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1. 发明授权

US08642351B2 Apparatus and methods of fluid chromatography 有权
标题翻译：流体色谱仪的设备和方法
公开(公告)号：US08642351B2
公开(公告)日：2014-02-04
申请号：US12441732
申请日：2007-09-17
申请人： Hongji Liu , Jeffrey W. Finch
发明人： Hongji Liu , Jeffrey W. Finch
IPC分类号： G01N30/38
CPC分类号： G01N30/34 , G01N30/463
摘要： The invention provides improved methods and apparatus for fluid chromatography, and is particularly appropriate to high-pressure liquid chromatography carried out using eluent flow rates less than 1 μl/minute, for example on nanoflow columns. In both single- and multi-dimensional chromatography systems, especially those comprising trapping media to facilitate injection of relatively large volumes of sample on to nanoflow columns, the on-line addition of a diluting solvent enables stronger eluents and sample solvents to be employed without causing premature release of analytes from the trapping media or the degradation of the second dimension chromatographic separation. The invention may be advantageously used for two-dimension reverse phase/reverse phase separations, especially for the separation of complex mixtures of peptides.
摘要翻译：本发明提供用于流体色谱法的改进的方法和装置，并且特别适用于使用小于1mul /分钟的洗脱液流速进行的高压液相色谱法，例如在纳流方柱上。在单维和多维色谱系统中，特别是包含捕集介质以促进将相对较大体积的样品注入纳流柱上的系统，在线添加稀释溶剂使得能够使用更强的洗脱液和样品溶剂而不引起从捕集介质过早释放分析物或第二维色谱分离的降解。本发明可有利地用于二维反相/反相分离，特别是用于分离肽的复杂混合物。

2. 发明申请

US20090205409A1 SOLVENT DELIVERY SYSTEM FOR LIQUID CHROMATOGRAPHY THAT MAINTAINS FLUID INTEGRITY AND PRE-FORMS GRADIENTS 有权
标题翻译：用于保持流体完整性和前体梯度的液体色谱的溶剂输送系统
公开(公告)号：US20090205409A1
公开(公告)日：2009-08-20
申请号：US12280585
申请日：2007-03-16
申请人： Steven J. Ciavarini , Stanley P. Pensak, JR. , Jeffrey W. Finch , Keith Fadgen , Hongji Liu
发明人： Steven J. Ciavarini , Stanley P. Pensak, JR. , Jeffrey W. Finch , Keith Fadgen , Hongji Liu
IPC分类号： G01N30/02
CPC分类号： G01N30/34 , G01N30/32 , G01N2030/326 , G05D11/132
摘要： A solvent delivery subsystem for a chromatography device performs relatively low pressure, high flow mixing of solvents to form a gradient and subsequent high pressure, low flow delivery of the gradient to the separation column. The mixing of the gradient is independent and does not interfere with the gradient delivery. To form the gradient, the outputs of an aqueous pump and an organic pump are mixed to fill a storage capillary while a downstream point from the storage capillary is vented to atmosphere. After gradient formation, the vent to atmosphere is closed, the solvent delivery system rises to high pressure, and only the aqueous pump runs for gradient delivery. To maintain integrity of the fluid stream, the solvent delivery system uses feed forward compensation and controls at least one parameter selected from the group consisting of pressure and flow in the conduit means to follow a gradual ramp.
摘要翻译：用于色谱装置的溶剂递送子系统执行溶剂的相对低压，高流动混合以形成梯度并随后将高梯度梯度递送到分离塔。梯度的混合是独立的，并且不干扰梯度递送。为了形成梯度，将水性泵和有机泵的输出混合以填充储存毛细管，同时从储存毛细管的下游点排放到大气中。梯度形成后，关闭空气，溶剂输送系统升高至高压，只有水泵运行梯度输送。为了保持流体流的完整性，溶剂输送系统使用前馈补偿并且控制选自管道装置中的压力和流量的至少一个参数以跟随逐渐斜坡。

