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1. 发明授权

US06233533B1 Turning center with integrated non-contact inspection system 失效
标题翻译：车削中心配有非接触式检测系统
公开(公告)号：US06233533B1
公开(公告)日：2001-05-15
申请号：US09090087
申请日：1998-06-04
申请人： Hong Xu , Donald Lee Burgoon
发明人： Hong Xu , Donald Lee Burgoon
IPC分类号： G06F770
CPC分类号： G01R31/343 , G01R31/302
摘要： A non-contact inspection system has one or more pairs of non-contact sensors, pointing at the braking surfaces and a non-contact sensor pointing at the outer diameter of a disc. The non-contact sensors can be inductive sensors, capacitive probes and/or laser sensors. A controller is connected to each sensor for signal processing and measurement output. The system measures various features and characteristics, such as braking surface thickness variation, lateral run-out, flatness, parallelism and diameters. Measurements are made while the disc rotates at a specified speed or while the disc is stationary. The pairs of non-contact sensors continuously measure the distance from the sensor or calibrated surface to the pointed surface. Thereby the run-out and thickness variations can be calculated from the measurements at different radii. By combining the measurements on the same braking surface, the flatness and parallelism are calculated. The other two sensors continuously measure the distance from the sensor or the calibrated surface to the pointed surface. A diameter can be calculated knowing the center of the disc. The lateral run-out, thickness variation, flatness and parallelism can be measured on each brake disc within the turning center for final inspection and/or statistical process control. The diameter measurement and its run-out can be fed back to the turning center to monitor and compensate tool wear.
摘要翻译：非接触检查系统具有指向制动表面的一对或多对非接触传感器和指向盘的外径的非接触式传感器。非接触式传感器可以是电感式传感器，电容式探头和/或激光传感器。控制器连接到每个传感器用于信号处理和测量输出。该系统测量制动表面厚度变化，侧向跳动，平直度，平行度和直径等各种特征和特点。当盘以特定速度旋转或盘静止时进行测量。这些非接触传感器对连续测量从传感器或校准表面到尖面的距离。因此，可以从不同半径的测量计算出偏差和厚度变化。通过将相同制动表面上的测量结合在一起，计算平面度和平行度。另外两个传感器连续地测量从传感器或校准表面到尖面的距离。可以计算知道光盘中心的直径。可以在车削中心内的每个制动盘上测量横向偏移，厚度变化，平直度和平行度，以进行最终检查和/或统计过程控制。直径测量及其跳动可以反馈到车削中心，以监测和补偿刀具磨损。

2. 发明授权

US06175778B1 Computer vision-based rotor machining system apparatus and method 失效
标题翻译：基于计算机视觉的转子加工系统设备及方法
公开(公告)号：US06175778B1
公开(公告)日：2001-01-16
申请号：US09089223
申请日：1998-06-03
申请人： Hong Xu , Donald Lee Burgoon
发明人： Hong Xu , Donald Lee Burgoon
IPC分类号： B29C4500
CPC分类号： B23B5/04 , B23B2235/04 , F16D65/12 , F16D65/128 , F16D2065/1308 , F16D2065/1328 , Y10T82/2572 , Y10T409/303752
摘要： A system, apparatus and method for machining a rotor by determining a center plane of the rotor based two surfaces of the rotor, preferably two interior surfaces; positioning the rotor based on the determined center plane; and then machining the positioned rotor. The center plane of the rotor is determined using at least one image of the rotor. In some preferred embodiments, the center plane is determined using a series of successive images of the rotor. The center plane can be determined based on a measure of parallelism of two braking surfaces of the rotor or of two interior, non-braking surfaces of the rotor. Before and/or after the rotor is machined, it can also be inspected.
摘要翻译：一种用于通过确定转子的两个表面的转子的中心平面，优选地两个内表面来加工转子的系统，装置和方法; 基于确定的中心平面定位转子; 然后加工定位的转子。使用转子的至少一个图像确定转子的中心平面。在一些优选实施例中，使用转子的一系列连续图像确定中心平面。可以基于转子的两个制动表面或转子的两个内部非制动表面的平行度的测量来确定中心平面。在转子加工之前和/或之后，也可以进行检查。

