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1. 发明授权

US4443272A Process for producing cold rolled steel sheets having excellent press formability and ageing property 失效
标题翻译：具有优异的压制成形性和时效性的冷轧钢板的制造方法
公开(公告)号：US4443272A
公开(公告)日：1984-04-17
申请号：US416372
申请日：1982-09-09
申请人： Hiroshi Katoh , Hiromi Toyota , Kazuo Koyama , Kunihiko Komiya
发明人： Hiroshi Katoh , Hiromi Toyota , Kazuo Koyama , Kunihiko Komiya
IPC分类号： C22C38/00 , C21D8/02 , C21D8/04 , C21D9/48
CPC分类号： C21D8/0426 , C21D9/48 , C21D8/0473
摘要： Disclosed are processes for producing cold rolled steel sheets and strips having excellent press formability and ageing property by a continuous annealing method, in which specific heating cycles are adopted in combination with steel compositions with lowered phosphorus contents.
摘要翻译：公开了通过连续退火方法生产具有优异的压制成形性和时效性的冷轧钢板和带材的方法，其中采用特定的加热循环与具有降低的磷含量的钢组合物组合。

2. 发明授权

US4981531A Process for producing cold rolled steel sheets having excellent press formability and ageing property 失效
标题翻译：具有优异的压制成形性和时效性的冷轧钢板的制造方法
公开(公告)号：US4981531A
公开(公告)日：1991-01-01
申请号：US551369
申请日：1983-11-14
申请人： Hiroshi Katoh , Hiromi Toyota , Kazuo Koyama , Kunihiko Komiya
发明人： Hiroshi Katoh , Hiromi Toyota , Kazuo Koyama , Kunihiko Komiya
IPC分类号： C22C38/00 , C21D8/02 , C21D8/04 , C21D9/48
CPC分类号： C21D8/0426 , C21D9/48 , C21D8/0473
摘要： Disclosed are processes for producing cold rolled steel sheets and strips having excellent press formability and ageing property by a continuous annealing method, in which specific heating cycles are adopted in combination with steel compositions with lowered phosphorus contents.

3. 发明授权

US4391653A Process for producing cold rolled steel strip having excellent mechanical strength and useful for motor vehicles 失效
标题翻译：制造机械强度优异且用于机动车辆的冷轧钢带的制造方法
公开(公告)号：US4391653A
公开(公告)日：1983-07-05
申请号：US302450
申请日：1981-09-15
申请人： Hiroshi Takechi , Hiroshi Katoh , Kazuo Koyama , Kazuhide Usami
发明人： Hiroshi Takechi , Hiroshi Katoh , Kazuo Koyama , Kazuhide Usami
IPC分类号： C22C38/00 , B21B3/02 , C21D8/02 , C21D8/04 , C21D9/46
CPC分类号： C21D9/46 , B21B3/02 , C21D8/0436 , C21D8/0426 , C21D8/0473
摘要： A high strength cold rolled strip having excellent deep drawability and resistance to deterioration by natural aging and to planar cracking and useful for motor vehicles, is produced by hot rolling a steel slab comprising0.008-0.020% by weight of C,0.01-0.45% by weight of Mn,0.05-0.10% by weight of P,0.005-0.050% by weight of acid-soluble Al,and the balance consisting of Fe and unavoidable impurities in which N is limited to a content of 40 ppm or less, at a temperature of 1200.degree. C. or less but not lower than the Ar.sub.3 point of the steel slab; by cold rolling the resultant steel strip at a rolling reduction of 65% or more; by continuously annealing the cold rolled steel strip at a temperature of from 700.degree. to 900.degree. C. for 20 seconds to 3 minutes; by cooling the steel strip at a cooling rate of 5.degree. C./sec or more; by overaging the annealed steel strip at a temperature of from 320.degree. to 450.degree. C. for 1 to 10 minutes; by cooling said overaged steel strip to the ambient temperature, and, finally; by temper-rolling the cooled steel strip at the ambient temperature.
摘要翻译：通过将包含0.008-0.020重量％的C，0.01-0.45％的钢坯热轧在钢坯上，制造具有优异的深冲性和耐自然老化劣化和平面裂纹并且适用于机动车辆的高强度冷轧带 Mn重量为0.05-0.10％，P为0.005-0.050％（重量），余量由Fe和不可避免的杂质组成，其中N被限制在40ppm以下的含量温度在1200℃以下但不低于钢坯的Ar3点; 通过在65％以上的压下率下冷轧得到的钢带; 通过在700〜900℃的温度下连续退火冷轧钢带20秒〜3分钟; 通过以5℃/秒以上的冷却速度冷却钢带; 通过在320℃至450℃的温度下对退火的钢带进行1至10分钟的老化处理; 通过将所述过时的钢带冷却至环境温度，最后; 通过在环境温度下冷却冷却的钢带。

