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1. 发明授权

US06699995B1 Process for the preparation of oxazole derivatives 失效
标题翻译：恶唑衍生物的制备方法
公开(公告)号：US06699995B1
公开(公告)日：2004-03-02
申请号：US10088415
申请日：2002-03-18
申请人： Hiroyuki Tawada , Norihiko Ohashi , Motoki Ikeuchi
发明人： Hiroyuki Tawada , Norihiko Ohashi , Motoki Ikeuchi
IPC分类号： C07D26304
CPC分类号： C07D413/04 , C07D263/38 , C07D263/48
摘要： A production method of a compound represented by the formula wherein R1 and R2 are each a hydrogen atom, an optionally substituted hydrocarbon group or an optionally substituted heterocyclic group, R3 is an electron-withdrawing group, and R4, R5 and R6 are each a hydrogen atom or an optionally substituted hydrocarbon group, or a salt thereof, is provided as an industrially advantageous production. method for forming a carbon-carbon bond at the 5-position of oxazole, which method includes reacting a compound represented by the formula wherein the symbols in the formula are as defined above, or a salt thereof, with a compound represented by the formula wherein the symbols in the formula are as defined above, or a salt thereof, in the presence of an acid or a base.
摘要翻译：由式R 1和R 2表示的化合物的制备方法各自为氢原子，任选取代的烃基或任选取代的杂环基，R 3为吸电子基团，R 作为工业上有利的生产，提供了R 5和R 6各自为氢原子或任选取代的烃基或其盐。在恶唑的5-位上形成碳 - 碳键的方法，该方法包括使式中的符号表示的化合物或其盐与式中的化合物或其盐与式在式中如上所定义，或其盐在酸或碱的存在下进行。

2. 发明授权

US07132547B2 Preventives/remedies for urinary disturbance 有权
公开(公告)号：US07132547B2
公开(公告)日：2006-11-07
申请号：US10500217
申请日：2002-12-26
申请人： Yuji Ishihara , Yuji Ishichi , Takayuki Doi , Hiroshi Nagabukuro , Naoyuki Kanzaki , Motoki Ikeuchi
发明人： Yuji Ishihara , Yuji Ishichi , Takayuki Doi , Hiroshi Nagabukuro , Naoyuki Kanzaki , Motoki Ikeuchi
IPC分类号： C07D235/24
CPC分类号： A61K31/00 , A61K31/138 , A61K31/40 , A61K31/445 , A61K31/473 , A61K31/549 , A61K31/55 , A61K31/553 , C07C233/41 , C07C311/07 , C07C311/08 , C07C311/37 , C07C2602/08 , C07D209/08 , C07D209/14 , C07D209/48 , C07D211/32 , C07D215/227 , C07D217/04 , C07D217/06 , C07D217/08 , C07D223/16 , C07D235/26 , C07D239/80 , C07D265/36 , C07D285/14 , C07D285/22 , C07D307/78 , C07D307/79 , C07D311/58 , C07D319/18 , C07D333/22 , C07D471/06 , C07D513/06 , G01N2333/91215
摘要： Preventives/remedies for voiding disturbance containing a compound having both of an acetylcholinesterase inhibitory action and an α1 antagonistic action which exhibits an excellent effect of improving the urinary function of the bladder (i.e., effects of improving urine flow rate and voiding efficiency) without affecting the urinary pressure or the blood pressure.

