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    • 1. 发明授权
    • Process for the preparation of oxazole derivatives
    • 恶唑衍生物的制备方法
    • US06699995B1
    • 2004-03-02
    • US10088415
    • 2002-03-18
    • Hiroyuki TawadaNorihiko OhashiMotoki Ikeuchi
    • Hiroyuki TawadaNorihiko OhashiMotoki Ikeuchi
    • C07D26304
    • C07D413/04C07D263/38C07D263/48
    • A production method of a compound represented by the formula wherein R1 and R2 are each a hydrogen atom, an optionally substituted hydrocarbon group or an optionally substituted heterocyclic group, R3 is an electron-withdrawing group, and R4, R5 and R6 are each a hydrogen atom or an optionally substituted hydrocarbon group, or a salt thereof, is provided as an industrially advantageous production. method for forming a carbon-carbon bond at the 5-position of oxazole, which method includes reacting a compound represented by the formula wherein the symbols in the formula are as defined above, or a salt thereof, with a compound represented by the formula wherein the symbols in the formula are as defined above, or a salt thereof, in the presence of an acid or a base.
    • 由式R 1和R 2表示的化合物的制备方法各自为氢原子,任选取代的烃基或任选取代的杂环基,R 3为吸电子基团,R 作为工业上有利的生产,提供了R 5和R 6各自为氢原子或任选取代的烃基或其盐。 在恶唑的5-位上形成碳 - 碳键的方法,该方法包括使式中的符号表示的化合物或其盐与式中的化合物或其盐与式 在式中如上所定义,或其盐在酸或碱的存在下进行。