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1. 发明授权

US5137820A Superoxide dismutase derivatives, a method of producing the same and medicinal uses of the same 失效
标题翻译：超氧化物歧化酶衍生物，其生产方法及其药物用途
公开(公告)号：US5137820A
公开(公告)日：1992-08-11
申请号：US199809
申请日：1988-05-27
申请人： Hiroshi Maeda , Fujio Suzuki , Tatsuya Oda
发明人： Hiroshi Maeda , Fujio Suzuki , Tatsuya Oda
IPC分类号： A61K38/44 , C12N9/02
CPC分类号： C12N9/0089 , A61K38/446 , Y10S530/815
摘要： The invention provides a superoxide dismutase derivative of the general formula[SOD][Z].sub.nwherein [SOD] represents a superoxide dismutase having 1 to 22 or 24 groups each derived from an amino group by removal of one hydrogen atom in lieu of amino groups; [Z] represents a monovalent copolymer group, constituting units of which are a group of the formula ##STR1## wherein R.sup.1, R.sup.2, R.sup.3 and R.sup.4 each represents a hydrogen atom or a residue derived by removal of a hydroxyl group from an alkanol of 1 to 8 carbon atoms, an ethylene glycol monoalkyl ether containing an alkyl moiety of 1 to 4 carbon atoms or a glycerin dialkyl ether containing alkyl moieties of 1 to 4 carbon atoms, provided that either R.sup.1 or R.sup.2 and either R.sup.3 or R.sup.4 each represents a hydrogen atom, and a residue derived from the group of the above-mentioned formula by removal of OR.sup.1, OR.sup.2, OR.sup.3 or OR.sup.4 group from one of its COOR.sup.1, COOR.sup.2, COOR.sup.3 and COOR.sup.4 groups (where the bond on the carbon atom of the carbonyl group is attached to [SOD]), said monovalent copolymer group having an average molecular weight of 500 to 200,000; and n represents an integer of 1 to 22 or 24 corresponding to the number of said groups each derived from an amino group by removal of one hydrogen atom in said [SOD], or a pharmaceutically acceptable salt thereof. There also is provided a method for producing the above derivative and salt. The invention is further directed to medicinal uses and pharmaceutical compositions for oral administration.

