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1. 发明授权

US06512004B2 Promoters of neural regeneration 失效
公开(公告)号：US06512004B2
公开(公告)日：2003-01-28
申请号：US09900268
申请日：2001-07-06
申请人： Hong-jun Song , Mu-ming Poo , Guo-li Ming , Marc Tessier-Lavigne , Zhigang He
发明人： Hong-jun Song , Mu-ming Poo , Guo-li Ming , Marc Tessier-Lavigne , Zhigang He
IPC分类号： A61K3135
CPC分类号： A61K31/70
摘要： The invention provides methods and compositions for promoting neural cell growth and/or regeneration. The general methods involve contacting with an activator of a cyclic nucleotide dependent protein kinase a neural cell subject to growth repulsion mediated by a neural cell growth repulsion factor. The activator may comprise a direct or an indirect activator of the protein kinase; the repulsion factor typically comprises one or more natural, endogenous proteins mediating localized repulsion or inhibition of neural cell growth; and the target cells are generally vertebrate neurons, typically injured mammalian neurons. The subject compositions include mixtures comprising a neural cell, an activator of a cyclic nucleotide dependent protein kinase and a neural cell growth repulsion factor.

2. 发明授权

US06268352B1 Promoters of neural regeneration 失效
标题翻译：神经再生的启动子
公开(公告)号：US06268352B1
公开(公告)日：2001-07-31
申请号：US09145820
申请日：1998-09-02
申请人： Hong-jun Song , Mu-Ming Poo , Guo-li Ming , Marc Tessier-Lavigne , Zhigang He
发明人： Hong-jun Song , Mu-Ming Poo , Guo-li Ming , Marc Tessier-Lavigne , Zhigang He
IPC分类号： A61K3170
CPC分类号： A61K31/70
摘要： The invention provides methods and compositions for promoting neural cell growth and/or regeneration. The general methods involve contacting with an activator of a cyclic nucleotide dependent protein kinase a neural cell subject to growth repulsion mediated by a neural cell growth repulsion factor. The activator may comprise a direct or an indirect activator of the protein kinase; the repulsion factor typically comprises one or more natural, endogenous proteins mediating localized repulsion or inhibition of neural cell growth; and the target cells are generally vertebrate neurons, typically injured mammalian neurons. The subject compositions include mixtures comprising a neural cell, an activator of a cyclic nucleotide dependent protein kinase and a neural cell growth repulsion factor.
摘要翻译：本发明提供促进神经细胞生长和/或再生的方法和组合物。一般方法包括与环核苷酸依赖性蛋白激酶的激活剂接触受到由神经细胞生长排斥因子介导的生长排斥的神经细胞的接触。活化剂可以包含蛋白激酶的直接或间接激活剂; 排斥因子通常包含介导局部排斥或抑制神经细胞生长的一种或多种天然的内源性蛋白质; 并且靶细胞通常是脊椎动物神经元，通常是受损的哺乳动物神经元。主题组合物包括包含神经细胞，环核苷酸依赖性蛋白激酶的激活剂和神经细胞生长排斥因子的混合物。

3. 发明授权

US06623738B1 Semaphorin receptors 有权
标题翻译：信号素受体
公开(公告)号：US06623738B1
公开(公告)日：2003-09-23
申请号：US09439711
申请日：1999-11-12
申请人： Marc Tessier-Lavigne , Zhigang He , Hang Chen
发明人： Marc Tessier-Lavigne , Zhigang He , Hang Chen
IPC分类号： A61K39395
CPC分类号： C07K14/7056 , A61K38/00
摘要： The invention provides methods and compositions relating to two classes of semaphorin receptors, SR1 and SR2. The polypeptides may be produced recombinantly from transformed host cells from the disclosed SR encoding nucleic acids or purified from human cells. The invention provides isolated SR hybridization probes and primers, capable of specifically hybridizing with the disclosed SR genes. SR-specific binding agents such as specific antibodies, and methods of making and using the subject compositions in diagnosis, therapy and in the biopharmaceutical industry.
摘要翻译：本发明提供了与两类信号素受体SR1和SR2相关的方法和组合物。可以从所公开的SR编码核酸的转化的宿主细胞重组产生多肽或从人细胞纯化。本发明提供了能够与所公开的SR基因特异性杂交的分离的SR杂交探针和引物。 SR特异性结合剂，例如特异性抗体，以及在诊断，治疗和生物制药工业中制备和使用本发明组合物的方法。

