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1. 发明申请

US20130149369A1 COMPOSITION FOR NUCLEIC ACID TRANSFECTION 有权
标题翻译：用于核酸转运的组合物
公开(公告)号：US20130149369A1
公开(公告)日：2013-06-13
申请号：US13249120
申请日：2011-09-29
申请人： Hiroshi KIKUCHI , Hideo Kobayashi , Kouichi Hashimoto , Ayako Iijima , Daigo Asano , Junko Yasuda
发明人： Hiroshi KIKUCHI , Hideo Kobayashi , Kouichi Hashimoto , Ayako Iijima , Daigo Asano , Junko Yasuda
IPC分类号： A61K31/7088
CPC分类号： A61K31/7088 , A61K48/0025
摘要： The invention provides a nucleic-acid-transfecting composition which exhibits low cytotoxicity, which facilitates an effective nucleic acid transfection into a cell, and which improves expression of the nucleic acid in the cell.The composition for transfecting a nucleic acid into a cell, contains a di(C12-16 alkyl)dimethylammonium halide and a phospholipid.
摘要翻译：本发明提供了一种显示低细胞毒性的核酸转染组合物，其有利于有效的核酸转染到细胞中，并且其改善细胞中核酸的表达。用于将核酸转染入细胞的组合物含有二（C 12-16烷基）二甲基卤化铵和磷脂。

2. 发明授权

US08227248B2 Composition for nucleic-acid transfection 有权
标题翻译：用于核酸转染的组合物
公开(公告)号：US08227248B2
公开(公告)日：2012-07-24
申请号：US12306620
申请日：2007-06-29
申请人： Hiroshi Kikuchi , Hideo Kobayashi , Kouichi Hashimoto , Ayako Iijima , Daigo Asano
发明人： Hiroshi Kikuchi , Hideo Kobayashi , Kouichi Hashimoto , Ayako Iijima , Daigo Asano
IPC分类号： C12N15/88
CPC分类号： C12N15/88 , A61K9/1272
摘要： To provide a nucleic-acid-transfecting composition which exhibits low cytotoxicity, which facilitates a nucleic acid transfection into cells, and which improves expression of the nucleic acid in the cells. The invention provides a composition for transfecting a nucleic acid into a cell, including a compound represented by the following formula (I) (wherein each of R1 and R2, which are identical to or different from each other, represents a saturated or unsaturated hydrocarbon group; R3 represents a C1-6 alkyl group or a C1-6 hydroxyalkyl group; m is an integer from 1 to 10; and X represents a halogen atom), and a phospholipid.
摘要翻译：提供显示低细胞毒性的核酸转染组合物，其有助于核酸转染入细胞，并且其改善核酸在细胞中的表达。本发明提供一种用于将核酸转染入细胞的组合物，包括由下式（I）表示的化合物（其中R 1和R 2各自彼此相同或不同，表示饱和或不饱和的烃基 R 3表示C 1-6烷基或C 1-6羟基烷基; m表示1〜10的整数，X表示卤素原子）和磷脂。

3. 发明申请

US20090233366A1 COMPOSITION FOR INTRODUCTION OF NUCLEIC ACID 审中-公开
标题翻译：用于引入核酸的组合物
公开(公告)号：US20090233366A1
公开(公告)日：2009-09-17
申请号：US12432577
申请日：2009-04-29
申请人： Hiroshi Kikuchi , Kouichi Hashimoto , Hideo Kobayashi , Ayako Iijima , Daigo Asano
发明人： Hiroshi Kikuchi , Kouichi Hashimoto , Hideo Kobayashi , Ayako Iijima , Daigo Asano
IPC分类号： C12N15/88 , C07K5/10 , C07K7/06 , C07K7/08
CPC分类号： A61K9/127 , A61K48/0041
摘要： Composition with weak cytotoxicity for introducing a nucleic acid, such as a short oligonucleotide or a gene, into a cell for expression of the gene in the cell. The composition includes a lipid and a compound represented by a formula (I): (R1)n-R2-R3 (I) wherein (R1)n represents a polyamino acid residue consisting of a total of n amino acid residues, which are identical to or different from one another, the n residues being selected from an arginine residue, a lysine residue, and a histidine residue, and n being an integer of from 4 to 16; R2 represents a single bond or an amino acid residue; and R3 represents a phospholipid residue with 1 or 2 identical or different unsaturated fatty acid residues having from 12 to 20 carbon atoms. The composition is administered or supplied to a cell together with a nucleic acid.
摘要翻译：用于将核酸如短寡核苷酸或基因导入用于在细胞中表达基因的细胞的细胞毒性弱的组合物。组合物包括脂质和由式（I）表示的化合物：<？in-line-formula description =“In-line Formulas”end =“lead”？>（R1）n-R2-R3（I）其中（R1）n表示由总共n个氨基酸残基组成的聚氨基酸残基，它们彼此相同或不同。 n残基选自精氨酸残基，赖氨酸残基和组氨酸残基，n为4〜16的整数， R2表示单键或氨基酸残基; R3表示具有1或2个相同或不同的具有12至20个碳原子的不饱和脂肪酸残基的磷脂残基。组合物与核酸一起施用或提供给细胞。

