-03-02
申请人： C. Jeffrey Brinker , Yunfeng Lu , Hongyou Fan
发明人： C. Jeffrey Brinker , Yunfeng Lu , Hongyou Fan
IPC分类号： B05D302
CPC分类号： B82Y30/00
摘要： An evaporation-induced self-assembly method to prepare a porous, surfactant-templated, thin film by mixing a silica sol, a solvent, a surfactant, and an interstitial compound, evaporating a portion of the solvent to form a liquid, crystalline thin film mesophase material, and then removal of the surfactant template. Coating onto a substrate produces a thin film with the interstitial compound either covalently bonded to the internal surfaces of the ordered or disordered mesostructure framework or physically entrapped within the ordered or disordered mesostructured framework. Particles can be formed by aerosol processing or spray drying rather than coating onto a substrate. The selection of the interstitial compound provides a means for developing thin films for applications including membranes, sensors, low dielectric constant films, photonic materials and optical hosts.
摘要翻译：通过混合硅溶胶，溶剂，表面活性剂和间隙化合物制备多孔表面活性剂模板化薄膜的蒸发诱导自组装方法，蒸发溶剂的一部分以形成液体，晶体薄膜中间相材料，然后除去表面活性剂模板。涂覆在基材上产生薄膜，其中间隙化合物共价键合到有序或无序的介观结构框架的内表面或物理地截留在有序或无序的介观结构框架内。颗粒可以通过气溶胶处理或喷雾干燥形成，而不是涂覆在基材上。间隙化合物的选择提供了一种用于开发用于包括膜，传感器，低介电常数膜，光子材料和光学主体的薄膜的薄膜的方法。

5. 发明授权

US10179112B2 Viral vector nanocapsule for targeting gene therapy and its preparation 有权
公开(公告)号：US10179112B2
公开(公告)日：2019-01-15
申请号：US14651945
申请日：2013-12-16
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , Yunfeng Lu , Ming Yan , Irvin S. Y. Chen , Min Liang
发明人： Yunfeng Lu , Ming Yan , Irvin S. Y. Chen , Min Liang
IPC分类号： A61K9/51 , A61K35/76 , A61K48/00 , C12N15/86 , A61K31/7088 , A61K47/62 , A61K47/69
摘要： The invention provides novel methods, materials and systems that can be used to generate viral vectors having altered tissue and cell targeting abilities. In illustrative embodiments of the invention, the specificity of lentiviral vectors was modulated by a thin polymer shell that synthesized and coupled to the viral envelope in situ. The polymer shell can confers such vectors with new targeting ability via agents such as cyclic RGD (cRGD) peptides that are coupled to the polymer shell. These polymer encapsulated viral vectors exhibit a number of highly desirable characteristics including a higher thermal stability, resistance to serum inactivation in vivo, and an ability to infect dividing and non-dividing cells with high efficiencies.

6. 发明授权

US09993440B2 Enzyme responsive nanocapsules for protein delivery 有权
公开(公告)号：US09993440B2
公开(公告)日：2018-06-12
申请号：US14342524
申请日：2012-09-04
申请人： Yunfeng Lu , Tatiana Segura , Suwei Zhu , Jing Wen
发明人： Yunfeng Lu , Tatiana Segura , Suwei Zhu , Jing Wen
IPC分类号： A61K47/65 , A61K9/51 , A61K38/18 , A61K9/19
CPC分类号： A61K9/5169 , A61K9/19 , A61K9/5138 , A61K9/5192 , A61K38/1866 , A61K47/65
摘要： The invention provides methods of making and using compositions comprising a polymer shell designed to deliver polypeptides to selected environments. In embodiments of the invention, different environmental conditions are harnessed to allow the selective degradation of the polymer shell and the consequential release of one or polypeptides encapsulated therein. In illustrative embodiments, polymer components of the shell are interconnected by peptide-containing crosslinker moieties, linkages which maintain the integrity of the polymer shell under certain environmental conditions, but can also be cleaved when combined with a selected protease.

7. 发明申请

US20080173344A1 NANOSTRUCTURED BULK THERMOELECTRIC MATERIAL 有权
标题翻译：纳米结构热膨胀材料
公开(公告)号：US20080173344A1
公开(公告)日：2008-07-24
申请号：US11933584
申请日：2007-11-01
申请人： Minjuan Zhang , Yunfeng Lu
发明人： Minjuan Zhang , Yunfeng Lu
IPC分类号： H01L35/02 , H01L35/34 , H01L21/04
CPC分类号： H01L35/16 , H01L35/02 , H01L35/12 , H01L35/14 , H01L35/18 , H01L35/22 , H01L35/26 , H01L35/34
摘要： A thermoelectric material includes a composite having a first electrically conducting component and second low thermal conductivity component. The first component may include a semiconductor and the second component may include an inorganic oxide. The thermoelectric composite includes a network of the first component having nanoparticles of the second component dispersed in the network.
摘要翻译：热电材料包括具有第一导电组分和第二低热导率组分的复合材料。第一组分可以包括半导体，第二组分可以包括无机氧化物。热电复合材料包括具有分散在网络中的第二组分的纳米颗粒的第一组分的网络。

