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1. 发明授权

US08502440B2 Organic electroluminescent light source 有权
标题翻译：有机电致发光光源
公开(公告)号：US08502440B2
公开(公告)日：2013-08-06
申请号：US12989196
申请日：2009-04-10
申请人： Hiroyasu Inoue , Hirotoshi Tanimoto
发明人： Hiroyasu Inoue , Hirotoshi Tanimoto
IPC分类号： H01L51/50
CPC分类号： H01L51/5268 , H01L51/524 , H01L51/5271
摘要： An organic electroluminescent light source device includes, in the following order from a light-emitting surface side, a first transparent electrode layer, a luminescent layer, a second transparent electrode layer, and a reflecting layer, wherein the reflecting layer includes a concavo-convex structure with an average inclination angle of 12 to 45°. An organic electroluminescent light source device includes, in the following order, a first transparent electrode layer, a luminescent layer, a second transparent electrode layer, a diffusing layer, and a reflecting-scattering layer, wherein the diffusing layer has a concavo-convex surface including a concavo-convex structure with an average inclination angle of 17 to 45°.
摘要翻译：一种有机电致发光光源装置，从发光面侧依次包括第一透明电极层，发光层，第二透明电极层和反射层，其中反射层包括凹凸平均倾角为12〜45°的结构。有机电致发光光源装置按照以下顺序包括第一透明电极层，发光层，第二透明电极层，漫射层和反射散射层，其中漫射层具有凹凸表面包括平均倾斜角为17°〜45°的凹凸结构。

2. 发明申请

US20110050082A1 ORGANIC ELECTROLUMINESCENT LIGHT SOURCE 有权
标题翻译：有机电致发光源
公开(公告)号：US20110050082A1
公开(公告)日：2011-03-03
申请号：US12989196
申请日：2009-04-10
申请人： Hiroyasu Inoue , Hirotoshi Tanimoto
发明人： Hiroyasu Inoue , Hirotoshi Tanimoto
IPC分类号： H01J1/62
CPC分类号： H01L51/5268 , H01L51/524 , H01L51/5271
摘要： An organic electroluminescent light source device includes, in the following order from a light-emitting surface side, a first transparent electrode layer, a luminescent layer, a second transparent electrode layer, and a reflecting layer, wherein the reflecting layer includes a concavo-convex structure with an average inclination angle of 12 to 45°. An organic electroluminescent light source device includes, in the following order, a first transparent electrode layer, a luminescent layer, a second transparent electrode layer, a diffusing layer, and a reflecting-scattering layer, wherein the diffusing layer has a concavo-convex surface including a concavo-convex structure with an average inclination angle of 17 to 45°.
摘要翻译：一种有机电致发光光源装置，从发光面侧依次包括第一透明电极层，发光层，第二透明电极层和反射层，其中反射层包括凹凸平均倾角为12〜45°的结构。有机电致发光光源装置按照以下顺序包括第一透明电极层，发光层，第二透明电极层，漫射层和反射散射层，其中漫射层具有凹凸表面包括平均倾斜角为17°〜45°的凹凸结构。

3. 发明申请

US20090274618A1 TADG-15: an extracellular serine protease overexpressed in carcinomas 有权
标题翻译： TADG-15：细胞外丝氨酸蛋白酶在癌中过表达
公开(公告)号：US20090274618A1
公开(公告)日：2009-11-05
申请号：US11978259
申请日：2007-10-29
申请人： Timothy J. O'Brien , Hirotoshi Tanimoto
发明人： Timothy J. O'Brien , Hirotoshi Tanimoto
IPC分类号： A61K51/00 , C12N15/00 , C12N1/21 , C12N5/06 , C12N5/04 , C12N15/87 , C12N15/82 , C12N15/11 , A61K31/7088 , A61K39/395 , A61K39/00 , C12Q1/37
CPC分类号： C12N9/6424 , A61K39/00 , C12Q1/6851 , C12Q1/6886 , C12Q2600/136 , Y10T436/25
摘要： The present invention provides DNA encoding a TADG-15 protein as well as a TADG-15 protein. Also provided is a vector capable of expressing the DNA of the present invention adapted for expression in a recombinant cell and regulatory elements necessary for expression of the DNA in the cell. The present invention further provides for methods of inhibiting TADG-15 expression and/or protease activity, methods of detecting TADG-15 mRNA and/or protein and methods of screening for TADG-15 inhibitors. Additionally, the present invention provides for cell-specific targeting via TADG-15 and methods of vaccinating an individual against TADG-15. The methods described are useful in the diagnosis, treatment and prevention of cancer, particularly breast and ovarian cancer.
摘要翻译：本发明提供编码TADG-15蛋白质和TADG-15蛋白质的DNA。还提供了能够表达适于在重组细胞中表达的本发明的DNA的载体和在细胞中表达DNA所需的调节元件。本发明还提供了抑制TADG-15表达和/或蛋白酶活性的方法，检测TADG-15mRNA和/或蛋白质的方法以及筛选TADG-15抑制剂的方法。另外，本发明提供了通过TADG-15进行的细胞特异性靶向和针对TADG-15接种个体的方法。所描述的方法可用于诊断，治疗和预防癌症，特别是乳腺癌和卵巢癌。

