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1. 发明授权

US4234691A L-Lysine .alpha.-oxidase 失效
标题翻译： L-赖氨酸α-氧化酶
公开(公告)号：US4234691A
公开(公告)日：1980-11-18
申请号：US15179
申请日：1979-02-26
申请人： Hitoshi Kusakabe , Kenjiro Kodama , Yuichiro Midorikawa , Akira Kuninaka , Haruo Misono , Kenji Soda
发明人： Hitoshi Kusakabe , Kenjiro Kodama , Yuichiro Midorikawa , Akira Kuninaka , Haruo Misono , Kenji Soda
IPC分类号： A61K38/44 , C12N9/06 , C12Q1/26
CPC分类号： C12N9/0022 , C12Q1/26 , C12Y104/03014 , A61K38/00 , Y10S435/945
摘要： An L-lysine .alpha.-oxidase, that is, a novel L-amino acid oxidase having very high substrate-specificity to L-lysine is produced by culturing a specific microorganism belonging to Trichoderma in a medium.
摘要翻译：通过在培养基中培养属于木霉属的特定微生物，产生L-赖氨酸α-氧化酶，即对L-赖氨酸具有非常高的底物特异性的新的L-氨基酸氧化酶。

2. 发明授权

US4224407A Assay of L-lysine 失效
标题翻译： L-赖氨酸的测定
公开(公告)号：US4224407A
公开(公告)日：1980-09-23
申请号：US15177
申请日：1979-02-26
申请人： Hitoshi Kusakabe , Akira Kuninaka , Kenji Soda
发明人： Hitoshi Kusakabe , Akira Kuninaka , Kenji Soda
IPC分类号： C12P13/00 , A61K38/44 , C12N9/06 , C12P17/12 , C12Q1/26 , C12Q1/28 , C12R1/885 , G01N33/02 , G01N33/68 , C07G7/02
CPC分类号： C12N9/0022 , C12Q1/26 , C12Y104/03014 , A61K38/00 , Y10S435/945
摘要： L-lysine contained in a sample can be efficiently determined by using the L-lysine .alpha.-oxidase. The preferred enzyme is an L-lysine .alpha.-oxidase, that is, a novel L-amino acid oxidase having very high substrate-specificity to L-lysine is produced by culturing a specific microorganism belonging to Trichoderma in a medium.
摘要翻译：通过使用L-赖氨酸α-氧化酶可以有效地测定样品中所含的L-赖氨酸。优选的酶是L-赖氨酸α-氧化酶，即通过在培养基中培养属于木霉属的特定微生物而产生对L-赖氨酸具有非常高的底物特异性的新型L-氨基酸氧化酶。

3. 发明授权

US3930955A Process for producing pterin deaminases having antitumor activity 失效
标题翻译：用于生产具有抗肿瘤活性的苦杏仁苷的方法
公开(公告)号：US3930955A
公开(公告)日：1976-01-06
申请号：US469689
申请日：1974-05-13
申请人： Hitoshi Kusakabe , Kenjiro Kodama , Yuichirow Midorikawa , Haruhiko Machida , Akira Kuninaka , Hiroshi Yoshino
发明人： Hitoshi Kusakabe , Kenjiro Kodama , Yuichirow Midorikawa , Haruhiko Machida , Akira Kuninaka , Hiroshi Yoshino
IPC分类号： A61K36/06 , A61K38/00 , A61K38/43 , A61K38/46 , A61P35/00 , C12N9/78 , A61K37/48 , C12D13/10
CPC分类号： C12N9/78 , A61K38/00 , Y10S435/913 , Y10S435/918 , Y10S435/931 , Y10S435/933 , Y10S435/939
摘要： The enzyme pterin deaminase may be used as an antitumor agent, and can be produced from cultures of the fungal genera Aspergillus, Mucor, Rhizopus, and Penicillium.

