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1. 发明授权

US4948589A Granular composition for ruminant 失效
标题翻译：反刍动物颗粒组成
公开(公告)号：US4948589A
公开(公告)日：1990-08-14
申请号：US293783
申请日：1989-01-05
申请人： Hitoshi Iijima , Masayuki Kiuchi , Masahiro Nakao , Kunio Nishimura , Shigeaki Sato
发明人： Hitoshi Iijima , Masayuki Kiuchi , Masahiro Nakao , Kunio Nishimura , Shigeaki Sato
IPC分类号： A23K50/10 , A23K20/174 , A23K40/10 , A61K9/16 , A61K31/14
CPC分类号： A61K9/1617 , A23K20/174 , A23K40/10 , A23K40/35
摘要： A granular composition for a ruminant containing as a main component choline or a physiologically acceptable derivative thereof, wherein the composition is prepared by (1) granulating the choline or it derivative having an average particle size of 100 .mu.m or less and a maximum particle size of 150 .mu.m or less, an excipient having an average particle size of 10 .mu.m or less and a maximum particle size of 20 .mu.m or less, and a hydrophobic binder under a relative humidity of 10% or less by using an agitation granulator, followed by cooling, separating and classifying the resultant granules to obtain spherical granules having a particle size of 0.5 to 2.5 mm and (ii) forming a thin film on the surface of the granules at a temperature of at least 5.degree. C. less than a melting point of the binder and 5.degree. C. to 25.degree. C. less than a melting point of the overcoating agent under a relative humidity of 30% or less in an agitation granulator by adding 20 to 40 parts by weight, based on 100 parts by weight of the granules, of a heated molten mixture of a hydrophobic overcoating agent and a solubility modifier in the form of a fine powder in a weight ratio of 1:0.2-1.
摘要翻译：一种含有作为主要成分胆碱或其生理学上可接受的衍生物的反刍动物的粒状组合物，其中，所述组合物通过（1）将平均粒径为100μm以下的胆碱或其衍生物或最大粒径 150μm以下的平均粒径为10μm以下，最大粒径为20μm以下的赋形剂和相对湿度为10％以下的疏水性粘合剂，使用搅拌造粒机然后冷却，分离和分级得到的颗粒，得到粒度为0.5至2.5mm的球形颗粒，和（ii）在至少5℃的温度下在颗粒表面上形成薄膜，小于在搅拌造粒机中，相对湿度为30％以下的外敷剂的熔点低于5℃〜25℃，加入20〜40重量份，基于100 pa 颗粒重量，疏水性外涂剂的加热熔融混合物和重量比为1:0.2-1的细粉末形式的溶解度调节剂。

