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1. 发明授权

US07767812B2 Crystals of pyrimidine compound and process for producing the same 失效
标题翻译：嘧啶化合物的晶体及其制备方法
公开(公告)号：US07767812B2
公开(公告)日：2010-08-03
申请号：US12346544
申请日：2008-12-30
申请人： Hitoshi Harada , Hiroshi Ishihara , Yoshiaki Sato , Hiroyuki Chiba , Yuki Komatsu , Susumu Inoue , Naoki Ozeki
发明人： Hitoshi Harada , Hiroshi Ishihara , Yoshiaki Sato , Hiroyuki Chiba , Yuki Komatsu , Susumu Inoue , Naoki Ozeki
IPC分类号： C07D401/00 , C07D403/00 , C07D405/00 , C07D409/00 , C07D411/00 , C07D413/00 , C07D417/00 , C07D419/00
CPC分类号： C07D405/14 , C07D405/06
摘要： Crystals of 5-[2-amino-4-(2-furyl)pyrimidin-5-yl]-1-methylpyridin-2(1H)-one having a diffraction peak at a diffraction angle (2θ±0.2°) of 9.7° and/or 21.9° in a powder X-ray diffraction are suitable for an active ingredient of a preventing and therapeutic agent for diseases such as constipation. Crystals of 5-[2-amino-4-(2-furyl)pyrimidin-5-yl]-1-methylpyridin-2(1H)-one hydrate and amorphous 5-[2-amino-4-(2-furyl)pyrimidin-5-yl]-1-methylpyridin-2(1H)-one hydrate are also suitable for an active ingredient of a preventing and therapeutic agent for diseases such as constipation.
摘要翻译：在衍射角（2θ;±0.2°）为9.7°的衍射峰的5- [2-氨基-4-（2-呋喃基）嘧啶-5-基] -1-甲基吡啶-2（1H） - 酮的晶体 °和/或21.9°在粉末X射线衍射中适用于诸如便秘的疾病的预防和治疗剂的活性成分。 5- [2-氨基-4-（2-呋喃基）嘧啶-5-基] -1-甲基吡啶-2（1H） - 酮水合物和无定形的5- [2-氨基-4-（2-呋喃基）嘧啶-5-基] -1-甲基吡啶-2（1H） - 酮水合物也适用于诸如便秘等疾病的预防和治疗剂的活性成分。

2. 发明申请

US20070078151A1 Crystalline and amorphous pyrimidine compounds and processes for preparing pyrimidine compounds 失效
标题翻译：结晶和无定形嘧啶化合物及制备嘧啶化合物的方法
公开(公告)号：US20070078151A1
公开(公告)日：2007-04-05
申请号：US11378307
申请日：2006-03-20
申请人： Hitoshi Harada , Hiroshi Ishihara , Yoshiaki Sato , Hiroyuki Chiba , Yuki Komatsu , Susumu Inoue , Naoki Ozeki
发明人： Hitoshi Harada , Hiroshi Ishihara , Yoshiaki Sato , Hiroyuki Chiba , Yuki Komatsu , Susumu Inoue , Naoki Ozeki
IPC分类号： A61K31/506 , C07D405/14
CPC分类号： C07D405/14 , C07D405/06
摘要： Crystals of 5-[2-amino-4-(2-furyl)pyrimidin-5-yl]-1-methylpyridin-2(1H)-one having a diffraction peak at a diffraction angle (2θ±0.2°) of 9.7° and/or 21.9° in a powder X-ray diffraction are suitable for an active ingredient of a preventing and therapeutic agent for diseases such as constipation. Crystals of 5-[2-amino-4-(2-furyl)pyrimidin-5-yl]-1-methylpyridin-2(1H)-one hydrate and amorphous 5-[2-amino-4-(2-furyl)pyrimidin-5-yl]-1-methylpyridin-2(1H)-one hydrate are also suitable for an active ingredient of a preventing and therapeutic agent for diseases such as constipation.
摘要翻译：在衍射角（2θ±0.2°）为9.7°的衍射峰的5- [2-氨基-4-（2-呋喃基）嘧啶-5-基] -1-甲基吡啶-2（1H） - 酮的晶体和/或21.9°在粉末X射线衍射中适用于诸如便秘的疾病的预防和治疗剂的活性成分。 5- [2-氨基-4-（2-呋喃基）嘧啶-5-基] -1-甲基吡啶-2（1H） - 酮水合物和无定形的5- [2-氨基-4-（2-呋喃基）嘧啶-5-基] -1-甲基吡啶-2（1H） - 酮水合物也适用于诸如便秘等疾病的预防和治疗剂的活性成分。