4. 发明授权

US4769088A Process for producing hot-rolled steel sheet having high r value 失效
标题翻译：具有高，高值的热轧钢板的制造方法
公开(公告)号：US4769088A
公开(公告)日：1988-09-06
申请号：US11824
申请日：1987-02-06
申请人： Atsushi Itami , Kazuo Koyama , Hiroshi Katoh , Nobuhiko Matsuzu
发明人： Atsushi Itami , Kazuo Koyama , Hiroshi Katoh , Nobuhiko Matsuzu
IPC分类号： C21D9/46 , C21D8/02 , C21D8/04 , C21D9/48 , C22C38/00 , C22C38/12 , C22C38/14
CPC分类号： C21D8/0226 , C22C38/12 , C22C38/14 , C21D8/04
摘要： An r value of a hot-rolled steel sheet is enhanced by: a specific composition consisting of not more than 0.015 wt % of C, from 1.0 to 2.5 wt % of Mn, from 0.005 to 0.10 wt % of Al, from 0.01 to 0.06 wt % of Nb, from 0.01 to 0.1 wt % of Ti; and, controlled rolling, characterized by in the rough rolling, imparting, in a temperature range of from 980.degree. to 1100.degree. C., a heavy reduction of not less than 20% per pass to the steel sheet; completing a finishing rolling at from Ar.sub.3 to 930.degree. C. and maintaining a total reduction at a temperature of not more than Ar.sub.3 +150.degree. C. to not less than 90%; and, coiling at a temperature of from 600.degree. to 800.degree. C.
摘要翻译：通过以下方式提高热轧钢板的上下限值：由不大于0.015重量％的C，1.0〜2.5重量％的Mn，0.005〜0.10重量％的Al，0.01〜 0.06重量％的Nb，0.01〜0.1重量％的Ti; 并进行轧制，其特征在于粗轧，在980℃〜1100℃的温度范围内，每次通过钢板的重量减少20％以上; 完成从Ar3到930℃的精轧，并且在不高于Ar3 + 150℃的温度下保持总的还原至不低于90％; 并在600〜800℃的温度下卷取。

5. 发明授权

US08766715B2 Amplifier circuit 有权
标题翻译：放大器电路
公开(公告)号：US08766715B2
公开(公告)日：2014-07-01
申请号：US13511233
申请日：2011-08-29
申请人： Kazuo Koyama
发明人： Kazuo Koyama
IPC分类号： H03F3/45
CPC分类号： H03F3/45475 , H03F3/3022 , H03F3/45183 , H03F3/45928 , H03F2203/45082 , H03F2203/45528
摘要： An amplifier circuit capable of reducing load of a circuit at the previous stage by providing increased input impedance producing less noises. The amplifier circuit includes a fully-differential operational amplifier composed of an inverting input terminal, a non-inverting input terminal receiving a signal different from a signal to be input to the inverting input terminal, an inverting output terminal with the same polarity of the inverting input terminal, and a non-inverting output terminal with reverse polarity; an input impedance element with one end connected to the inverting input terminal; an input impedance element with one end connected to the non-inverting input terminal; and positive feedback impedance elements, with one end of connected to the other end of the input impedance element and the other end connected to the inverting output terminal or to the non-inverting output terminal.
摘要翻译：一种放大器电路，其能够通过提供增加的输入阻抗产生较少的噪声来减小前一电路的负载。放大器电路包括由反相输入端子，非反相输入端子接收与要输入到反相输入端子的信号不同的信号的全差分运算放大器，反相输出端子具有与反相输入端子相同极性的反相输出端子输入端子和反相输出端子; 输入阻抗元件，其一端连接到反相输入端子; 输入阻抗元件，其一端连接到非反相输入端子; 和正反馈阻抗元件，其一端连接到输入阻抗元件的另一端，另一端连接到反相输出端或非反相输出端。

