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1. 发明申请

US20050214740A1 Device for measuring extracellular potential and manufacturing method of the same 审中-公开
标题翻译：用于测量细胞外电位的装置及其制造方法
公开(公告)号：US20050214740A1
公开(公告)日：2005-09-29
申请号：US11081759
申请日：2005-03-17
申请人： Hiroshi Ushio , Masaya Nakatani , Hiroaki Oka , Nobuhiko Ozaki
发明人： Hiroshi Ushio , Masaya Nakatani , Hiroaki Oka , Nobuhiko Ozaki
IPC分类号： G01N33/48 , A61B5/04 , C12M1/00 , C12M1/34 , C12P21/06 , C12Q1/00 , G01N33/487
CPC分类号： G01N33/48728
摘要： A device for measuring extracellular potential includes a diaphragm and a detecting electrode. The diaphragm is formed on one surface thereof with a depression including at least one curved surface, and a hole is provided so as to penetrate from the curved surface of the depression through to the other surface of the diaphragm. An opening on the curved surface of the depression is smaller than an opening on the other side, and a detecting electrode is provided on the wall surface of the hole.
摘要翻译：用于测量细胞外电位的装置包括隔膜和检测电极。隔膜在其一个表面上形成有包括至少一个弯曲表面的凹陷，并且设置有从凹部的弯曲表面穿透到隔膜的另一个表面的孔。凹陷的曲面上的开口小于另一侧的开口，并且在孔的壁面上设置有检测电极。

2. 发明授权

US08247218B2 Extracellular potential sensing element, device for measuring extracellular potential, apparatus for measuring extracellular potential and method of measuring extracellular potential by using the same 有权
标题翻译：细胞外电位感测元件，用于测量细胞外电位的装置，用于测量细胞外电位的装置和使用该细胞外电位测量细胞外电位的方法
公开(公告)号：US08247218B2
公开(公告)日：2012-08-21
申请号：US12133452
申请日：2008-06-05
申请人： Masaya Nakatani , Nobuhiko Ozaki , Hiroaki Oka
发明人： Masaya Nakatani , Nobuhiko Ozaki , Hiroaki Oka
IPC分类号： C12M1/34
CPC分类号： G01N33/48728
摘要： A sensing element for measuring extracellular potential including a substrate, a well provided in a substrate, a guide section provided on the wall of the well, and a detective electrode formed at a lower surface of the substrate. The guide section is for guiding drug. The well is provided at the bottom with a depression, and a first throughhole penetrating through the depression and the lower surface of the substrate. The well is for mixing a subject cell, a culture solution and the drug together. The above-configured sensing element accurately measures a change generated by a subject cell.
摘要翻译：用于测量细胞外电位的感测元件，包括衬底，设置在衬底中的阱，设置在阱的壁上的引导部分和形成在衬底的下表面处的检测电极。指导部分是指导药物。井在底部设置有凹陷，并且第一通孔穿过基底的凹陷和下表面。该井用于将主体细胞，培养液和药物混合在一起。上述构成的感测元件精确地测量由被摄体单元产生的变化。

3. 发明授权

US07736477B2 Probe for measuring electric potential of cell 失效
标题翻译：用于测量电池电位的探头
公开(公告)号：US07736477B2
公开(公告)日：2010-06-15
申请号：US10595275
申请日：2005-07-14
申请人： Masaya Nakatani , Nobuhiko Ozaki , Hiroaki Oka
发明人： Masaya Nakatani , Nobuhiko Ozaki , Hiroaki Oka
IPC分类号： G01N33/487
CPC分类号： G01N33/48728
摘要： A probe for measuring an electric potential of a cell includes a plate having a surface having a first cavity provided therein, and a sensor element provided in the first cavity. A second cavity is provided in the bottomsurface of the first cavity. The first flow passage having first and second openings is provided in the plate. The first and second openings of the first flow passage open to the second cavity and outside the plate, respectively. The sensor element includes a thin plate, and a supporting substrate provided around the thin plate and in the first cavity of the plate. The thin plate has a through-hole therein having a first opening and a second opening communicating with the second cavity of the plate. The first flow passage allows fluid to flow therein. A sucking device is coupled with the second opening of the first flow passage as to suck the fluid flowing in the first flow passage. This probe can measure an electric potential of a cell floating in solution as it is in this environment.
摘要翻译：用于测量电池的电位的探针包括具有设置在其中的具有第一腔的表面的板和设置在第一腔中的传感器元件。在第一腔的底面设有第二腔。具有第一和第二开口的第一流动通道设置在板中。第一流动通道的第一和第二开口分别向第二腔室和板外开口。传感器元件包括薄板，以及设置在薄板周围和板的第一腔中的支撑基板。薄板的通孔中具有第一开口和与板的第二腔连通的第二开口。第一流道允许流体流入其中。抽吸装置与第一流动通道的第二开口联接以吸收在第一流动通道中流动的流体。该探头可以在这种环境中测量浮动在溶液中的电池的电位。