3. 发明授权

US08809000B2 Methods of screening heteromeric T1R2/T1R3 receptors for compounds which modulate sweet taste signaling 有权
标题翻译：筛选异源性T1R2 / T1R3受体调节甜味信号的化合物的方法
公开(公告)号：US08809000B2
公开(公告)日：2014-08-19
申请号：US13357110
申请日：2012-01-24
申请人： Jon E. Adler , Xiaodong Li , Lena Staszewski , Hong Xu , Fernando Echeverri
发明人： Jon E. Adler , Xiaodong Li , Lena Staszewski , Hong Xu , Fernando Echeverri
IPC分类号： G01N33/567 , C07K1/00 , C07K14/00 , C07K17/00
CPC分类号： G01N33/5041 , C07K14/723 , G01N33/5008 , G01N33/5023 , G01N33/74 , G01N2333/705 , G01N2333/726 , G01N2500/00
摘要： Newly identified mammalian taste-cell-specific G protein-coupled receptors which function as hetero-oligomeric complexes in the sweet taste transduction pathway, and the genes and cDNA encoding said receptors are described. Specifically, T1R G protein-coupled receptors active in sweet taste signaling as hetero-oligomeric complexes, and the genes and cDNA encoding the same, are described, along with methods for isolating such genes and for isolating and expressing such receptors. Methods for identifying putative taste modulating compounds using such hetero-oligomeric complexes also described, as is a novel surface expression facilitating peptide useful for targeting integral plasma membrane proteins to the surface of a cell.
摘要翻译：描述了在甜味转导途径中作为异寡聚复合物起作用的新鉴定的哺乳动物味细胞特异性G蛋白偶联受体，以及编码所述受体的基因和cDNA。具体来说，描述了作为异寡聚复合物的甜味信号传导中起作用的T1R G蛋白偶联受体，以及编码相同基因和cDNA的方法，以及用于分离这些基因并分离和表达此类受体的方法。还描述了使用这种异寡聚复合物鉴定推定的味觉调节化合物的方法，以及用于靶向细胞表面的整合质膜蛋白的新颖的表达表达促进肽。

4. 发明授权

US08404455B2 Chimeric T1R taste receptor polypeptides and nucleic acid sequences encoding and cell lines that express said chimeric T1R polypeptides 有权
公开(公告)号：US08404455B2
公开(公告)日：2013-03-26
申请号：US12852941
申请日：2010-08-09
申请人： Xiaodong Li , Lena Staszewski , Hong Xu
发明人： Xiaodong Li , Lena Staszewski , Hong Xu
IPC分类号： G01N33/566 , C07K14/705
CPC分类号： G01N33/543 , A23L2/56 , A23L27/202 , A23L27/203 , A23L27/2054 , A23L27/88 , A23V2002/00 , A61K8/4973 , A61K8/55 , A61K47/22 , A61K47/24 , C07C233/65 , C07C235/54 , C07C275/30 , C07C275/34 , C07D307/84 , C07D317/68 , C07D405/12 , C07F9/65517 , G01N33/5041 , G01N33/566 , G01N33/74 , G01N2333/726
摘要： The invention relates to compounds that specifically bind a T1R1/T1R3 or T1R2/T1R3 receptor or fragments or sub-units thereof. The present invention also relates to the use of hetero-oligomeric and chimeric taste receptors comprising T1R1/T1R3 and T1R2/T1R3 in assays to identify compounds that respectively respond to umami taste stimuli and sweet taste stimuli. Further, the invention relates to the constitutive of cell lines that stably or transiently co-express a combination of T1R1 and T1R3; or T1R2 and T1R3; under constitutive or inducible conditions. The use of these cells lines in cell-based assays to identify umami and sweet taste modulatory compounds is also provided, particularly high throughput screening assays that detect receptor activity by use of fluorometric imaging.

