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1. 发明授权

US5376380A Method of producing liposomal products from freeze or spray-dried preparations of liposomes 失效
标题翻译：由脂质体的冷冻或喷雾干燥的制剂生产脂质体产品的方法
公开(公告)号：US5376380A
公开(公告)日：1994-12-27
申请号：US79842
申请日：1993-06-22
申请人： Hiroshi Kikuchi , Kiyoto Yachi , Hiromi Morita , Sadao Hirota
发明人： Hiroshi Kikuchi , Kiyoto Yachi , Hiromi Morita , Sadao Hirota
IPC分类号： A61K9/127 , A61K9/107 , B01J13/02 , B01J13/20
CPC分类号： A61K9/1277
摘要： A method of producing liposomal products which comprises treating a positively or negatively charged, freeze- or spray-dried liposomal preparation with an aqueous solution of a drug charged oppositely to the charge of the liposomes.
摘要翻译：一种生产脂质体产物的方法，其包括用与所述脂质体的电荷相反的药物的水溶液处理带正电荷或带负电荷的，冻干或喷雾干燥的脂质体制剂。

2. 发明授权

US6060080A Liposomal products 失效
标题翻译：脂质体产品
公开(公告)号：US6060080A
公开(公告)日：2000-05-09
申请号：US409924
申请日：1995-03-23
申请人： Hiroshi Kikuchi , Kiyoto Yachi , Sadao Hirota
发明人： Hiroshi Kikuchi , Kiyoto Yachi , Sadao Hirota
IPC分类号： A61K9/127
CPC分类号： A61K9/127
摘要： A liposomal aqueous dispersion and method of making the liposomal aqueous dispersion is useful for encapsulation of drugs. The liposomal aqueous dispersion comprises: an aqueous suspension medium; multilamellar liposomes comprising an anionic phospholipid and cholesterol as essential components; neutral phospholipid in a mole ratio of 0 to 40% based on the total amount of said multilamellar liposomes; and a cation moiety-containing water-soluble drug, wherein the electrolyte concentration of said aqueous suspension medium is not more than 40 mM.
摘要翻译：脂质体水分散体和制备脂质体水分散体的方法可用于药物的包封。脂质体水性分散体包含：水性悬浮液; 包含阴离子磷脂和胆固醇作为必需组分的多层脂质体; 中性磷脂的摩尔比为0〜40％，基于所述多层脂质体的总量; 和含阳离子部分的水溶性药物，其中所述水性悬浮介质的电解质浓度不超过40mM。

3. 发明授权

US5626751A Filter unit and high-pressure sizing apparatus 失效
标题翻译：过滤单元和高压定型设备
公开(公告)号：US5626751A
公开(公告)日：1997-05-06
申请号：US91714
申请日：1993-07-15
申请人： Hiroshi Kikuchi , Hitoshi Yamauchi , Kiyoto Yachi , Hiroshi Honda , Norio Suzuki , Akinori Hoshio , Takazo Hirose
发明人： Hiroshi Kikuchi , Hitoshi Yamauchi , Kiyoto Yachi , Hiroshi Honda , Norio Suzuki , Akinori Hoshio , Takazo Hirose
IPC分类号： A61K9/127 , B01D29/05 , B01D61/14 , B01D63/08 , B01D63/00 , B01D35/30
CPC分类号： B01D61/147 , A61K9/127 , B01D29/05 , B01D63/08 , B01D63/081 , Y10T156/1057
摘要： A filter unit comprises a metallic supporting plate possessed of stepped through holes opening with a larger diameter in one main surface and with a smaller diameter in the other main surface (wherein the diameter ratio of larger-diameter openings to smaller-diameter openings is desired to be in the range of 1:0.01 to 1:0.5) or a pressureproof supporting plate having in one surface thereof inclined liquid flow grooves arranged in a radial pattern and concentric circular liquid flow grooves adapted to intersect the radially arranged liquid flow grooves and a membrane filter disposed on the surface of the supporting plate containing larger-diameter openings or liquid flow grooves. This filter unit is ideally used for finely dividing and uniformly sizing suspended lipid particles assuming a definite average particle size and a specific particle size distribution. The high-pressure sizing apparatus and the method for production of suspended lipid particles utilize the filter unit constructed as described above and rely essentially for their operation on effecting fine division of lipid particles in the suspension by supplying the suspension of lipid particles from the membrane filter side under pressure and causing the suspension to pass through the membrane filter. Thus, they constitute themselves effective measures for pharmacological products and cosmetic products which are in need of lipid particles assuming a definite average particle size and a specific particle size distribution.
摘要翻译：过滤器单元包括金属支撑板，其具有在一个主表面中具有较大直径的阶梯状通孔，并且在另一个主表面中具有较小直径（其中大直径开口与较小直径开口的直径比期望为在1：0.01〜1：0.5的范围内）或者在一个表面上具有倾斜的液体流槽的径向图案的压力支撑板和适于与径向布置的液体流槽相交的同心圆形液体流动槽过滤器设置在包含较大直径开口或液体流动槽的支撑板的表面上。这种过滤器单元理想地用于假定具有确定的平均粒度和特定的粒度分布的悬浮脂质颗粒的细分和均匀的尺寸。高压施胶装置和悬浮脂质颗粒的生产方法利用如上所述构造的过滤器单元，并且主要依靠它们的操作来通过从膜过滤器中提供脂质颗粒的悬浮液来实现悬浮液中脂质颗粒的精细分配并使悬浮液通过膜过滤器。因此，它们构成了需要脂质颗粒的药理产品和化妆品的有效措施，其具有确定的平均粒度和特定的粒度分布。

4. 发明授权

US5676928A Liposomes 失效
标题翻译：脂质体
公开(公告)号：US5676928A
公开(公告)日：1997-10-14
申请号：US468743
申请日：1995-06-06
申请人： Jo Klaveness , Arne Berg , Trond Vegard Jacobsen , Pal Rongved , Thorfinn Ege , Hiroshi Kikuchi , Kiyoto Yachi
发明人： Jo Klaveness , Arne Berg , Trond Vegard Jacobsen , Pal Rongved , Thorfinn Ege , Hiroshi Kikuchi , Kiyoto Yachi
IPC分类号： A61K49/04 , A61K49/18 , A61K49/22 , A61K51/12 , A61K9/127
CPC分类号： A61K49/227 , A61K49/0466 , A61K49/1812
摘要： The invention provides a diagnostic composition for administration to human or animal subjects, the composition containing multilamellar liposomes, optionally together with unilamellar liposomes, the liposomes containing at least one imaging agent and being suspended in an aqueous medium containing said imaging agent, wherein the liposomes comprise a neutral phospholipid and a charged phospholipid, the average particle diameter of the liposomes is 50-3000 nm and the concentration of imaging agent in any aqueous phase filling the interior of the liposomes is substantially the same as that in the aqueous medium in which the liposomes are suspended. The contrast agents concerned are typically X-ray, MRI or ultrasound contrast agents.
摘要翻译：本发明提供了一种用于向人或动物受试者施用的诊断组合物，所述组合物包含多层脂质体，任选地与单层脂质体一起，所述脂质体含有至少一种成像剂并悬浮在含有所述显像剂的水性介质中，其中所述脂质体包含中性磷脂和带电磷脂，脂质体的平均粒径为50-3000nm，填充脂质体内部的任何水相中显像剂的浓度基本上与脂质体的水性介质中相同被暂停。相关的造影剂通常是X射线，MRI或超声造影剂。

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