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1. 发明授权

US08193358B2 Process for producing high-purity prasugrel and acid addition salt thereof 有权
标题翻译：制备高纯度普拉格雷及其酸加成盐的方法
公开(公告)号：US08193358B2
公开(公告)日：2012-06-05
申请号：US12225762
申请日：2007-04-06
申请人： Masahiko Hagihara , Hiroyuki Miyata , Yukinori Wada , Naoyuki Yokota
发明人： Masahiko Hagihara , Hiroyuki Miyata , Yukinori Wada , Naoyuki Yokota
IPC分类号： C07D495/04
CPC分类号： C07D495/04
摘要： The present invention is directed to providing prasugrel hydrochloride or the like with a reduced content of OXTP. A method for producing prasugrel hydrochloride with a reduced content of OXTP, comprising dissolving free prasugrel containing OXTP in an inert solvent and adding hydrochloric acid optionally dropwise to the solution for reaction is also provided.
摘要翻译：本发明涉及提供具有降低的OXTP含量的普拉格雷盐酸盐等。还提供了一种生产具有降低的OXTP含量的普拉格雷盐酸盐的方法，包括将含有OXTP的游离普拉格雷溶解在惰性溶剂中，并将盐酸任选地滴加到反应溶液中。

2. 发明申请

US20100094013A1 PROCESS FOR PRODUCTION OF PRASUGREL HYDROCHLORIDE HAVING HIGH PURITY 审中-公开
标题翻译：生产具有高纯度的高氯酸氢盐的方法
公开(公告)号：US20100094013A1
公开(公告)日：2010-04-15
申请号：US12449810
申请日：2008-02-29
申请人： Hiroyuki Miyata , Yukinori Wada , Naoyuki Yokota
发明人： Hiroyuki Miyata , Yukinori Wada , Naoyuki Yokota
IPC分类号： C07D471/02
CPC分类号： C07D495/04 , Y02P20/55
摘要： An object of the present invention is to provide prasugrel hydrochloride with a reduced content of CATP, and the like. In the formulae, R represents a protecting group for a hydroxyl group.A method for producing prasugrel hydrochloride represented by the above formula is provided, characterized by comprising, in step (i), controlling, at low values, the temperature during the addition, optionally dropwise, of a chlorinating agent and the reaction temperature after the addition, optionally dropwise, of the chlorinating agent.
摘要翻译：本发明的目的是提供具有降低的CATP含量的盐酸普拉格雷等。式中，R表示羟基的保护基。提供了一种由上式表示的普拉格雷盐酸盐的制造方法，其特征在于，在步骤（i）中，在低值下，控制加入时，任选地滴加氯化剂的温度和加入后的反应温度，任选地滴加氯化剂。

3. 发明申请

US20090203729A1 Process for Producing High-Purity Prasugrel and Acid Addition Salt Thereof 有权
标题翻译：生产高纯普拉格雷和酸加成盐的方法
公开(公告)号：US20090203729A1
公开(公告)日：2009-08-13
申请号：US12225762
申请日：2007-04-06
申请人： Teruhiko Inoue , Kazuyoshi Nakamura , Masahiko Hagihara , Hiroyuki Miyata , Yukinori Wada , Naoyuki Yokota
发明人： Teruhiko Inoue , Kazuyoshi Nakamura , Masahiko Hagihara , Hiroyuki Miyata , Yukinori Wada , Naoyuki Yokota
IPC分类号： A61K31/4365 , C07D495/04 , A61P7/00
CPC分类号： C07D495/04
摘要： The present invention is directed to providing prasugrel hydrochloride or the like with a reduced content of OXTP. A method for producing prasugrel hydrochloride with a reduced content of OXTP, comprising dissolving free prasugrel containing OXTP in an inert solvent and adding hydrochloric acid optionally dropwise to the solution for reaction is also provided.
摘要翻译：本发明涉及提供具有降低的OXTP含量的普拉格雷盐酸盐等。还提供了一种生产具有降低的OXTP含量的普拉格雷盐酸盐的方法，包括将含有OXTP的游离普拉格雷溶解在惰性溶剂中，并将盐酸任选地滴加到反应溶液中。