2. 发明授权

US08017587B2 2-O- (β-D-glucopyranosyl) ascorbic acid, process for its production, and foods and cosmetics containing compositions comprising it 有权
标题翻译： 2-O-（＆bgr--D-吡喃葡萄糖基）抗坏血酸，其生产方法，以及含有组合物的组合物的食品和化妆品
公开(公告)号：US08017587B2
公开(公告)日：2011-09-13
申请号：US11898121
申请日：2007-09-10
申请人： Mitsuru Maeda , Masahiro Nakao , Harukazu Fukami
发明人： Mitsuru Maeda , Masahiro Nakao , Harukazu Fukami
IPC分类号： A01N43/04 , A01N43/08
CPC分类号： A61K8/676 , A23L33/105 , A23L33/15 , A23V2002/00 , A61K8/602 , A61K31/375 , A61K2800/52 , A61Q17/04 , A61Q19/00 , A61Q19/02 , C07H1/08 , C07H17/04 , C12P19/60 , A23V2250/708
摘要： The present invention provides a novel ascorbic acid derivative as a provitamin C with improved stability in the body and prolonged life in the body compared to conventionally known 2-O-(α-D-glucopyranosyl)ascorbic acid.The composition comprising the novel compound 2-O-(β-D-glucopyranosyl)ascorbic acid has been extracted from plants such as from Ningxia Lycium barbarum L. and/or Lycium chinense Mill. The compositions comprising 2-O-(β-D-glucopyranosyl)ascorbic acid may be enzymatically synthesized using β-D-glucosyltransferase. Pure 2-O-(β-D-glucopyranosyl)ascorbic acid may be produced from such compositions. Alternatively, 2-O-(β-D-glucopyranosyl)ascorbic acid may be produced by chemical synthesis. The 2-O-(β-D-glucopyranosyl)ascorbic acid results in higher stability and a prolonged life of vitamin C when ingested in the body compared to the corresponding α-D-glucopyranosyl derivative, and is therefore highly suitable as a provitamin C to be used in cosmetics and foods.
摘要翻译：与常规已知的2-O-（α-D-吡喃葡萄糖基）抗坏血酸相比，本发明提供了一种新型抗坏血酸衍生物作为维生素C，具有改善体内的稳定性和延长的身体寿命。从宁夏枸杞子和/或枸杞子植物提取含有新化合物2-O-（＆bgr-D-吡喃葡萄糖基）抗坏血酸的组合物。可以使用β-葡萄糖基转移酶酶法合成包含2-O-（β-谷氨酰-D-吡喃葡萄糖基）抗坏血酸的组合物。可以从这样的组合物制备纯2-O-（＆bgr-D-吡喃葡萄糖基）抗坏血酸。或者，可通过化学合成制备2-O-（＆bgr-D-吡喃葡萄糖基）抗坏血酸。与对应的α-D-吡喃葡萄糖基衍生物相比，2-O-（＆bgr-D-吡喃葡萄糖基）抗坏血酸在身体摄取时导致更高的稳定性和更长的维生素C的使用寿命，因此非常适合作为维生素 C用于化妆品和食品。

3. 发明申请

US20080058409A1 Esterified Catechins, Processes for Producing the Same, and Foods and Beverages as well as Cosmetics Containing Such Esterified Catechins 审中-公开
标题翻译：酯化儿茶素，其制备方法，食品和饮料以及含有这种酯化儿茶素的化妆品
公开(公告)号：US20080058409A1
公开(公告)日：2008-03-06
申请号：US11795959
申请日：2006-01-25
申请人： Harukazu Fukami , Masahiro Nakao , Koshi Namikawa , Mitsuru Maeda
发明人： Harukazu Fukami , Masahiro Nakao , Koshi Namikawa , Mitsuru Maeda
IPC分类号： A61K31/352 , A61P31/04 , C07D311/04 , C12P17/06
CPC分类号： C12P17/06 , A01N43/16 , A23L3/3472 , A23L3/3517 , A61K8/498 , A61Q17/005 , C07D311/62
摘要： The present invention provides substances having sufficiently antibacterial activity against heat-resistant spore-forming bacteria that they can be used to improve the shelf life of beverages and processed foods, as well as to control the growth of microorganisms in cosmetics. The present invention provides a catechin ester in which at least one of the hydroxyl groups of a catechin is esterified with a medium-chain fatty acid. This medium-chain fatty acid ester of a catechin, which may be used either alone or as a composition, shows a strong growth suppressing effect on heat-resistant spore-forming bacteria and, if added to foods or beverages, can prevent them from rotting or deterioration and, if added to cosmetics, can prevent their rotting or deterioration.
摘要翻译：本发明提供对耐热孢子形成细菌具有足够抗菌活性的物质，它们可用于改善饮料和加工食品的保质期，以及控制化妆品中微生物的生长。本发明提供一种儿茶素酯，其中儿茶素的至少一个羟基与中链脂肪酸酯化。可以单独或作为组合物使用的儿茶素的该中链脂肪酸酯对耐热孢子形成细菌具有强烈的生长抑制作用，如果添加到食品或饮料中，可以防止它们的腐烂或变质，如果添加到化妆品中，可以防止其腐烂或变质。