4. 发明授权

US08030059B2 Apparatus for measuring extracellular potential 有权
标题翻译：用于测量细胞外电位的装置
公开(公告)号：US08030059B2
公开(公告)日：2011-10-04
申请号：US12133461
申请日：2008-06-05
申请人： Masaya Nakatani , Nobuhiko Ozaki , Hiroaki Oka
发明人： Masaya Nakatani , Nobuhiko Ozaki , Hiroaki Oka
IPC分类号： C12M1/34
CPC分类号： G01N33/48728
摘要： A sensing element for measuring extracellular potential including a substrate, a well provided in a substrate, a guide section provided on the wall of the well, and a detective electrode formed at a lower surface of the substrate. The guide section is for guiding drug. The well is provided at the bottom with a depression, and a first throughhole penetrating through the depression and the lower surface of the substrate. The well is for mixing a subject cell, a culture solution and the drug together. The above-configured sensing element accurately measures a change generated by a subject cell.
摘要翻译：用于测量细胞外电位的感测元件，包括衬底，设置在衬底中的阱，设置在阱的壁上的引导部分和形成在衬底的下表面处的检测电极。指导部分是指导药物。井在底部设置有凹陷，并且第一通孔穿过基底的凹陷和下表面。该井用于将主体细胞，培养液和药物混合在一起。上述构成的感测元件精确地测量由被摄体单元产生的变化。

5. 发明申请

US20100147682A1 PROBE FOR MEASURING ELECTRIC POTENTIAL OF CELL 审中-公开
标题翻译：用于测量细胞电位的探针
公开(公告)号：US20100147682A1
公开(公告)日：2010-06-17
申请号：US12712370
申请日：2010-02-25
申请人： Masaya Nakatani , Nobuhiko Ozaki , Hiroaki Oka
发明人： Masaya Nakatani , Nobuhiko Ozaki , Hiroaki Oka
IPC分类号： G01N27/26
CPC分类号： G01N33/48728
摘要： A probe for measuring an electric potential of a cell includes a plate having a surface having a first cavity provided therein, and a sensor element provided in the first cavity. A second cavity is provided in the bottom surface of the first cavity. The first flow passage having first and second openings is provided in the plate. The first and second openings of the first flow passage open to the second cavity and outside the plate, respectively. The sensor element includes a thin plate, and a supporting substrate provided around the thin plate and in the first cavity of the plate. The thin plate has a through-hole therein having a first opening and a second opening communicating with the second cavity of the plate. The first flow passage allows fluid to flow therein. A sucking device is coupled with the second opening of the first flow passage as to suck the fluid flowing in the first flow passage. This probe can measure an electric potential of a cell floating in solution as it is in this environment.
摘要翻译：用于测量电池的电位的探针包括具有设置在其中的具有第一腔的表面的板和设置在第一腔中的传感器元件。在第一腔的底表面中设置第二腔。具有第一和第二开口的第一流动通道设置在板中。第一流动通道的第一和第二开口分别向第二腔室和板外开口。传感器元件包括薄板，以及设置在薄板周围和板的第一腔中的支撑基板。薄板的通孔中具有第一开口和与板的第二腔连通的第二开口。第一流道允许流体流入其中。抽吸装置与第一流动通道的第二开口联接以吸收在第一流动通道中流动的流体。该探头可以在这种环境中测量浮动在溶液中的电池的电位。

