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1. 发明申请

US20100227866A1 TETRAHYDROISOQUINOLIN-1-ONE DERIVATIVE OR SALT THEREOF 有权
标题翻译：四氢喹啉-1-酮衍生物或其盐
公开(公告)号：US20100227866A1
公开(公告)日：2010-09-09
申请号：US12600894
申请日：2008-05-26
申请人： Hiroyuki Hisamichi , Itsuro Shimada , Tsukasa Ishihara , Tomofumi Takuwa , Takafumi Shimizu , Noriko Ishikawa , Kyoichi Maeno , Norio Seki
发明人： Hiroyuki Hisamichi , Itsuro Shimada , Tsukasa Ishihara , Tomofumi Takuwa , Takafumi Shimizu , Noriko Ishikawa , Kyoichi Maeno , Norio Seki
IPC分类号： A61K31/4725 , C07D401/12 , C07D401/14 , A61K31/53 , A61K31/506 , A61P1/00 , A61P35/00
CPC分类号： A61K31/4725 , A61K31/435 , A61K31/439 , A61K31/445 , A61K31/472 , A61K31/496 , A61K31/497 , A61K31/501 , A61K31/506 , A61K31/5377 , A61K31/695 , C07D217/26 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D405/04 , C07D405/06 , C07D405/14 , C07D409/12 , C07D413/12 , C07D417/12 , C07D453/02 , C07D471/04
摘要： [Problems] To provide a pharmaceutical, in particular a compound which can be used as a therapeutic agent for irritable bowel syndrome (IBS).[Means for Solving Problems] It was found that a tetrahydroisoquinolin-1-one derivative having an amide group at the 4-position or a pharmaceutically acceptable salt thereof has an excellent bombesin 2 (BB2) receptor antagonistic action. It is also found that the tetrahydroisoquinolin-1-one derivative is highly effective on bowel movement disorders. From the above, the tetrahydroisoquinolin-1-one derivative of the present invention is useful as a therapeutic agent for diseases associated with a BB2 receptor, in particular IBS.
摘要翻译： [问题]提供药物，特别是可用作肠易激综合征（IBS）治疗剂的化合物。 [解决问题的手段]发现在4-位具有酰胺基的四氢异喹啉-1-酮衍生物或其药学上可接受的盐具有优异的铃蟾肽2（BB2）受体拮抗作用。还发现四氢异喹啉-1-酮衍生物对肠运动障碍是高度有效的。从上述可以看出，本发明的四氢异喹啉-1-酮衍生物可用作与BB2受体，特别是IBS相关疾病的治疗剂。

2. 发明授权

US08486970B2 Tetrahydroisoquinolin-1-one derivative or salt thereof 有权
标题翻译：四氢异喹啉-1-酮衍生物或其盐
公开(公告)号：US08486970B2
公开(公告)日：2013-07-16
申请号：US12600894
申请日：2008-05-26
申请人： Hiroyuki Hisamichi , Itsuro Shimada , Tsukasa Ishihara , Tomofumi Takuwa , Takafumi Shimizu , Noriko Ishikawa , Kyoichi Maeno , Norio Seki
发明人： Hiroyuki Hisamichi , Itsuro Shimada , Tsukasa Ishihara , Tomofumi Takuwa , Takafumi Shimizu , Noriko Ishikawa , Kyoichi Maeno , Norio Seki
IPC分类号： A01N43/40 , A61K31/445
CPC分类号： A61K31/4725 , A61K31/435 , A61K31/439 , A61K31/445 , A61K31/472 , A61K31/496 , A61K31/497 , A61K31/501 , A61K31/506 , A61K31/5377 , A61K31/695 , C07D217/26 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D405/04 , C07D405/06 , C07D405/14 , C07D409/12 , C07D413/12 , C07D417/12 , C07D453/02 , C07D471/04
摘要： [Problems] To provide a pharmaceutical, in particular a compound which can be used as a therapeutic agent for irritable bowel syndrome (IBS).[Means for Solving Problems] It was found that a tetrahydroisoquinolin-1-one derivative having an amide group at the 4-position or a pharmaceutically acceptable salt thereof has an excellent bombesin 2 (BB2) receptor antagonistic action. It is also found that the tetrahydroisoquinolin-1-one derivative is highly effective on bowel movement disorders. From the above, the tetrahydroisoquinolin-1-one derivative of the present invention is useful as a therapeutic agent for diseases associated with a BB2 receptor, in particular IBS.
摘要翻译： [问题]提供药物，特别是可用作肠易激综合征（IBS）治疗剂的化合物。 [解决问题的手段]发现在4-位具有酰胺基的四氢异喹啉-1-酮衍生物或其药学上可接受的盐具有优异的铃蟾肽2（BB2）受体拮抗作用。还发现四氢异喹啉-1-酮衍生物对肠运动障碍是高度有效的。从上述可以看出，本发明的四氢异喹啉-1-酮衍生物可用作与BB2受体，特别是IBS相关疾病的治疗剂。