3. 发明申请

US20090111986A1 NOVEL CRYSTALS OF PYRIMIDINE COMPOUND AND PROCESS FOR PRODUCING THE SAME 失效
标题翻译：吡啶化合物的新型结晶及其制造方法
公开(公告)号：US20090111986A1
公开(公告)日：2009-04-30
申请号：US12346544
申请日：2008-12-30
申请人： Hitoshi HARADA , Hiroshi Ishihara , Yoshiaki Sato , Hiroyuki Chiba , Yuki Komatsu , Susumu Inoue , Naoki Ozeki
发明人： Hitoshi HARADA , Hiroshi Ishihara , Yoshiaki Sato , Hiroyuki Chiba , Yuki Komatsu , Susumu Inoue , Naoki Ozeki
IPC分类号： C07D405/14 , C07D405/02
CPC分类号： C07D405/14 , C07D405/06
摘要： Crystals of 5-[2-amino-4-(2-furyl)pyrimidin-5-yl]-1-methylpyridin-2(1H)-one having a diffraction peak at a diffraction angle (2θ±0.2°) of 9.7° and/or 21.9° in a powder X-ray diffraction are suitable for an active ingredient of a preventing and therapeutic agent for diseases such as constipation. Crystals of 5-[2-amino-4-(2-furyl)pyrimidin-5-yl]-1-methylpyridin-2(1H)-one hydrate and amorphous 5-[2-amino-4-(2-furyl)pyrimidin-5-yl]-1-methylpyridin-2(1H)-one hydrate are also suitable for an active ingredient of a preventing and therapeutic agent for diseases such as constipation.
摘要翻译：在衍射角（2θ±0.2°）为9.7°的衍射峰的5- [2-氨基-4-（2-呋喃基）嘧啶-5-基] -1-甲基吡啶-2（1H） - 酮的晶体和/或21.9°在粉末X射线衍射中适用于诸如便秘的疾病的预防和治疗剂的活性成分。 5- [2-氨基-4-（2-呋喃基）嘧啶-5-基] -1-甲基吡啶-2（1H） - 酮水合物和无定形的5- [2-氨基-4-（2-呋喃基）嘧啶-5-基] -1-甲基吡啶-2（1H） - 酮水合物也适用于诸如便秘等疾病的预防和治疗剂的活性成分。