3. 发明授权

US09103814B2 Solvent delivery system for liquid chromatography that maintains fluid integrity and pre-forms gradients 有权
标题翻译：用于液相色谱的溶剂输送系统，保持流体完整性和预形成梯度
公开(公告)号：US09103814B2
公开(公告)日：2015-08-11
申请号：US12280585
申请日：2007-03-16
申请人： Steven J. Ciavarini , Stanley P. Pensak, Jr. , Jeffrey W. Finch , Keith Fadgen , Hongji Liu
发明人： Steven J. Ciavarini , Stanley P. Pensak, Jr. , Jeffrey W. Finch , Keith Fadgen , Hongji Liu
IPC分类号： G01N30/34
CPC分类号： G01N30/34 , G01N30/32 , G01N2030/326 , G05D11/132
摘要： A solvent delivery subsystem for a chromatography device performs relatively low pressure, high flow mixing of solvents to form a gradient and subsequent high pressure, low flow delivery of the gradient to the separation column. The mixing of the gradient is independent and does not interfere with the gradient delivery. To form the gradient, the outputs of an aqueous pump and an organic pump are mixed to fill a storage capillary while a downstream point from the storage capillary is vented to atmosphere. After gradient formation, the vent to atmosphere is closed, the solvent delivery system rises to high pressure, and only the aqueous pump runs for gradient delivery. To maintain integrity of the fluid stream, the solvent delivery system uses feed forward compensation and controls at least one parameter selected from the group consisting of pressure and flow in the conduit means to follow a gradual ramp.
摘要翻译：用于色谱装置的溶剂递送子系统执行溶剂的相对低压，高流动混合以形成梯度并随后将高梯度梯度递送到分离塔。梯度的混合是独立的，并且不干扰梯度递送。为了形成梯度，将水性泵和有机泵的输出混合以填充储存毛细管，同时从储存毛细管的下游点排放到大气中。梯度形成后，关闭空气，溶剂输送系统升高至高压，只有水泵运行梯度输送。为了保持流体流的完整性，溶剂输送系统使用前馈补偿并且控制选自管道装置中的压力和流量的至少一个参数以跟随逐渐斜坡。

4. 发明申请

US20100107742A1 APPARATUS AND METHODS OF FLUID CHROMATOGRAPHY 有权
标题翻译：流体色谱的设备和方法
公开(公告)号：US20100107742A1
公开(公告)日：2010-05-06
申请号：US12441732
申请日：2007-09-17
申请人： Hongji Liu , Jeffrey W. Finch
发明人： Hongji Liu , Jeffrey W. Finch
IPC分类号： G01N30/28
CPC分类号： G01N30/34 , G01N30/463
摘要： The invention provides improved methods and apparatus for fluid chromatography, and is particularly appropriate to high-pressure liquid chromatography carried out using eluent flow rates less than 1 μl/minute, for example on nanoflow columns. In both single- and multi-dimensional chromatography systems, especially those comprising trapping media to facilitate injection of relatively large volumes of sample on to nanoflow columns, the on-line addition of a diluting solvent enables stronger eluents and sample solvents to be employed without causing premature release of analytes from the trapping media or the degradation of the second dimension chromatographic separation. The invention may be advantageously used for two-dimension reverse phase/reverse phase separations, especially for the separation of complex mixtures of peptides.
摘要翻译：本发明提供了用于流体色谱法的改进的方法和装置，并且特别适用于使用低于1μl/分钟的洗脱液流速进行的高压液相色谱法，例如在纳流方柱上。在单维和多维色谱系统中，特别是包含捕集介质以促进将相对较大体积的样品注入纳流柱上的系统，在线添加稀释溶剂使得能够使用更强的洗脱液和样品溶剂而不引起从捕集介质过早释放分析物或第二维色谱分离的降解。本发明可有利地用于二维反相/反相分离，特别是用于分离肽的复杂混合物。