3. 发明授权

US08388799B2 Composition for forming polishing layer of chemical mechanical polishing pad, chemical mechanical polishing pad and chemical mechanical polishing method 有权
标题翻译：用于形成化学机械抛光垫抛光层，化学机械抛光垫和化学机械抛光方法的组合物
公开(公告)号：US08388799B2
公开(公告)日：2013-03-05
申请号：US12357706
申请日：2009-01-22
申请人： Rikimaru Kuwabara , Takahiro Okamoto , Yukio Hosaka , Takafumi Shimizu , Tsuyoshi Watanabe
发明人： Rikimaru Kuwabara , Takahiro Okamoto , Yukio Hosaka , Takafumi Shimizu , Tsuyoshi Watanabe
IPC分类号： H01L21/304 , C08G18/42 , C08G18/48 , C08G18/62
CPC分类号： C08G18/3206 , B24B37/042 , B24B37/24 , C08G18/44 , C08G18/4854 , C08G18/6674 , C08G18/675 , C08G18/69 , C08K5/14 , C08L75/16 , C08L75/14 , C08L2666/26
摘要： A composition for forming a chemical mechanical polishing pad having polishing characteristics such as a high polishing rate, an excellent planarity of the polished object, and less scratches of the polished object. The composition includes (A) a polyurethane having a carbon-carbon double bond on a side chain and (B) a cross-linking agent. The polyurethane (A) is preferably a thermoplastic polyurethane (A′) obtained by mixing at least components (a11) to (a13) and component (a2) in a proportion satisfying the following conditions (1) and (2) and reacting them.
摘要翻译：一种用于形成化学机械抛光垫的组合物，其具有抛光特性如抛光速度高，抛光物体的平坦度优异，并且抛光对象的划痕较少。该组合物包括（A）侧链上具有碳 - 碳双键的聚氨酯和（B）交联剂。聚氨酯（A）优选为通过以满足以下条件（1）和（2）的比例混合至少组分（a11）至（a13）和组分（a2）而得到的热塑性聚氨酯（A'）并使其反应。

4. 发明授权

US4485270A Method for transmitting a charging signal 失效
标题翻译：发送充电信号的方法
公开(公告)号：US4485270A
公开(公告)日：1984-11-27
申请号：US419926
申请日：1982-09-20
申请人： Isao Honda , Takafumi Shimizu
发明人： Isao Honda , Takafumi Shimizu
IPC分类号： H04M15/00 , G08C25/00 , H04M15/28 , H04M17/00 , H04M17/02 , H04W4/24 , H04W84/14 , H04Q7/04
CPC分类号： H04W84/14 , G08C25/00 , H04M15/28 , H04M17/023 , H04W4/24 , H04M2215/32
摘要： In a system for transmitting a charging signal from an exchange to a telephone system together with a voice signal, radio equipment in the exchange side detects the charging signal sent from the exchange and encodes it into a pulse code signal comprising a plurality of continuous pulses. Thereafter, this pulse signal is modulated into a frequency signal outside the voice transmitting frequency band and then transmitted as a radio signal after it is superimposed on the voice signal. Radio equipment on the telephone side detects this charging signal carrier and demodulates it into the pulse code signal, then counts it and transfers the charging signal when the counted value reaches a specified value. In addition, the radio equipment in the exchange side previously executes a deep amplitude limitation only for the voice signal onto which the out-of-band frequency signal is superimposed, and, thereby, the charging signal superimposed is protected from degradation due to amplitude limitation by a limiter circuit provided in a stage preceding a modulator.
摘要翻译：在用于从交换机与电话系统一起发送计费信号与语音信号的系统中，交换侧的无线电设备检测从交换机发送的充电信号，并将其编码成包括多个连续脉冲的脉冲编码信号。此后，该脉冲信号被调制成声音发送频带外的频率信号，然后在叠加在语音信号上之后作为无线电信号发送。电话侧的无线电设备检测该充电信号载波并将其解调为脉冲码信号，然后对其计数并在计数值达到指定值时传送充电信号。此外，交换侧的无线电设备先前对叠加有带外频率信号的语音信号执行深度限幅，从而保护叠加的充电信号免受由于幅度限制的劣化通过设置在调制器之前的阶段中的限幅器电路。