4. 发明授权

US07538117B2 Crystalline and amorphous pyrimidine compounds and processes for preparing pyrimidine compounds 失效
标题翻译：结晶和无定形嘧啶化合物及制备嘧啶化合物的方法
公开(公告)号：US07538117B2
公开(公告)日：2009-05-26
申请号：US11378307
申请日：2006-03-20
申请人： Hitoshi Harada , Hiroyuki Chiba , Yuki Komatsu , Susumu Inoue , Naoki Ozeki
发明人： Hitoshi Harada , Hiroyuki Chiba , Yuki Komatsu , Susumu Inoue , Naoki Ozeki
IPC分类号： A01N43/54 , A61K31/505
CPC分类号： C07D405/14 , C07D405/06
摘要： Crystals of 5-[2-amino-4-(2-furyl)pyrimidin-5-yl]-1-methylpyridin-2(1H)-one having a diffraction peak at a diffraction angle (2θ±0.2°) of 9.7° and/or 21.9° in a powder X-ray diffraction are suitable for an active ingredient of a preventing and therapeutic agent for diseases such as constipation. Crystals of 5-[2-amino-4-(2-furyl)pyrimidin-5-yl]-1-methylpyridin-2(1H)-one hydrate and amorphous 5-[2-amino-4-(2-furyl)pyrimidin-5-yl]-1-methylpyridin-2(1H)-one hydrate are also suitable for an active ingredient of a preventing and therapeutic agent for diseases such as constipation.
摘要翻译：在衍射角（2θ±0.2°）为9.7°的衍射峰的5- [2-氨基-4-（2-呋喃基）嘧啶-5-基] -1-甲基吡啶-2（1H） - 酮的晶体和/或21.9°在粉末X射线衍射中适用于诸如便秘的疾病的预防和治疗剂的活性成分。 5- [2-氨基-4-（2-呋喃基）嘧啶-5-基] -1-甲基吡啶-2（1H） - 酮水合物和无定形的5- [2-氨基-4-（2-呋喃基）嘧啶-5-基] -1-甲基吡啶-2（1H） - 酮水合物也适用于诸如便秘等疾病的预防和治疗剂的活性成分。

5. 发明授权

US06573384B1 Process for production of indole derivatives and intermediates therefor 失效
标题翻译：吲哚衍生物及其中间体的制备方法
公开(公告)号：US06573384B1
公开(公告)日：2003-06-03
申请号：US09937929
申请日：2001-11-13
申请人： Manabu Shasho , Yuki Komatsu , Mamoru Miyazawa , Kimihiro Matsuo , Susumu Inoue , Kohshi Ueno
发明人： Manabu Shasho , Yuki Komatsu , Mamoru Miyazawa , Kimihiro Matsuo , Susumu Inoue , Kohshi Ueno
IPC分类号： C07D40104
CPC分类号： C07D401/04
摘要： To provide a novel, industrially superior process for producing a 1,4-substituted cyclic amine compound which is useful as a pharmaceutical, and an intermediate for the process. That is, a process for producing an indole compound (I), which comprises reducing a 1,4-subsutituted 2-nitrophenyl compound (VII) to give a 1,4-substituted 2-aminophenyl compound (V); reacting the compound (V) with an N-substituted 4-piperidone compound (VI) to give a 1,4-substituted 2-piperidylaminophenyl compound (IV); cyclizing the compound (IV) to give a 2-oxoindoline compound (III); halogenating the compound (III) to give a 2-halogenated indole compound (II); reducing the compound (II); and if necessary subjecting the resulting compound to alcoholysis or aminolysis. wherein each of R1 and R2 represents a substituent; X represents a halogen atom; and n is a numerical subscript.
摘要翻译：提供一种工业上优异的制备用作药物的1,4-取代的环胺化合物的方法，以及该方法的中间体。也就是说，制备吲哚化合物（I）的方法，其包括还原1,4-取代的2-硝基苯基化合物（VII）以得到1,4-取代的2-氨基苯基化合物（V）; 使化合物（V）与N-取代的4-哌啶酮化合物（Ⅵ）反应，得到1,4-取代的2-哌啶基氨基苯基化合物（Ⅳ）。使化合物（IV）环化，得到2-氧代二氢吲哚化合物（III）; 卤化化合物（Ⅲ）得到2-卤代吲哚化合物（Ⅱ）; 还原化合物（II）; 并且如果需要，将所得化合物进行醇解或氨解。其中R 1和R 2各自表示取代基; X表示卤原子; n是数字下标。