4. 发明授权

US08377922B2 Benzazepinone compound 有权
标题翻译：苯扎西酮化合物
公开(公告)号：US08377922B2
公开(公告)日：2013-02-19
申请号：US12743223
申请日：2008-11-14
申请人： Naoto Suzuki , Yasunori Tsuzaki , Kimihiko Yoshimura , Masahiko Hagihara , Yukinori Wada , Masao Maruyama , Nobuyoshi Fujii , Yasuhiro Aga
发明人： Naoto Suzuki , Yasunori Tsuzaki , Kimihiko Yoshimura , Masahiko Hagihara , Yukinori Wada , Masao Maruyama , Nobuyoshi Fujii , Yasuhiro Aga
IPC分类号： C07D487/04 , A61K31/55
CPC分类号： C07D487/04 , C07D223/16
摘要： The present invention relates to a benzazepinone compound represented by the following formula (I): wherein R1 represents a C1-C6 alkyl group or halogeno C1-C6 alkyl group, R2 represents a carboxyl group which may be protected, and Y represents a group represented by the formula (II): wherein Z represents CH or a nitrogen atom, or a pharmaceutically acceptable salt thereof.
摘要翻译：本发明涉及由下式（I）表示的苯并氮杂酮化合物：其中R1表示C1-C6烷基或卤代C1-C6烷基，R2表示可被保护的羧基，Y表示其中Z表示CH或氮原子，或其药学上可接受的盐。

5. 发明申请

US20110162283A1 DOOR OPENING AND CLOSING APPARATUS FOR VEHICLE 有权
标题翻译：车门打开和关闭装置
公开(公告)号：US20110162283A1
公开(公告)日：2011-07-07
申请号：US13063534
申请日：2009-09-22
申请人： Shoichi Hashiba , Yuichi Inoue , Yukinori Wada
发明人： Shoichi Hashiba , Yuichi Inoue , Yukinori Wada
IPC分类号： E05B1/00
CPC分类号： E05B81/78 , B62D35/00 , E05B77/34 , E05B81/77 , E05B85/16 , Y10T16/458
摘要： A door opening and closing device for a vehicle that can remove an object attached to operation surface of a door handle with a simpler structure is provided. The device includes a door handle 41. The door handle 41 includes a grip 44 and a deflective portion 47. The grip 44 protrudes outward and defines a space 32 between the outer surface of the door outer panel 3 and the grip 44 to allow gripping by a user. The grip includes an outer surface and an operation surface opposing to the outer surface of the door outer panel 3. The deflective portion is located at an end of the grip 44 and extends from the outer surface of the grip 44 along the outer surface of the door outer panel 13 in a direction crossing front and rear directions of the vehicle to direct air flow flowing along the outer surface of the door outer panel 3 to flow through at least the space 32 of the grip 44 to the operation surface 44a.
摘要翻译：提供一种用于车辆的门打开和关闭装置，其能够以更简单的结构去除附接到门把手的操作表面的物体。该装置包括门把手41.门把手41包括把手44和偏转部分47.把手44向外突出并且在门外板3的外表面和把手44之间限定了一个空间32，以允许通过一个用户把手包括外表面和与门外板3的外表面相对的操作表面。偏转部分位于把手44的端部，并且从把手44的外表面沿着外表面延伸门外板13沿车辆前后方向引导沿着外门面板3的外表面流动的空气流动，至少通过把手44的空间32流到操作表面44a。

6. 发明申请

US20100249396A1 BENZAZEPINONE COMPOUND 有权
标题翻译：苯扎酮化合物
公开(公告)号：US20100249396A1
公开(公告)日：2010-09-30
申请号：US12743223
申请日：2008-11-14
申请人： Naoto Suzuki , Yasunori Tsuzaki , Kimihiko Yoshimura , Masahiko Hagihara , Yukinori Wada , Masao Maruyama , Nobuyoshi Fujii , Yasuhiro Aga
发明人： Naoto Suzuki , Yasunori Tsuzaki , Kimihiko Yoshimura , Masahiko Hagihara , Yukinori Wada , Masao Maruyama , Nobuyoshi Fujii , Yasuhiro Aga
IPC分类号： C07D223/16
CPC分类号： C07D487/04 , C07D223/16
摘要： The present invention relates to a benzazepinone compound represented by the following formula (I): wherein R1 represents a C1-C6 alkyl group or halogeno C1-C6 alkyl group, R2 represents a carboxyl group which may be protected, and Y represents a group represented by the formula (II): wherein Z represents CH or a nitrogen atom, or a pharmaceutically acceptable salt thereof.
摘要翻译：本发明涉及由下式（I）表示的苯并氮杂酮化合物：其中R1表示C1-C6烷基或卤代C1-C6烷基，R2表示可被保护的羧基，Y表示其中Z表示CH或氮原子，或其药学上可接受的盐。

