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1. 发明授权

US07087158B2 Oxygen-supply-capable cooling water equipment, filtration-equipment and filtration-equipped cooling water equipment incorporated with these equipment 失效
标题翻译：配有供氧设备的冷却水设备，过滤设备和配备有过滤设备的冷却水设备
公开(公告)号：US07087158B2
公开(公告)日：2006-08-08
申请号：US10928132
申请日：2004-08-30
申请人： Hisashi Miyamoto , Akira Nakano
发明人： Hisashi Miyamoto , Akira Nakano
IPC分类号： A01K63/04
CPC分类号： A01K63/045 , A01K63/042 , F28C1/02
摘要： Filtration-function-equipped cooling water equipment that includes: filtration equipment connected to water-purifying, oxygen-supply-capable cooling water equipment, wherein the filtration equipment includes a filtration space for a filter, wherein the water-purifying, oxygen-supply-capable cooling water equipment comprises a cooling oxidation unit disposed inside of a tank body and comprising a honeycombed or latticed porous material, wherein the filtration-function-equipped cooling water equipment operates to enlarge a contact area between water and air when untreated water drips onto the cooling oxidation unit and flows through the cooling oxidation unit while forced air flows in a counter current against the flow of water in the cooling oxidation unit, thereby facilitating solubility of oxygen in the untreated water and augmenting a cooling capability due to evaporation provided by the water-purifying, oxygen-supply-capable cooling water equipment.
摘要翻译：具有过滤功能的冷却水设备，包括：与净水，供氧能力的冷却水设备连接的过滤设备，其中过滤设备包括用于过滤器的过滤空间，其中净水，供氧 - 冷却水设备包括设置在罐体内部并包括蜂窝状或网状多孔材料的冷却氧化单元，其中配备过滤功能的冷却水设备用于当未处理的水滴入到水中时扩大水和空气之间的接触面积冷却氧化单元并流过冷却氧化单元，同时强制空气以相对于冷却氧化单元中的水流的逆流流动，从而促进氧在未处理水中的溶解度并且由于由水提供的蒸发而增加冷却能力纯化，供氧能力的冷却水设备。

2. 发明申请

US20050029176A1 Oxygen-supply-capable cooling water equipment and filtration-function-equipped cooling water equipment incorporated with these equipment 失效
标题翻译：配备有供氧能力的冷却水设备和配备过滤功能的冷却水设备
公开(公告)号：US20050029176A1
公开(公告)日：2005-02-10
申请号：US10928132
申请日：2004-08-30
申请人： Hisashi Miyamoto , Akira Nakano
发明人： Hisashi Miyamoto , Akira Nakano
IPC分类号： A01K63/04 , A01K63/06 , C02F1/00 , C02F3/04 , F28C1/02 , F28C1/10 , F28C1/16 , F28F25/04 , F28F25/06 , F28F25/08 , C02F3/02
CPC分类号： A01K63/045 , A01K63/042 , F28C1/02
摘要： Filtration-function-equipped cooling water equipment that includes: filtration equipment connected to water-purifying, oxygen-supply-capable cooling water equipment, wherein the filtration equipment includes a filtration space for a filter, wherein the water-purifying, oxygen-supply-capable cooling water equipment comprises a cooling oxidation unit disposed inside of a tank body and comprising a honeycombed or latticed porous material, wherein the filtration-function-equipped cooling water equipment operates to enlarge a contact area between water and air when untreated water drips onto the cooling oxidation unit and flows through the cooling oxidation unit while forced air flows in a counter current against the flow of water in the cooling oxidation unit, thereby facilitating solubility of oxygen in the untreated water and augmenting a cooling capability due to evaporation provided by the water-purifying, oxygen-supply-capable cooling water equipment.
摘要翻译：具有过滤功能的冷却水设备，包括：与净水，供氧能力的冷却水设备连接的过滤设备，其中过滤设备包括用于过滤器的过滤空间，其中净水，供氧 - 冷却水设备包括设置在罐体内部并包括蜂窝状或网状多孔材料的冷却氧化单元，其中配备过滤功能的冷却水设备用于当未处理的水滴入到水中时扩大水和空气之间的接触面积冷却氧化单元并流过冷却氧化单元，同时强制空气以相对于冷却氧化单元中的水流的逆流流动，从而促进氧在未处理水中的溶解度并且由于由水提供的蒸发而增加冷却能力纯化，供氧能力的冷却水设备。