4. 发明授权

US4935549A Process for producing acetic acid 失效
标题翻译：生产乙酸的方法
公开(公告)号：US4935549A
公开(公告)日：1990-06-19
申请号：US35209
申请日：1987-04-06
申请人： Taiji Kamiguchi , Mutsuo Yamada , Yoshijiro Arikawa , Hirotoshi Tanimoto , Yasuyuki Nishimura
发明人： Taiji Kamiguchi , Mutsuo Yamada , Yoshijiro Arikawa , Hirotoshi Tanimoto , Yasuyuki Nishimura
IPC分类号： C07C51/21 , B01J31/00 , C07B61/00 , C07C51/00 , C07C51/25 , C07C53/08 , C07C67/00
CPC分类号： C07C51/25
摘要： A process for producing acetic acid directly from ethylene under mild conditions is provided, wherein ethylene and oxygen are respectively coordinated with the respective transition metals contained in a specified composite catalyst system, and ethylene activated thereby is successively oxidized by two kinds of oxygen complexes contained in the system and having their electric charge states adjusted, the composite catalyst system comprising a complex represented by a formula (MmXn.Ll) and a complex represented by a formula (M'm'Xn'.L'l') wherein is a transition metal of the groups I, IV.about.VII and iron group; X, an anion; L, an organic phosphorus compound as a ligand; M', a transition metal of Pt group; L', a nitrile, organic fluorine compound or organic phosphorus compound as a ligand; m, m', n and n', each a number determined by the valences of the transition metals and anion; and l and l' each the number of ligands.
摘要翻译：提供了一种在温和条件下直接从乙烯生产乙酸的方法，其中乙烯和氧分别与指定的复合催化剂体系中所含的各种过渡金属配位，由此活化的乙烯依次被两种含有该系统并且调整其电荷状态，复合催化剂体系包含由式（MmXn.L1）表示的络合物和由式（M'm'Xn'L'1'）表示的络合物，其中， I，IV差异VII和铁组的金属; X，阴离子; L，有机磷化合物作为配体; M'，Pt族的过渡金属; L'，腈，有机氟化合物或有机磷化合物作为配体; m，m'，n和n'，每个数字由过渡金属和阴离子的化合价决定; 和l和l'各自配体的数目。

5. 发明申请

US20090142328A1 Uses of antileukoprotease in carcinoma 审中-公开
标题翻译：癌细胞中抗白蛋白酶的使用
公开(公告)号：US20090142328A1
公开(公告)日：2009-06-04
申请号：US11906596
申请日：2007-10-03
申请人： Timothy J. O'Brien , Lowell J. Underwood , Hirotoshi Tanimoto , Kazushi Shigemasa
发明人： Timothy J. O'Brien , Lowell J. Underwood , Hirotoshi Tanimoto , Kazushi Shigemasa
IPC分类号： A61K38/48
CPC分类号： A61K38/57 , C12Q1/37 , G01N33/57449
摘要： The present invention provides a method of detecting/monitoring tumor growth and progression in a tissue by measuring the level of antileukoprotease. Also provided is a method of treating an individual having a tumor by administering antileukoprotease to inhibit the activity of stratum corneum chymotryptic enzyme. Specifically, the tumor is an ovarian carcinoma.
摘要翻译：本发明提供了通过测定抗白蛋白酶水平来检测/监测组织中肿瘤生长和进展的方法。还提供了通过施用抗白蛋白酶来抑制角质层糜蛋白酶的活性来治疗患有肿瘤的个体的方法。具体来说，肿瘤是卵巢癌。

