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1. 发明授权

US09938340B2 Amino acid sequence presenting fusion polypeptide and its use 有权
公开(公告)号：US09938340B2
公开(公告)日：2018-04-10
申请号：US14877475
申请日：2015-10-07
申请人： HOFFMANN-LA ROCHE INC.
发明人： Herbert Andres , David Casagolda Vallribera , Hartmut Duefel , Michael Gerg , Christian Scholz , Michael Schraeml
IPC分类号： C07K16/22 , C12N9/90 , C07K16/12 , G01N33/74 , C07K16/40 , G01N33/573 , C07K14/475 , C07K14/65
CPC分类号： C07K16/22 , C07K14/475 , C07K14/65 , C07K16/1203 , C07K16/40 , C07K2317/34 , C07K2317/565 , C07K2317/92 , C07K2319/00 , C07K2319/21 , C07K2319/22 , C07K2319/23 , C07K2319/24 , C07K2319/35 , C07K2319/41 , C07K2319/43 , C12N9/90 , C12Y502/01008 , G01N33/573 , G01N33/74 , G01N2333/99
摘要： Herein is reported a fusion polypeptide according to formula I NH2—S2—X1—S1—COOH (formula I) wherein X1 comprises either a random amino acid sequence or an amino acid sequence derived from a first polypeptide, S2 and S1 are non-overlapping amino acid sequences derived from a second polypeptide, and — denotes a peptide bond, wherein the second polypeptide is a polypeptide with peptidyl-prolyl cis/trans-isomerase activity (PPIase activity) or is derived from the FKBP-fold domain family, wherein X1 is inserted in place of the insert-in-flap-domain of the second polypeptide.

2. 发明申请

US20150175685A1 HUMANIZED ANTI-Tau(pS422) ANTIBODIES AND METHODS OF USE 有权
标题翻译：人类抗体（pS422）抗体和使用方法
公开(公告)号：US20150175685A1
公开(公告)日：2015-06-25
申请号：US14575067
申请日：2014-12-18
申请人： Hoffmann-La Roche Inc.
发明人： Fiona Grueninger , Guy Georges , Olaf Mundigl , Michael Schraeml , Bernd Bohrmann , Ulrich Goepfert , Joerg Benz , Hubert Kettenberger
IPC分类号： C07K16/18 , A61K39/395
CPC分类号： C07K16/18 , A61K39/3955 , A61K2039/507 , C07K14/4711 , C07K2317/24 , C07K2317/33 , C07K2317/34 , C07K2317/56 , C07K2317/71 , C07K2317/92
摘要： The invention provides humanized anti-human Tau(pS422) antibodies and methods of using the same.
摘要翻译：本发明提供人源化抗人Tau（pS422）抗体及其使用方法。

3. 发明授权

US11579151B2 Method to screen high affinity antibody 有权
公开(公告)号：US11579151B2
公开(公告)日：2023-02-14
申请号：US16028241
申请日：2018-07-05
申请人： Hoffmann-La Roche Inc.
发明人： Michael Schraeml , Leopold Von Proff
IPC分类号： G01N33/68 , G01N21/552 , C07K16/26
摘要： The current invention reports a method for producing an antibody comprising the steps of a) providing a plurality of hybridoma cells each expressing an antibody, b) determining the time dependent amount of said antibody bound to the respective antigen by surface plasmon resonance at different temperatures and different antibody concentrations, c) calculating with the time dependent amount determined in b) based on equations (II) to (XIII) at least the thermodynamic parameters (i) standard association binding entropy (ΔS°‡ass), (ii) standard dissociation binding entropy (ΔS°‡diss), (iii) standard binding entropy (ΔS°), (iv) free standard binding enthalpy (ΔG°), (v) standard dissociation free binding enthalpy (ΔG°‡diss), (vi) standard association free binding enthalpy (ΔG°‡ass), (vii) −TΔS°, (viii) dissociation rate constant kd, (ix) equilibrium binding constant KD, and (x) association rate constant ka, d) selecting a hybridoma cell producing an antibody with at least two of the following: i) a standard association binding entropy of less than 10 J/K*mol, ii) an absolute standard dissociation binding entropy of 100 J/mol*K or more, iii) an absolute standard binding entropy of 100 J/mol*K or more, e) producing an antibody by cultivating said selected cell under conditions suitable for the expression of said antibody and recovering said antibody from the cells or/and the cultivation medium.