3. 发明申请

US20070131596A1 OXYGEN-SUPPLY-CAPABLE COOLING WATER EQUIPMENT, FILTRATION EQUIPMENT AND FILTRATION-FUNCTION-EQUIPPED COOLING WATER EQUIPMENT INCORPORATED WITH THESE EQUIPMENT 审中-公开
标题翻译：氧气供应冷却水设备，过滤设备和过滤功能设备冷却水设备与这些设备合并
公开(公告)号：US20070131596A1
公开(公告)日：2007-06-14
申请号：US11457915
申请日：2006-07-17
申请人： Hisashi Miyamoto , Akira Nakano
发明人： Hisashi Miyamoto , Akira Nakano
IPC分类号： C02F3/04
CPC分类号： A01K63/045 , A01K63/042 , F28C1/02
摘要： Filtration-function-equipped cooling water equipment that includes: filtration equipment connected to water-purifying, oxygen-supply-capable cooling water equipment, wherein the filtration equipment includes a filtration space for a filter, wherein the water-purifying, oxygen-supply-capable cooling water equipment comprises a cooling oxidation unit disposed inside of a tank body, and comprising a honeycombed or latticed porous material, wherein the filtration-function-equipped cooling water equipment operates to enlarge a contact area between water and air when untreated water drips onto the cooling oxidation unit and flows through the cooling oxidation unit while forced air flows in a counter current against the flow of water in the cooling oxidation unit, thereby facilitating solubility of oxygen in the untreated water and augmenting a cooling capability due to evaporation provided by the water-purifying, oxygen-supply-capable cooling water equipment.
摘要翻译：具有过滤功能的冷却水设备，包括：与净水，供氧能力的冷却水设备连接的过滤设备，其中过滤设备包括用于过滤器的过滤空间，其中净水，供氧 - 能够使用的冷却水设备包括设置在罐体内部的冷却氧化单元，并且包括蜂窝状或网状多孔材料，其中，过滤功能配备的冷却水设备用于当未处理的水滴入到其上时扩大水和空气之间的接触面积冷却氧化单元，并且在强制空气以相反的流动相对于冷却氧化单元中的水流动流动时流过冷却氧化单元，从而促进氧在未处理水中的溶解度，并增加由于所提供的蒸发提供的蒸发的冷却能力净水，供氧能力的冷却水设备。

4. 发明授权

US5563138A Benzoheterocyclic compounds 失效
标题翻译：苯并杂环化合物
公开(公告)号：US5563138A
公开(公告)日：1996-10-08
申请号：US179239
申请日：1988-04-08
申请人： Hiraki Ueda , Hisashi Miyamoto , Hiroshi Yamashita , Hitoshi Tone
发明人： Hiraki Ueda , Hisashi Miyamoto , Hiroshi Yamashita , Hitoshi Tone
IPC分类号： C07D215/56 , A61K31/47 , A61K31/495 , A61K31/535 , A61K31/5375 , A61K31/54 , A61K31/55 , A61P31/04 , C07C25/02 , C07C25/13 , C07C63/04 , C07C63/06 , C07C63/70 , C07C69/716 , C07C69/738 , C07C205/11 , C07C205/12 , C07C211/47 , C07C211/52 , C07C229/30 , C07C229/34 , C07C321/16 , C07C323/29 , C07D207/09 , C07D207/14 , C07D215/22 , C07D241/04 , C07D295/04 , C07D295/16 , C07D319/06 , C07D401/04 , C07D405/06 , C07D405/12 , C07D409/04 , C07D413/04 , C07D487/04 , C07D491/04 , C07D498/04 , C07D498/06 , C07F5/04
CPC分类号： C07D491/04 , C07D215/56 , C07D401/04 , C07D405/12 , C07D409/04 , C07D487/04
摘要： Novel 4-oxoquinoline-3-carboxylic acid compounds of the formula: ##STR1## wherein R.sup.1 is cyclopropyl which may have 1 to 3 substituents of alkyl and halogen; phenyl which may be substituted by 1 to 3 substituents of alkoxy, halogen and OH; alkyl which may be substituted by halogen, alkanoyloxy or OH; alkenyl; or thienyl, R.sup.2 is 5- to 9-membered saturated or unsaturated heterocyclic ring which may be sustituted, R.sup.3 is alkyl, R is H or alkyl, and X is halogen, and pharmaceutically acceptable salts thereof, said compounds having excellent antimicrobial activity and hence being useful as an antimicrobial agent, and a pharmaceutical composition containing said compound as an active ingredient.
摘要翻译：具有下式的新型4-氧代喹啉-3-羧酸化合物：其中R 1是可以具有1至3个烷基和卤素取代基的环丙基; 可被1至3个烷氧基，卤素和OH取代基取代的苯基; 可被卤素，烷酰氧基或OH取代的烷基; 烯基; 或噻吩基，R 2为可被取代的5-至9-元饱和或不饱和杂环，R 3为烷基，R为H或烷基，X为卤素及其药学上可接受的盐，所述化合物具有优异的抗微生物活性，因此可用作抗微生物剂，以及含有所述化合物作为活性成分的药物组合物。