2. 发明授权

US5180582A Superoxide dismutase derivatives, a method of producing the same and medicinal uses of the same 失效
标题翻译：超氧化物歧化酶衍生物，其制备方法及其药用用途
公开(公告)号：US5180582A
公开(公告)日：1993-01-19
申请号：US836861
申请日：1992-02-19
申请人： Hiroshi Maeda , Fujio Suzuki , Tatsuya Oda
发明人： Hiroshi Maeda , Fujio Suzuki , Tatsuya Oda
IPC分类号： A61K38/44 , C12N9/02
CPC分类号： C12N9/0089 , A61K38/446
摘要： The invention provides a superoxide dismutase derivative of the general formula[SOD][Z]wherein [SOD] represents a superoxide dismutase having 1 to 22 or 24 groups each derived from an amino groups by removal of one hydrogen atom in lieu of amino groups; [Z] represents a monovalent copolymer group, constituting units of which are a group of the formula ##STR1## wherein R.sup.1, R.sup.2, R.sup.3 and R.sup.4 each represents a hydrogen atom or a residue derived by a removal of a hydroxyl group from an alkanol of 1 to 8 carbon atoms, an ethylene glycol monoalkyl ether containing an alkyl moiety of 1 to 4 carbon atoms or a glycerin dialkyl ether containing alkyl moieties of 1 to 4 carbon atoms, provided that either R.sup.1 or R.sup.2 and either R.sup.3 or R.sup.4 each represents a hydrogen atom, and a residue derived from the group of the above-mentioned formula by removal of OR.sup.1, OR.sup.2, OR.sup.3 or OR.sup.4 group from one of its COOR.sup.1, COOR.sup.2, COOR.sup.3 and COOR.sup.4 groups (where the bond on the carbon atom of the carbonyl group is attached to [SOD]), said monovalent copolymer group having an average molecular weight of 500 to 200,000; and n represents an integer of 1 to 22 or 24 corresponding to the number of said groups each derived from an amino group by removal of one hydrogen atom in said [SOD], or a pharmaceutically acceptable salt thereof. There also is provided a method for producing the above derivative and salt. The invention is further directed to medicinal uses and pharmaceutical compositions for oral administration.
摘要翻译：本发明提供了一种通式[SOD] [Z]的超氧化物歧化酶衍生物，其中[SOD]代表通过除去一个氢原子代替氨基，每个衍生自氨基的具有1至22个或24个基团的超氧化物歧化酶; [Z]表示单价共聚物基团，其构成单元为式“IMAGE”的基团，其中R 1，R 2，R 3和R 4各自表示氢原子或通过从烷醇中除去羟基而得到的残基 1至8个碳原子的烷基部分，含有1至4个碳原子的烷基部分的乙二醇单烷基醚或含有1至4个碳原子的烷基部分的甘油二烷基醚，条件是R 1或R 2以及R 3或R 4各自表示氢原子和衍生自上述式的基团的残基，通过从其COOR1，COOR2，COOR3和COOR4基团之一除去OR1，OR2，OR3或OR4基团（其中羰基的碳原子上的键所述单价共聚物基团的平均分子量为500〜200,000; n表示通过除去所述[SOD]中的一个氢原子而衍生自氨基的所述基团的数目的1-22或24的整数或其药学上可接受的盐。还提供了制备上述衍生物和盐的方法。本发明进一步涉及药物用途和用于口服给药的药物组合物。

3. 外观设计

USD526253S1 Grill for an automobile 有权
公开(公告)号：USD526253S1
公开(公告)日：2006-08-08
申请号：US29234344
申请日：2005-07-18
申请人： Tatsuya Oda
设计人： Tatsuya Oda

4. 外观设计

USD528680S1 Rear combination lamp for an automobile 有权
公开(公告)号：USD528680S1
公开(公告)日：2006-09-19
申请号：US29234352
申请日：2005-07-18
申请人： Tatsuya Oda
设计人： Tatsuya Oda

5. 外观设计

USD460022S1 Vehicle body 失效
公开(公告)号：USD460022S1
公开(公告)日：2002-07-09
申请号：US29148250
申请日：2001-09-18
申请人： Ricky Hsu , Tatsuya Oda
设计人： Ricky Hsu , Tatsuya Oda

6. 外观设计

USD582820S1 Front bumper for automobiles 有权
公开(公告)号：USD582820S1
公开(公告)日：2008-12-16
申请号：US29290594
申请日：2007-12-19
申请人： Damon A. Schell , Tatsuya Oda
设计人： Damon A. Schell , Tatsuya Oda

