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1. 发明申请

US20130172317A1 TRIAZINE DERIVATIVE AND PHARMACEUTICAL COMPOSITION HAVING AN ANALGESIC ACTIVITY COMPRISING THE SAME 有权
标题翻译：具有包括其同源活性的TRIAZINE衍生物和药物组合物
公开(公告)号：US20130172317A1
公开(公告)日：2013-07-04
申请号：US13814346
申请日：2011-08-09
申请人： Hiroyuki Kai , Takayuki Kameyama , Tohru Horiguchi , Kentaro Asahi , Takeshi Endoh , Yasuhiko Fujii , Takuya Shintani , Ken'ichiroh Nakamura , Sae Jikihara , Tsuyoshi Hasegawa , Miho Oohara , Yukio Tada , Toshikatsu Maki , Akira Iida
发明人： Hiroyuki Kai , Takayuki Kameyama , Tohru Horiguchi , Kentaro Asahi , Takeshi Endoh , Yasuhiko Fujii , Takuya Shintani , Ken'ichiroh Nakamura , Sae Jikihara , Tsuyoshi Hasegawa , Miho Oohara , Yukio Tada , Toshikatsu Maki , Akira Iida
IPC分类号： C07D251/46 , C07D417/12 , C07D413/12 , C07D405/06 , C07D401/14 , C07D251/52 , C07D405/14 , C07D401/12 , C07D403/12 , C07D403/04 , C07D413/14
CPC分类号： C07D251/46 , C07D251/52 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/12 , C07D405/06 , C07D405/12 , C07D405/14 , C07D409/06 , C07D413/06 , C07D413/12 , C07D413/14 , C07D417/06 , C07D417/12 , C07D417/14
摘要： The present invention provides novel compounds having a P2X3 and/or P2X2/3 receptor antagonistic effect.A pharmaceutical composition having an analgesic effect or an improving effect of urination disorder comprising a compound of the formula (I): wherein Rh and Rj are taken together to form a bond; Ra and Rb and/or Rd and Re are taken together to form oxo or the like; Rc is hydrogen, substituted or unsubstituted alkyl or the like; Rf is —(CR4aR4b)n—R2; R4a and R4b are hydrogen, substituted or unsubstituted alkyl or the like; R2 is substituted or unsubstituted cycloalkyl or the like; n is an integer of 1 to 4; —Rg is —X—R3; —X— is —O—, —S— or the like; R3 is substituted or unsubstituted cycloalkyl or the like, or its pharmaceutically acceptable salt or a solvate thereof.
摘要翻译：本发明提供具有P2X3和/或P2X2 / 3受体拮抗作用的新化合物。一种具有止痛作用或排尿障碍改善作用的药物组合物，其包含式（I）化合物：其中Rh和Rj一起形成键; Ra和Rb和/或Rd和Re一起形成氧代等; Rc是氢，取代或未取代的烷基等; Rf是 - （CR4aR4b）n-R2; R4a和R4b是氢，取代或未取代的烷基等; R2是取代或未取代的环烷基等; n为1〜4的整数， -Rg为-X-R3; -X-是-O-，-S-等; R3是取代或未取代的环烷基等，或其药学上可接受的盐或溶剂合物。

2. 发明申请

US20110319414A1 NOVEL TRIAZINE DERIVATIVE AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME 有权
标题翻译：新型TRIAZINE衍生物和药物组合物
公开(公告)号：US20110319414A1
公开(公告)日：2011-12-29
申请号：US13201209
申请日：2010-02-10
申请人： Hiroyuki Kai , Takayuki Kameyama , Tsuyoshi Hasegawa , MIho Oohara , Yukio Tada , Takeshi Endoh
发明人： Hiroyuki Kai , Takayuki Kameyama , Tsuyoshi Hasegawa , MIho Oohara , Yukio Tada , Takeshi Endoh
IPC分类号： A61K31/53 , C07D251/46 , C07D403/06 , A61P7/00 , C07D413/12 , A61K31/5377 , A61P29/00 , A61P25/00 , C07D251/38 , C07D251/52
CPC分类号： C07D251/46 , C07D251/16 , C07D251/44 , C07D251/52 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/12 , C07D405/06 , C07D405/12 , C07D409/06 , C07D413/12
摘要： The present invention provides a novel P2X3 and/or P2X2/3 receptor antagonist.A compound represented by the formula (I); wherein Ra, Rb and Rc are, (a) Ra and Rb are taken together ═Z; and Rc is a group represented by R1c; or (b) Rb and Rc are taken together to form a bond; and Ra is a group represented by —Y—R1a; R1a and R1c are each independently hydrogen, substituted or unsubstituted alkyl, etc.; R2 and R3 are each independently substituted or unsubstituted aryl, etc.; R4a and R4b are each independently hydrogen, substituted or unsubstituted alkyl, etc.; X is —N(R5)—, etc.; R5 is hydrogen, substituted or unsubstituted lower alkyl, etc.; —Y— is —O—, etc.; ═Z is ═O, etc.; and n is an integer of 0 to 4.
摘要翻译：本发明提供了一种新型的P2X3和/或P2X2 / 3受体拮抗剂。由式（I）表示的化合物; 其中Ra，Rb和Rc为（a）Ra和Rb一起为= Z; Rc为由R1c表示的基团; 或（b）Rb和Rc一起形成键; 并且R a是由-Y-R 1a表示的基团; R1a和R1c各自独立地为氢，取代或未取代的烷基等; R2和R3各自独立地是取代或未取代的芳基等; R4a和R4b各自独立地为氢，取代或未取代的烷基等; X是-N（R 5） - 等; R5是氢，取代或未取代的低级烷基等; -Y-是-O-等; ═Z是═O等; n为0〜4的整数。