5. 发明申请

US20130004961A1 METHODS OF DETECTING A SWEET-SENSITIVE CELL 有权
标题翻译：检测敏感细胞的方法
公开(公告)号：US20130004961A1
公开(公告)日：2013-01-03
申请号：US13477907
申请日：2012-05-22
申请人： Mark Zoller , Xiaodong Li , Lana Staszewski , Shawn O'Connell , Sergey Zozulya , Jon Elliot Adler , Hong Xu , Fernando Echeverri
发明人： Mark Zoller , Xiaodong Li , Lana Staszewski , Shawn O'Connell , Sergey Zozulya , Jon Elliot Adler , Hong Xu , Fernando Echeverri
IPC分类号： G01N33/566 , C12N15/85 , C07K14/705 , C12Q1/68 , C12P21/02 , C12N15/12 , C12N5/10
CPC分类号： G01N33/5041 , A01K2217/05 , C07K14/705 , C07K2319/00 , C12Q1/6876 , C12Q2600/124 , C12Q2600/158 , G01N33/5008 , G01N33/566 , G01N2333/4719 , G01N2333/705 , G01N2333/726 , G01N2500/04
摘要： The present invention relates to the discovery that the T1R receptors assemble to form functional taste receptors. Particularly, it has been discovered that co-expression of T1R1 and T1R3 results in a taste receptor that responds to umami taste stimuli, including monosodium glutamate. Also, it has been discovered that co-expression of the T1R2 and T1R3 receptors results in a taste receptor that responds to sweet taste stimuli including naturally occurring and artificial sweeteners.Also the present invention relates to the use of hetero-oligomeric taste receptors comprising T1R1/T1R3 and T1R2/T1R3 in assays to identify compounds that respectively respond to umami taste stimuli and sweet taste stimuli.
摘要翻译：本发明涉及T1R受体组装形成功能性味觉受体的发现。特别地，已经发现，T1R1和T1R3的共表达导致对鲜味刺激（包括谷氨酸钠）起反应的味觉感受器。此外，已经发现，T1R2和T1R3受体的共表达导致对包括天然存在的和人造甜味剂的甜味刺激有反应的味觉受体。本发明还涉及在测定中使用包含T1R1 / T1R3和T1R2 / T1R3的异低聚味觉感受器来鉴定分别响应于鲜味刺激和甜味刺激的化合物。

6. 发明授权

US08318447B2 Use of bitter taste receptor to screen for compounds that offset the bitter taste of chlorogenic lactone containing coffee compositions 有权
标题翻译：使用苦味受体筛选抵消含绿色内酯的咖啡组合物的苦味的化合物
公开(公告)号：US08318447B2
公开(公告)日：2012-11-27
申请号：US13094974
申请日：2011-04-27
申请人： Xiaodong Li , Hong Xu , Qing Li , Huixian Tang
发明人： Xiaodong Li , Hong Xu , Qing Li , Huixian Tang
IPC分类号： G01N33/567 , C07K14/705
CPC分类号： C07K14/705 , G01N33/566 , G01N2333/726 , G01N2500/00 , G01N2500/10 , Y10S514/974
摘要： The present invention relates to the discovery that specific human taste receptors in the T2R taste receptor family respond to particular bitter compounds, i.e., chlorogenic lactone compounds that contribute at least partially to the bitter taste of many coffee beverages. The present invention further relates to the use of these receptors in assays for identifying ligands that modulate the activation of these taste receptors by chlorogenic lactones and related compounds and which may be used as additives and/or removed from foods, beverages and medicinals in order to modify (block) T2R-associated bitter taste. A preferred embodiment is the use of the identified compounds as additives in coffee and coffee-flavored foods, beverages and medicinals.
摘要翻译：本发明涉及T2R味觉受体家族中的特定人味受体对特定苦味化合物的反应的发现，即，至少部分地促成许多咖啡饮料的苦味的绿色内酯化合物。本发明还涉及这些受体在测定中用于鉴定调节绿色内酯和相关化合物来调节这些味觉受体的活化并可以用作添加剂和/或从食品，饮料和药物中去除的配体的用途，以便修改（阻断）T2R相关的苦味。优选的实施方案是使用所鉴定的化合物作为咖啡和咖啡风味食品，饮料和药物中的添加剂。

7. 发明申请

US20120270328A1 Methods of Cationic Polymer Detection 有权
标题翻译：阳离子聚合物检测方法
公开(公告)号：US20120270328A1
公开(公告)日：2012-10-25
申请号：US13119295
申请日：2010-12-21
申请人： Guixi Zhang , Sijing Wang , Hong Xu , Xiaofeng Tang
发明人： Guixi Zhang , Sijing Wang , Hong Xu , Xiaofeng Tang
IPC分类号： G01N21/49
CPC分类号： G01N21/49
摘要： The present invention concerns a method of detecting cationic polymers comprising: obtaining a target water sample containing a cationic polymer; adding a polymer dispersant solution and a phosphate solution to the target water sample, the polymer dispersant solution is comprised of a polymer dispersant with calcium and magnesium hardness and the phosphate solution is comprised of a phosphate; standing the target water sample; and measuring the turbidity of the target water sample; comparing the turbidity of said target water sample with a calibration curve of the turbidity of samples containing known concentrations of cationic polymers to determine the concentration of cationic polymers in said target water sample.
摘要翻译：本发明涉及一种检测阳离子聚合物的方法，包括：获得含有阳离子聚合物的目标水样品; 将聚合物分散剂溶液和磷酸盐溶液加入到目标水样品中，聚合物分散剂溶液由具有钙和镁硬度的聚合物分散剂组成，磷酸盐溶液由磷酸盐组成; 站在目标水样上; 并测量目标水样品的浊度; 将所述目标水样品的浊度与含有已知浓度的阳离子聚合物的样品的浊度的校准曲线进行比较，以确定所述目标水样品中阳离子聚合物的浓度。

