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1. 发明授权

US09523085B2 Thermostable type-A DNA polymerase mutants with increased polymerization rate and resistance to inhibitors 有权
标题翻译：具有增加的聚合速率和对抑制剂的抗性的热稳定型A-DNA聚合酶突变体
公开(公告)号：US09523085B2
公开(公告)日：2016-12-20
申请号：US12848765
申请日：2010-08-02
申请人： Holly Hogrefe , Michelle Cayouette , Jeffrey Fox , Connie J. Hansen , Jennifer Lapira , Bahram Arezi , Nancy McKinney
发明人： Holly Hogrefe , Michelle Cayouette , Jeffrey Fox , Connie J. Hansen , Jennifer Lapira , Bahram Arezi , Nancy McKinney
IPC分类号： C12N9/12 , C12P19/34
CPC分类号： C12N9/1252
摘要： The present invention provides mutants of DNA polymerases having an increased rate of incorporation of nucleotides into nucleic acids undergoing polymerization and having an enhanced resistance to inhibitors of DNA polymerase activity. The mutant polymerases are well suited for fast PCR applications, for PCR amplification of targets in samples that contain inhibitors of wild-type polymerases, and for fast PCR amplification of samples containing DNA polymerase inhibitors. In exemplary embodiments, the mutants are mutants of Taq DNA polymerase.
摘要翻译：本发明提供了DNA聚合酶的突变体，其具有增加的核苷酸掺入到经历聚合的核酸中并且具有增强的抗DNA聚合酶活性抑制剂的能力的突变体。突变型聚合酶非常适用于快速PCR应用，用于PCR扩增含有野生型聚合酶抑制剂的样品中的靶标，以及用于快速PCR扩增含有DNA聚合酶抑制剂的样品。在示例性实施方案中，突变体是Taq DNA聚合酶的突变体。

2. 发明申请

US20110027833A1 THERMOSTABLE TYPE-A DNA POLYMERASE MUTANTS WITH INCREASED POLYMERIZATION RATE AND RESISTANCE TO INHIBITORS 有权
标题翻译：具有增加的聚合速率和耐药性的可热型TYPE-A DNA聚合酶突变体
公开(公告)号：US20110027833A1
公开(公告)日：2011-02-03
申请号：US12848765
申请日：2010-08-02
申请人： Holly Hogrefe , Michelle Cayouette , Jeffrey Fox , Connie J. Hansen , Jennifer Lapira , Bahram Arezi , Nancy McKinney
发明人： Holly Hogrefe , Michelle Cayouette , Jeffrey Fox , Connie J. Hansen , Jennifer Lapira , Bahram Arezi , Nancy McKinney
IPC分类号： C12P19/34 , C12N9/10 , C07H21/04
CPC分类号： C12N9/1252
摘要： The present invention provides mutants of DNA polymerases having an increased rate of incorporation of nucleotides into nucleic acids undergoing polymerization and having an enhanced resistance to inhibitors of DNA polymerase activity. The mutant polymerases are well suited for fast PCR applications, for PCR amplification of targets in samples that contain inhibitors of wild-type polymerases, and for fast PCR amplification of samples containing DNA polymerase inhibitors. In exemplary embodiments, the mutants are mutants of Taq DNA polymerase.
摘要翻译：本发明提供了DNA聚合酶的突变体，其具有增加的核苷酸掺入到经历聚合的核酸中并且具有增强的抗DNA聚合酶活性抑制剂的能力的突变体。突变型聚合酶非常适用于快速PCR应用，用于PCR扩增含有野生型聚合酶抑制剂的样品中的靶标，以及用于快速PCR扩增含有DNA聚合酶抑制剂的样品。在示例性实施方案中，突变体是Taq DNA聚合酶的突变体。

3. 发明申请

US20080064071A1 Zwitterionic detergents for the storage and use of DNA polymerases 审中-公开
标题翻译：两性离子洗涤剂用于储存和使用DNA聚合酶
公开(公告)号：US20080064071A1
公开(公告)日：2008-03-13
申请号：US11828107
申请日：2007-07-25
申请人： Holly Hogrefe , Jeffrey Fox , Michael Borns , Jeffrey Braman
发明人： Holly Hogrefe , Jeffrey Fox , Michael Borns , Jeffrey Braman
IPC分类号： C12P19/34
CPC分类号： C12Q1/686 , C12Q2527/125 , C12Q2521/101
摘要： The present invention provides methods, compositions, and kits for storing and enhancing the activity of thermostable polymerases. The methods comprise mixing a thermostable polymerase with at least one zwitterionic detergent or non-detergent surfactant. Compositions and kits for performing the process according to the invention are also provided.
摘要翻译：本发明提供用于储存和增强热稳定聚合酶活性的方法，组合物和试剂盒。所述方法包括将热稳定聚合酶与至少一种两性离子洗涤剂或非洗涤剂表面活性剂混合。还提供了用于执行根据本发明的方法的组合物和试剂盒。