5. 发明授权

US07888637B2 Sample preparation plate for mass spectrometry 有权
标题翻译：用于质谱的样品制备板
公开(公告)号：US07888637B2
公开(公告)日：2011-02-15
申请号：US11829613
申请日：2007-07-27
申请人： Jeffrey W. Finch , John C. Gebler , Santiago Vazquez
发明人： Jeffrey W. Finch , John C. Gebler , Santiago Vazquez
IPC分类号： H01J49/42 , H01J49/04
CPC分类号： H01J49/0418 , G01N1/40 , G01N35/028 , G01N2001/4027 , H01J49/0413
摘要： Disclosed herein is a sample preparation plate used to prepare a sample for mass spectrometry. In particular, a sample plate used to concentrate a sample as well as remove contaminants from the sample while providing easy manipulation of small liquid droplets on a surface with minimal sample loss.
摘要翻译：本文公开了用于制备用于质谱的样品的样品制备板。特别地，用于浓缩样品以及从样品中除去污染物的样品板，同时以最小的样品损失容易地操纵表面上的小液滴。

6. 发明申请

US20080277574A1 Apparatus and Method For Positioning a Discharge Tube With Respect to an Orifice 有权
标题翻译：一种放电管相对于孔口定位的装置和方法
公开(公告)号：US20080277574A1
公开(公告)日：2008-11-13
申请号：US11815569
申请日：2006-02-06
申请人： Jeffrey W. Finch , Charles T. Murphy
发明人： Jeffrey W. Finch , Charles T. Murphy
IPC分类号： H01J49/26
CPC分类号： G01N30/7246 , H01J49/0404
摘要： Embodiments of the present invention facilitate servicing or changing a discharge tube or modifying the position of a discharge tube with respect to a orifice of a detector and/or a nebulizing gas conduit. The apparatus features a discharge tube housing that slidably receives a discharge tube. A union coupling the discharge tube to a source of fluid is slidably mounted to a mounting assembly holding the tube housing.
摘要翻译：本发明的实施例有利于维护或改变放电管或改变放电管相对于检测器和/或雾化气体导管的孔口的位置。该装置具有可滑动地容纳放电管的放电管外壳。将放电管耦合到流体源的联接器可滑动地安装到保持管壳体的安装组件。

7. 发明授权

US07872224B2 Apparatus and method for positioning a discharge tube with respect to an orifice 有权
标题翻译：用于将放电管相对于孔口定位的装置和方法
公开(公告)号：US07872224B2
公开(公告)日：2011-01-18
申请号：US11815569
申请日：2006-02-06
申请人： Jeffrey W. Finch , Charles Murphy
发明人： Jeffrey W. Finch , Charles Murphy
IPC分类号： H01J49/26 , B01D59/44
CPC分类号： G01N30/7246 , H01J49/0404
摘要： Embodiments of the present invention facilitate servicing or changing a discharge tube or modifying the position of a discharge tube with respect to a orifice of a detector and/or a nebulizing gas conduit. The apparatus features a discharge tube housing that slidably receives a discharge tube. A union coupling the discharge tube to a source of fluid is slidably mounted to a mounting assembly holding the tube housing.
摘要翻译：本发明的实施例有利于维护或改变放电管或改变放电管相对于检测器和/或雾化气体导管的孔口的位置。该装置具有可滑动地容纳放电管的放电管外壳。将放电管耦合到流体源的联接器可滑动地安装到保持管壳体的安装组件。