8. 发明授权

US08206938B2 In vitro methods of detecting cells sensitive to sweet tastants by detecting expression of hetero-oligomeric T1R2/T1R3 taste receptors 有权
标题翻译：通过检测异低聚T1R2 / T1R3味觉受体的表达来检测对甜味滋味物敏感的细胞的体外方法
公开(公告)号：US08206938B2
公开(公告)日：2012-06-26
申请号：US13099327
申请日：2011-05-02
申请人： Mark Zoller , Xiaodong Li , Lena Staszewski , Shawn O'Connell , Sergey Zozulya , Jon Elliot Adler , Hong Xu , Fernando Echeverri
发明人： Mark Zoller , Xiaodong Li , Lena Staszewski , Shawn O'Connell , Sergey Zozulya , Jon Elliot Adler , Hong Xu , Fernando Echeverri
IPC分类号： G01N33/53 , G01N33/567 , C12Q1/68
CPC分类号： G01N33/5041 , A01K2217/05 , C07K14/705 , C07K2319/00 , C12Q1/6876 , C12Q2600/124 , C12Q2600/158 , G01N33/5008 , G01N33/566 , G01N2333/4719 , G01N2333/705 , G01N2333/726 , G01N2500/04
摘要： The present invention relates to the discovery that the T1R receptors assemble to form functional taste receptors. Particularly, it has been discovered that co-expression of T1R1 and T1R3 results in a taste receptor that responds to umami taste stimuli, including monosodium glutamate. Also, it has been discovered that co-expression of the T1R2 and T1R3 receptors results in a taste receptor that responds to sweet taste stimuli including naturally occurring and artificial sweeteners.Also the present invention relates to the use of hetero-oligomeric taste receptors comprising T1R1/T1R3 and T1R2/T1R3 in assays to identify compounds that respectively respond to umami taste stimuli and sweet taste stimuli.Further, the invention relates to the constitutive of cell lines that stably or transiently co-express a combination of T1R1 and T1R3; or T1R2 and T1R3; under constitutive or inducible conditions. The use of these cells lines in cell-based assays to identify umami and sweet taste modulatory compounds is also provided, particularly high throughput screening assays that detect receptor activity by use of fluorometric imaging.Finally, the invention relates to the discovery that some compounds, e.g., lactisole, inhibit both the activities of human T1R2/T1R3 and T1R1/T1R3 receptors, and accordingly the sweet and umami taste, suggesting that these receptors may be the only sweet and umami receptors.
摘要翻译：本发明涉及T1R受体组装形成功能性味觉受体的发现。特别地，已经发现，T1R1和T1R3的共表达导致对鲜味刺激（包括谷氨酸钠）起反应的味觉感受器。此外，已经发现，T1R2和T1R3受体的共表达导致对包括天然存在的和人造甜味剂的甜味刺激有反应的味觉受体。本发明还涉及在测定中使用包含T1R1 / T1R3和T1R2 / T1R3的异低聚味觉感受器来鉴定分别响应于鲜味刺激和甜味刺激的化合物。此外，本发明涉及稳定或瞬时共表达T1R1和T1R3的组合的细胞系的组成; 或T1R2和T1R3; 在组成型或诱导性条件下。还提供了在基于细胞的测定中使用这些细胞系以鉴定鲜味和甜味调节化合物，特别是通过使用荧光成像检测受体活性的高通量筛选测定。最后，本发明涉及一些发现，一些化合物，例如乳酸，抑制人T1R2 / T1R3和T1R1 / T1R3受体的活性，因此抑制甜味和鲜味，这表明这些受体可能是唯一的甜味和鲜味受体。