4. 发明申请

US20100308155A1 HELICOPTER, ROTOR THEREOF, AND CONTROL METHOD THEREOF 有权
标题翻译：直升机，转子及其控制方法
公开(公告)号：US20100308155A1
公开(公告)日：2010-12-09
申请号：US12811295
申请日：2009-01-09
申请人： Masahiro Nakao
发明人： Masahiro Nakao
IPC分类号： B64C27/54 , B64C11/12
CPC分类号： B64C27/51 , B64C27/54
摘要： A helicopter rotor include a blade, a rotor hub which supports the blade, and a lead-lag angle mechanism configured to change a lead-lag angle of the blade, in synchronization with a rotation of the rotor hub. The lead-lag angle mechanism changes the lead-lag angle of the blade such that a circumferential speed of a blade tip of the blade (3) is slow on a forward side and fast on a backward side. Accordingly, a helicopter, a helicopter rotor, and a control method of helicopter that enable high speed flight are provided.
摘要翻译：直升机转子包括叶片，支撑叶片的转子轮毂和与转子毂的旋转同步地改变叶片的牵引滞后角的引导滞后角机构。超前滞后角机构改变叶片的超前滞后角，使得叶片（3）的叶片尖端的圆周速度在前侧缓慢并且在后方快速。因此，提供直升机，直升机转子和能够实现高速飞行的直升机的控制方法。

5. 发明申请

US20100256345A1 METHOD FOR GLYCOSYLATION OF FLAVONOID COMPOUNDS 有权
标题翻译：氟虫腈化合物的糖苷化方法
公开(公告)号：US20100256345A1
公开(公告)日：2010-10-07
申请号：US12523065
申请日：2008-01-18
申请人： Misa Ochiai , Harukazu Fukami , Masahiro Nakao , Akio Noguchi
发明人： Misa Ochiai , Harukazu Fukami , Masahiro Nakao , Akio Noguchi
IPC分类号： C07H17/04 , C12P19/60 , C12N9/24
CPC分类号： A61K31/7048 , A23L2/52 , A23L29/06 , A23L33/105 , A23V2002/00 , A61K8/602 , A61K31/7034 , A61Q19/00 , C07H15/203 , C07H17/065 , C12P19/14 , A23V2250/21166 , A23V2250/208
摘要： The present invention provides a method for preparing a glycoside of a flavonoid compound, which comprises the step of treating flavonoid and a glycosyl donor with an enzymatic agent having glycosylation activity and being derived from the genus Trichoderma (preferably Trichoderma viride or Trichoderma reesei). Such a flavonoid compound includes a catechin compound or a methylated derivative thereof, and the glycosyl donor includes a carbohydrate containing a maltotriose residue (preferably maltotriose, maltotetraose, maltopentaose, maltohexaose, maltoheptaose, dextrin, γ-cyclodextrin or soluble starch). Glycosides obtained by the present invention have higher water solubility, improved taste, and increased stability. The present invention also provides novel glycosides of catechin compounds, which are obtained by the method of the present invention.
摘要翻译：本发明提供了一种制备类黄酮化合物的糖苷的方法，其包括用具有糖基化活性的酶促处理类黄酮和糖基供体的步骤，其衍生自木霉属（优选绿色木霉或里氏木霉）。这种类黄酮化合物包括儿茶素化合物或其甲基化衍生物，糖基供体包括含有麦芽三糖残基（优选麦芽三糖，麦芽四糖，麦芽五糖，麦芽六糖，麦芽七糖，糊精，γ-环糊精或可溶性淀粉）的碳水化合物。通过本发明获得的糖苷具有较高的水溶性，改善的味道和增加的稳定性。本发明还提供了通过本发明的方法获得的新颖的儿茶素化合物的糖苷。

