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1. 发明授权

US08399223B2 Composition containing arazyme for the prevention and treatment of cancer 有权
标题翻译：含有arazyme用于预防和治疗癌症的组合物
公开(公告)号：US08399223B2
公开(公告)日：2013-03-19
申请号：US13225317
申请日：2011-09-02
申请人： Ho-Yong Park , Kwang-Hee Son , Dong-Ha Shin , Kyu-Shik Jeong
发明人： Ho-Yong Park , Kwang-Hee Son , Dong-Ha Shin , Kyu-Shik Jeong
IPC分类号： A61K38/48
CPC分类号： A61K38/4886 , A23C15/065 , A23G1/423 , A23G3/366 , A23G4/123 , A23G9/363 , A23L2/02 , A23L2/66 , A23L13/424 , A23L13/48 , A23L23/00 , A23L33/19
摘要： The invention provides a method for treating lung cancer or breast cancer wherein the method comprises administering a pharmaceutically effective dose of arazyme enzyme to a subject with lung cancer or breast cancer. The arazyme enzyme is either a protein comprising the amino acid sequence of SEQ ID NO: 1; and/or a protein encoded by DNA comprising the coding region of the nucleotide sequence of SEQ ID NO: 2.
摘要翻译：本发明提供了一种治疗肺癌或乳腺癌的方法，其中所述方法包括向患有肺癌或乳腺癌的受试者施用药学有效剂量的阿拉酵酶。所述arazyme酶是包含SEQ ID NO：1的氨基酸序列的蛋白质; 和/或由包含SEQ ID NO：2的核苷酸序列的编码区的DNA编码的蛋白质。

2. 发明申请

US20100322917A1 PHARMACEUTICAL COMPOSITION CONTAINING ARAZYME FOR THE PREVENTION OF LIVER DYSFUNCTION 审中-公开
标题翻译：含有ARAZYME用于预防肝功能障碍的药物组合物
公开(公告)号：US20100322917A1
公开(公告)日：2010-12-23
申请号：US12521618
申请日：2006-12-28
申请人： Ho-Yong Park , Kwang-Hee Son , Dong-Ha Shin , Kyu-Shik Jeong
发明人： Ho-Yong Park , Kwang-Hee Son , Dong-Ha Shin , Kyu-Shik Jeong
IPC分类号： A61K38/48 , A61P1/16 , A61P35/00 , C12N9/52
CPC分类号： A61K38/4886 , A23L33/10 , A23L33/135
摘要： The present invention relates to a pharmaceutical composition for the prevention of liver dysfunction which contains arazyme as an active ingredient, more precisely a pharmaceutical composition for the prevention of liver dysfunction which contains arazyme produced by Aranicola proteolyticus. The arazyme of the present invention inhibits apoptosis in injured liver cells, increases SMP30 expression, inhibits P-smad3 expression and protects liver by inhibiting liver injury around central vein region. Therefore, the arazyme of the invention can be effectively used as a pharmaceutical composition for the prevention of liver dysfunction.
摘要翻译：本发明涉及一种用于预防肝功能障碍的药物组合物，其含有作为活性成分的阿拉木霉，更准确地说，涉及含有由Aranicola proteolyticus产生的arazyme的用于预防肝功能障碍的药物组合物。本发明的arazyme抑制受损肝细胞凋亡，增加SMP30表达，抑制P-smad3表达，通过抑制中心静脉区域周围的肝损伤来保护肝脏。因此，本发明的芳脒可以有效地用作预防肝功能障碍的药物组合物。