5. 发明授权

US09157783B2 Method for producing conductive segment 有权
标题翻译：导电段的制造方法
公开(公告)号：US09157783B2
公开(公告)日：2015-10-13
申请号：US13555396
申请日：2012-07-23
申请人： Toshio Oike , Kenichi Tanaka , Ryo Hirose , Takafumi Shimizu
发明人： Toshio Oike , Kenichi Tanaka , Ryo Hirose , Takafumi Shimizu
IPC分类号： B05D5/12 , G01F23/36 , H01C1/142 , H01C17/28 , C22C5/02 , C22C5/06 , B05D7/00 , B05D3/02 , B32B15/01
CPC分类号： G01F23/36 , B05D3/02 , B05D5/12 , B05D7/50 , B32B15/01 , C22C5/02 , C22C5/06 , H01C1/142 , H01C17/281 , Y10T428/12889
摘要： A method for producing a conductive segment, includes: a step of printing a metal conductive paste on a substrate, and drying the paste; a step of printing other metal conductive paste on the metal conductive paste after drying, and drying the paste; and a step of burning the metal conductive paste after drying and the other metal conductive paste after drying, wherein the conductive metal paste is an Ag—Pd conductive paste comprising silver (Ag) and palladium (Pd), and the other metal conductive paste is an Au conductive paste comprising gold (Au) as a main component; or the metal conductive paste is an Au conductive paste comprising gold (Au) as a main component, and the other metal conductive paste is an Ag—Pd conductive paste comprising silver (Ag) and palladium (Pd).
摘要翻译：一种导电段的制造方法，其特征在于，包括：在基板上印刷金属导电性糊剂，干燥所述糊料的工序; 干燥后在金属导电糊上印刷其它金属导电糊的步骤，干燥糊剂; 干燥后的金属导电糊的烧成工序和干燥后的其他金属导电膏，其特征在于，所述导电性金属糊是包含银（Ag）和钯（Pd）的Ag-Pd导电性膏，另一方的金属导电膏为包含金（Au）作为主要成分的Au导电膏; 或金属导电浆料是以金（Au）为主要成分的Au导电膏，另一种金属导电膏为包含银（Ag）和钯（Pd）的Ag-Pd导电糊。

6. 发明授权

US08514614B2 Magnetic memory 有权
标题翻译：磁记忆
公开(公告)号：US08514614B2
公开(公告)日：2013-08-20
申请号：US12885175
申请日：2010-09-17
申请人： Takafumi Shimizu , Kenji Tsuchida , Yoshihiro Ueda
发明人： Takafumi Shimizu , Kenji Tsuchida , Yoshihiro Ueda
IPC分类号： G11C11/00
CPC分类号： G11C11/1675 , G11C11/1673
摘要： According to one embodiment, a magnetic memory includes a magnetoresistive element includes a fixed layer whose magnetization direction is fixed, a recording layer whose magnetization direction is variable and a nonmagnetic layer disposed between the fixed layer and the recording layer. A direction of a read current is set to a first direction in a case where an expression of MR ratio ≧|Ic+/Ic−|−1 is satisfied if a critical current of the first direction used to write the magnetoresistive element to the parallel state is set to Ic− and a critical current of a second direction used to write the magnetoresistive element to the anti-parallel state is set to Ic+.
摘要翻译：根据一个实施例，磁存储器包括磁阻元件，其包括其磁化方向固定的固定层，其磁化方向可变的记录层和设置在固定层和记录层之间的非磁性层。如果用于将磁阻元件写入平行的第一方向的临界电流满足MR ratio> = | Ic + / Ic- | -1的表达式的情况下，将读取电流的方向设置为第一方向状态被设定为Ic-，将用于将磁阻元件写入反并联状态的第二方向的临界电流设定为Ic +。