7. 发明授权

US07294625B2 Pyrazole compounds 失效
标题翻译：吡唑化合物
公开(公告)号：US07294625B2
公开(公告)日：2007-11-13
申请号：US10528994
申请日：2003-09-25
申请人： Masahiko Hagihara , Nobuhiko Shibakawa , Masamichi Nishihara , Toshiyuki Shirai , Motohisa Shimizu , Tohru Hasegawa , Yasunori Tokunaga , Naoto Suzuki , Yukinori Wada
发明人： Masahiko Hagihara , Nobuhiko Shibakawa , Masamichi Nishihara , Toshiyuki Shirai , Motohisa Shimizu , Tohru Hasegawa , Yasunori Tokunaga , Naoto Suzuki , Yukinori Wada
IPC分类号： C07D487/04 , C07D401/14 , C07D403/14 , A61K31/501 , A61K31/5025
CPC分类号： C07D401/14 , A61K31/501 , A61K31/5025 , A61K31/506 , C07D403/14 , C07D487/04
摘要： The present invention relates to pyrazole compounds represented by the formula (I): wherein R1 represents phenyl which may be substituted, R2 represents H, halogen, alkyl, alkoxy, alkylthio, alkylsulfinyl, alkylsulfonyl or substituted amino, Q represents CH or N, R3 represents H, alkyl or amino, R4 represents the formula (II) to (V): wherein R7 represents H or alkyl, R8 represents H, alkyl or substituted amino, R9 represents H or alkyl, R12 represents H, alkyl, halogeno alkyl or substituted amino, or pharmaceutically acceptable salts thereof, and a medical composition containing the same as effective ingredient.
摘要翻译：本发明涉及由式（I）表示的吡唑化合物：其中R 1表示可被取代的苯基，R 2表示H，卤素，烷基，烷氧基，烷硫基，烷基亚磺酰基，烷基磺酰基或取代的氨基，Q表示CH或N，R 3表示H，烷基或氨基，R 4表示式（II）至（V）：其中R 7表示H或烷基，R 8表示H，烷基或取代的氨基，R 9表示H或烷基，R SUP > 12表示H，烷基，卤代烷基或取代的氨基或其药学上可接受的盐，以及含有与有效成分相同的药物组合物。

8. 发明授权

US09370408B2 Vibrational frequency adjustment device and water flow type oral cavity cleaning device using same 有权
标题翻译：振动频率调节装置和水流式口腔清洁装置使用相同
公开(公告)号：US09370408B2
公开(公告)日：2016-06-21
申请号：US13390599
申请日：2010-08-09
申请人： Yukinori Wada , Masahiro Nishiura
发明人： Yukinori Wada , Masahiro Nishiura
IPC分类号： A61C17/02 , F15B15/06 , A61C17/028 , A61C17/20 , A61C17/22
CPC分类号： A61C17/0202 , A61C17/028 , A61C17/20 , A61C17/22 , Y10T74/18056 , Y10T74/18288
摘要： A vibrational frequency adjustment device comprises, as a vibrational frequency adjustment means (22): a first conversion means (40) which is provided with an input-side rotating member (41), an output-side rotating member (42), and a one-way clutch (44) for transmitting only the rotational motion in one direction of the input-side rotating member (41) to the output-side rotating member (42) and which, by causing the input-side rotating member (41) to pivot in a reciprocating manner by a set angle by means of the reciprocating linear motion of an output shaft (10), transmits only the forward motion or the reverse motion of the input-side rotating member (41) to the output-side rotating member (42) through the one-way clutch (44) to thereby rotate the output-side rotating member (42) by a given angle; and a second conversion means (50) which converts the rotational motion of the output-side rotating member (42) into the reciprocating linear motion of a second shaft member (43).
摘要翻译：振动频率调节装置包括作为振动频率调节装置（22）的第一转换装置（40），设置有输入侧旋转部件（41），输出侧旋转部件（42）和单向离合器（44），用于仅将输入侧旋转构件（41）的一个方向上的旋转运动传递到输出侧旋转构件（42），并且通过使输入侧旋转构件（41）通过输出轴（10）的往复直线运动以往复运动方式枢转定位角，仅将输入侧旋转构件（41）的向前运动或反向运动传递到输出侧旋转构件（42）通过单向离合器（44），从而使输出侧旋转构件（42）旋转给定的角度; 以及第二转换装置（50），其将输出侧旋转部件（42）的旋转运动转换成第二轴部件（43）的往复直线运动。