5. 发明授权

US5495020A Benzoheterocyclic compounds 失效
标题翻译：苯并杂环化合物
公开(公告)号：US5495020A
公开(公告)日：1996-02-27
申请号：US562034
申请日：1990-08-02
申请人： Hiraki Ueda , Hisashi Miyamoto , Hiroshi Yamashita , Hitoshi Tone
发明人： Hiraki Ueda , Hisashi Miyamoto , Hiroshi Yamashita , Hitoshi Tone
IPC分类号： C07D215/56 , A61K31/47 , A61K31/495 , A61K31/535 , A61K31/5375 , A61K31/54 , A61K31/55 , A61P31/04 , C07C25/02 , C07C25/13 , C07C63/04 , C07C63/06 , C07C63/70 , C07C69/716 , C07C69/738 , C07C205/11 , C07C205/12 , C07C211/47 , C07C211/52 , C07C229/30 , C07C229/34 , C07C321/16 , C07C323/29 , C07D207/09 , C07D207/14 , C07D215/22 , C07D241/04 , C07D295/04 , C07D295/16 , C07D319/06 , C07D401/04 , C07D405/06 , C07D405/12 , C07D409/04 , C07D413/04 , C07D487/04 , C07D491/04 , C07D498/04 , C07D498/06 , C07F5/04
CPC分类号： C07D491/04 , C07D215/56 , C07D401/04 , C07D405/12 , C07D409/04 , C07D487/04
摘要： Useful as intermediates for antimicrobacterial agents are compounds of the formulas ##STR1## wherein R.sup.1A is a cyclopropyl which may be substituted by 1 to 3 substituents selected from the group consisting of a C.sub.1 -C.sub.6 alkyl and a halogen atom; a phenyl which may be substituted by 1 to 3 substituents selected from the group consisting of a C.sub.1 -C.sub.6 alkoxy, a halogen atom and hydroxy on the phenyl group; a C.sub.1 -C.sub.6 alkyl which may be substituted by a halogen atom, a C.sub.1 -C.sub.6 alkanoyloxy or hydroxy; a C.sub.2 -C.sub.6 alkenyl; or thienyl,R.sup.3A is a C.sub.1 -C.sub.6 alkyl group, or a halogen atom,R.sup.4 is a C.sub.1 -C.sub.6 alkyl group,R.sup.14 is a hydrogen atom, a lower alkyl group, or a group of the formula ##STR2## R.sup.31 is hydrogen or a C.sub.1 -C.sub.6 alkyl group, and X and X.sup.4 are halogen atoms, and salts thereof.
摘要翻译：作为抗微生物剂的中间体有用的是下式的化合物：其中R 1A是可以被1-3个选自C1-C6烷基和卤素原子的取代基取代的环丙基; 可以被1-3个选自C1-C6烷氧基，卤素原子和苯基上的羟基的取代基取代的苯基; 可被卤素原子取代的C1-C6烷基，C1-C6烷酰氧基或羟基; C 2 -C 6烯基; 或噻吩基，R 3A为C1-C6烷基或卤素原子，R4为C1-C6烷基，R14为氢原子，低级烷基或式为R3的基团为氢或 C 1 -C 6烷基，X和X 4为卤素原子，及其盐。