8. 发明授权

US06835929B2 Coaxial atmospheric pressure photoionization source for mass spectrometers 有权
标题翻译：用于质谱仪的同轴大气压光电离源
公开(公告)号：US06835929B2
公开(公告)日：2004-12-28
申请号：US10351696
申请日：2003-01-27
申请人： Jeffrey W. Finch
发明人： Jeffrey W. Finch
IPC分类号： H01V4928
CPC分类号： H01J49/162 , H01J49/045 , H01J49/049
摘要： Disclosed herein is a mass spectrometer having an atmospheric pressure photoionization (APPI) source that comprises a discharge lamp coupled to a nebulizer, wherein the nebulizer is at, or near, atmospheric pressure. The discharge lamp curves around the vapor path and this coaxial design offers significant advantages over the prior art such as increased photon flux resulting in increased photoionization efficiency. One of the significant benefits of an increase in photon flux is that absorption of the UV radiation by solvents such as acetonitrile is minimized. The APPI source described herein also facilitates a larger photoionization interaction zone with effluent from the nebulizer, which may be heated. Additionally, no dopant is required in this coaxial APPI system.
摘要翻译：本文公开了具有大气压光电离（APPI）源的质谱仪，其包括耦合到雾化器的放电灯，其中雾化器处于或接近大气压。放电灯在蒸气路径周围弯曲，并且该同轴设计提供了优于现有技术的显着优点，例如增加的光子通量导致光电离效率的提高。光子通量增加的一个显着的优点是最小化了溶剂如乙腈对紫外线辐射的吸收。本文描述的APPI源还有助于具有来自喷雾器的流出物的较大的光离子化相互作用区域，其可以被加热。此外，在该同轴APPI系统中不需要掺杂剂。

9. 发明授权

US06674069B1 In-line reflecting time-of-flight mass spectrometer for molecular structural analysis using collision induced dissociation 有权
标题翻译：使用碰撞诱导离解进行分子结构分析的在线反映飞行时间质谱仪
公开(公告)号：US06674069B1
公开(公告)日：2004-01-06
申请号：US09868345
申请日：2001-09-12
申请人： Charles D. Martin , Gary L. Samuelson , Edward E. Owen , Jeffrey W. Finch
发明人： Charles D. Martin , Gary L. Samuelson , Edward E. Owen , Jeffrey W. Finch
IPC分类号： H01J4940
CPC分类号： H01J49/405 , H01J49/005
摘要： A tandem mass spectrometer apparatus includes an ion source (29); a first mass spectrometer MS-1 having a magnetic sector (24) and an electric sector (21); and a second mass spectrometer MS-2 having a CID cell (13), an offset parabolic ion mirror (17) and an ion detector (18).
摘要翻译：串联质谱仪装置包括离子源（29）; 具有磁扇区（24）和电扇（21）的第一质谱仪MS-1; 和具有CID单元（13），偏移抛物离子反射镜（17）和离子检测器（18）的第二质谱仪MS-2。

10. 发明授权

US08299426B2 Conductive conduits for chemical analyses, and methods for making such conduits 有权
标题翻译：用于化学分析的导电管道，以及制造这种导管的方法
公开(公告)号：US08299426B2
公开(公告)日：2012-10-30
申请号：US11916228
申请日：2006-05-24
申请人： Ananya Dubey , Jeffrey W. Finch , Jennifer H. Granger , James P. Murphy
发明人： Ananya Dubey , Jeffrey W. Finch , Jennifer H. Granger , James P. Murphy
IPC分类号： H01J49/26
CPC分类号： F16L9/125 , B05D5/12 , B05D7/222 , F16L11/127 , H01J49/167
摘要： A method for making a fluid-processing apparatus involves mixing a colloidal suspension with a matrix material, applying the mixture to a surface of a conduit, and curing the applied mixture to provide a conductive coating. A fluid-processing apparatus includes a conduit and a conductive layer adjacent to a surface of the conduit. The conductive layer includes graphite particles embedded in a matrix. The fluid-processing apparatus supports, for example, electrospray-ionization for mass spectrometry, capillary electrophoresis, or capillary electro-chromatography.
摘要翻译：制备流体处理装置的方法包括将胶体悬浮液与基质材料混合，将混合物施加到导管的表面，并固化所施加的混合物以提供导电涂层。流体处理设备包括导管和与导管表面相邻的导电层。导电层包括嵌入基质中的石墨颗粒。流体处理装置支持例如用于质谱法，毛细管电泳或毛细管电色谱的电喷雾离子化。

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