3. 发明申请

US20060063769A1 Preventives/remedies for urinary disturbance 有权
标题翻译：预防/治疗尿路障碍
公开(公告)号：US20060063769A1
公开(公告)日：2006-03-23
申请号：US10500217
申请日：2002-12-26
申请人： Yuji Ishihara , Yuji Ishichi , Takayuki Doi , Hiroshi Nagabukuro , Naoyuki Kanzaki , Motoki Ikeuchi
发明人： Yuji Ishihara , Yuji Ishichi , Takayuki Doi , Hiroshi Nagabukuro , Naoyuki Kanzaki , Motoki Ikeuchi
IPC分类号： A61K31/517 , A61K31/454
CPC分类号： A61K31/00 , A61K31/138 , A61K31/40 , A61K31/445 , A61K31/473 , A61K31/549 , A61K31/55 , A61K31/553 , C07C233/41 , C07C311/07 , C07C311/08 , C07C311/37 , C07C2602/08 , C07D209/08 , C07D209/14 , C07D209/48 , C07D211/32 , C07D215/227 , C07D217/04 , C07D217/06 , C07D217/08 , C07D223/16 , C07D235/26 , C07D239/80 , C07D265/36 , C07D285/14 , C07D285/22 , C07D307/78 , C07D307/79 , C07D311/58 , C07D319/18 , C07D333/22 , C07D471/06 , C07D513/06 , G01N2333/91215
摘要： Preventives/remedies for voiding disturbance containing a compound having both of an acetylcholinesterase inhibitory action and an α1 antagonistic action which exhibits an excellent effect of improving the urinary function of the bladder (i.e., effects of improving urine flow rate and voiding efficiency) without affecting the urinary pressure or the blood pressure.
摘要翻译：含有具有乙酰胆碱酯酶抑制作用的化合物和α1拮抗作用的化合物的预防/补救措施，其显示出改善膀胱尿功能的优异效果（即，改善尿流率和排尿效率的效果）而不影响尿压或血压。

4. 发明申请

US20050197362A1 Preventives/remedies for urinary disturbance 失效
标题翻译：预防/治疗尿路障碍
公开(公告)号：US20050197362A1
公开(公告)日：2005-09-08
申请号：US10935646
申请日：2004-09-08
申请人： Yuji Ishihara , Yuji Ishichi , Takayuki Doi , Hiroshi Nagabukuro , Naoyuki Kanzaki , Motoki Ikeuchi
发明人： Yuji Ishihara , Yuji Ishichi , Takayuki Doi , Hiroshi Nagabukuro , Naoyuki Kanzaki , Motoki Ikeuchi
IPC分类号： A61K31/00 , A61K31/138 , A61K31/40 , A61K31/445 , A61K31/473 , A61P13/00 , A61P13/08 , A61P43/00 , C07C233/41 , C07C311/07 , C07C311/08 , C07C311/37 , C07D209/08 , C07D209/14 , C07D209/48 , C07D211/32 , C07D215/22 , C07D215/227 , C07D217/04 , C07D217/06 , C07D217/08 , C07D223/16 , C07D235/26 , C07D239/80 , C07D265/36 , C07D285/14 , C07D285/22 , C07D307/79 , C07D311/58 , C07D319/18 , C07D333/22 , C07D471/06 , C07D513/06
CPC分类号： A61K31/00 , A61K31/138 , A61K31/40 , A61K31/445 , A61K31/473 , A61K31/549 , A61K31/55 , A61K31/553 , C07C233/41 , C07C311/07 , C07C311/08 , C07C311/37 , C07C2602/08 , C07D209/08 , C07D209/14 , C07D209/48 , C07D211/32 , C07D215/227 , C07D217/04 , C07D217/06 , C07D217/08 , C07D223/16 , C07D235/26 , C07D239/80 , C07D265/36 , C07D285/14 , C07D285/22 , C07D307/78 , C07D307/79 , C07D311/58 , C07D319/18 , C07D333/22 , C07D471/06 , C07D513/06 , G01N2333/91215
摘要： Preventives/remedies for voiding disturbance containing a compound having both of an acetylcholinesterase inhibitory action and an α1 antagonistic action which exhibits an excellent effect of improving the urinary function of the bladder (i.e., effects of improving urine flow rate and voiding efficiency) without affecting the urinary pressure or the blood pressure.
摘要翻译：含有具有乙酰胆碱酯酶抑制作用的化合物和α1拮抗作用的化合物的预防/补救措施，其显示出改善膀胱尿功能的优异效果（即，改善尿流率和排尿效率的效果）而不影响尿压或血压。