4. 发明授权

US10877030B2 Velocity factor 有权
公开(公告)号：US10877030B2
公开(公告)日：2020-12-29
申请号：US15287453
申请日：2016-10-06
申请人： Hoffmann-La Roche Inc.
发明人： Michael Schraeml , Leopold Von Proff
IPC分类号： G01N33/68 , C07K16/00 , C07K16/46 , G01N33/557
CPC分类号： G01N33/557 , C07K16/00 , C07K16/461 , G01N33/6854 , C07K2317/24 , C07K2317/90 , C07K2317/92 , C07K2317/94
摘要： The current invention is directed to the velocity factor. Based on the velocity factor antibodies can be classified, i.e. antibodies can be characterized on their binding properties as e.g. entropic or enthalpic antigen binder. A velocity factor based classification does not require detailed thermodynamic determinations and/or calculations. The velocity factor is the ratio of the antigen-antibody complex association rate constants ka determined at 37° C. and 13° C. As only two experimental determinations are required to calculate the velocity factor this is a fast and high-throughput suited method.

5. 发明授权

US10364290B2 Anti-HER3/HER4 antibodies binding to the beta-hairpin of HER3 and the beta-hairpin of HER4 有权
公开(公告)号：US10364290B2
公开(公告)日：2019-07-30
申请号：US15668396
申请日：2017-08-03
申请人： Hoffmann-La Roche Inc.
发明人： Birgit Bossenmaier , Guy Georges , Michael Gerg , Gerhard Niederfellner , Christian Scholz , Michael Schraeml
IPC分类号： C07H21/00 , C07K16/28 , C07K16/32 , A61K47/68 , A61K39/00
摘要： The invention relates to anti-HER3/HER4 antigen binding proteins, e.g. anti-HER3/HER4 antibodies, that bind to the beta-hairpin of HER3 and the beta-hairpin of HER4, methods for selecting these antigen binding proteins, their preparation and use as medicament.

6. 发明申请

US20190041397A1 METHOD TO SCREEN HIGH AFFINITY ANTIBODY 审中-公开
公开(公告)号：US20190041397A1
公开(公告)日：2019-02-07
申请号：US16028241
申请日：2018-07-05
申请人： Hoffmann-La Roche Inc.
发明人： Michael Schraeml , Leopold Von Proff
IPC分类号： G01N33/68 , G01N21/552 , C07K16/26
摘要： The current invention reports a method for producing an antibody comprising the steps of a) providing a plurality of hybridoma cells each expressing an antibody, b) determining the time dependent amount of said antibody bound to the respective antigen by surface plasmon resonance at different temperatures and different antibody concentrations, c) calculating with the time dependent amount determined in b) based on equations (II) to (XIII) at least the thermodynamic parameters (i) standard association binding entropy (ΔS°‡ass), (ii) standard dissociation binding entropy (ΔS°‡diss), (iii) standard binding entropy (ΔS°), (iv) free standard binding enthalpy (ΔG°), (v) standard dissociation free binding enthalpy (ΔG°‡diss), (vi) standard association free binding enthalpy (ΔG°‡ass), (vii) −TΔS°, (viii) dissociation rate constant kd, (ix) equilibrium binding constant KD, and (x) association rate constant ka, d) selecting a hybridoma cell producing an antibody with at least two of the following: i) a standard association binding entropy of less than 10 J/K*mol, ii) an absolute standard dissociation binding entropy of 100 J/mol*K or more, iii) an absolute standard binding entropy of 100 J/mol*K or more, e) producing an antibody by cultivating said selected cell under conditions suitable for the expression of said antibody and recovering said antibody from the cells or/and the cultivation medium.