6. 发明授权

US07992048B2 Computer system and method for performing failure detecting processing for a logical path 有权
标题翻译：用于对逻辑路径执行故障检测处理的计算机系统和方法
公开(公告)号：US07992048B2
公开(公告)日：2011-08-02
申请号：US12611272
申请日：2009-11-03
申请人： Yuki Komatsu , Makoto Aoki
发明人： Yuki Komatsu , Makoto Aoki
IPC分类号： G06F11/00 , G06F11/34
CPC分类号： G06F11/201 , G06F3/0611 , G06F3/0635 , G06F3/067
摘要： Provided is a computer system including at least one host computer; and at least one storage system, characterized in that: the storage system has a disk drive and a disk controller, and provides a storage area of the disk drive as at least one logical unit; upon detecting a failure in a logical path serving as an access route from the host computer to the logical unit, the host computer specifies logical paths for accessing the same logical unit that is connected to the logical path where the failure is detected; the host computer executes failure detecting processing for the specified logical paths to judge whether the specified logical paths are normal or not; the host computer selects normal logical paths out of the specified logical paths; and the host computer accesses the logical unit via the normal logical paths selected.
摘要翻译：提供了一种包括至少一台主机的计算机系统; 以及至少一个存储系统，其特征在于：所述存储系统具有磁盘驱动器和磁盘控制器，并且提供所述磁盘驱动器的存储区域作为至少一个逻辑单元; 在检测到从主计算机到逻辑单元的访问路由的逻辑路径中的故障时，主计算机指定用于访问连接到检测到故障的逻辑路径的相同逻辑单元的逻辑路径; 主计算机对指定的逻辑路径执行故障检测处理，以判断指定的逻辑路径是否正常; 主机从指定的逻辑路径中选择正常的逻辑路径; 并且主机通过所选择的正常逻辑路径访问逻辑单元。

7. 发明申请

US20070094357A1 Computer system for balancing access load of storage systems and control method therefor 失效
标题翻译：用于平衡存储系统的访问负载的计算机系统及其控制方法
公开(公告)号：US20070094357A1
公开(公告)日：2007-04-26
申请号：US11296313
申请日：2005-12-08
申请人： Hiroshi Sugitani , Yuki Komatsu
发明人： Hiroshi Sugitani , Yuki Komatsu
IPC分类号： G06F15/16
CPC分类号： G06F9/505 , G06F2209/5019 , H04L67/1002 , H04L67/1008 , H04L67/1012 , H04L67/1029 , H04L67/1031 , H04L67/1097
摘要： Provided is a control method for a computer system including one or more host computers, one or more storage systems, and a management computer. The storage system includes a plurality of controllers connected to the host computers through a network, and one or more logical volumes for storing data used by the host computers. At least one of the logical volumes is assigned to at least one of the controllers. According to the control method, when performance information of a controller exceeds a predetermined threshold, the logical volume assigned to the controller is assigned to another controller other than the controller. Thus, access loads on a storage system used in a network environment are balanced.
摘要翻译：提供一种用于包括一个或多个主计算机，一个或多个存储系统和管理计算机的计算机系统的控制方法。存储系统包括通过网络连接到主计算机的多个控制器以及用于存储主计算机使用的数据的一个或多个逻辑卷。至少一个逻辑卷被分配给至少一个控制器。根据控制方法，当控制器的性能信息超过预定阈值时，分配给控制器的逻辑卷分配给控制器以外的另一个控制器。因此，在网络环境中使用的存储系统上的访问负载是平衡的。

8. 发明申请

US20090204733A1 PATH MAINTENANCE MECHANISM 有权
标题翻译：路径维护机制
公开(公告)号：US20090204733A1
公开(公告)日：2009-08-13
申请号：US12415346
申请日：2009-03-31
申请人： Yuki Komatsu , Makoto Aoki
发明人： Yuki Komatsu , Makoto Aoki
IPC分类号： G06F3/00
CPC分类号： G06F11/201 , H04L45/02
摘要： In the computer system including a host computer and a storage system, the storage system includes a physical disk and a disk controller, and provides a storage area of the physical disk as at least one logical unit. The processor obtains, at a first time point and a second time point different from the first time point, a relation between a logical path and a component through which the logical path passes, stores, as logical path connection information, the relations obtained at the first time point and the second time point, refers to the logical path connection information to compare the logical paths existing at the first time point and the logical paths existing at the second time point with each other, and specifies the logical path which does not exist at the second time point among the logical paths existing at the first time point.
摘要翻译：在包括主计算机和存储系统的计算机系统中，存储系统包括物理盘和盘控制器，并且将物理盘的存储区域提供为至少一个逻辑单元。处理器在与第一时间点不同的第一时间点和第二时间点获得逻辑路径与逻辑路径通过的部件之间的关系，将作为逻辑路径连接信息的关系存储在第一时间点和第二时间点是指逻辑路径连接信息，用于比较存在于第一时间点的逻辑路径和第二时间点存在的逻辑路径，并指定不存在的逻辑路径在第一时间点存在的逻辑路径中的第二时间点。