7. 发明授权

US08506359B2 Aqueous dispersion for chemical mechanical polishing and chemical mechanical polishing method 有权
标题翻译：化学机械抛光和化学机械抛光方法的水分散体
公开(公告)号：US08506359B2
公开(公告)日：2013-08-13
申请号：US12866571
申请日：2009-01-16
申请人： Hirotaka Shida , Takafumi Shimizu , Masatoshi Ikeda , Shou Kubouchi , Yousuke Shibata , Kazuhito Uchikura , Akihiro Takemura
发明人： Hirotaka Shida , Takafumi Shimizu , Masatoshi Ikeda , Shou Kubouchi , Yousuke Shibata , Kazuhito Uchikura , Akihiro Takemura
IPC分类号： H01L21/302
CPC分类号： H01L21/3212 , C09G1/02 , C09K3/1409 , C09K3/1436 , C09K3/1463 , H01L21/31053
摘要： A chemical mechanical polishing aqueous dispersion including (A) silica particles, and (B1) an organic acid, the sodium content, the potassium content, and the ammonium ion content of the silica particles (A) determined by ICP atomic emission spectrometry, ICP mass spectrometry, or ammonium ion quantitative analysis using ion chromatography having a relationship in which the sodium content is 5 to 500 ppm and at least one of the potassium content and the ammonium ion content is 100 to 20,000 ppm.
摘要翻译：包含（A）二氧化硅颗粒和（B1）有机酸的化学机械研磨水分散体，通过ICP原子发射光谱法测定的二氧化硅颗粒（A）的钠含量，钾含量和铵离子含量，ICP质量使用具有钠含量为5〜500ppm，钾含量和铵离子含量中的至少一种为100〜20000ppm的关系的离子色谱法进行光谱法或铵离子定量分析。

8. 发明申请

US20110063900A1 MAGNETIC MEMORY 有权
标题翻译：磁记忆
公开(公告)号：US20110063900A1
公开(公告)日：2011-03-17
申请号：US12885175
申请日：2010-09-17
申请人： Takafumi Shimizu , Kenji Tsuchida , Yoshihiro Ueda
发明人： Takafumi Shimizu , Kenji Tsuchida , Yoshihiro Ueda
IPC分类号： G11C11/00
CPC分类号： G11C11/1675 , G11C11/1673
摘要： According to one embodiment, a magnetic memory includes a magnetoresistive element includes a fixed layer whose magnetization direction is fixed, a recording layer whose magnetization direction is variable and a nonmagnetic layer disposed between the fixed layer and the recording layer. A direction of a read current is set to a first direction in a case where an expression of MR ratio ≧|Ic+/Ic−|−1 is satisfied if a critical current of the first direction used to write the magnetoresistive element to the parallel state is set to Ic− and a critical current of a second direction used to write the magnetoresistive element to the anti-parallel state is set to Ic+.
摘要翻译：根据一个实施例，磁存储器包括磁阻元件，其包括其磁化方向固定的固定层，其磁化方向可变的记录层和设置在固定层和记录层之间的非磁性层。如果用于将磁阻元件写入平行状态的第一方向的临界电流满足MR比≧| Ic + / Ic- | -1的表达式的情况下，读取电流的方向被设定为第一方向被设定为Ic-，将用于将磁阻元件写入反并联状态的第二方向的临界电流设定为Ic +。