4. 发明申请

US20090239222A1 COMPOSITION FOR NUCLEIC-ACID TRANSFECTION 有权
标题翻译：用于核酸转运的组合物
公开(公告)号：US20090239222A1
公开(公告)日：2009-09-24
申请号：US12306620
申请日：2007-06-29
申请人： Hiroshi Kikuchi , Hideo Kobayashi , Kouichi Hashimoto , Ayako Iijima , Daigo Asano
发明人： Hiroshi Kikuchi , Hideo Kobayashi , Kouichi Hashimoto , Ayako Iijima , Daigo Asano
IPC分类号： C12Q1/68 , C07C233/00
CPC分类号： C12N15/88 , A61K9/1272
摘要： To provide a nucleic-acid-transfecting composition which exhibits low cytotoxicity, which facilitates a nucleic acid transfection into cells, and which improves expression of the nucleic acid in the cells.The invention provides a composition for transfecting a nucleic acid into a cell, including a compound represented by the following formula (I) (wherein each of R1 and R2, which are identical to or different from each other, represents a saturated or unsaturated hydrocarbon group; R3 represents a C1-6 alkyl group or a C1-6 hydroxyalkyl group; m is an integer from 1 to 10; and X represents a halogen atom), and a phospholipid.
摘要翻译：提供显示低细胞毒性的核酸转染组合物，其有助于核酸转染入细胞，并且其改善核酸在细胞中的表达。本发明提供一种用于将核酸转染入细胞的组合物，包括由下式（I）表示的化合物（其中R 1和R 2各自彼此相同或不同，表示饱和或不饱和的烃基 R 3表示C 1-6烷基或C 1-6羟基烷基; m表示1〜10的整数，X表示卤素原子）和磷脂。

5. 发明授权

US08920832B2 Composition for nucleic acid transfection 有权
标题翻译：用于核酸转染的组合物
公开(公告)号：US08920832B2
公开(公告)日：2014-12-30
申请号：US13249120
申请日：2011-09-29
申请人： Hiroshi Kikuchi , Hideo Kobayashi , Kouichi Hashimoto , Ayako Iijima , Daigo Asano , Junko Yasuda
发明人： Hiroshi Kikuchi , Hideo Kobayashi , Kouichi Hashimoto , Ayako Iijima , Daigo Asano , Junko Yasuda
IPC分类号： A61K31/7088 , A61K48/00
CPC分类号： A61K31/7088 , A61K48/0025
摘要： The invention provides a nucleic-acid-transfecting composition which exhibits low cytotoxicity, which facilitates an effective nucleic acid transfection into a cell, and which improves expression of the nucleic acid in the cell.The composition for transfecting a nucleic acid into a cell, contains a di(C12-16 alkyl)dimethylammonium halide and a phospholipid.
摘要翻译：本发明提供了一种显示低细胞毒性的核酸转染组合物，其有利于有效的核酸转染到细胞中，并且其改善细胞中核酸的表达。用于将核酸转染入细胞的组合物含有二（C 12-16烷基）二甲基卤化铵和磷脂。

6. 发明授权

US09095600B2 Prophylactic and/or therapeutic agent for cardiac infarction 有权
标题翻译：心脏梗塞的预防和/或治疗剂
公开(公告)号：US09095600B2
公开(公告)日：2015-08-04
申请号：US12562887
申请日：2009-09-18
申请人： Tetsuo Minamino , Masafumi Kitakaze , Masatsugu Hori , Hiroyuki Takahama , Hiroshi Kikuchi , Kouichi Hashimoto , Hideo Kobayashi , Ayako Iijima , Daigo Asano
发明人： Tetsuo Minamino , Masafumi Kitakaze , Masatsugu Hori , Hiroyuki Takahama , Hiroshi Kikuchi , Kouichi Hashimoto , Hideo Kobayashi , Ayako Iijima , Daigo Asano
IPC分类号： A61K9/127 , A61K31/7076
CPC分类号： A61K31/7076 , A61K9/127
摘要： The present invention relates to a novel preventive and/or therapeutic drug for myocardial infarction.The present invention provides a preventive and/or therapeutic drug for myocardial infarction or myocardial ischemia-reperfusion injury, the drug containing a lipid membrane structure retaining adenosine.
摘要翻译：本发明涉及用于心肌梗塞的新型预防和/或治疗药物。本发明提供了用于心肌梗塞或心肌缺血 - 再灌注损伤的预防和/或治疗药物，该药物含有保留腺苷的脂质膜结构。