5. 发明授权

US07462628B2 Preventives/remedies for urinary disturbance 失效
标题翻译：预防/治疗尿路障碍
公开(公告)号：US07462628B2
公开(公告)日：2008-12-09
申请号：US11333375
申请日：2006-01-18
申请人： Yuji Ishihara , Yuji Ishichi , Takayuki Doi , Hiroshi Nagabukuro , Naoyuki Kanzaki , Motoki Ikeuchi
发明人： Yuji Ishihara , Yuji Ishichi , Takayuki Doi , Hiroshi Nagabukuro , Naoyuki Kanzaki , Motoki Ikeuchi
IPC分类号： A61K31/44 , C07D451/00 , C07D453/00 , C07D455/00
CPC分类号： A61K31/00 , A61K31/138 , A61K31/40 , A61K31/445 , A61K31/473 , A61K31/549 , A61K31/55 , A61K31/553 , C07C233/41 , C07C311/07 , C07C311/08 , C07C311/37 , C07C2602/08 , C07D209/08 , C07D209/14 , C07D209/48 , C07D211/32 , C07D215/227 , C07D217/04 , C07D217/06 , C07D217/08 , C07D223/16 , C07D235/26 , C07D239/80 , C07D265/36 , C07D285/14 , C07D285/22 , C07D307/78 , C07D307/79 , C07D311/58 , C07D319/18 , C07D333/22 , C07D471/06 , C07D513/06 , G01N2333/91215
摘要： Preventives/remedies for voiding disturbance containing a compound having both of an acetylcholinesterase inhibitory action and an α1 antagonistic action which exhibits an excellent effect of improving the urinary function of the bladder (i.e., effects of improving urine flow rate and voiding efficiency) without affecting the urinary pressure or the blood pressure.
摘要翻译：含有具有乙酰胆碱酯酶抑制作用的化合物和α1拮抗作用的化合物的预防/补救措施，其显示出改善膀胱尿功能的优异效果（即，改善尿流率和排尿效率的效果）而不影响尿压或血压。

6. 发明授权

US5952512A Production of optically active benzothiepin salts 失效
标题翻译：生产光学活性苯并噻in盐
公开(公告)号：US5952512A
公开(公告)日：1999-09-14
申请号：US702675
申请日：1996-09-11
申请人： Yoshiharu Maeda , Motoki Ikeuchi , Shigeo Yabuno
发明人： Yoshiharu Maeda , Motoki Ikeuchi , Shigeo Yabuno
IPC分类号： C07D495/04 , C07D337/12
CPC分类号： C07D495/04
摘要： A method of producing an amine salt of an optically active benzothiepin derivative, which is characterized by allowing a benzothiepin derivative represented by the formula (I) ##STR1## wherein R stands for a lower alkyl group, to react with an optically active amine.
摘要翻译： PCT No.PCT / JP96 / 02056 Sec。 371日期：1996年9月11日 102（e）1996年9月11日PCT PCT 1996年7月23日PCT公布。公开号WO97 / 03989 日期1997年2月6日制备光学活性苯并硫代衍生物的胺盐的方法，其特征在于，使式（I）表示的苯并硫代衍生物（其中R表示低级烷基）与光学活性胺反应。