6. 发明授权

US07566698B2 2-O-(β-D-glucopyranosyl) ascorbic acid, process for its production, and foods and cosmetics containing compositions comprising it 有权
标题翻译： 2-O-（β-D-吡喃葡萄糖基）抗坏血酸，其生产方法，以及含有组合物的食品和化妆品
公开(公告)号：US07566698B2
公开(公告)日：2009-07-28
申请号：US10500334
申请日：2002-12-27
申请人： Mitsuru Maeda , Masahiro Nakao , Harukazu Fukami
发明人： Mitsuru Maeda , Masahiro Nakao , Harukazu Fukami
IPC分类号： A01N43/04 , A01N43/08 , C07H15/00 , C07H15/06
CPC分类号： A61K8/676 , A23L33/105 , A23L33/15 , A23V2002/00 , A61K8/602 , A61K31/375 , A61K2800/52 , A61Q17/04 , A61Q19/00 , A61Q19/02 , C07H1/08 , C07H17/04 , C12P19/60 , A23V2250/708
摘要： The present invention provides a novel ascorbic acid derivative as a provitamin C with improved stability in the body and prolonged life in the body compared to conventionally known 2-O-(α-D-glucopyranosyl)ascorbic acid. The composition comprising the novel compound 2-O-(β-D-glucopyranosyl)ascorbic acid has been extracted from plants such as from Ningxia Lycium barbarum L. and/or Lycium chinense Mill. The compositions comprising 2-O-(β-D-glucopyranosyl)ascorbic acid may be enzymatically synthesized using β-D-glucosyltransferase. Pure 2-O-(β-D-glucopyranosyl)ascorbic acid may be produced from such compositions. Alternatively, 2-O-(β-D-glucopyranosyl)ascorbic acid may be produced by chemical synthesis. The 2-O-(β-D-glucopyranosyl)ascorbic acid results in higher stability and a prolonged life of vitamin C when ingested in the body compared to the corresponding α-D-glucopyranosyl derivative, and is therefore highly suitable as a provitamin C to be used in cosmetics and foods.
摘要翻译：与常规已知的2-O-（α-D-吡喃葡萄糖基）抗坏血酸相比，本发明提供了一种新型抗坏血酸衍生物作为维生素C，其具有改善的身体稳定性和延长的身体寿命。含有新化合物2-O-（β-D-吡喃葡萄糖基）抗坏血酸的组合物已经从宁夏枸杞子和/或枸杞子等植物中提取出来。包含2-O-（β-D-吡喃葡萄糖基）抗坏血酸的组合物可以使用β-D-葡糖基转移酶酶促合成。可以从这样的组合物制备纯的2-O-（β-D-吡喃葡萄糖基）抗坏血酸。或者，可通过化学合成制备2-O-（β-D-吡喃葡萄糖基）抗坏血酸。与相应的α-D-吡喃葡萄糖基衍生物相比，2-O-（β-D-吡喃葡萄糖基）抗坏血酸产生更高的稳定性和摄取维生素C的寿命，因此非常适合作为维生素C 用于化妆品和食品。

7. 发明申请

US20070269454A1 Composition for External Use 有权
标题翻译：外部使用的组成
公开(公告)号：US20070269454A1
公开(公告)日：2007-11-22
申请号：US10561916
申请日：2004-06-25
申请人： Mitsuru Maeda , Masahiro Nakao , Harukazu Fukami
发明人： Mitsuru Maeda , Masahiro Nakao , Harukazu Fukami
IPC分类号： A61K31/7004 , A61K36/06 , A61P17/00
CPC分类号： A61Q19/02 , A61K8/676 , A61K8/99 , A61K31/704 , A61K2800/522 , A61K2800/70 , A61K2800/75 , A61K2800/782 , A61Q19/00 , Y10S435/913 , Y10S435/914 , Y10S435/918
摘要： A composition for external use, comprising 2-O-(β-D-glucopyranosyl)ascorbic acid represented by the formula (I): or a salt or ester thereof which is safe to the human body, and a koji mold or a processed koji. The composition for external use is excellent in skin permeability, containing an ascorbic acid derivative which is excellent in stability, utilized persistently in the living body, and strong in antioxidant activity, and has little skin irritation.
摘要翻译：一种外用组合物，其包含由式（I）表示的2-O-（β-D-吡喃葡萄糖基）抗坏血酸：或其对人体安全的盐或酯，以及曲霉或加工曲。外用组合物的皮肤透过性优异，含有稳定性优异的抗坏血酸衍生物，在生物体中持续使用，抗氧化活性强，皮肤刺激性小。