9. 发明申请

US20060063934A1 Pyrazole compounds 失效
标题翻译：吡唑化合物
公开(公告)号：US20060063934A1
公开(公告)日：2006-03-23
申请号：US10528994
申请日：2003-09-25
申请人： Masahiko Hagihara , Nobuhiko Shibakawa , Masamichi Nishihara , Toshiyuki Shirai , Motohisa Shimizu , Tohru Hasegawa , Yasunori Tokunaga , Naoto Suzuki , Yukinori Wada
发明人： Masahiko Hagihara , Nobuhiko Shibakawa , Masamichi Nishihara , Toshiyuki Shirai , Motohisa Shimizu , Tohru Hasegawa , Yasunori Tokunaga , Naoto Suzuki , Yukinori Wada
IPC分类号： C07D403/04
CPC分类号： C07D401/14 , A61K31/501 , A61K31/5025 , A61K31/506 , C07D403/14 , C07D487/04
摘要： The present invention relates to pyrazole compounds represented by the formula (I): wherein R1 represents phenyl which may be substituted, R2 represents H, halogen, alkyl, alkoxy, alkylthio, alkylsulfinyl, alkylsulfonyl or substituted amino, Q represents CH or N, R3 represents H, alkyl or amino, R4 represents the formula (II) to (V): wherein R7 represents H or alkyl, R8 represents H, alkyl or substituted amino, R9 represents H or alkyl, R12 represents H, alkyl, halogeno alkyl or substituted amino, or pharmaceutically acceptable salts thereof, and a medical composition containing the same as effective ingredient.
摘要翻译：本发明涉及由式（I）表示的吡唑化合物：

10. 发明授权

US08276318B2 Door opening and closing apparatus for vehicle 有权
标题翻译：车辆开门装置
公开(公告)号：US08276318B2
公开(公告)日：2012-10-02
申请号：US13063534
申请日：2009-09-22
申请人： Shoichi Hashiba , Yuichi Inoue , Yukinori Wada
发明人： Shoichi Hashiba , Yuichi Inoue , Yukinori Wada
IPC分类号： E05B1/00
CPC分类号： E05B81/78 , B62D35/00 , E05B77/34 , E05B81/77 , E05B85/16 , Y10T16/458
摘要： A door opening and closing device for a vehicle that can remove an object attached to operation surface of a door handle with a simpler structure is provided. The device includes a door handle. The door handle includes a grip and a deflective portion. The grip protrudes outward and defines a space between the outer surface of the door outer panel and the grip to allow gripping by a user. The deflective portion is located at an end of the grip and extends from the outer surface of the grip along the outer surface of the door outer panel in a direction crossing front and rear directions of the vehicle to direct air flow flowing along the outer surface of the door outer panel to flow through at least the space of the grip to the operation surface.
摘要翻译：提供一种用于车辆的门打开和关闭装置，其能够以更简单的结构去除附接到门把手的操作表面的物体。该装置包括门把手。门把手包括把手和偏转部分。把手向外突出并且在门外板的外表面和把手之间限定一个空间，以允许使用者抓握。偏转部分位于手柄的端部，并且沿着车门外板的外表面沿着车辆的前后方向从手柄的外表面延伸，以引导沿着车辆的外表面流动的气流门外板至少将手柄的空间流过操作表面。

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