7. 发明申请

US20180118837A1 ANTI-HER3/HER4 ANTIBODIES BINDING TO THE BETA-HAIRPIN OF HER3 AND THE BETA-HAIRPIN OF HER4 审中-公开
公开(公告)号：US20180118837A1
公开(公告)日：2018-05-03
申请号：US15668396
申请日：2017-08-03
申请人： Hoffmann-La Roche Inc.
发明人： Birgit Bossenmaier , Guy Georges , Michael Gerg , Gerhard Niederfellner , Christian Scholz , Michael Schraeml
IPC分类号： C07K16/28 , C07K16/32 , A61K39/00
CPC分类号： C07K16/2863 , A61K47/6803 , A61K47/6829 , A61K47/6851 , A61K47/6855 , A61K2039/505 , C07K16/32 , C07K2317/24 , C07K2317/33 , C07K2317/34 , C07K2317/55 , C07K2317/73 , C07K2317/75 , C07K2317/77
摘要： The invention relates to anti-HER3/HER4 antigen binding proteins, e.g. anti-HER3/HER4 antibodies, that bind to the beta-hairpin of HER3 and the beta-hairpin of HER4, methods for selecting these antigen binding proteins, their preparation and use as medicament.

8. 发明申请

US20200223912A1 HUMANIZED ANTI-TAU(PS422) ANTIBODIES AND METHODS OF USE 审中-公开
公开(公告)号：US20200223912A1
公开(公告)日：2020-07-16
申请号：US16565424
申请日：2019-09-09
申请人： HOFFMANN-LA ROCHE INC.
发明人： Fiona Grueninger , Guy Georges , Olaf Mundigl , Michael Schraeml , Bernd Bohrmann , Ulrich Goepfert , Joerg Benz , Hubert Kettenberger
IPC分类号： C07K16/18 , C07K14/47 , A61K39/395
摘要： The invention provides humanized anti-human Tau(pS422) antibodies and methods of using the same.

9. 发明申请

US20190137523A1 METHOD AND MEANS FOR DETECTING THE LEVEL OF TOTAL VEGF-A 审中-公开
公开(公告)号：US20190137523A1
公开(公告)日：2019-05-09
申请号：US16245016
申请日：2019-01-10
申请人： Hoffmann-La Roche Inc.
发明人： Alfred Engel , Johann Karl , Christina Rabe , Michael Schraeml , Monika Soukupova , Peter Stegmueller , Norbert Wild
IPC分类号： G01N33/74 , C07K16/22
摘要： The present invention relates to a method for measuring the level of VEGF-A in the presence of a VEGF-A antagonist, kits comprising means for detecting VEGF-A in the presence of a VEGF-A antagonist, compositions of matter comprising a first and a second antibody suitable for detecting the level of VEGF-A in the presence of a VEGF-A antagonist, as well as methods of detecting a complex comprising human VEGF-A and a non-human or chimeric protein.

10. 发明授权

US09488661B2 Velocity factor 有权
公开(公告)号：US09488661B2
公开(公告)日：2016-11-08
申请号：US14090456
申请日：2013-11-26
申请人： Hoffmann-La Roche Inc.
发明人： Michael Schraeml , Leopold Von Proff
IPC分类号： G01N33/557 , G01N33/68 , C07K16/00 , C07K16/46
CPC分类号： G01N33/557 , C07K16/00 , C07K16/461 , C07K2317/24 , C07K2317/90 , C07K2317/92 , C07K2317/94 , G01N33/6854
摘要： The current invention is directed to the velocity factor. Based on the velocity factor antibodies can be classified, i.e. antibodies can be characterized on their binding properties as e.g. entropic or enthalpic antigen binder. A velocity factor based classification does not require detailed thermodynamic determinations and/or calculations. The velocity factor is the ratio of the antigen-antibody complex association rate constants ka determined at 37° C. and 13° C. As only two experimental determinations are required to calculate the velocity factor this is a fast and high-throughput suited method.

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