6. 发明申请

US20090286809A1 Preventives or remedies for alzheimer's disease, or amyloid protein fibril-formation inhibitors, which include a nitrogen-containing heteroaryl compound 审中-公开
公开(公告)号：US20090286809A1
公开(公告)日：2009-11-19
申请号：US12458891
申请日：2009-07-27
申请人： Masaki Meguro , Tomiichiro Oda , Yasuhiro Nakagami , Shinji Marumoto , Kazuo Koyama , Isao Kaneko
发明人： Masaki Meguro , Tomiichiro Oda , Yasuhiro Nakagami , Shinji Marumoto , Kazuo Koyama , Isao Kaneko
IPC分类号： A61K31/4965 , A61K31/505 , C07D239/02 , C07D237/02 , C07D241/02 , A61K31/50 , A61P25/28
CPC分类号： C07D239/48 , A61K31/50 , A61K31/505 , A61K31/53 , C07D237/20 , C07D237/22 , C07D239/50 , C07D241/20 , C07D251/18 , C07D251/48 , C07D251/52 , C07D251/70
摘要： The present invention relates to preventives or remedies for Alzheimer's disease, or to amyloid protein fibril-formation inhibitors, which include as an active ingredient a compound of general formula (I) below or a pharmacologically permitted salt thereof; and also to nitrogen-containing heteroaryl derivatives having specific substituents, or pharmacologically permitted salts thereof, which are valuable as preventives or remedies for Alzheimer's disease, or as amyloid protein fibril-formation inhibitors: (where, R1 and R2 are H or alkyl; Z1 and Z2 are H, alkyl, alkoxy, haloalkyl or halogeno; Z3 is alkoxy, SH, alkylthio, NH2, mono- or di-alkylamino, OH or halogeno; Z4 and Z5 are H or halogeno; and A is 4,6-pyrimidine-1,3-diyl, 1,3,5-triazine-2,6-diyl, etc).

7. 发明授权

US07589105B2 Preventives or remedies for alzheimer's disease, or amyloid protein fibril-formation inhibitors, which include a nitrogen-containing heteroaryl compound 失效
标题翻译：阿尔茨海默病或淀粉样蛋白原纤维形成抑制剂的预防或补救措施，其包括含氮杂芳基化合物
公开(公告)号：US07589105B2
公开(公告)日：2009-09-15
申请号：US10497183
申请日：2002-11-25
申请人： Masaki Meguro , Tomiichiro Oda , Yasuhiro Nakagami , Shinji Marumoto , Kazuo Koyama , Isao Kaneko
发明人： Masaki Meguro , Tomiichiro Oda , Yasuhiro Nakagami , Shinji Marumoto , Kazuo Koyama , Isao Kaneko
IPC分类号： A01N43/60 , A01N43/42
CPC分类号： C07D239/48 , A61K31/50 , A61K31/505 , A61K31/53 , C07D237/20 , C07D237/22 , C07D239/50 , C07D241/20 , C07D251/18 , C07D251/48 , C07D251/52 , C07D251/70
摘要： Pharmaceutical compositions and methods of treatment are provided for treating amyloidosis, containing, as an active ingredient, at least one nitrogen-containing heteroaryl compound represented by the following general formula or a pharmacologically permitted salt thereof; together with nitrogen-containing heteroaryl derivatives, and pharmacologically permitted salts thereof: where, R1, R2, Z1-Z5, and A are as defined herein.
摘要翻译：提供药物组合物和治疗方法用于治疗淀粉样变性，其含有至少一种由以下通式表示的含氮杂芳基化合物或其药理学允许的盐作为活性成分; 连同含氮杂芳基衍生物及其药理学允许的盐：其中，R1，R2，Z1-Z5和A如本文所定义。