9. 发明申请

US20080005397A1 Path maintenance mechanism 审中-公开
标题翻译：路径维护机制
公开(公告)号：US20080005397A1
公开(公告)日：2008-01-03
申请号：US11483669
申请日：2006-07-11
申请人： Yuki Komatsu , Makoto Aoki
发明人： Yuki Komatsu , Makoto Aoki
IPC分类号： G06F3/00 , G06F5/00
CPC分类号： G06F11/201 , H04L45/02
摘要： In the computer system including a host computer and a storage system, the storage system includes a physical disk and a disk controller, and provides a storage area of the physical disk as at least one logical unit. The processor obtains, at a first time point and a second time point different from the first time point, a relation between a logical path and a component through which the logical path passes, stores, as logical path connection information, the relations obtained at the first time point and the second time point, refers to the logical path connection information to compare the logical paths existing at the first time point and the logical paths existing at the second time point with each other, and specifies the logical path which does not exist at the second time point among the logical paths existing at the first time point.
摘要翻译：在包括主计算机和存储系统的计算机系统中，存储系统包括物理盘和盘控制器，并且将物理盘的存储区域提供为至少一个逻辑单元。处理器在与第一时间点不同的第一时间点和第二时间点获得逻辑路径与逻辑路径通过的部件之间的关系，将作为逻辑路径连接信息的关系存储在第一时间点和第二时间点是指逻辑路径连接信息，用于比较存在于第一时间点的逻辑路径和第二时间点存在的逻辑路径，并指定不存在的逻辑路径在第一时间点存在的逻辑路径中的第二时间点。

10. 发明授权

US08683482B2 Computer system for balancing access load of storage systems and control method therefor 失效
标题翻译：用于平衡存储系统的访问负载的计算机系统及其控制方法
公开(公告)号：US08683482B2
公开(公告)日：2014-03-25
申请号：US11296313
申请日：2005-12-08
申请人： Hiroshi Sugitani , Yuki Komatsu
发明人： Hiroshi Sugitani , Yuki Komatsu
IPC分类号： G06F9/46
CPC分类号： G06F9/505 , G06F2209/5019 , H04L67/1002 , H04L67/1008 , H04L67/1012 , H04L67/1029 , H04L67/1031 , H04L67/1097
摘要： Provided is a control method for a computer system including one or more host computers, one or more storage systems, and a management computer. The storage system includes a plurality of controllers connected to the host computers through a network, and one or more logical volumes for storing data used by the host computers. At least one of the logical volumes is assigned to at least one of the controllers. According to the control method, when performance information of a controller exceeds a predetermined threshold, the logical volume assigned to the controller is assigned to another controller other than the controller. Thus, access loads on a storage system used in a network environment are balanced.
摘要翻译：提供一种用于包括一个或多个主计算机，一个或多个存储系统和管理计算机的计算机系统的控制方法。存储系统包括通过网络连接到主计算机的多个控制器以及用于存储主计算机使用的数据的一个或多个逻辑卷。至少一个逻辑卷被分配给至少一个控制器。根据控制方法，当控制器的性能信息超过预定阈值时，分配给控制器的逻辑卷分配给控制器以外的另一个控制器。因此，在网络环境中使用的存储系统上的访问负载是平衡的。

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