9. 发明申请

US20100194795A1 IMAGE FORMING APPARATUS, IMAGE FORMING SYSTEM AND COMPUTER-READABLE STORAGE MEDIUM 有权
标题翻译：图像形成装置，图像形成系统和计算机可读存储介质
公开(公告)号：US20100194795A1
公开(公告)日：2010-08-05
申请号：US12692683
申请日：2010-01-25
申请人： Tomokazu Tsuchiya , Takafumi Shimizu
发明人： Tomokazu Tsuchiya , Takafumi Shimizu
IPC分类号： B41J2/01
CPC分类号： B41J11/007
摘要： An image forming apparatus includes a voltage applying unit to apply a voltage to and charge a surface of transport belt, a leak judging unit to judge a charge leak on the surface of the transport belt, and a recovery operation unit to perform a charge leak recovery operation in which the transport belt is driven in a state where the voltage applying unit applies no voltage to the transport belt, if the leak judging unit judges that the charge leak is generated on the surface of the transport belt. The leak judging unit again judges whether the charge leak is generated on the surface of the transport belt after the recovery operation unit performs the charge leak recovery operation.
摘要翻译：图像形成装置包括对输送带的表面施加电压并向其充电的电压施加单元，用于判断输送带表面上的电荷泄漏的泄漏判断单元和进行电荷泄漏恢复的恢复操作单元如果泄漏判断单元判断在传送带的表面上产生电荷泄漏，那么在电压施加单元向输送带施加电压的状态下驱动传送带的操作。泄漏判断单元再次判断在恢复操作单元执行充电泄漏恢复操作之后在输送带的表面上是否产生电荷泄漏。

10. 发明授权

US09108977B2 Benzazepine compound 有权
标题翻译：苯扎西平化合物
公开(公告)号：US09108977B2
公开(公告)日：2015-08-18
申请号：US13613948
申请日：2012-09-13
申请人： Hiroyuki Koshio , Norio Asai , Taisuke Takahashi , Takafumi Shimizu , Yasuhito Nagai , Keiko Kawabata , Karl Bruce Thor
发明人： Hiroyuki Koshio , Norio Asai , Taisuke Takahashi , Takafumi Shimizu , Yasuhito Nagai , Keiko Kawabata , Karl Bruce Thor
IPC分类号： A61K31/55 , C07D471/04 , C07D498/04 , C07D487/04
CPC分类号： C07D498/04 , A61K31/55 , C07D471/04 , C07D487/04
摘要： Provided is a compound which is useful as an agent for treating or preventing 5-HT2C receptor-related diseases, particularly incontinence such as stress urinary incontinence, urge urinary incontinence, mixed urinary incontinence, and the like, sexual dysfunction such as erectile dysfunction syndrome and the like, obesity, and the like. The present inventors have investigated compounds having a 5-HT2C receptor agonist activity and have found that the benzazepine compounds of the present invention have an excellent 5-HT2C receptor agonist activity, thereby completing the present invention. That is, the benzazepine compounds of the present invention have a 5-HT2C receptor agonist activity and can be used as an agent for treating or preventing 5-HT2C receptor-related diseases, particularly incontinence such as stress urinary incontinence, urge urinary incontinence, mixed urinary incontinence, and the like, sexual dysfunction such as erectile dysfunction syndrome and the like, obesity, and the like.
摘要翻译：本发明提供可用作治疗或预防5-HT 2C受体相关疾病，特别是尿失禁，尿失禁尿，尿失禁等尿失禁的药物的化合物，勃起功能障碍综合征等性功能障碍，类似物，肥胖症等。本发明人研究了具有5-HT 2C受体激动剂活性的化合物，并且发现本发明的苯并氮杂化合物具有优异的5-HT 2C受体激动剂活性，从而完成了本发明。也就是说，本发明的苯并氮杂化合物具有5-HT 2C受体激动剂活性，可用作治疗或预防5-HT 2C受体相关疾病的药剂，特别是尿失禁，压力性尿失禁，压力性尿失禁，混合型尿失禁等，性功能障碍如勃起功能障碍综合征等，肥胖等。

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