9. 发明授权

US08168401B2 Methods of detecting T1R2- and T1R3-expressing cells potentially sensitive to sweet tastants 有权
标题翻译：检测对甜味滋味剂有潜在敏感性的T1R2-和T1R3表达细胞的方法
公开(公告)号：US08168401B2
公开(公告)日：2012-05-01
申请号：US13023462
申请日：2011-02-08
申请人： Mark Zoller , Xiaodong Li , Lena Staszewski , Shawn O'Connell , Sergey Zozulya , Jon Elliot Adler , Hong Xu , Femando Echeverri
发明人： Mark Zoller , Xiaodong Li , Lena Staszewski , Shawn O'Connell , Sergey Zozulya , Jon Elliot Adler , Hong Xu , Femando Echeverri
IPC分类号： G01N33/53 , G01N33/567
CPC分类号： G01N33/5041 , A01K2217/05 , C07K14/705 , C07K2319/00 , C12Q1/6876 , C12Q2600/124 , C12Q2600/158 , G01N33/5008 , G01N33/566 , G01N2333/4719 , G01N2333/705 , G01N2333/726 , G01N2500/04
摘要： The present invention relates to the discovery that the T1R receptors assemble to form functional taste receptors. Particularly, it has been discovered that co-expression of T1R1 and T1R3 results in a taste receptor that responds to umami taste stimuli, including monosodium glutamate. Also, it has been discovered that co-expression of the T1R2 and T1R3 receptors results in a taste receptor that responds to sweet taste stimuli including naturally occurring and artificial sweeteners.Also the present invention relates to the use of hetero-oligomeric taste receptors comprising T1R1/T1R3 and T1R2/T1R3 in assays to identify compounds that respectively respond to umami taste stimuli and sweet taste stimuli.Further, the invention relates to the constitutive of cell lines that stably or transiently co-express a combination of T1R1 and T1R3; or T1R2 and T1R3; under constitutive or inducible conditions. The use of these cells lines in cell-based assays to identify umami and sweet taste modulatory compounds is also provided, particularly high throughput screening assays that detect receptor activity by use of fluorometric imaging.Finally, the invention relates to the discovery that some compounds, e.g., lactisole, inhibit both the activities of human T1R2/T1R3 and T1R1/T1R3 receptors, and accordingly the sweet and umami taste, suggesting that these receptors may be the only sweet and umami receptors.
摘要翻译：本发明涉及T1R受体组装形成功能性味觉受体的发现。特别地，已经发现，T1R1和T1R3的共表达导致对鲜味刺激（包括谷氨酸钠）起反应的味觉感受器。此外，已经发现，T1R2和T1R3受体的共表达导致对包括天然存在的和人造甜味剂的甜味刺激有反应的味觉受体。本发明还涉及在测定中使用包含T1R1 / T1R3和T1R2 / T1R3的异低聚味觉感受器来鉴定分别响应于鲜味刺激和甜味刺激的化合物。此外，本发明涉及稳定或瞬时共表达T1R1和T1R3的组合的细胞系的组成; 或T1R2和T1R3; 在组成型或诱导性条件下。还提供了在基于细胞的测定中使用这些细胞系以鉴定鲜味和甜味调节化合物，特别是通过使用荧光成像检测受体活性的高通量筛选测定。最后，本发明涉及一些发现，一些化合物，例如乳酸，抑制人T1R2 / T1R3和T1R1 / T1R3受体的活性，因此抑制甜味和鲜味，这表明这些受体可能是唯一的甜味和鲜味受体。

10. 发明授权

US08067185B2 Methods of quantifying taste of compounds for food or beverages 有权
标题翻译：量化化合物食物或饮料味道的方法
公开(公告)号：US08067185B2
公开(公告)日：2011-11-29
申请号：US12270841
申请日：2008-11-13
申请人： Mark Zoller , Xiaodong Li , Lena Staszewski , Shawn O'Connell , Sergey Zozulya , Jon Elliot Adler , Hong Xu , Fernando Echeverri
发明人： Mark Zoller , Xiaodong Li , Lena Staszewski , Shawn O'Connell , Sergey Zozulya , Jon Elliot Adler , Hong Xu , Fernando Echeverri
IPC分类号： G01N33/53 , G01N33/567 , G01N33/566
CPC分类号： G01N33/5041 , A01K2217/05 , C07K14/705 , C07K2319/00 , C12Q1/6876 , C12Q2600/124 , C12Q2600/158 , G01N33/5008 , G01N33/566 , G01N2333/4719 , G01N2333/705 , G01N2333/726 , G01N2500/04
摘要： Methods of quantifying the taste of compounds for food and beverages are provided. These methods comprise contacting the compounds with an isolated heteromeric receptor comprising at least one T1R1 polypeptide and at least one T1R3 polypeptide.
摘要翻译：提供了定量食品和饮料化合物味道的方法。这些方法包括使化合物与包含至少一种T1R1多肽和至少一种T1R3多肽的分离的异聚受体接触。

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