6. 发明授权

US07026486B2 Process for production cilostazol 失效
标题翻译：西洛他唑生产工艺
公开(公告)号：US07026486B2
公开(公告)日：2006-04-11
申请号：US10488951
申请日：2003-09-09
申请人： Akihiro Yamamoto , Norihiro Fukuyama , Yoshihiko Okaichi , Yasuhiro Yamada , Hisashi Miyamoto , Michiaki Tominaga
发明人： Akihiro Yamamoto , Norihiro Fukuyama , Yoshihiko Okaichi , Yasuhiro Yamada , Hisashi Miyamoto , Michiaki Tominaga
IPC分类号： C07D215/16 , C07D215/20
CPC分类号： C07D401/12
摘要： The present invention provides a process for producing cilostazol [I] in a high yield and a high purity, by reacting a carbostyril derivative [II] with a tetrazole derivative [III] in the presence of an inorganic basic compound in a solvent of water, wherein water is used in an amount of 3 to 7-fold weight to that of the carbostyril derivative [II] and the inorganic basic compound is used in an amount of 1 to 6 mol per mol of the carbostyril derivative [II]. The process of the present invention is the improved and environment-friendly process for producing cilostazol being useful for pharmaceuticals
摘要翻译：本发明通过在无机碱性化合物存在下，在水的溶剂中使喹诺酮衍生物[II]与四唑衍生物[III]反应，提供了高产率和高纯度的西洛他唑[I]的制备方法，其中水的用量为喹诺酮衍生物[II]的3〜7倍，无机碱性化合物的用量为每摩尔喹诺酮衍生物[II]为1〜6摩尔。本发明的方法是用于制备用于药物的西洛他唑的改进和环境友好的方法

7. 发明授权

US5811576A Intermediates for anti-microbial quinolone carboxylic acids 失效
标题翻译：抗微生物喹诺酮羧酸的中间体
公开(公告)号：US5811576A
公开(公告)日：1998-09-22
申请号：US922108
申请日：1997-09-03
申请人： Hiraki Ueda , Hisashi Miyamoto , Hiroshi Yamashita , Hitoshi Tone
发明人： Hiraki Ueda , Hisashi Miyamoto , Hiroshi Yamashita , Hitoshi Tone
IPC分类号： C07D215/56 , A61K31/47 , A61K31/495 , A61K31/535 , A61K31/5375 , A61K31/54 , A61K31/55 , A61P31/04 , C07C25/02 , C07C25/13 , C07C63/04 , C07C63/06 , C07C63/70 , C07C69/716 , C07C69/738 , C07C205/11 , C07C205/12 , C07C211/47 , C07C211/52 , C07C229/30 , C07C229/34 , C07C321/16 , C07C323/29 , C07D207/09 , C07D207/14 , C07D215/22 , C07D241/04 , C07D295/04 , C07D295/16 , C07D319/06 , C07D401/04 , C07D405/06 , C07D405/12 , C07D409/04 , C07D413/04 , C07D487/04 , C07D491/04 , C07D498/04 , C07D498/06 , C07F5/04
CPC分类号： C07D491/04 , C07D215/56 , C07D401/04 , C07D405/12 , C07D409/04 , C07D487/04
摘要： Novel 4-oxoquinoline-3-carboxylic acid compounds of the formula: ##STR1## wherein R.sup.1 is cyclopropyl which may have 1 to 3 substituents of alkyl and halogen; phenyl which may be substituted by 1 to 3 substituents of alkoxy, halogen and OH; alkyl which may be substituted by halogen, alkanoyloxy or OH; alkenyl; or thienyl, R.sup.2 is 5- to 9-membered saturated or unsaturated heterocyclic ring which may be substituted, R.sup.3 is alkyl, R is H or alkyl, and X is halogen, and pharmaceutically acceptable salts thereof, said compounds having excellent antimicrobial activity and hence being useful as an antimicrobial agent, and a pharmaceutical composition containing said compound as an active ingredient.
摘要翻译：具有下式的新型4-氧代喹啉-3-羧酸化合物：其中R 1是可以具有1至3个烷基和卤素取代基的环丙基; 可被1至3个烷氧基，卤素和OH取代基取代的苯基; 可被卤素，烷酰氧基或OH取代的烷基; 烯基; 或噻吩基，R 2为可被取代的5至9元饱和或不饱和杂环，R 3为烷基，R为H或烷基，X为卤素及其药学上可接受的盐，所述化合物具有优异的抗微生物活性，因此可用作抗微生物剂，以及含有所述化合物作为活性成分的药物组合物。