4. 发明申请

US20070250682A1 Method and apparatus for operating a computer processor array 审中-公开
标题翻译：用于操作计算机处理器阵列的方法和装置
公开(公告)号：US20070250682A1
公开(公告)日：2007-10-25
申请号：US11731747
申请日：2007-03-30
申请人： Charles Moore , John Rible , Jeffrey Fox
发明人： Charles Moore , John Rible , Jeffrey Fox
IPC分类号： G06F15/00
CPC分类号： G06F15/8023 , G06F9/5066 , G06F9/547
摘要： A computer array (10) has a plurality of computers (12) for accomplishing a larger task that is divided into smaller tasks, each of the smaller tasks being assigned to one or more of the computers (12). Each of the computers (12) may be configured for specific functions and individual input/output circuits (26) associated with exterior computers (12) are specifically adapted for particular input/output functions. An example of 24 computers (12) arranged in the computer array (10) has a centralized computational core (34) with the computers (12) nearer the edge of the die (14) being configured for input and/or output. Mechanisms are described for communications between computers (12) and the outside environment.
摘要翻译：计算机阵列（10）具有用于完成更大任务的多个计算机（12），其被划分成较小的任务，每个较小的任务分配给一个或多个计算机（12）。每个计算机（12）可以被配置为用于特定功能，并且与外部计算机（12）相关联的各个输入/输出电路（26）特别适用于特定的输入/输出功能。布置在计算机阵列（10）中的24台计算机（12）的示例具有集中式计算核心（34），其中靠近管芯（14）边缘的计算机（12）被配置为用于输入和/或输出。描述了用于计算机（12）和外部环境之间的通信的机制。

5. 发明申请

US20070249948A1 Method of Identifying Strategies for Treatment or Prevention of Ventricular Fibrillation and Ventricular Tachycardia 有权
标题翻译：识别心室颤动和室性心动过速治疗或预防策略的方法
公开(公告)号：US20070249948A1
公开(公告)日：2007-10-25
申请号：US10588395
申请日：2005-02-02
申请人： Robert Gilmour , Jeffrey Fox , Mark Riccio
发明人： Robert Gilmour , Jeffrey Fox , Mark Riccio
IPC分类号： A61B5/04
CPC分类号： A61B5/0464 , A61B5/046 , A61B5/4884 , A61N1/3621
摘要： The present invention relates to evaluating the effect of physiological conditions on the occurrence of ventricular fibrillation, identifying strategies for treatment or prevention of ventricular fibrillation or ventricular tachycardia, and evaluating a subject for induction of ventricular fibrillation from a condition of ventricular tachycardia.
摘要翻译：本发明涉及评估生理条件对心室颤动发生的影响，鉴定治疗或预防心室纤维性颤动或室性心动过速的策略，以及评估受试者从室性心动过速的状况诱发心室颤动。

6. 发明申请

US20050086921A1 COTTON FEEDING ROLLER STRUCTURE 有权
标题翻译：棉花喂料滚筒结构
公开(公告)号：US20050086921A1
公开(公告)日：2005-04-28
申请号：US10695096
申请日：2003-10-28
申请人： Robert Bares , Jeffrey Fox , Michael Pearson
发明人： Robert Bares , Jeffrey Fox , Michael Pearson
IPC分类号： A01D46/08
CPC分类号： A01D46/08
摘要： Lower spiked rollers in the bottom of a cotton accumulator are inclined in the downstream direction towards an opening and rotate in the same direction to pull cotton down to the opening. An upper spiked roller located above the opening and above the last of the lower spiked rollers is only partially exposed to the cotton in the accumulator. The upper roller meters the cotton and tears apart clumps. An opening above the upper roller defines an upper discharge opening over the main discharge opening. When in a non-rotating condition, the spiked rollers act as a floor for the accumulator and prevent egress of the cotton through the openings.
摘要翻译：在棉花收集器底部的下部加标辊在向下游方向朝向开口倾斜，并沿同一方向旋转以将棉花向下拉到开口。位于开口上方和最后一个下加标辊上方的上加料辊仅部分暴露于蓄液器中的棉花。上面的辊子测量了棉花，并分开了团块。上辊上方的开口限定了主排出口上方的上排气口。当处于非旋转状态时，加标辊作为蓄能器的底板，并防止棉花通过开口排出。