3. 发明授权

US09150546B2 Triazine derivative and pharmaceutical composition comprising the same 有权
标题翻译：三嗪衍生物及其组合物
公开(公告)号：US09150546B2
公开(公告)日：2015-10-06
申请号：US13201209
申请日：2010-02-10
申请人： Hiroyuki Kai , Takayuki Kameyama , Tsuyoshi Hasegawa , Miho Oohara , Yukio Tada , Takeshi Endoh
发明人： Hiroyuki Kai , Takayuki Kameyama , Tsuyoshi Hasegawa , Miho Oohara , Yukio Tada , Takeshi Endoh
IPC分类号： A61K31/535 , A61K31/53 , C07D403/06 , C07D251/46 , C07D251/52 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D405/06 , C07D405/12 , C07D409/06 , C07D413/12
CPC分类号： C07D251/46 , C07D251/16 , C07D251/44 , C07D251/52 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/12 , C07D405/06 , C07D405/12 , C07D409/06 , C07D413/12
摘要： The present invention provides a novel P2X3 and/or P2X2/3 receptor antagonist.A compound represented by the formula (I): wherein Ra, Rb and Rc are, (a) Ra and Rb are taken together ═Z; and Rc is a group represented by R1c; or (b) Rb and Rc are taken together to form a bond; and Ra is a group represented by —Y—R1a; R1a and R1c are each independently hydrogen, substituted or unsubstituted alkyl, etc.; R2 and R3 are each independently substituted or unsubstituted aryl, etc.; R4a and R4b are each independently hydrogen, substituted or unsubstituted alkyl, etc.; X is —N(R5)—, etc.; R5 is hydrogen, substituted or unsubstituted lower alkyl, etc.; —Y— is —O—, etc.; ═Z is ═O, etc.; and n is an integer of 0 to 4.
摘要翻译：本发明提供了一种新型的P2X3和/或P2X2 / 3受体拮抗剂。由式（I）表示的化合物：其中Ra，Rb和Rc为（a）Ra和Rb一起为= Z; Rc为由R1c表示的基团; 或（b）Rb和Rc一起形成键; 并且R a是由-Y-R 1a表示的基团; R1a和R1c各自独立地为氢，取代或未取代的烷基等; R2和R3各自独立地是取代或未取代的芳基等; R4a和R4b各自独立地为氢，取代或未取代的烷基等; X是-N（R 5） - 等; R5是氢，取代或未取代的低级烷基等; -Y-是-O-等; ═Z是═O等; n为0〜4的整数。

4. 发明授权

US08101644B2 Pyrrolinone derivative and pharmaceutical composition comprising the same 有权
标题翻译：吡咯啉酮衍生物及其组合物
公开(公告)号：US08101644B2
公开(公告)日：2012-01-24
申请号：US12450548
申请日：2008-03-28
申请人： Hiroyuki Kai , Shunji Shinohara , Takayuki Kameyama
发明人： Hiroyuki Kai , Shunji Shinohara , Takayuki Kameyama
IPC分类号： A61K31/4162 , A61K31/407 , C07D487/02 , C07D231/00
CPC分类号： C07D207/38 , A61K31/40 , A61K31/4025 , A61K31/4162 , A61K31/422 , A61K31/427 , A61K31/4439 , A61K31/454 , A61K31/5517 , C07D401/04 , C07D401/06 , C07D405/06 , C07D405/10 , C07D409/06 , C07D413/10 , C07D413/14 , C07D417/04 , C07D487/04
摘要： The present invention provides a compound represented by the formula (I): wherein R1, R2, R3, Z1, Z2, Ra, Rb, q, A and n are as defined in the description, a pharmaceutically acceptable salt or solvate thereof. The compound is useful as P2X3 and/or P2X2/3 receptor antagonist.
摘要翻译：本发明提供由式（I）表示的化合物：其中R1，R2，R3，Z1，Z2，Ra，Rb，q，A和n如说明书中所定义，其药学上可接受的盐或溶剂化物。该化合物可用作P2X3和/或P2X2 / 3受体拮抗剂。