4. 发明授权

US6054293A Semaphorin receptors 失效
标题翻译：信号素受体
公开(公告)号：US6054293A
公开(公告)日：2000-04-25
申请号：US936135
申请日：1997-09-24
申请人： Marc Tessier-Lavigne , Zhigang He , Hang Chen
发明人： Marc Tessier-Lavigne , Zhigang He , Hang Chen
IPC分类号： G01N33/50 , A61K38/00 , A61P25/00 , A61P43/00 , C07K14/435 , C07K14/705 , C07K16/18 , C07K16/28 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12N15/12 , C12P21/02 , G01N33/15 , G01N33/53 , C07H21/04 , C12N15/63
CPC分类号： C07K14/7056 , A61K38/00
摘要： The invention provides methods and compositions relating to two classes of semaphorin receptors, SR1 and SR2. The polypeptides may be produced recombinantly from transformed host cells from the disclosed SR encoding nucleic acids or purified from human cells. The invention provides isolated SR hybridization probes and primers capable of specifically hybridizing with the disclosed SR genes, SR-specific binding agents such as specific antibodies, and methods of making and using the subject compositions in diagnosis, therapy and in the biopharmaceutical industry.
摘要翻译：本发明提供了与两类信号素受体SR1和SR2相关的方法和组合物。可以从所公开的SR编码核酸的转化的宿主细胞重组产生多肽或从人细胞纯化。本发明提供能够与所公开的SR基因，SR-特异性结合剂如特异性抗体特异性杂交的分离的SR杂交探针和引物，以及在诊断，治疗和生物制药工业中制备和使用该主题组合物的方法。

5. 发明授权

US07959901B2 EGFR inhibitors promote axon regeneration 有权
标题翻译： EGFR抑制剂促进轴突再生
公开(公告)号：US07959901B2
公开(公告)日：2011-06-14
申请号：US12026758
申请日：2008-02-06
申请人： Zhigang He , Vuk Koprivica
发明人： Zhigang He , Vuk Koprivica
IPC分类号： A61K38/18
CPC分类号： A61K31/517 , A61K9/0085 , A61K31/47 , A61K31/5377 , A61K31/57 , A61L27/54 , A61L31/16 , A61L2300/436 , A61L2430/32 , A61K2300/00
摘要： Compositions and methods for promoting neural regeneration in a patient determined to have a lesion in a mature CNS neuron are disclosed. The method comprises the step of contacting the neuron with an EGFR inhibitor sufficient to promote regeneration of the neuron.
摘要翻译：公开了确定在成熟CNS神经元中具有病变的患者中促进神经再生的组合物和方法。该方法包括使神经元与足以促进神经元再生的EGFR抑制剂接触的步骤。

6. 发明申请

US20090305333A1 Promoting Axon Regeneration in the Adult CNS through Control of Protein Translation 有权
标题翻译：通过控制蛋白质翻译促进成人CNS中的轴突再生
公开(公告)号：US20090305333A1
公开(公告)日：2009-12-10
申请号：US12479805
申请日：2009-06-06
申请人： Zhigang He , Kevin Park , Kai Liu , Yang Hu
发明人： Zhigang He , Kevin Park , Kai Liu , Yang Hu
IPC分类号： C12Q1/02
CPC分类号： A61K31/4745 , A61K31/28 , A61K31/4375 , A61K31/555
摘要： Survival of, or axon regeneration in a lesioned mature central nervous system (CNS) neuron is promoted by (a) contacting the neuron with a therapeutically effective amount of an exogenous activator of protein translation; and (b) detecting the resultant promotion of the survival of, or axon regeneration in the neuron.
摘要翻译：通过（a）使神经元与治疗有效量的外源蛋白质翻译激活剂接触，促进损伤的成熟中枢神经系统（CNS）神经元中的轴突再生或轴突再生; 和（b）检测导致神经元生存或轴突再生的促进。