6. 发明申请

US20050158725A1 Method of amplifying nucleic acid by electromagnetic induction heating and reaction container and reaction device to be used therein 审中-公开
标题翻译：通过电磁感应加热和反应容器放大核酸的方法及其中使用的反应装置
公开(公告)号：US20050158725A1
公开(公告)日：2005-07-21
申请号：US10510819
申请日：2003-09-24
申请人： Tetsuo Yukimasa , Nobuhiko Ozaki , Masaya Nakatani , Hidenobu Yaku , Hiroaki Oka , Kimi Fukahi
发明人： Tetsuo Yukimasa , Nobuhiko Ozaki , Masaya Nakatani , Hidenobu Yaku , Hiroaki Oka , Kimi Fukahi
IPC分类号： C07H21/00 , C12Q1/68 , C12M1/34
CPC分类号： C07H21/00 , C12Q1/6844
摘要： The present invention provides a reaction container, a reaction device, and a method of amplifying a nucleic acid, which are suitable for locally heating a sample which contains a nucleic acid, enable rapid control of temperature changes in the sample, provide easy fabrication, and are low cost. The invention provides a reaction container used for a nucleic acid amplification reaction, which includes a sample holding portion formed from a cavity in the reaction container; and a heating element for heating a sample which contains a nucleic acid and which is held in the sample holding portion, wherein the heating element is made of a conductive material and arranged at a location where the sample or the sample and the periphery of the cavity is (are) to be locally heated, the conductive material generating heat by electromagnetic induction.
摘要翻译：本发明提供一种反应容器，反应装置和扩增核酸的方法，其适用于局部加热含有核酸的样品，能够快速控制样品中的温度变化，提供容易的制造，以及是低成本的。本发明提供了用于核酸扩增反应的反应容器，其包括由反应容器中的空腔形成的样品保持部分; 以及加热元件，用于加热含有核酸并被保持在样品保持部分中的样品，其中所述加热元件由导电材料制成并且布置在样品或样品和空腔周边的位置被局部加热，导电材料通过电磁感应产生热量。

7. 发明授权

US07396673B2 Device for measuring extracellular potential 有权
标题翻译：用于测量细胞外电位的装置
公开(公告)号：US07396673B2
公开(公告)日：2008-07-08
申请号：US10991269
申请日：2004-11-17
申请人： Masaya Nakatani , Nobuhiko Ozaki , Hiroaki Oka
发明人： Masaya Nakatani , Nobuhiko Ozaki , Hiroaki Oka
IPC分类号： C12M1/34
CPC分类号： G01N33/48728
摘要： A sensing element for measuring extracellular potential including a substrate, a well provided in a substrate, a guide section provided on the wall of the well, and a detective electrode formed at a lower surface of the substrate. The guide section is for guiding drug. The well is provided at the bottom with a depression, and a first throughhole penetrating through the depression and the lower surface of the substrate. The well is for mixing a subject cell, a culture solution and the drug together. The above-configured sensing element accurately measures a change generated by a subject cell.
摘要翻译：用于测量细胞外电位的感测元件，包括衬底，设置在衬底中的阱，设置在阱的壁上的引导部分和形成在衬底的下表面处的检测电极。指导部分是指导药物。井在底部设置有凹陷，并且第一通孔穿过基底的凹陷和下表面。该井用于将主体细胞，培养液和药物混合在一起。上述构成的感测元件精确地测量由被摄体单元产生的变化。

8. 发明申请

US20050112756A1 Extracellular potential sensing element, device for measuring extracellular potential, apparatus for measuring extracellular potential and method of measuring extracellular potential by using the same 有权
标题翻译：细胞外电位感测元件，用于测量细胞外电位的装置，用于测量细胞外电位的装置和使用该细胞外电位测量细胞外电位的方法
公开(公告)号：US20050112756A1
公开(公告)日：2005-05-26
申请号：US10991269
申请日：2004-11-17
申请人： Masaya Nakatani , Nobuhiko Ozaki , Hiroaki Oka
发明人： Masaya Nakatani , Nobuhiko Ozaki , Hiroaki Oka
IPC分类号： G01N33/50 , C12M1/34 , C12Q1/02 , G01N27/327 , G01N27/416 , G01N33/15 , G01N33/487
CPC分类号： G01N33/48728
摘要： A sensing element for measuring extracellular potential including a substrate, a well provided in a substrate, a guide section provided on the wall of the well, and a detective electrode formed at a lower surface of the substrate. The guide section is for guiding drug. The well is provided at the bottom with a depression, and a first throughhole penetrating through the depression and the lower surface of the substrate. The well is for mixing a subject cell, a culture solution and the drug together. The above-configured sensing element accurately measures a change generated by a subject cell.
摘要翻译：用于测量细胞外电位的感测元件，包括衬底，设置在衬底中的阱，设置在阱的壁上的引导部分和形成在衬底的下表面处的检测电极。指导部分是指导药物。井在底部设置有凹陷，并且第一通孔穿过基底的凹陷和下表面。该井用于将主体细胞，培养液和药物混合在一起。上述构成的感测元件精确地测量由被摄体单元产生的变化。