6. 发明授权

US5138003A Ring opening method and reaction solution 失效
标题翻译：开环法和反应液
公开(公告)号：US5138003A
公开(公告)日：1992-08-11
申请号：US764992
申请日：1991-09-23
申请人： Kin-ichi Okumura , Munetoshi Nakano , Hirotoshi Tanimoto , Motoyuki Yamato
发明人： Kin-ichi Okumura , Munetoshi Nakano , Hirotoshi Tanimoto , Motoyuki Yamato
IPC分类号： B29C39/00 , B29C45/00 , C08G61/02 , C08G61/06 , C08G61/08
CPC分类号： C08G61/02 , B29K2023/00 , B29K2023/083 , Y02P70/26
摘要： Described herein is an oily, transparent reaction product which is prepared by heat treating at 110.degree.-220.degree. C. a dicyclopentadiene and a vinyl aromatic compound. This reaction product can be polymerized by ring-opening in presence or absence of a norbornene monomer to produce a thermoset polymer. Freezing point of the reaction product is below 10.degree. C.
摘要翻译：本文描述了一种油状透明的反应产物，其通过在110℃-220℃下热处理制备二环戊二烯和乙烯基芳族化合物。该反应产物可以在存在或不存在降冰片烯单体的情况下通过开环聚合以产生热固性聚合物。反应产物的凝固点低于10℃

7. 发明授权

US4806692A Process for producing an oxygen-containing organic compound from olefins 失效
标题翻译：从烯烃生产含氧有机化合物的方法
公开(公告)号：US4806692A
公开(公告)日：1989-02-21
申请号：US820004
申请日：1986-01-21
申请人： Mutsuo Yamada , Taiji Kamiguchi , Hirotoshi Tanimoto , Yoshijiro Arikawa , Hiroyuki Kaku , Shigehito Takamoto
发明人： Mutsuo Yamada , Taiji Kamiguchi , Hirotoshi Tanimoto , Yoshijiro Arikawa , Hiroyuki Kaku , Shigehito Takamoto
IPC分类号： C07C47/06 , C07C45/27 , C07C45/28 , C07C45/30 , C07C45/34 , C07F15/00 , C07C45/33
CPC分类号： C07F15/00 , C07C45/27 , C07C45/28 , C07C45/30 , C07C45/34
摘要： A process for producing an oxygen-containing organic compound by oxidizing olefins under milder conditions is provided, which process comprises oxidizing an olefin activated by its complex formation, in the presence of a platinum group metal complex capable of forming an olefin complex through coordination of the platinum group metal with said olefin, and also in the presence of water, and further oxidizing and regenerating the resulting reduced platinum group metal complex with oxygen coordinated with a transition metal and activated thereby.
摘要翻译：提供了一种通过在较温和的条件下氧化烯烃来生产含氧有机化合物的方法，该方法包括在能够形成烯烃络合物的铂族金属配合物的存在下氧化由其络合物形成活化的烯烃，铂族金属与所述烯烃反应，并且还在水的存在下进一步氧化和再生所得到的还原的铂族金属络合物与过渡金属配位的氧并被活化。

8. 发明授权

US07939321B2 TADG-15: an extracellular serine protease overexpressed in carcinomas 有权
标题翻译： TADG-15：细胞外丝氨酸蛋白酶在癌中过表达
公开(公告)号：US07939321B2
公开(公告)日：2011-05-10
申请号：US11978259
申请日：2007-10-29
申请人： Timothy J. O'Brien , Hirotoshi Tanimoto
发明人： Timothy J. O'Brien , Hirotoshi Tanimoto
IPC分类号： C12N5/00 , C12N5/02 , C12N5/06 , C12N5/07 , C12N5/071 , C12N5/078 , C12N5/0781 , C12N5/0783 , C12N5/0784 , C12N5/08 , C12N5/10 , G01N1/00
CPC分类号： C12N9/6424 , A61K39/00 , C12Q1/6851 , C12Q1/6886 , C12Q2600/136 , Y10T436/25
摘要： The present invention provides DNA encoding a TADG-15 protein as well as a TADG-15 protein. Also provided is a vector capable of expressing the DNA of the present invention adapted for expression in a recombinant cell and regulatory elements necessary for expression of the DNA in the cell. The present invention further provides for methods of inhibiting TADG-15 expression and/or protease activity, methods of detecting TADG-15 mRNA and/or protein and methods of screening for TADG-15 inhibitors. Additionally, the present invention provides for cell-specific targeting via TADG-15 and methods of vaccinating an individual against TADG-15. The methods described are useful in the diagnosis, treatment and prevention of cancer, particularly breast and ovarian cancer.
摘要翻译：本发明提供编码TADG-15蛋白质和TADG-15蛋白质的DNA。还提供了能够表达适于在重组细胞中表达的本发明的DNA的载体和在细胞中表达DNA所需的调节元件。本发明还提供了抑制TADG-15表达和/或蛋白酶活性的方法，检测TADG-15mRNA和/或蛋白质的方法以及筛选TADG-15抑制剂的方法。另外，本发明提供了通过TADG-15进行的细胞特异性靶向和针对TADG-15接种个体的方法。所描述的方法可用于诊断，治疗和预防癌症，特别是乳腺癌和卵巢癌。