7. 发明申请

US20060121122A1 Process for producing microcapsule 审中-公开
标题翻译：微胶囊生产工艺
公开(公告)号：US20060121122A1
公开(公告)日：2006-06-08
申请号：US10525108
申请日：2003-09-17
申请人： Mitsutoshi Nakajima , Tatsuya Oda , Shinji Sugiura
发明人： Mitsutoshi Nakajima , Tatsuya Oda , Shinji Sugiura
IPC分类号： A61K9/50 , B01J13/04
CPC分类号： B01F3/0807 , A61K9/5036 , A61K9/5047 , A61K9/5089 , A61K48/00 , B01F5/0485 , B01F13/0059 , B01J13/06
摘要： A polyelectrolyte solution as a disperse phase is fed into one of the chambers which are partitioned by a plate having a plurality of narrow holes (microchannels), a continuous phase is fed into the other chamber, and pressure is applied to the disperse phase forcing it through the holes into the continuous phase so as to prepare an emulsion. This emulsion is demulsified, and at the same time the disperse phase is brought into contact with a polyelectrolyte solution having a reverse electric charge to the disperse phase or a polyvalent ion solution, and a gel layer is formed around the spherical disperse phase by a polyelectrolyte reaction. Thereby, a double-structured capsule is obtained, in which the outside is insoluble gel and the inside is a polyelectrolyte solution to which a cell has been added.
摘要翻译：作为分散相的聚电解质溶液被供给到由具有多个窄孔（微通道）的板分隔的一个室中，将连续相进料到另一个室中，并且将压力施加到分散相上，迫使其通过孔进入连续相，以制备乳液。该乳液被破乳，同时使分散相与分散相或多价离子溶液具有反向电荷的聚电解质溶液接触，并且通过聚电解质在球形分散相周围形成凝胶层反应。由此，得到双层结构的胶囊，其中外部是不溶性凝胶，内部是已经添加了电池的聚电解质溶液。

8. 发明授权

US06676218B2 Vehicle seat 失效
标题翻译：车座
公开(公告)号：US06676218B2
公开(公告)日：2004-01-13
申请号：US10053829
申请日：2002-01-22
申请人： Etsunori Fujita , Seiji Kawsaki , Seiji Sesaki , Tatsuya Oda , Yuji Ikeda
发明人： Etsunori Fujita , Seiji Kawsaki , Seiji Sesaki , Tatsuya Oda , Yuji Ikeda
IPC分类号： A47C702
CPC分类号： B60N2/70 , B60N2/5891 , D04B21/16 , D10B2403/0213
摘要： An object of the present invention is to minimize the dependency of the vibration characteristic exhibited by the sheet-shaped supporting member supported by the metal springs on the added load. In a plurality of metal springs 41 to 44 supporting a sheet-shaped supporting member 30, a third metal spring 43 provided on the position to support the vicinity of the greater trochanter of the seated person is provided in a manner that an engagement portion with a frame member is positioned lower than the engagement portion with the sheet-shaped supporting member 30 when no load is applied. Accordingly, the feeling of something foreign created by such a third metal spring 43 can be reduced, and within a predetermined range of the added load, the third metal spring does not work functionally because respective engagement portions 43a and 43b take their positional relationship to be substantially horizontal in a static seating state, while it works functionally when the added load exceeds the above-described range. As a result, difference in added load can be reduced.
摘要翻译：本发明的目的是最小化由金属弹簧支撑的片状支撑构件所显示的振动特性对所加载荷的依赖性。在支撑片状支撑构件30的多个金属弹簧41〜44中，设置在支撑就座者的大转子附近的位置的第三金属弹簧43设置成具有当没有施加负载时，框架构件定位成低于与片状支撑构件30的接合部分。因此，可以减少由这种第三金属弹簧43产生的异物的感觉，并且在附加载荷的预定范围内，第三金属弹簧在功能上不起作用，因为各个接合部43a和43b的位置关系为基本上水平地处于静态就座状态，而当加载负载超过上述范围时，其功能正常。结果，可以减少加载负载的差异。

9. 外观设计

USD436067S1 Front bumper for an automobile 失效
公开(公告)号：USD436067S1
公开(公告)日：2001-01-09
申请号：US29118097
申请日：2000-02-04
申请人： Harumi Okano , Tatsuya Oda
设计人： Harumi Okano , Tatsuya Oda

10. 外观设计

USD349666S Automobile 失效
公开(公告)号：USD349666S
公开(公告)日：1994-08-16
申请号：US935
申请日：1992-10-29
申请人： Akira Shimoyama , Harumi Okano , Junji Yuki , Mutsumi Koshiishi , Tatsuya Oda , Shuichi Etoh
设计人： Akira Shimoyama , Harumi Okano , Junji Yuki , Mutsumi Koshiishi , Tatsuya Oda , Shuichi Etoh

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