7. 发明申请

US20100055684A1 COMPOSITION FOR NUCLEIC ACID TRANSFECTION 审中-公开
标题翻译：用于核酸转运的组合物
公开(公告)号：US20100055684A1
公开(公告)日：2010-03-04
申请号：US12306993
申请日：2007-06-29
申请人： Hiroshi Kikuchi , Hideo Kobayashi , Kouichi Hashimoto , Ayako Iijima , Daigo Asano , Junko Yasuda
发明人： Hiroshi Kikuchi , Hideo Kobayashi , Kouichi Hashimoto , Ayako Iijima , Daigo Asano , Junko Yasuda
IPC分类号： C12Q1/68 , C12N15/88
CPC分类号： A61K31/7088 , A61K48/0025
摘要： The invention provides a nucleic-acid-transfecting composition which exhibits low cytotoxicity, which facilitates an effective nucleic acid transfection into a cell, and which improves expression of the nucleic acid in the cell.The composition for transfecting a nucleic acid into a cell, contains a di(C12-16 alkyl)dimethylammonium halide and a phospholipid.
摘要翻译：本发明提供了一种显示低细胞毒性的核酸转染组合物，其有利于有效的核酸转染到细胞中，并且其改善细胞中核酸的表达。将核酸转染入细胞的组合物含有二（C 12-16烷基）二甲基卤化铵和磷脂。

8. 发明授权

US07345808B2 Deformable mirror and device for observing retina of eye 失效
标题翻译：用于观察眼睛视网膜的变形镜和装置
公开(公告)号：US07345808B2
公开(公告)日：2008-03-18
申请号：US11175393
申请日：2005-07-07
申请人： Michiko Nakanishi , Akio Kobayashi , Isao Minegishi , Ayako Iijima
发明人： Michiko Nakanishi , Akio Kobayashi , Isao Minegishi , Ayako Iijima
IPC分类号： G02B26/00
CPC分类号： G03B15/14 , A61B3/14
摘要： A deformable mirror, in which the distance between an electrode substrate and a membrane can be accurately maintained and which can be produced at a low material cost, is provided. The deformable mirror comprises: an electrode substrate 11 having a plurality of electrodes (16a, 16b, 16c, 16d and 16e) formed on a surface of the electrode substrate; a silicon membrane 13 having a counter electrode opposed to the plurality of electrodes formed on the electrode substrate 11; a reflection section 15 provided on the side of the silicon membrane 13 opposite the counter electrode; and a support plate 19 integrally bonded to the electrode substrate 11 for restraining the displacements of the plurality of electrodes which adversely affect the deformation of the silicon membrane 13, in which a plurality of layers of wiring patterns (11a, 11b, 11c, 11d and 11e) for supplying drive voltages to the plurality of electrodes are formed in the electrode substrate 11.
摘要翻译：提供了可以精确地保持电极基板和膜之间的距离并且可以以低材料成本生产的可变形反射镜。可变形反射镜包括：电极基板11，其具有形成在电极基板的表面上的多个电极（16a，16b，16c，16d和16e）具有与形成在电极基板11上的多个电极相对的对置电极的硅膜13; 设置在与对置电极相对的硅膜13一侧的反射部15; 以及与电极基板11一体地结合的支撑板19，用于抑制对硅膜13的变形产生不利影响的多个电极的位移，其中多层布线图案（11a，11b，11c ，11d和11e）用于在多个电极中提供驱动电压。

9. 发明申请

US20060159490A1 Deformable mirror and device for observing retina of eye 失效
标题翻译：用于观察眼睛视网膜的变形镜和装置
公开(公告)号：US20060159490A1
公开(公告)日：2006-07-20
申请号：US11175393
申请日：2005-07-07
申请人： Michiko Nakanishi , Akio Kobayashi , Isao Minegishi , Ayako Iijima
发明人： Michiko Nakanishi , Akio Kobayashi , Isao Minegishi , Ayako Iijima
IPC分类号： G03G15/041
CPC分类号： G03B15/14 , A61B3/14
摘要： A deformable mirror, in which the distance between an electrode substrate and a membrane can be accurately maintained and which can be produced at a low material cost, is provided. The deformable mirror comprises: an electrode substrate 11 having a plurality of electrodes (16a, 16b, 16c, 16d and 16e) formed on a surface of the electrode substrate; a silicon membrane 13 having a counter electrode opposed to the plurality of electrodes formed on the electrode substrate 11; a reflection section 15 provided on the side of the silicon membrane 13 opposite the counter electrode; and a support plate 19 integrally bonded to the electrode substrate 11 for restraining the displacements of the plurality of electrodes which adversely affect the deformation of the silicon membrane 13, in which a plurality of layers of wiring patterns (11a, 11b, 11c, 11d and 11e) for supplying drive voltages to the plurality of electrodes are formed in the electrode substrate 11.
摘要翻译：提供了可以精确地保持电极基板和膜之间的距离并且可以以低材料成本生产的可变形反射镜。可变形反射镜包括：电极基板11，其具有形成在电极基板的表面上的多个电极（16a，16b，16c，16d和16e）具有与形成在电极基板11上的多个电极相对的对置电极的硅膜13; 设置在与对置电极相对的硅膜13一侧的反射部15; 以及与电极基板11一体地结合的支撑板19，用于抑制对硅膜13的变形产生不利影响的多个电极的位移，其中多层布线图案（11a，11b，11c ，11d和11e）用于在多个电极中提供驱动电压。

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