4. 发明授权

US4542021A Antitumor compositions for non-injection administration 失效
标题翻译：用于非注射给药的抗肿瘤组合物
公开(公告)号：US4542021A
公开(公告)日：1985-09-17
申请号：US205592
申请日：1980-11-10
申请人： Kenjiro Kodama , Akira Kuninaka , Mineo Saneyoshi
发明人： Kenjiro Kodama , Akira Kuninaka , Mineo Saneyoshi
IPC分类号： A61K31/70 , A61K31/7042 , A61K31/7052 , A61K31/7064 , A61K31/7068 , A61P35/00 , C07H19/10
CPC分类号： A61K31/70 , C07H19/10 , Y10S514/908 , Y10S514/966
摘要： An antitumor composition comprising a pharmacologically effective quantity of an ester of 1-.beta.-D-arabinofuranosylcytosine-5'-phosphate represented by the general formula ##STR1## where R is a monovalent aliphatic hydrocarbon group having 14 to 23 carbon atoms, and A designates a hydrogen atom or a pharmaceutically-acceptable alkali cation, and a vehicle is effective when administered by a non-injection method, particularly orally.
摘要翻译：一种抗肿瘤组合物，其包含药理学有效量的由通式（IMAGE）表示的1β-D-阿拉伯呋喃糖基胞嘧啶-5'-磷酸酯的酯，其中R是具有14-23个碳原子的一价脂族烃基，A表示氢原子或药学上可接受的碱性阳离子，并且当通过非注射方法，特别是口服施用时，载体是有效的。

5. 发明授权

US4115538A Assay kit for cAMP and/or cGMP and method of using the same 失效
标题翻译：用于cAMP和/或cGMP的测定试剂盒及其使用方法
公开(公告)号：US4115538A
公开(公告)日：1978-09-19
申请号：US766509
申请日：1977-02-07
申请人： Tomokazu Satoh , Junichi Takezawa , Akira Kuninaka , Miyuki Honma , Michio Ui
发明人： Tomokazu Satoh , Junichi Takezawa , Akira Kuninaka , Miyuki Honma , Michio Ui
IPC分类号： G01N33/53 , G01N33/537 , G01N33/74 , G01N33/16 , A61K43/00 , B65D81/32
CPC分类号： G01N33/537 , G01N33/5308 , Y10S436/804 , Y10S436/808 , Y10S436/815 , Y10S436/826
摘要： An assay kit for assaying adenosine-3',5'-cyclic monophosphate, which is herein referred to as cAMP, guanosine-3',5'-cyclic monophosphate, which is herein referred to as a cGMP, or both; and said assay kit comprising,A container of Reagent 1 comprising succinyl cAMP tyrosine methyl ester; succinyl cGMP tyrosine methyl ester; succinyl cAMP tyrosine methyl ester and succinyl cGMP tyrosine methyl ester in admixture or both succinyl cAMP tyrosine methyl ester and succinyl cGMP tyrosine methyl ester in separate containers, said esters labelled with radioactive iodine;A container of Reagent 2 comprising an anti-cAMP serum, an anti-cGMP serum, an anti-cAMP and anti-cGMP serum in admixture or both anti-cAMP serum and anti-cGMP serum in separate containers;A container of Reagent 3 comprising an imidazole buffer solution of 0.1 M or higher concentration;A container of Reagent 4 comprising a material for separation;A container of Reagent 5 comprising a solution of succinic anhydride in an organic solvent;A container of Reagent 6 comprising an organic tertiary amine; andA container of Reagent 7 comprising a standard solution of cAMP, cGMP, cAMP and cGMP in admixture or both cAMP and cGMP in separate containers.
摘要翻译：用于测定腺苷-3'，5'-环状单磷酸的测定试剂盒，其在本文中称为cAMP，鸟苷-3'，5'-环状单磷酸酯，其在本文中称为cGMP或两者; 并且所述测定试剂盒包含：包含琥珀酰cAMP酪氨酸甲酯的试剂1的容器; 琥珀酰基cGMP酪氨酸甲酯; 琥珀酰基cAMP酪氨酸甲酯和琥珀酰基cGMP酪氨酸甲酯混合，或琥珀酰基cAMP酪氨酸甲酯和琥珀酰基cGMP酪氨酸甲酯在分开的容器中，所述酯用放射性碘标记; 包含抗cAMP血清，抗cGMP血清，抗cAMP和抗cGMP血清的混合物的试剂2或分开的容器中的抗cAMP血清和抗cGMP血清; 试剂3的容器，其包含0.1M或更高浓度的咪唑缓冲溶液; 试剂4的容器，其包含用于分离的材料; 包含琥珀酸酐在有机溶剂中的溶液的试剂容器5; 包含有机叔胺的试剂6的容器; 和试剂7的容器，其包含cAMP，cGMP，cAMP和cGMP的标准溶液，或者在分开的容器中混合cAMP和cGMP两者。

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