8. 发明授权

US06264741B1 Self-assembly of nanocomposite materials 有权
标题翻译：纳米复合材料的自组装
公开(公告)号：US06264741B1
公开(公告)日：2001-07-24
申请号：US09449036
申请日：1999-11-24
申请人： C. Jeffrey Brinker , Alan Sellinger , Yunfeng Lu
发明人： C. Jeffrey Brinker , Alan Sellinger , Yunfeng Lu
IPC分类号： C30B1110
CPC分类号： B82Y30/00 , C09K19/00
摘要： A method of making a nanocomposite self-assembly is provided where at least one hydrophilic compound, at least one hydrophobic compound, and at least one amphiphilic surfactant are mixed in an aqueous solvent with the solvent subsequently evaporated to form a self-assembled liquid crystalline mesophase material. Upon polymerization of the hydrophilic and hydrophobic compounds, a robust nanocomposite self-assembled material is formed. Importantly, in the reaction mixture, the amphiphilic surfactant has an initial concentration below the critical micelle concentration to allow formation of the liquid-phase micellar mesophase material. A variety of nanocomposite structures can be formed, depending upon the solvent evaporazation process, including layered mesophases, tubular mesophases, and a hierarchical composite coating composed of an isotropic worm-like micellar overlayer bonded to an oriented, nanolaminated underlayer.
摘要翻译：提供制备纳米复合自组装的方法，其中至少一种亲水性化合物，至少一种疏水性化合物和至少一种两亲表面活性剂在水性溶剂中与溶剂混合，随后蒸发形成自组装液晶中间相材料。在聚合亲水和疏水化合物时，形成了坚固的纳米复合材料自组装材料。重要的是，在反应混合物中，两亲表面活性剂的初始浓度低于临界胶束浓度以允许形成液相胶束中间相材料。可以形成各种纳米复合结构，这取决于溶剂蒸发过程，包括层状中间相，管状中间相，和由定向的纳米层压底层粘合的各向同性的蠕虫状胶束覆盖层组成的分级复合涂层。

9. 发明授权

US09283194B2 Methods for protease assisted protein delivery 有权
标题翻译：蛋白酶辅助蛋白递送的方法
公开(公告)号：US09283194B2
公开(公告)日：2016-03-15
申请号：US13089117
申请日：2011-04-18
申请人： Yi Tang , Zhen Gu , Yunfeng Lu , Ming Yan , Anuradha Biswas , Guoping Fan
发明人： Yi Tang , Zhen Gu , Yunfeng Lu , Ming Yan , Anuradha Biswas , Guoping Fan
IPC分类号： A61K9/51 , A61K31/7088 , A61K41/00 , A61K47/48
CPC分类号： A61K9/5169 , A61K9/5138 , A61K9/5192 , A61K31/7088 , A61K38/02 , A61K41/0042 , A61K47/48176 , A61K47/58 , A61K48/00
摘要： A method for intracellular delivery of single proteins or other cargo molecules by encapsulation within nanocapsules formed by interfacial polymerization of one or more types of monomers and selected protease cleavable cross-linkers is provided. The thin positively charged capsules are readily brought into the cytosol of target cells by endocytosis. The capsules are degraded by the action of endogenous proteases or co-delivered proteases on the cross-linkers releasing the functional cargo unaltered. The cross-linkers can be adapted to be cleavable by specific enzymes selected from available intracellular enzymes within the target cell or co-delivered or self-cleaving when the cargo itself is a protease. The nanocapsules produced by the methods have been shown to have long-term stability, high cell penetration capability, low toxicity and efficient protease-modulated specific degradability without affecting cargo protein function.
摘要翻译：提供了通过包封在由一种或多种类型的单体和选择的可切割蛋白酶切割交联剂的界面聚合形成的纳米胶囊内单细胞或其他货物分子的细胞内递送的方法。细胞带正电的胶囊容易通过内吞作用进入靶细胞的胞质溶胶。通过内源性蛋白酶或共同递送的蛋白酶对交联物的作用降解胶囊，释放功能性货物未改变。当货物本身是蛋白酶时，交联剂可以被适应成可以通过选自目标细胞内可用的细胞内酶的特定酶或共同递送或自分离的特异性酶切割。通过该方法生产的纳米胶囊已被证明具有长期稳定性，高细胞穿透能力，低毒性和有效的蛋白酶调节特异性降解性，而不影响货物蛋白质功能。

10. 发明授权

US08840816B2 Making nanocrystalline mesoporous spherical particles 有权
标题翻译：制备纳米晶介孔球形颗粒
公开(公告)号：US08840816B2
公开(公告)日：2014-09-23
申请号：US13226733
申请日：2011-09-07
申请人： Qiangfeng Xiao , Mei Cai , Hiesang Sohn , Yunfeng Lu
发明人： Qiangfeng Xiao , Mei Cai , Hiesang Sohn , Yunfeng Lu
IPC分类号： B29B9/00 , B22F9/30 , B22F1/00 , C22C1/10
CPC分类号： B22F9/30 , B22F1/0048 , B22F2302/10 , B22F2302/25 , B22F2304/00 , B22F2998/10 , B29B9/00 , C22C1/1026
摘要： Spherical particles of one or more elemental metals and carbon are prepared from a precursor in the form of a metal oleate. The metal oleate precursor is dispersed in a liquid vehicle and aerosol droplets of the dispersed precursor are formed in a stream of an inert gas. The aerosol droplets are heated in the stream to decompose the oleate ligand portion of the precursor and form spherical particles that have a mesoporous nanocrystalline structure. The open mesopores of the spherical particles provide a high surface area for contact with fluids in many applications. For example, the mesopores can be infiltrated with a hydrogen absorbing material, such as magnesium hydride, in order to increase the hydrogen storage capacity of the particles.
摘要翻译：由金属油酸盐形式的前体制备一种或多种元素金属和碳的球形颗粒。金属油酸酯前体分散在液体载体中，并且分散的前体的气溶胶小滴以惰性气体流形成。气溶胶液滴在流中被加热以分解前体的油酸酯配体部分并形成具有介孔纳米晶体结构的球形颗粒。在许多应用中，球形颗粒的开放的中孔提供了与流体接触的高表面积。例如，为了增加颗粒的储氢能力，可以用吸氢材料如氢化镁渗透介孔。

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