8. 发明授权

US5290934A Benzoheterocyclic compounds 失效
标题翻译：苯并杂环化合物
公开(公告)号：US5290934A
公开(公告)日：1994-03-01
申请号：US711273
申请日：1991-06-04
申请人： Hiraki Ueda , Hisashi Miyamoto , Hiroshi Yamashita , Hitoshi Tone
发明人： Hiraki Ueda , Hisashi Miyamoto , Hiroshi Yamashita , Hitoshi Tone
IPC分类号： C07D215/56 , C07D401/04 , C07D405/12 , C07D409/04 , C07D487/04 , C07D491/04 , C07D498/06 , C07D215/283
CPC分类号： C07D215/56 , C07D401/04 , C07D405/12 , C07D409/04 , C07D487/04 , C07D491/04
摘要： Novel 4-oxoquinoline-3-carboxylic acid compounds of the formula: ##STR1## wherein R.sup.1 is cyclopropyl which may have 1 to 3 substituents of alkyl and halogen; phenyl which may be substituted by 1 to 3 substituents of alkoxy, halogen and OH; alkyl which may be substituted by halogen, alkanoyloxy or OH; alkenyl; or thienyl, R.sup.2 is 5- to 9-membered saturated or unsaturated heterocyclic ring which may be substituted, R.sup.3 is alkyl, R is H or alkyl, and X is halogen, and pharmaceutically acceptable salts thereof, said compounds having excellent antimicrobial activity and hence being useful as an antimicrobial agent, and a pharmaceutical composition containing said compound as an active ingredient.
摘要翻译：具有下式的新型4-氧代喹啉-3-羧酸化合物：其中R 1是可以具有1至3个烷基和卤素取代基的环丙基; 可被1至3个烷氧基，卤素和OH取代基取代的苯基; 可被卤素，烷酰氧基或OH取代的烷基; 烯基; 或噻吩基，R 2为可被取代的5至9元饱和或不饱和杂环，R 3为烷基，R为H或烷基，X为卤素及其药学上可接受的盐，所述化合物具有优异的抗微生物活性，因此可用作抗微生物剂，以及含有所述化合物作为活性成分的药物组合物。