8. 发明授权

US07514475B2 Benzylamine analogues 失效
标题翻译：苄胺类似物
公开(公告)号：US07514475B2
公开(公告)日：2009-04-07
申请号：US11583499
申请日：2006-10-19
申请人： Kazuo Koyama , Shinji Marumoto , Narihiro Toda , Hiroshi Kogen , Keiko Suzuki
发明人： Kazuo Koyama , Shinji Marumoto , Narihiro Toda , Hiroshi Kogen , Keiko Suzuki
IPC分类号： A61K31/137 , C07C205/04
CPC分类号： C07C219/30 , C07C271/44 , C07C323/20 , C07C323/25 , C07C333/04 , C07D213/64 , C07D213/68 , C07D215/20 , C07D317/58 , C07D333/38
摘要： A compound of the formula (I): wherein R1 is a C1-C6 alkyl, an amino, a (C1-C6 alkyl)amino, a di(C1-C6 alkyl)amino or a nitrogen-containing saturated heterocyclic; R2 and R3 are the same or different and are a hydrogen or a C1-C6 alkyl; Arom is an unsubstituted or substituted aryl or an unsubstituted or substituted heteroaryl; wherein the substituted aryl is substituted at 1 to 5 positions and the substituted heteroaryl is substituted at 1 to 3 positions; wherein the heteroaryl is furyl, thiolyl, pyrrolyl, azepinyl, pyrazolyl, imidazolyl, oxazolyl, isoxazolyl, thiazolyl, isothiazolyl, 1,2,3 oxadiazolyl, pyranyl, pyridyl, pyridazinyl, pyrimidinyl, pyrazinyl or quinolyl; and wherein the substituents of the substituted aryl and of the substituted heteroaryl are independently halogen, C1-C6 alkyl, halogeno C1-C6 alkyl, C1-C6 alkoxy, C1-C6 alkylthio, C1-C3 alkylenedioxy, C1-C7 alkanoyl, C2-C7 alkyloxycarbonyl, amino, C1-C7 alkanoylamino, hydroxyl, mercapto, cyano, nitro or carboxyl; A is an ethylene or propylene; Ra is a hydrogen, a C1-C6 alkyl or a C2-C6 alkenyl; E is a single bond, an oxygen, a sulfur or —NR4—, wherein R4 is a hydrogen or a C1-C7 alkanoyl; X1 and X2 are the same or different and are an oxygen or a sulfur, or a pharmacologically acceptable salt or ester thereof.
摘要翻译：式（I）的化合物：其中R1是C1-C6烷基，氨基，（C1-C6烷基）氨基，二（C1-C6烷基）氨基或含氮饱和杂环; R2和R3相同或不同，为氢或C1-C6烷基; Arom是未取代或取代的芳基或未取代或取代的杂芳基; 其中取代的芳基在1至5个位置被取代，并且取代的杂芳基在1至3个位置被取代; 吡唑基，咪唑基，恶唑基，异恶唑基，噻唑基，异噻唑基，1,2,3-恶二唑基，吡喃基，吡啶基，哒嗪基，嘧啶基，吡嗪基或喹啉基;其中杂芳基为呋喃基，噻吩基，吡咯基，并且其中取代的芳基和取代的杂芳基的取代基独立地为卤素，C 1 -C 6烷基，卤代C 1 -C 6烷基，C 1 -C 6烷氧基，C 1 -C 6烷硫基，C 1 -C 3亚烷基二氧基，C 1 -C 7烷酰基， C7烷氧基羰基，氨基，C1-C7烷酰基氨基，羟基，巯基，氰基，硝基或羧基; A是乙烯或丙烯; R a是氢，C 1 -C 6烷基或C 2 -C 6烯基; E是单键，氧，硫或-NR4-，其中R4是氢或C1-C7烷酰基; X1和X2相同或不同，为氧或硫，或其药理学上可接受的盐或酯。