7. 发明申请

US20090181420A1 Inhibiting Smad signaling promotes neuron regeneration 审中-公开
标题翻译：抑制Smad信号促进神经元再生
公开(公告)号：US20090181420A1
公开(公告)日：2009-07-16
申请号：US12404076
申请日：2009-03-13
申请人： Zhigang He , Fan Wang
发明人： Zhigang He , Fan Wang
IPC分类号： C12Q1/02
CPC分类号： C07K14/4702 , A61K48/005
摘要： Regeneration of a lesioned CNS axon of a mature neuron, determined to be subject to regeneration inhibition by Smad2/3 signaling, is promoted by contacting the neuron with an inhibitor of Smad2/3 signaling sufficient to promote regeneration of the axon.
摘要翻译：通过使神经元与足以促进轴突再生的Smad2 / 3信号抑制剂接触，促进通过Smad2 / 3信号通路进行再生抑制的成熟神经元的损伤CNS轴突的再生。

8. 发明授权

US07449442B2 EGFR inhibitors promote axon regeneration 失效
标题翻译： EGFR抑制剂促进轴突再生
公开(公告)号：US07449442B2
公开(公告)日：2008-11-11
申请号：US11180070
申请日：2005-07-12
申请人： Zhigang He , Vuk Koprivica
发明人： Zhigang He , Vuk Koprivica
IPC分类号： A61K31/00
CPC分类号： A61K31/517 , A61K9/0085 , A61K31/47 , A61K31/5377 , A61K31/57 , A61L27/54 , A61L31/16 , A61L2300/436 , A61L2430/32 , A61K2300/00
摘要： Compositions and methods for promoting neural regeneration in a patient determined to have a lesion in a mature CNS neuron are disclosed. The method comprises the step of contacting the neuron with an EGFR inhibitor sufficient to promote regeneration of the neuron.
摘要翻译：公开了确定在成熟CNS神经元中具有病变的患者中促进神经再生的组合物和方法。该方法包括使神经元与足以促进神经元再生的EGFR抑制剂接触的步骤。

9. 发明申请

US20170181564A1 Multifunctional Cooking Pot 审中-公开
公开(公告)号：US20170181564A1
公开(公告)日：2017-06-29
申请号：US15223593
申请日：2016-07-29
申请人： Zhigang He , Hui Zheng
发明人： Zhigang He , Hui Zheng
IPC分类号： A47J27/00
摘要： A cooking pot comprises a pot body, a control device, an electrical heating device, a thermostat and a temperature sensor, wherein the electrical heating device, thermostat and temperature sensor are provided in the pot body, and the control device is connected with the electrical heating device, thermostat and temperature sensor, characterized in that the said pot body is provided with an outer pot and an inner pot, the electrical heating device clings to or is close to the outer pot, the inner pot is provided inside the outer pot, and the external bottom surface of the inner port is in contact with the internal bottom surface of the outer pot.

10. 发明申请

US20130255509A1 ELECTRIC PRESSURE COOKER WITH REMOVABLE FLIP COVER 审中-公开
标题翻译：带可拆卸翻盖盖的电压烹饪机
公开(公告)号：US20130255509A1
公开(公告)日：2013-10-03
申请号：US13825968
申请日：2011-12-22
申请人： Zhigang He , Zhibin Huang
发明人： Zhigang He , Zhibin Huang
IPC分类号： A47J27/08
CPC分类号： A47J27/0804
摘要： Disclosed is an electric pressure cooker with a removable flip cover comprising a cooker body (1) and cooker cover (2), wherein a supporting arm (3) is provided on the surface of the cooker cover (2), a positioning seat (5) corresponding to the supporting arm (3) is arranged at the edge of the cooker body (1), a positioning and supporting point (7) is provided on the positioning seat (5), and the lower part of the supporting arm (3) movably slips over and slidably contacts the positioning and supporting point (7). The electric pressure cooker has a simple structure and it is convenient to wash the flip cover without the need for special parts.
摘要翻译：公开了一种具有可拆卸翻盖的电压力锅，包括炊具主体（1）和炊具盖（2），其中在炊具盖（2）的表面上设有支撑臂（3），定位座）配置在炊具主体（1）的边缘处，在定位座（5）上设有定位支承点（7），支撑臂（3）的下部）可移动地滑动并滑动地接触定位和支撑点（7）。电压力锅具有结构简单，无需特殊零件便于清洗翻盖。

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