3. 发明申请

US20090317374A1 COMPOSITION CONTAINING ARAZYME FOR THE PREVENTION AND TREATMENT OF CANCER 审中-公开
标题翻译：含有ARAZYME用于预防和治疗癌症的组合物
公开(公告)号：US20090317374A1
公开(公告)日：2009-12-24
申请号：US12521676
申请日：2007-12-28
申请人： Ho-Yong Park , Kwang-Hee Son , Dong-Ha Shin , Kyu-Shik Jeong
发明人： Ho-Yong Park , Kwang-Hee Son , Dong-Ha Shin , Kyu-Shik Jeong
IPC分类号： A61K38/48 , A61P35/00
CPC分类号： A61K38/4886 , A23C15/065 , A23G1/423 , A23G3/366 , A23G4/123 , A23G9/363 , A23L2/02 , A23L2/66 , A23L13/424 , A23L13/48 , A23L23/00 , A23L33/19
摘要： The present invention relates to a pharmaceutical composition for the prevention and treatment of cancer comprising arazyme as an active ingredient. More precisely, when arazyme produced by Aranicola proteolycius was administered to the nude mice transplanted with human lung carcinoma cell line, weight gaining, inhibition of tumor cell growth and infiltration, and down-regulations of MMP-9, NF-κB and PCNA, were observed. In addition, when arazyme was treated to human breast cancer cells (MDA-MB-231), down regulations of p21, PCNA (Proliferating Cell Nuclear Antigen), VEGF (Vascular Endothelial Growth Factor), BCl2 (B-cell CLL/lymphoma 2), p-p38, PKC (Protein Kinase C) and MMP-1 (Matrix MetalloProteinase-1) which are involved in tumor cell growth, differentiation, proliferation and metastasis, were observed along with the up-regulation of catalase which inhibits tumor development. Therefore, the arazyme can be effectively used as a pharmaceutical composition for the prevention and treatment of cancer.
摘要翻译：本发明涉及一种用于预防和治疗癌症的药物组合物，其包含作为活性成分的胂酸盐。更准确地说，当将Aranicola proteolycius产生的arazyme给予移植有人肺癌细胞系的裸鼠时，体重增加，抑制肿瘤细胞生长和浸润以及MMP-9，NF-κB和PCNA的下调均为观察到的。另外，当将arazyme处理到人乳腺癌细胞（MDA-MB-231）时，下调p21，PCNA（增殖细胞核抗原），VEGF（血管内皮生长因子），BCl2（B细胞CLL /淋巴瘤2 ），参与肿瘤细胞生长，分化，增殖和转移的p-p38，PKC（蛋白激酶C）和MMP-1（基质金属蛋白酶-1）以及抑制肿瘤发生的过氧化氢酶的上调。因此，可以有效地使用胂酸盐作为预防和治疗癌症的药物组合物。

4. 发明授权

US08367060B2 Pharmaceutical composition containing arazyme for the prevention of liver dysfunction 有权
标题翻译：含有arazyme用于预防肝功能障碍的药物组合物
公开(公告)号：US08367060B2
公开(公告)日：2013-02-05
申请号：US13234847
申请日：2011-09-16
申请人： Ho-Yong Park , Kwang-Hee Son , Dong-Ha Shin , Kyu-Shik Jeong
发明人： Ho-Yong Park , Kwang-Hee Son , Dong-Ha Shin , Kyu-Shik Jeong
IPC分类号： A61K38/48
CPC分类号： A61K38/4886 , A23L33/10 , A23L33/135
摘要： The present invention relates to a composition and a method for the treatment of liver dysfunction which contains administration of a composition containing arazyme as an active ingredient, more precisely arazyme produced by Aranicola proteolyticus. The arazyme of the present invention inhibits apoptosis in injured liver cells, increases SMP30 expression, inhibits P-smad3 expression and protects the liver by inhibiting liver injury around the central vein region. Therefore, the arazyme of the invention can be effectively used as a composition for the treatment of liver dysfunction.
摘要翻译：本发明涉及一种治疗肝功能障碍的组合物和方法，其包含施用含有阿拉木霉作为活性成分的组合物，更准确地说是由Aranicola proteolyticus产生的arazyme。本发明的arazyme抑制受损肝细胞凋亡，增加SMP30表达，抑制P-smad3表达，并通过抑制中心静脉区周围的肝损伤来保护肝脏。因此，本发明的胂酸盐可以有效地用作治疗肝功能障碍的组合物。

5. 发明申请

US20100278806A1 Composition Containing Arazyme for the Prevention and Treatment of Arthritis 审中-公开
标题翻译：包含关于预防和治疗关节炎的疯狂的组合
公开(公告)号：US20100278806A1
公开(公告)日：2010-11-04
申请号：US12812388
申请日：2009-01-09
申请人： Ho-Yong Park , Kwang-Hee Son , Dong-Ha Shin , Kyu-Shik Jeong
发明人： Ho-Yong Park , Kwang-Hee Son , Dong-Ha Shin , Kyu-Shik Jeong
IPC分类号： A61K38/48 , A61P19/02
CPC分类号： A61K38/4886
摘要： Disclosed herein is a composition containing arazyme as an active ingredient for prevention and treatment of arthritis. More specifically, arazyme produced from Aranicola proteolyticus of the present invention may be useful as a composition for prevention and treatment of arthritis by inhibiting the expression of TNF-α which is an inflammation-inducing factor and preventing the loss of proteoglycan and collagen from joint cartilage to inhibit the progression of arthritis and protect joints.
摘要翻译：本文公开了含有作为预防和治疗关节炎的活性成分的阿拉木霉的组合物。更具体地说，本发明的由Aranicola proteolyticus产生的arazyme可用作通过抑制作为炎性诱导因子的TNF-α的表达来预防和治疗关节炎的组合物，并防止蛋白聚糖和胶原从关节软骨中的损失抑制关节炎的进展并保护关节。