8. 发明授权

US08207320B2 Lipase 有权
标题翻译：脂肪酶
公开(公告)号：US08207320B2
公开(公告)日：2012-06-26
申请号：US12981929
申请日：2010-12-30
申请人： Masahiro Nakao , Masaki Kanamori , Harukazu Fukami , Hiroaki Kasai , Misa Ochiai
发明人： Masahiro Nakao , Masaki Kanamori , Harukazu Fukami , Hiroaki Kasai , Misa Ochiai
IPC分类号： C07H21/02 , C12N1/20 , C12N15/00
CPC分类号： C12N9/20 , C12P7/6409 , C12P7/6436 , C12R1/01
摘要： The present invention provides a novel lipase with a molecular weight of about 32 kDa, which is produced by a strain belonging to the genus Tetrasphaera, as well as a gene encoding the same. This lipase has the ability to recognize a medium-chain fatty acid as a substrate. The present invention also provides a novel lipase with a molecular weight of about 40 kDa, which is produced by a strain belonging to the genus Tetrasphaera and has the ability to recognize both a medium-chain fatty acid and a long-chain fatty acid as substrates, as well as a polynucleotide encoding the same. The present invention further provides Tetrasphaera sp. strain NITE P-154. The lipase of the present invention can be used as an immobilized enzyme and is useful in fields such as production of digestants and/or flavorings, production of clinical laboratory reagents, detergent enzymes and/or fats, as well as production of optically active intermediates for agricultural chemicals and pharmaceutical preparations.
摘要翻译：本发明提供了一种分子量约32kDa的新型脂肪酶，其由属于四联属属的菌株产生，以及编码该脂肪酶的基因。该脂肪酶具有识别中链脂肪酸作为底物的能力。本发明还提供了一种分子量约40kDa的新型脂肪酶，其由属于四味子属的菌株产生，并且具有将中链脂肪酸和长链脂肪酸同时识别为底物的能力，以及编码该多核苷酸的多核苷酸。本发明进一步提供了Tetrasphaera sp。菌株NITE P-154。本发明的脂肪酶可以用作固定化酶，可用于生产消化剂和/或调味剂，生产临床实验室试剂，洗涤剂酶和/或脂肪等领域，以及生产光学活性中间体农药和药物制剂。

9. 发明授权

US07943583B2 2-O-(β-D-glucopyranosyl) ascorbic acid, process for its production, and foods cosmetics containing compositions comprising it 有权
标题翻译： 2-O-（＆bgr-D-吡喃葡萄糖基）抗坏血酸，其生产方法，以及含有组合物的食品化妆品
公开(公告)号：US07943583B2
公开(公告)日：2011-05-17
申请号：US11501074
申请日：2006-08-09
申请人： Mitsuru Maeda , Masahiro Nakao , Harukazu Fukami
发明人： Mitsuru Maeda , Masahiro Nakao , Harukazu Fukami
IPC分类号： A01N43/04 , A01N43/06
CPC分类号： A61K8/676 , A23L33/105 , A23L33/15 , A23V2002/00 , A61K8/602 , A61K31/375 , A61K2800/52 , A61Q17/04 , A61Q19/00 , A61Q19/02 , C07H1/08 , C07H17/04 , C12P19/60 , A23V2250/708
摘要： The present invention provides a novel ascorbic acid derivative as a provitamin C with improved stability in the body and prolonged life in the body compared to conventionally known 2-O-(β-D-glucopyranosyl)ascorbic acid. The composition comprising the novel compound 2-O- (β-D-glucopyranosyl)ascorbic acid has been extracted from plants such as from Ningxia Lycium barbarum L. and/or Lycium chinense Mill. The compositions comprising 2-O-(βD-glucopyranosyl) ascorbic acid may be enzymatically synthesized using β-D-glucosyltransferase. Pure 2-O-(β-D-glucopyranosyl)ascorbic acid may be produced from such compositions. Alternatively, 2-O-(β-D-glucopyranosyl)ascorbic acid may be produced by chemical synthesis. The 2-O-(β-D-glucopyranosyl)ascorbic acid results in higher stability and a prolonged life of vitamin C when ingested in the body compared to the corresponding α-D-glucopyranosyl derivative, and is therefore highly suitable as a provitamin C to be used in cosmetics and foods.
摘要翻译：本发明提供了一种新颖的抗坏血酸衍生物作为前维生素C，与常规已知的2-O-（β-葡萄糖-D-吡喃葡萄糖基）抗坏血酸相比，体内的稳定性和体内寿命延长。含有新化合物2-O-（＆bgr-D-吡喃葡萄糖基）抗坏血酸的组合物已经从宁夏枸杞子和/或枸杞子等植物中提取出来。包含2-O-（β-葡萄糖吡喃糖基）抗坏血酸的组合物可以使用β-葡糖基转移酶酶促合成。可以从这样的组合物制备纯2-O-（＆bgr-D-吡喃葡萄糖基）抗坏血酸。或者，可通过化学合成制备2-O-（＆bgr-D-吡喃葡萄糖基）抗坏血酸。与对应的α-D-吡喃葡萄糖基衍生物相比，2-O-（＆bgr-D-吡喃葡萄糖基）抗坏血酸在身体摄取时导致更高的稳定性和更长的维生素C的使用寿命，因此非常适合作为维生素 C用于化妆品和食品。