9. 发明授权

US07022821B1 Antibody kit for the detection of TADG-15 protein 失效
标题翻译：用于检测TADG-15蛋白的抗体试剂盒
公开(公告)号：US07022821B1
公开(公告)日：2006-04-04
申请号：US09421213
申请日：1999-10-20
申请人： Timothy J. O'Brien , Hirotoshi Tanimoto
发明人： Timothy J. O'Brien , Hirotoshi Tanimoto
IPC分类号： C07K16/00 , C07K1/00 , C07K14/00 , C07K17/00 , C12P21/08
CPC分类号： C12N9/6424 , A61K39/00 , C12Q1/6851 , C12Q1/6886 , C12Q2600/136 , Y10T436/25
摘要： The present invention provides DNA encoding a TADG-15 protein as well as a TADG-15 protein. Also provided is a vector capable of expressing the DNA of the present invention adapted for expression in a recombinant cell and regulatory elements necessary for expression of the DNA in the cell. The present invention further provides for methods of inhibiting TADG-15 expression and/or protease activity, methods of detecting TADG-15 mRNA and/or protein and methods of screening for TADG-15 inhibitors. Additionally, the present invention provides for cell-specific targeting via TADG-15 and methods of vaccinating an individual against TADG-15. The instant invention also includes a kit containing antibodies for the detection of TADG-15 protein. The methods described are useful in the diagnosis, treatment and prevention of cancer, particularly breast and ovarian cancer.
摘要翻译：本发明提供编码TADG-15蛋白质和TADG-15蛋白质的DNA。还提供了能够表达适于在重组细胞中表达的本发明的DNA的载体和在细胞中表达DNA所需的调节元件。本发明还提供了抑制TADG-15表达和/或蛋白酶活性的方法，检测TADG-15mRNA和/或蛋白质的方法以及筛选TADG-15抑制剂的方法。另外，本发明提供了通过TADG-15进行的细胞特异性靶向和针对TADG-15接种个体的方法。本发明还包括含有用于检测TADG-15蛋白的抗体的试剂盒。所描述的方法可用于诊断，治疗和预防癌症，特别是乳腺癌和卵巢癌。

10. 发明授权

US06649741B1 TADG-15: an extracellular serine protease overexpressed in carcinomas 有权
标题翻译： TADG-15：细胞外丝氨酸蛋白酶在癌中过表达
公开(公告)号：US06649741B1
公开(公告)日：2003-11-18
申请号：US09654600
申请日：2000-09-01
申请人： Timothy J. O'Brien , Hirotoshi Tanimoto
发明人： Timothy J. O'Brien , Hirotoshi Tanimoto
IPC分类号： C07K1600
CPC分类号： C12N9/6424 , A61K39/00 , C12Q1/6851 , C12Q1/6886 , C12Q2600/136 , Y10T436/25
摘要： The present invention provides DNA encoding a TADG-15 protein as well as a TADG-15 protein. Also provided is a vector capable of expressing the DNA of the present invention adapted for expression in a recombinant cell and regulatory elements necessary for expression of the DNA in the cell. The present invention further provides for methods of inhibiting TADG-15 expression and/or protease activity methods of detecting TADG-15 mRNA and/or protein and methods of screening for TADG-15 inhibitors. Additionally, the present invention provides for cell-specific targeting via TADG-15 and methods of vaccinating an individual against TADG-15. The methods described are useful in the diagnosis. treatment and prevention of cancer particularly breast and ovarian cancer.
摘要翻译：本发明提供编码TADG-15蛋白质和TADG-15蛋白质的DNA。还提供了能够表达适于在重组细胞中表达的本发明的DNA的载体和在细胞中表达DNA所需的调节元件。本发明还提供了抑制TADG-15 mRNA和/或蛋白质的TADG-15表达和/或蛋白酶活性检测方法以及筛选TADG-15抑制剂的方法。另外，本发明提供了通过TADG-15进行的细胞特异性靶向和针对TADG-15接种个体的方法。所述方法在诊断中是有用的。治疗和预防癌症，特别是乳腺癌和卵巢癌。

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