6. 发明申请

US20140227762A1 NOVEL MANNANASE PRODUCED FROM CELLULOSIMICROBIUM SP. STRAIN HY-13 有权
标题翻译：从细胞膜生成的新型甘露聚糖菌株HY-13
公开(公告)号：US20140227762A1
公开(公告)日：2014-08-14
申请号：US14232483
申请日：2011-12-28
申请人： Ho-Yong Park , Kwang-Hee Son , Do Young Kim , Dong-Ha Shin , Han-Young Cho
发明人： Ho-Yong Park , Kwang-Hee Son , Do Young Kim , Dong-Ha Shin , Han-Young Cho
IPC分类号： A23L1/305 , C12N9/24
CPC分类号： A23L1/3058 , A23K10/14 , A23K20/168 , A23K20/189 , A23K50/30 , A23K50/75 , A23L33/195 , C12N9/2491 , C12Y302/01025
摘要： The present invention relates to a mannanase produced from Celluosimicrobium sp. strain HY-13 and more particularly to a highly active novel mannanase produced from Cellulosimicrobium sp. strain HY-13 as separated from an invertebrate. The mannanase produced from the said Cellulosimicrobium ap. strain HY-13 can be used in the decomposition of a mannan found in hemicellulose contained in grains and plants and in enhancing the utility value of a hydrolysate, which uses the decomposed mannan, for the transformation of biomass or as an animal feed material.
摘要翻译：本发明涉及由Celluosimicrobes sp。生产的甘露聚糖酶。菌株HY-13，更具体地涉及由Cellulosimicrobes sp。生产的高活性新型甘露聚糖酶。菌株HY-13与无脊椎动物分离。由所述纤维素微球形成的甘露聚糖酶。菌株HY-13可用于在谷物和植物中含有的半纤维素中发现的甘露聚糖的分解，并且用于分解甘露聚糖的水解产物的效用值用于转化生物质或作为动物饲料。

7. 发明授权

US09307782B2 Mannanase produced from Cellulosimicrobium sp. strain HY-13 有权
标题翻译：由纤维素微生物产生的甘露聚糖酶菌株HY-13
公开(公告)号：US09307782B2
公开(公告)日：2016-04-12
申请号：US14232483
申请日：2011-12-28
申请人： Ho-Yong Park , Kwang-Hee Son , Do Young Kim , Dong-Ha Shin , Han-Young Cho
发明人： Ho-Yong Park , Kwang-Hee Son , Do Young Kim , Dong-Ha Shin , Han-Young Cho
IPC分类号： C12N9/24 , A23K1/16 , A23K1/165 , A23K1/18 , A23L1/305
CPC分类号： A23L1/3058 , A23K10/14 , A23K20/168 , A23K20/189 , A23K50/30 , A23K50/75 , A23L33/195 , C12N9/2491 , C12Y302/01025
摘要： The present invention relates to a mannanase produced from Celluosimicrobium sp. strain HY-13 and more particularly to a highly active novel mannanase produced from Cellulosimicrobium sp. strain HY-13 as separated from an invertebrate. The mannanase produced from the said Cellulosimicrobium sp. strain HY-13 can be used in the decomposition of a mannan found in hemicellulose contained in grains and plants and in enhancing the utility value of a hydrolysate, which uses the decomposed mannan, for the transformation of biomass or as an animal feed material.
摘要翻译：本发明涉及由Celluosimicrobes sp。生产的甘露聚糖酶。菌株HY-13，更具体地涉及由Cellulosimicrobes sp。生产的高活性新型甘露聚糖酶。菌株HY-13与无脊椎动物分离。由所述纤维素微生物产生的甘露聚糖酶。菌株HY-13可用于在谷物和植物中含有的半纤维素中发现的甘露聚糖的分解，并且用于分解甘露聚糖的水解产物的效用值用于转化生物质或作为动物饲料。