7. 发明申请

US20070192566A1 Method and apparatus for monitoring inputs to a computer 有权
标题翻译：监控计算机输入的方法和装置
公开(公告)号：US20070192566A1
公开(公告)日：2007-08-16
申请号：US11441818
申请日：2006-05-26
申请人： Charles Moore , Jeffrey Fox , John Rible
发明人： Charles Moore , Jeffrey Fox , John Rible
IPC分类号： G06F15/00
CPC分类号： G06F1/324 , G06F1/3209 , Y02D10/126
摘要： A computer array (10) has a plurality of computers (12). The computers (12) communicate with each other asynchronously, and the computers (12) themselves operate in a generally asynchronous manner internally. When one computer (12) attempts to communicate with another it goes to sleep until the other computer (12) is ready to complete the transaction, thereby saving power and reducing heat production. The sleeping computer (12) can be awaiting data or instructions (12). In the case of instructions, the sleeping computer (12) can be waiting to store the instructions or to immediately execute the instructions. In the later case, the instructions are placed in an instruction register (30a) when they are received and executed therefrom, without first placing the instructions first into memory. The instructions can include a micro-loop (100) which is capable of performing a series of operations repeatedly. In one application, the sleeping computer (12) is awakened by an input such that it commences an action that would otherwise have required an interrupt of an otherwise active computer.
摘要翻译：计算机阵列（10）具有多个计算机（12）。计算机（12）以异步方式彼此通信，并且计算机（12）本身以内部的大致异步方式进行操作。当一台计算机（12）尝试与另一台计算机（12）进行通信时，它将进入睡眠状态，直到另一台计算机（12）准备完成交易，从而节省电力并减少热量产生。休眠计算机（12）可以等待数据或指令（12）。在指令的情况下，睡眠计算机（12）可以等待存储指令或者立即执行指令。在后一种情况下，当它们被接收和执行时，这些指令被放置在指令寄存器（30a）中，而不首先将指令首先置于存储器中。指令可以包括能够重复执行一系列操作的微循环（100）。在一个应用中，休眠计算机（12）被输入唤醒，使得它开始了否则将需要另外活动的计算机的中断的动作。

8. 发明申请

US20060070557A1 Table 有权
标题翻译：表
公开(公告)号：US20060070557A1
公开(公告)日：2006-04-06
申请号：US11287958
申请日：2005-11-28
申请人： Kwang-Ho Baik , Jeffrey Fox
发明人： Kwang-Ho Baik , Jeffrey Fox
IPC分类号： A47B3/00
CPC分类号： A47B3/0912
摘要： A folding table having a table top and a support frame which includes a perimeter frame assembly and a central support/pivot assembly. The perimeter frame assembly includes first and second leg assemblies which are pivotally attached to said the central support/pivot assembly. Also a frame for a folding table.
摘要翻译：一种折叠桌，其具有桌面和包括周边框架组件和中心支撑/枢转组件的支撑框架。周边框架组件包括枢转地附接到所述中心支撑/枢轴组件的第一和第二腿部组件。还有一个折叠桌的框架。

9. 发明申请

US20050086922A1 Separation hood for a cotton harvester 有权
公开(公告)号：US20050086922A1
公开(公告)日：2005-04-28
申请号：US10695095
申请日：2003-10-28
申请人： Robert Bares , Jeffrey Fox , Michael Pearson
发明人： Robert Bares , Jeffrey Fox , Michael Pearson
IPC分类号： A01D46/08
CPC分类号： A01D46/08
摘要： A hood receives a stream of material including a mix of cotton, air and debris from an air delivery system on a cotton harvester. A forward deflector directs the mixture towards the rear of an accumulator. The deflected mixture passes under finger grates which retains cotton but allows some of the air and light trash to pass through out of the stream. A curved rear deflector forces the remaining mix downwardly towards the accumulator and prevents build-up on receptacle walls. Air and light debris change direction abruptly at the bottom of the rear deflector and exit through an inlet area and upwardly directed path at the back of the deflector. The momentum of the heavier cotton prevents cotton from making the tight turn around the bottom of the deflector and directs the cotton towards the receptacle or accumulator. The inlet area can be adjusted or closed completely to prevent cotton loss in certain conditions.

10. 发明申请

US20070226457A1 Computer system with increased operating efficiency 有权
标题翻译：提高运行效率的计算机系统
公开(公告)号：US20070226457A1
公开(公告)日：2007-09-27
申请号：US11653187
申请日：2007-01-12
申请人： Charles Moore , Jeffrey Fox , John Rible
发明人： Charles Moore , Jeffrey Fox , John Rible
IPC分类号： G06F15/00
CPC分类号： G06F1/32
摘要： A microprocessor system in which an array of processors communicates more efficiently through the use of a worker mode function. Processors that are not currently executing code remain in an inactive but alert state until a task is sent to them by an adjacent processor. Processors can also be programmed to temporarily suspend a task to check for incoming tasks or messages.
摘要翻译：一种微处理器系统，其中处理器阵列通过使用工作模式功能更有效地进行通信。当前不执行代码的处理器保持处于非活动状态，但是在相邻处理器发送任务之前，该状态保持不活动状态。处理器也可以编程为暂时挂起任务以检查传入的任务或消息。

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