7. 发明授权

US07138533B2 Preventives/remedies for urinary disturbance 失效
公开(公告)号：US07138533B2
公开(公告)日：2006-11-21
申请号：US10935646
申请日：2004-09-08
申请人： Yuji Ishihara , Yuji Ishichi , Takayuki Doi , Hiroshi Nagabukuro , Naoyuki Kanzaki , Motoki Ikeuchi
发明人： Yuji Ishihara , Yuji Ishichi , Takayuki Doi , Hiroshi Nagabukuro , Naoyuki Kanzaki , Motoki Ikeuchi
IPC分类号： C07D307/78 , C07D307/87 , C07D307/93
CPC分类号： A61K31/00 , A61K31/138 , A61K31/40 , A61K31/445 , A61K31/473 , A61K31/549 , A61K31/55 , A61K31/553 , C07C233/41 , C07C311/07 , C07C311/08 , C07C311/37 , C07C2602/08 , C07D209/08 , C07D209/14 , C07D209/48 , C07D211/32 , C07D215/227 , C07D217/04 , C07D217/06 , C07D217/08 , C07D223/16 , C07D235/26 , C07D239/80 , C07D265/36 , C07D285/14 , C07D285/22 , C07D307/78 , C07D307/79 , C07D311/58 , C07D319/18 , C07D333/22 , C07D471/06 , C07D513/06 , G01N2333/91215
摘要： Preventives/remedies for voiding disturbance containing a compound having both of an acetylcholinesterase inhibitory action and an α1 antagonistic action which exhibits an excellent effect of improving the urinary function of the bladder (i.e., effects of improving urine flow rate and voiding efficiency) without affecting the urinary pressure or the blood pressure.

8. 发明申请

US20060211675A1 Preventives/remedies for urinary disturbance 失效
标题翻译：预防/治疗尿路障碍
公开(公告)号：US20060211675A1
公开(公告)日：2006-09-21
申请号：US11333375
申请日：2006-01-18
申请人： Yuji Ishihara , Yuji Ishichi , Takayuki Doi , Hiroshi Nagabukuro , Naoyuki Kanzaki , Motoki Ikeuchi
发明人： Yuji Ishihara , Yuji Ishichi , Takayuki Doi , Hiroshi Nagabukuro , Naoyuki Kanzaki , Motoki Ikeuchi
IPC分类号： A61K31/55 , A61K31/549 , A61K31/553
CPC分类号： A61K31/00 , A61K31/138 , A61K31/40 , A61K31/445 , A61K31/473 , A61K31/549 , A61K31/55 , A61K31/553 , C07C233/41 , C07C311/07 , C07C311/08 , C07C311/37 , C07C2602/08 , C07D209/08 , C07D209/14 , C07D209/48 , C07D211/32 , C07D215/227 , C07D217/04 , C07D217/06 , C07D217/08 , C07D223/16 , C07D235/26 , C07D239/80 , C07D265/36 , C07D285/14 , C07D285/22 , C07D307/78 , C07D307/79 , C07D311/58 , C07D319/18 , C07D333/22 , C07D471/06 , C07D513/06 , G01N2333/91215
摘要： Preventives/remedies for voiding disturbance containing a compound having both of an acetylcholinesterase inhibitory action and an al antagonistic action which exhibits an excellent effect of improving the urinary function of the bladder (i.e., effects of improving urine flow rate and voiding efficiency) without affecting the urinary pressure or the blood pressure.
摘要翻译：包含具有乙酰胆碱酯酶抑制作用的化合物和具有改善膀胱尿功能的优异效果（即，改善尿流率和排尿效率）的优异效果的排尿障碍的预防/补救措施，而不影响尿压或血压。

9. 发明授权

US06627630B1 Condensed pyridazine derivatives, their production and use 失效
标题翻译：冷凝哒嗪衍生物，其生产和使用
公开(公告)号：US06627630B1
公开(公告)日：2003-09-30
申请号：US09807806
申请日：2001-04-18
申请人： Yasuhiko Kawano , Hideaki Nagaya , Michiyo Gyoten , Yukio Hara , Motoki Ikeuchi
发明人： Yasuhiko Kawano , Hideaki Nagaya , Michiyo Gyoten , Yukio Hara , Motoki Ikeuchi
IPC分类号： A61K3150
CPC分类号： C07D487/04
摘要： A condensed pyridazine derivative which is useful as a pharmaceutical composition for preventing or treating allergic skin diseases such as contact dermatitis, pruritus, dried dermatitis, acute urticaria and prurigo.
摘要翻译：可用作预防或治疗接触性皮炎，瘙痒，干性皮炎，急性荨麻疹，痒疹等过敏性皮肤病的药物组合物的缩合哒嗪衍生物。

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