9. 发明申请

US20080255095A1 Benzylamine analogues 审中-公开
标题翻译：苄胺类似物
公开(公告)号：US20080255095A1
公开(公告)日：2008-10-16
申请号：US11820218
申请日：2007-06-18
申请人： Kazuo Koyama , Shinji Marumoto , Narihiro Toda , Hiroshi Kogen , Keiko Suzuki
发明人： Kazuo Koyama , Shinji Marumoto , Narihiro Toda , Hiroshi Kogen , Keiko Suzuki
IPC分类号： A61K31/55 , C07D333/22 , C07D215/38 , C07D263/34 , A61K31/50 , A61P25/28 , A61K31/4965 , C07D261/02 , C07D277/00 , C07D275/02
CPC分类号： C07C219/30 , C07C271/44 , C07C323/20 , C07C323/25 , C07C333/04 , C07D213/64 , C07D213/68 , C07D215/20 , C07D317/58 , C07D333/38
摘要： A compound of the formula (I): wherein R1 is C1-C6 alkyl, amino, (C1-C6 alkyl)amino, di(C1-C6 alkyl)amino or a nitrogen-containing saturated heterocyclic; R2 and R3 are hydrogen or C1-C6 alkyl; Arom is phenyl, idenyl, napthyl, phenanthrenyl, furyl, thiolyl, pyrrolyl, azepinyl, pyrazolyl, imidazolyl, oxazolyl, isoxazolyl, thiazolyl, isothiazolyl, 1,2,3 oxadiazolyl, pyranyl, pyridyl, pyridazinyl, pyrimidinyl, pyrazinyl or quinolyl; A is C1-C6 alkylene; Ra is hydrogen, C1-C6 alkyl or C2-C6 alkenyl; E is a single bond, oxygen, sulfur or —NR4—, wherein R4 is hydrogen or C1-C7 alkanoyl; X1 and X2 are oxygen or sulfur; or a pharmacologically acceptable salt or ester thereof.
摘要翻译：式（I）的化合物：其中R 1是C 1 -C 6烷基，氨基，（C 1）（C 1 -C 6烷基）氨基或含氮饱和杂环基;（C 1 -C 6烷基）氨基， R 2和R 3是氢或C 1 -C 6烷基; 芳基是苯基，烯基，萘基，菲基，呋喃基，噻吩基，吡咯基，氮杂基，吡唑基，咪唑基，恶唑基，异恶唑基，噻唑基，异噻唑基，1,2,3-恶二唑基，吡喃基，吡啶基，哒嗪基，嘧啶基，吡嗪基或喹啉基。 A是C 1 -C 6亚烷基; R a是氢，C 1 -C 6烷基或C 2 -C 6烷基或C 2 -C 6 - 链烯基; E是单键，氧，硫或-NR 4 - ，其中R 4是氢或C 1 -C 7 烷酰基; X 1和X 2是氧或硫; 或其药理学上可接受的盐或酯。

10. 发明申请

US20080182846A1 Preventives or remedies for Alzheimer's disease, or amyloid protein fibril-formation inhibitors, which include a nitrogen-containing heteroaryl compound 失效
标题翻译：包括含氮杂芳基化合物的阿尔茨海默病或淀粉样蛋白原纤维形成抑制剂的预防或治疗
公开(公告)号：US20080182846A1
公开(公告)日：2008-07-31
申请号：US12068407
申请日：2008-02-06
申请人： Masaki Meguro , Tomichiro Oda , Yasuhiro Nakagami , Shinji Marumoto , Kazuo Koyama , Isao Kaneko
发明人： Masaki Meguro , Tomichiro Oda , Yasuhiro Nakagami , Shinji Marumoto , Kazuo Koyama , Isao Kaneko
IPC分类号： A61K31/53 , C07D251/18 , A61P25/28
CPC分类号： C07D239/48 , A61K31/50 , A61K31/505 , A61K31/53 , C07D237/20 , C07D237/22 , C07D239/50 , C07D241/20 , C07D251/18 , C07D251/48 , C07D251/52 , C07D251/70
摘要： The present invention relates to preventives or remedies for Alzheimer's disease, or to amyloid protein fibril-formation inhibitors, which include as an active ingredient a compound of general formula (I) below or a pharmacologically permitted salt thereof; and also to nitrogen-containing heteroaryl derivatives having specific substituents, or pharmacologically permitted salts thereof, which are valuable as preventives or remedies for Alzheimer's disease, or as amyloid protein fibril-formation inhibitors: (where, R1 and R2 are H or alkyl; Z1 and Z2 are H, alkyl, alkoxy, haloalkyl or halogeno; Z3 is alkoxy, SH, alkylthio, NH2, mono- or di-alkylamino, OH or halogeno; Z4 and Z5 are H or halogeno; and A is 4,6-pyrimidine-1,3-diyl, 1,3,5-triazine-2,6-diyl, etc).
摘要翻译：本发明涉及阿尔茨海默病的预防药物或补救剂，或淀粉样蛋白原纤维形成抑制剂，其包括作为活性成分的下列通式（I）的化合物或其药理学允许的盐; 以及具有特定取代基的含氮杂芳基衍生物或其药理学上允许的盐，其作为阿尔茨海默氏病的预防剂或治疗剂是有价值的，或作为淀粉样蛋白原纤维形成抑制剂：（其中R 1，和R 2是H或烷基; Z 1和Z 2是H，烷基，烷氧基，卤代烷基或卤代; Z 3 烷氧基，SH，烷硫基，NH 2，单或二烷基氨基，OH或卤素; Z 4和Z 5 >为H或卤素; A为4,6-嘧啶-1,3-二基，1,3,5-三嗪-2,6-二基等）。

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