8. 发明申请

US20120309074A1 NOVEL XYLANASE PRODUCED FROM CELLULOSIMICROBIUM FUNKEI HY-13 审中-公开
标题翻译：来自蜂窝霉素FUNKEI HY-13的新型XYLANASE
公开(公告)号：US20120309074A1
公开(公告)日：2012-12-06
申请号：US13577811
申请日：2010-03-18
申请人： Ho-Yong Park , Kwang-Hee Son , Do Young Kim , Tae-Sook Jeong , Sung Uk Kim , Dong-Ha Shin
发明人： Ho-Yong Park , Kwang-Hee Son , Do Young Kim , Tae-Sook Jeong , Sung Uk Kim , Dong-Ha Shin
IPC分类号： C12N9/24 , C12N1/19 , C12N5/10 , C12N1/21
CPC分类号： C12N9/2482 , A23K10/14 , A23K20/189 , A23K50/30 , A23K50/75 , C12Y302/01008
摘要： There are provided a novel xylanase and a use of the same. In detail, there are provided a xylanase separated from a Cellulosimicrobium funkei HY-13 strain, a Fibronectin Type 3 domain of the xylanase, and a use thereof. Since determining that the xylanase having substrate specificity degrades xylan at neutral and basic pH with high efficiency and the Fn3 domain does an important role with respect to the substrate specificity, the xylanase according to the present invention may be added to various vegetable feed materials or be efficiently used to improve degradation ability of cellulosic biomass.
摘要翻译：提供了一种新型的木聚糖酶及其用途。详细地，提供了从纤维素微球菌HY-13菌株，木聚糖酶的纤连蛋白3型结构域分离的木聚糖酶及其用途。由于确定具有底物特异性的木聚糖酶在中性和碱性pH下以高效率降解木聚糖，并且Fn3结构域在底物特异性方面起重要作用，根据本发明的木聚糖酶可以加入到各种植物饲料中，或者有效地用于提高纤维素生物质的降解能力。

9. 发明授权

US07563872B2 Protease, a gene therefor and the use thereof 有权
标题翻译：蛋白酶，其基因及其用途
公开(公告)号：US07563872B2
公开(公告)日：2009-07-21
申请号：US11853899
申请日：2007-09-12
申请人： Ho-Yong Park , Kwang-Hee Son , Doo-Sang Park , Sang-Woon Shin , Hyun-Woo Oh , Mi-Gwang Kim , Dong-Ha Shin
发明人： Ho-Yong Park , Kwang-Hee Son , Doo-Sang Park , Sang-Woon Shin , Hyun-Woo Oh , Mi-Gwang Kim , Dong-Ha Shin
IPC分类号： C07K14/00
CPC分类号： A61Q19/00 , A61K8/66 , A61K38/00 , A61K2800/86 , C11D3/386 , C12N9/52
摘要： The present invention relates to a protease, and more specifically to a protease derived from Aranicola proteolyticus, a gene coding for said enzyme, a gene expression system for said protease, a process for purifying the protease, and the uses of said protease in industrial applications, such as for example, detergents, cosmetics, leather processing agents, chemicals for laboratory research, solubilizing or softening agents for food, meat modifier, feed or food additives, or oil and fat separating agents, as well as pharmaceutical compositions.
摘要翻译：本发明涉及一种蛋白酶，更具体地说涉及来源于蛋白水解伞菌的蛋白酶，编码所述酶的基因，所述蛋白酶的基因表达系统，蛋白酶的纯化方法以及所述蛋白酶在工业应用中的用途，例如洗涤剂，化妆品，皮革加工剂，用于实验室研究的化学品，用于食品的增溶或软化剂，肉改性剂，饲料或食品添加剂或油脂分离剂，以及药物组合物。

10. 发明申请

US20080069846A1 Protease, a Gene Therefor and the Use Thereof 有权
标题翻译：蛋白酶，其基因及其用途
公开(公告)号：US20080069846A1
公开(公告)日：2008-03-20
申请号：US11853899
申请日：2007-09-12
申请人： Ho-Yong Park , Kwang-Hee Son , Doo-Sang Park , Sang-Woon Shin , Hyun-Woo Oh , Mi-Gwang Kim , Dong-Ha Shin
发明人： Ho-Yong Park , Kwang-Hee Son , Doo-Sang Park , Sang-Woon Shin , Hyun-Woo Oh , Mi-Gwang Kim , Dong-Ha Shin
IPC分类号： A61K8/02 , A61K38/48 , C07H21/04 , C11D3/386 , C12N15/00 , C12N5/02
CPC分类号： A61Q19/00 , A61K8/66 , A61K38/00 , A61K2800/86 , C11D3/386 , C12N9/52
摘要： The present invention relates to a protease, and more specifically to a protease derived from Aranicola proteolyticus, a gene coding for said enzyme, a gene expression system for said protease, a process for purifying the protease, and the uses of said protease in industrial applications, such as for example, detergents, cosmetics, leather processing agents, chemicals for laboratory research, solubilizing or softening agents for food, meat modifier, feed or food additives, or oil and fat separating agents, as well as pharmaceutical compositions.
摘要翻译：本发明涉及一种蛋白酶，更具体地说涉及来源于蛋白水解伞菌的蛋白酶，编码所述酶的基因，所述蛋白酶的基因表达系统，蛋白酶的纯化方法以及所述蛋白酶在工业应用中的用途，例如洗涤剂，化妆品，皮革加工剂，用于实验室研究的化学品，用于食品的增溶或软化剂，肉改性剂，饲料或食品添加剂或油脂分离剂，以及药物组合物。

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