5. 发明申请

US20120010199A1 NOVEL PYRROLINONE DERIVATIVE AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME 失效
标题翻译：新型吡咯烷酮衍生物和包含其的药物组合物
公开(公告)号：US20120010199A1
公开(公告)日：2012-01-12
申请号：US13242518
申请日：2011-09-23
申请人： Hiroyuki Kai , Shunji Shinohara , Takayuki Kameyama
发明人： Hiroyuki Kai , Shunji Shinohara , Takayuki Kameyama
IPC分类号： A61K31/422 , C07D413/14 , A61P25/00 , A61K31/454 , C07D487/04 , A61K31/551 , C07D413/10 , A61K31/4439
CPC分类号： C07D207/38 , A61K31/40 , A61K31/4025 , A61K31/4162 , A61K31/422 , A61K31/427 , A61K31/4439 , A61K31/454 , A61K31/5517 , C07D401/04 , C07D401/06 , C07D405/06 , C07D405/10 , C07D409/06 , C07D413/10 , C07D413/14 , C07D417/04 , C07D487/04
摘要： The present invention provides a compound represented by the formula (I): wherein R1, R2, R3, Z1, Z2, Ra, Rb, q, A and n are as defined in the description, a pharmaceutically acceptable salt or solvate thereof. The compound is useful as P2X3 and/or P2X2/3 receptor antagonist.
摘要翻译：本发明提供由式（I）表示的化合物：其中R1，R2，R3，Z1，Z2，Ra，Rb，q，A和n如说明书中所定义，其药学上可接受的盐或溶剂化物。该化合物可用作P2X3和/或P2X2 / 3受体拮抗剂。

6. 发明授权

US08497263B2 Pyrrolinone derivative and pharmaceutical composition comprising the same 失效
标题翻译：吡咯啉酮衍生物及其组合物
公开(公告)号：US08497263B2
公开(公告)日：2013-07-30
申请号：US13242518
申请日：2011-09-23
申请人： Hiroyuki Kai , Shunji Shinohara , Takayuki Kameyama
发明人： Hiroyuki Kai , Shunji Shinohara , Takayuki Kameyama
IPC分类号： A61K31/422 , A61K31/454 , A61K31/551 , A61K31/4439 , A61K31/4025 , C07D413/14 , C07D487/04 , C07D413/10 , C07D207/26 , C07D261/06
CPC分类号： C07D207/38 , A61K31/40 , A61K31/4025 , A61K31/4162 , A61K31/422 , A61K31/427 , A61K31/4439 , A61K31/454 , A61K31/5517 , C07D401/04 , C07D401/06 , C07D405/06 , C07D405/10 , C07D409/06 , C07D413/10 , C07D413/14 , C07D417/04 , C07D487/04
摘要： The present invention provides a compound represented by the formula (I): wherein R1, R2, R3, Z1, Z2, Ra, Rb, q, A and n are as defined in the description, a pharmaceutically acceptable salt or solvate thereof. The compound is useful as P2X3 and/or P2X2/3 receptor antagonist.
摘要翻译：本发明提供由式（I）表示的化合物：其中R1，R2，R3，Z1，Z2，Ra，Rb，q，A和n如说明书中所定义，其药学上可接受的盐或溶剂化物。该化合物可用作P2X3和/或P2X2 / 3受体拮抗剂。