10. 发明申请

US20050113312A1 2-0-(-d-glucopyranosyl) ascorbic acid, process for its production, and foods and cosmetics containning compositions comprising it 有权
标题翻译： 2-0 - （ - d-吡喃葡萄糖基）抗坏血酸，其生产方法，以及包含它的食品和化妆品包含组合物
公开(公告)号：US20050113312A1
公开(公告)日：2005-05-26
申请号：US10500334
申请日：2002-12-27
申请人： Mitsuru Maeda , Masahiro Nakao , Harukazu Fukami
发明人： Mitsuru Maeda , Masahiro Nakao , Harukazu Fukami
IPC分类号： A23L1/30 , A23L1/302 , A61K8/00 , A61K8/60 , A61K8/67 , A61K8/96 , A61K8/97 , A61K31/7048 , A61K36/81 , A61P3/02 , A61P9/10 , A61P17/00 , A61P17/16 , A61P35/00 , A61P37/04 , A61P39/06 , A61P43/00 , A61Q17/00 , A61Q17/04 , A61Q19/00 , A61Q19/02 , A61Q19/08 , C07H1/08 , C07H17/04 , C12P19/60 , A61K31/70 , C07H15/04
CPC分类号： A61K8/676 , A23L33/105 , A23L33/15 , A23V2002/00 , A61K8/602 , A61K31/375 , A61K2800/52 , A61Q17/04 , A61Q19/00 , A61Q19/02 , C07H1/08 , C07H17/04 , C12P19/60 , A23V2250/708
摘要： The present invention provides a novel ascorbic acid derivative as a provitamin C with improved stability in the body and prolonged life in the body compared to conventionally known 2-O-(α-D-glucopyranosyl)ascorbic acid. The composition comprising the novel compound 2-β-(-D-glucopyranosyl)ascorbic acid has been extracted from plants such as from Ningxia Lycium barbarum L. and/or Lycium chinense Mill. The compositions comprising 2-O-(β-D-glucopyranosyl)ascorbic acid may be enzymatically synthesized using β-D-glucosyltransferase. Pure 2-O-(β-D-glucopyranosyl)ascorbic acid may be produced from such compositions. Alternatively, 2-O-(β-D-glucopyranosyl)ascorbic acid may be produced by chemical synthesis. The 2-O-(β-D-glucopyranosyl)ascorbic acid results in higher stability and a prolonged life of vitamin C when ingested in the body compared to the corresponding α-D-glucopyranosyl derivative, and is therefore highly suitable as a provitamin C to be used in cosmetics and foods.
摘要翻译：与常规已知的2-O-（α-D-吡喃葡萄糖基）抗坏血酸相比，本发明提供了一种新型抗坏血酸衍生物作为维生素C，其具有改善的身体稳定性和延长的身体寿命。含有新化合物2-β-D-吡喃葡萄糖基抗坏血酸的组合物已经从宁夏枸杞子和/或枸杞子植物中提取出来。包含2-O-（β-D-吡喃葡萄糖基）抗坏血酸的组合物可以使用β-D-葡糖基转移酶酶促合成。可以从这样的组合物制备纯的2-O-（β-D-吡喃葡萄糖基）抗坏血酸。或者，可通过化学合成制备2-O-（β-D-吡喃葡萄糖基）抗坏血酸。与相应的α-D-吡喃葡萄糖基衍生物相比，2-O-（β-D-吡喃葡萄糖基）抗坏血酸产生更高的稳定性和摄取维生素C的寿命，因此非常适合作为维生素C 用于化妆品和食品。

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