9. 发明申请

US20070105183A1 Probe for measuring electric potential of cell 失效
标题翻译：用于测量电池电位的探头
公开(公告)号：US20070105183A1
公开(公告)日：2007-05-10
申请号：US10595275
申请日：2005-07-14
申请人： Masaya Nakatani , Nobuhiko Ozaki , Hiroaki Oka
发明人： Masaya Nakatani , Nobuhiko Ozaki , Hiroaki Oka
IPC分类号： G01N27/26 , C12M1/24 , C12M1/42
CPC分类号： G01N33/48728
摘要： A probe for measuring an electric potential of a cell includes a plate having a surface having a first cavity provided therein, and a sensor element provided in the first cavity. A second cavity is provided in the bottom surface of the first cavity. The first flow passage having first and second openings is provided in the plate. The first and second openings of the first flow passage open to the second cavity and outside the plate, respectively. The sensor element includes a thin plate, and a supporting substrate provided around the thin plate and in the first cavity of the plate. The thin plate has a through-hole therein having a first opening and a second opening communicating with the second cavity of the plate. The first flow passage allows fluid to flow therein. A sucking device is coupled with the second opening of the first flow passage as to suck the fluid flowing in the first flow passage. This probe can measure an electric potential of a cell floating in solution as it is in this environment.
摘要翻译：用于测量电池的电位的探针包括具有设置在其中的具有第一腔的表面的板和设置在第一腔中的传感器元件。在第一腔的底表面中设置第二腔。具有第一和第二开口的第一流动通道设置在板中。第一流动通道的第一和第二开口分别向第二腔室和板外开口。传感器元件包括薄板，以及设置在薄板周围和板的第一腔中的支撑基板。薄板的通孔中具有第一开口和与板的第二腔连通的第二开口。第一流道允许流体流入其中。抽吸装置与第一流动通道的第二开口联接以吸收在第一流动通道中流动的流体。该探头可以在这种环境中测量浮动在溶液中的电池的电位。

10. 发明申请

US20090239033A1 DIAPHRAGM AND DEVICE FOR MEASURING CELLULAR POTENTIAL USING THE SAME, MANUFACTURING METHOD OF THE DIAPHRAGM 有权
标题翻译：用于测量细胞膜的膜片和装置，其制造方法
公开(公告)号：US20090239033A1
公开(公告)日：2009-09-24
申请号：US12359426
申请日：2009-01-26
申请人： Masaya Nakatani , Soichiro Hiraoka , Hiroshi Ushio , Akiyoshi Oshima , Hiroaki Oka , Fumiaki Emoto
发明人： Masaya Nakatani , Soichiro Hiraoka , Hiroshi Ushio , Akiyoshi Oshima , Hiroaki Oka , Fumiaki Emoto
IPC分类号： B32B3/10 , B44C1/22
CPC分类号： G01N33/48728 , Y10T428/24322
摘要： A diaphragm is formed by etching a substrate. This substrate has a first surface provided with a depression by isotropic dry etching, and a second surface opposite the first surface. Furthermore, a through-hole is formed from the depression to the second surface by anisotropic dry etching. The depression and the through-hole are formed by using one resist mask. The depression has a hemispherical shape or a semi-elliptical spherical shape.
摘要翻译：通过蚀刻基板形成隔膜。该基板具有通过各向同性干蚀刻设置有凹部的第一表面和与第一表面相对的第二表面。此外，通过各向异性干蚀刻从凹陷形成通孔到第二表面。通过使用一个抗蚀剂掩模形成凹陷和通孔。凹陷具有半球形或半椭圆形球形。

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