7. 发明申请

US20100210632A1 NOVEL PYRROLINONE DERIVATIVE AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME 有权
标题翻译：新型吡咯烷酮衍生物和包含其的药物组合物
公开(公告)号：US20100210632A1
公开(公告)日：2010-08-19
申请号：US12450548
申请日：2008-03-28
申请人： Hiroyuki Kai , Shunji Shinohara , Takayuki Kameyama
发明人： Hiroyuki Kai , Shunji Shinohara , Takayuki Kameyama
IPC分类号： A61K31/551 , C07D413/10 , A61K31/42 , C07D401/06 , A61K31/4439 , C07D487/04 , C07D413/14 , A61K31/5377 , A61P19/02
CPC分类号： C07D207/38 , A61K31/40 , A61K31/4025 , A61K31/4162 , A61K31/422 , A61K31/427 , A61K31/4439 , A61K31/454 , A61K31/5517 , C07D401/04 , C07D401/06 , C07D405/06 , C07D405/10 , C07D409/06 , C07D413/10 , C07D413/14 , C07D417/04 , C07D487/04
摘要： The present invention provides a compound represented by the formula (I): wherein R1, R2, R3, Z1, Z2, Ra, Rb, q, A and n are as defined in the description, a pharmaceutically acceptable salt or solvate thereof. The compound is useful as P2X3 and/or P2X2/3 receptor antagonist.
摘要翻译：本发明提供由式（I）表示的化合物：其中R1，R2，R3，Z1，Z2，Ra，Rb，q，A和n如说明书中所定义，其药学上可接受的盐或溶剂化物。该化合物可用作P2X3和/或P2X2 / 3受体拮抗剂。

8. 发明授权

US08315511B2 Finger authentication device 有权
标题翻译：手指认证设备
公开(公告)号：US08315511B2
公开(公告)日：2012-11-20
申请号：US12625130
申请日：2009-11-24
申请人： Katsuya Banno , Takayuki Kameyama
发明人： Katsuya Banno , Takayuki Kameyama
IPC分类号： G03B29/00 , G06K9/00
CPC分类号： G06K9/00013 , G06K2009/00932
摘要： A finger authentication device includes a base and an upper case which inclines to a proximal end side with respect to the base, which are integrally formed. The base includes a finger guide on which a finger is set, an optical system for guiding transmissive light penetrating the finger, and an image pick-up unit for picking up a pattern of the light guided by the optical system. Three LEDs each for irradiating the light to the finger set on the finger guide are arranged in the upper case. The light from the LEDs irradiates a center tip and both sides of the finger, respectively.
摘要翻译：手指认证装置包括基部和上壳体，其相对于基部倾斜到基端，所述基部一体地形成。底座包括一个手指导轨，一个手指放在其上，一个用于引导穿透手指的透射光的光学系统，以及用于拾取由该光学系统引导的光的图案的图像拾取单元。用于将光照射到手指引导件上的手指的三个LED布置在上壳体中。来自LED的光分别照射手指的中心尖端和两侧。

9. 发明授权

US06646404B2 Method for controlling robot and robot controller using the method 有权
公开(公告)号：US06646404B2
公开(公告)日：2003-11-11
申请号：US10026057
申请日：2001-12-21
申请人： Masayuki Okuyama , Takayuki Kameyama , Nobuyuki Setsuda
发明人： Masayuki Okuyama , Takayuki Kameyama , Nobuyuki Setsuda
IPC分类号： B25J922
CPC分类号： B25J9/1669 , G05B2219/39401 , G05B2219/40554 , G05B2219/45054
摘要： The current position of a work is sequentially updated in a conveyor coordinate system, and the path of a robot to follow the work is formed by transforming the position of the work from the conveyor coordinate system to a robot coordinate system.

10. 发明申请

US20100225442A1 FINGER AUTHENTICATION DEVICE 有权
标题翻译：指纹认证设备
公开(公告)号：US20100225442A1
公开(公告)日：2010-09-09
申请号：US12625130
申请日：2009-11-24
申请人： Katsuya BANNO , Takayuki Kameyama
发明人： Katsuya BANNO , Takayuki Kameyama
IPC分类号： G05B19/00
CPC分类号： G06K9/00013 , G06K2009/00932
摘要： A finger authentication device includes a base and an upper case which inclines to a proximal end side with respect to the base, which are integrally formed. The base includes a finger guide on which a finger is set, an optical system for guiding transmissive light penetrating the finger, and an image pick-up unit for picking up a pattern of the light guided by the optical system. Three LEDs each for irradiating the light to the finger set on the finger guide are arranged in the upper case. The light from the LEDs irradiates a center tip and both sides of the finger, respectively.
摘要翻译：手指认证装置包括基部和上壳体，其相对于基部倾斜到基端，所述基部一体地形成。底座包括一个手指导轨，一个手指放在其上，一个用于引导穿透手指的透射光的光学系统，以及用于拾取由该光学系统引导的光的图案的图像拾取单元。用于将光照射到手指引导件上的手指的三个LED布置在上壳体中。来自LED的光分别照射手指的中心尖端和两侧。

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