9. 发明授权

US5225402A Carbostyril derivatives 失效
标题翻译：卡波斯特灵衍生物
公开(公告)号：US5225402A
公开(公告)日：1993-07-06
申请号：US762736
申请日：1991-09-18
申请人： Hidenori Ogawa , Hisashi Miyamoto , Kazumi Kondo , Hiroshi Yamashita , Kenji Nakaya , Michiaki Tominaga , Yoichi Yabuuchi
发明人： Hidenori Ogawa , Hisashi Miyamoto , Kazumi Kondo , Hiroshi Yamashita , Kenji Nakaya , Michiaki Tominaga , Yoichi Yabuuchi
IPC分类号： C07D215/22 , C07D215/227 , C07D401/04 , C07D401/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D493/04 , C07D521/00 , C07H15/26
CPC分类号： C07D215/227 , C07D231/12 , C07D233/56 , C07D249/08 , C07D401/04 , C07D401/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D493/04 , C07H15/26
摘要： Novel carbostyril derivatives of the formula: ##STR1## wherein R.sup.1 is H, NO.sub.2, alkoxy, alkoxycarbonyl, alkyl, halogen, optionally substituted amino, OH, CN, COOH, alkanoyloxy, hydrazinocarbonyl; q is 1 to 3, and R is a group of the formula ##STR2## [wherein R.sup.2 is H, alkoxycarbonyl, optionally substituted phenoxycarbonyl, phenylalkenyl-CO-, optionally substituted phenylalkanoyl, alkanoyl, alkenyl-CO-, optionally substituted phenyl--SO.sub.2 --, --CONR.sup.8 R.sup.9, optionally substituted heterocyclic group--CO--, naphthyl--CO--, thienylalkanoyl, tricyclo[3.3.1.1]alkanoyl, ##STR3## (R.sup.13 is OH, optionally substituted alkoxy, --NR.sup.32 R.sup.33, --O--A--(E).sub.l --NR.sup.4 R.sup.5, --(B).sub.l 'NR.sup.6 R.sup.7, etc.), n is 1 or 2, m is 0 or 1 to 3, R.sup.3 is alkyl, R.sup.10 is --(CO).sub.l --NR.sup.11 R.sup.12 ], and the bond between 3- and 4-position of carbostyril nucleus is single or double bond, which have excellent vasopressin antagonistic activities and are useful as vasodilator, hypotensive agent, water diuretics, platelet agglutination inhibitor, and a vasopressin antagonistic composition containing the compound as the active ingredient.
摘要翻译：其中R1是H，NO2，烷氧基，烷氧基羰基，烷基，卤素，任选取代的氨基，OH，CN，COOH，烷酰氧基，肼基羰基; q为1至3，并且R为下式的基团：其中R 2为H，烷氧基羰基，任选取代的苯氧基羰基，苯基烯基-CO-，任选取代的苯基烷酰基，烷酰基，烯基-CO-，任选取代的苯基-SO 2 - ， - CONR 8 R 9，任选取代的杂环基-CO-，萘基-CO-，噻吩基烷酰基，三环[3.3.1.1]烷酰基，（R 13是OH，任选取代的烷氧基，-NR 32 R 33，-OA-（E） -NR 4 R 5， - （B）1 NR 6 R 7等），n为1或2，m为0或1〜3，R 3为烷基，R 10为 - （CO）1 -NR 11 R 12] 并且喹诺酮核的4-位是单或双键，其具有优异的加压素拮抗活性，并且可用作血管扩张剂，降血压剂，水利尿剂，血小板凝集抑制剂和含有该化合物作为活性成分的血管加压素拮抗剂组合物。

10. 发明授权

US4874764A Benzoheterocyclic compounds 失效
标题翻译：苯并杂环化合物
公开(公告)号：US4874764A
公开(公告)日：1989-10-17
申请号：US63401
申请日：1987-06-18
申请人： Hiraki Ueda , Hisashi Miyamoto , Shinji Aki , Tatsuya Otsuka
发明人： Hiraki Ueda , Hisashi Miyamoto , Shinji Aki , Tatsuya Otsuka
IPC分类号： C07D215/56 , C07D401/04 , C07D405/12 , C07D487/04
CPC分类号： C07D215/56 , C07D401/04 , C07D405/12 , C07D487/04
摘要： Novel 4-oxoquinoline-3-carboxylic acid compounds of the formula: ##STR1## wherein R.sup.3 is C.sub.1 -C.sub.6 alkyl and R.sup.F is C.sub.1 -C.sub.6 alkyl, and a pharmaceutically acceptable salts thereof, said compounds having excellent antimicrobial activity and hence being useful as an antimicrobial agent, and a pharmaceutical composition containing said compound as an active ingredient.
摘要翻译：具有下式的新颖的4-氧代喹啉-3-羧酸化合物：其中R 3是C 1 -C 6烷基且RF是C 1 -C 6烷基，其药学上可接受的盐，所述化合物具有优异的抗微生物活性，因此可用作抗微生物剂，以及含有所述化合物作为活性成分的药物组合物。

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