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1. 发明申请

US20070281009A1 N-Acetylglucosamine Tablet Disintegrating In Oral Cavity And Process For Producing The Same 审中-公开
标题翻译： N-乙酰葡萄糖胺片在口腔中的分解及其生产方法
公开(公告)号：US20070281009A1
公开(公告)日：2007-12-06
申请号：US11722955
申请日：2005-12-26
申请人： Hisayo Kamisono , Mamoru Okada , Yoshinari Tagata , Masatami Nakashima
发明人： Hisayo Kamisono , Mamoru Okada , Yoshinari Tagata , Masatami Nakashima
IPC分类号： A61K31/70 , A61K9/20 , A61P19/02
CPC分类号： A61K9/2018 , A61K9/0056 , A61K31/015 , A61K31/203 , A61K31/7008
摘要： It is intended to provide an N-acetylglucosamine tablet, with which N-acetylglucosamine can be taken in an amount at which a physiological activity can be expected in a small number of tablets, and which has an excellent disintegrating property and solubility in the oral cavity and has an adequate hardness to such an extent that it is not difficult to handle; and a process for producing the same. A saccharide having low moldability is mixed with or sprayed on N-acetylglucosamine to perform coating and/or granulation, and a saccharide having high moldability is mixed with the obtained granulated matter to perform molding, whereby the N-acetylglucosamine tablet disintegrating in oral cavity which has a tablet hardness of 5 to 20 kgf and a mass per tablet of 1,000 to 3,000 mg, and which rapidly disintegrates and dissolves in the oral cavity is obtained. The N-acetylglucosamine tablet disintegrating in oral cavity preferably contains 30 to 90% by mass of N-acetylglucosamine, and preferably contains 500 to 2,000 mg of N-acetylglucosamine per tablet.
摘要翻译：本发明提供一种N-乙酰氨基葡糖胺片剂，N-乙酰氨基葡糖胺可以以少量片剂预期的生理活性的量摄入N-乙酰葡糖胺，并且在口腔中具有优异的崩解性和溶解性并且具有足够的硬度至不难处理的程度; 及其制造方法。将具有低成型性的糖与N-乙酰葡糖胺混合或喷雾以进行包衣和/或造粒，并将具有高成型性的糖与所得颗粒物混合进行成型，由此N-乙酰葡糖胺片在口腔中崩解，片剂硬度为5〜20kgf，每片剂量为1,000〜3,000mg，能够快速地分解并溶解于口腔。在口腔中崩解的N-乙酰葡糖胺片剂优选含有30〜90质量％的N-乙酰葡糖胺，优选每片含有500〜2000mg N-乙酰葡糖胺。

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