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1. 发明申请

US20100168159A1 HETERO COMPOUND 有权
标题翻译： HETERO化合物
公开(公告)号：US20100168159A1
公开(公告)日：2010-07-01
申请号：US12696327
申请日：2010-01-29
申请人： Hironori Harada , Kazuyuki Hattori , Kazuya Fujita , Masataka Morita , Sunao Imada , Yoshito Abe , Hiromichi Itani , Tatsuaki Morokata , Hideo Tsutsumi
发明人： Hironori Harada , Kazuyuki Hattori , Kazuya Fujita , Masataka Morita , Sunao Imada , Yoshito Abe , Hiromichi Itani , Tatsuaki Morokata , Hideo Tsutsumi
IPC分类号： A61K31/4439 , A61K31/4709 , C07D471/04 , C07D413/14 , A61P35/02 , A61P37/06 , A61P29/00 , A61P9/10 , A61P35/00
CPC分类号： C07D413/04 , C07D417/04 , C07D471/04
摘要： [Problems]To provide a useful compound as an active ingredient for a preventing and/or treating agent for rejection in the transplantation of an organ, bone marrow, or a tissue, an autoimmune disease, or the like, which has an excellent S1P1 agonist activity.[Means for solving]Since the compound of the invention has an S1P1 agonist activity, it is useful as an active ingredient for a treating or preventing agent for a disease caused by unfavorable lymphocytic infiltration, for example, an autoimmune disease such as graft rejection in the transplantation of an organ, bone marrow, or a tissue, a graft-versus-host disease, rheumatic arthritis, multiple sclerosis, systemic lupus erythematosus, a nephrotic syndrome, encephalomeningitis, myasthenia gravis, pancreatitis, hepatitis, nephritis, diabetes, pulmonary disorder, asthma, atopic dermatitis, inflammatory bowel disease, atherosclerosis, ischemia-reperfusion injury, or an inflammatory disease, and further, a disease caused by the abnormal growth or accumulation of cells such as cancer and leukemia.
摘要翻译： [问题]提供一种有用的化合物作为活性成分，用于预防和/或治疗移植器官，骨髓或组织，自身免疫疾病等中的排斥反应，其具有优异的S1P1激动剂活动。 [解决方法]由于本发明的化合物具有S1P1激动剂活性，因此可用作由不利的淋巴细胞浸润引起的疾病的治疗或预防剂的活性成分，例如自身免疫性疾病如移植排斥反应器官移植，骨髓或组织，移植物抗宿主病，风湿性关节炎，多发性硬化，系统性红斑狼疮，肾病综合征，脑炎，重症肌无力，胰腺炎，肝炎，肾炎，糖尿病，肺功能障碍哮喘，特应性皮炎，炎症性肠病，动脉粥样硬化，局部缺血再灌注损伤，炎症性疾病等疾病，以及癌症，白血病等细胞异常生长或积累引起的疾病。

2. 发明授权

US07951825B2 Hetero compound 有权
标题翻译：杂环化合物
公开(公告)号：US07951825B2
公开(公告)日：2011-05-31
申请号：US12696327
申请日：2010-01-29
申请人： Hironori Harada , Kazuyuki Hattori , Kazuya Fujita , Masataka Morita , Sunao Imada , Yoshito Abe , Hiromichi Itani , Tatsuaki Morokata , Hideo Tsutsumi
发明人： Hironori Harada , Kazuyuki Hattori , Kazuya Fujita , Masataka Morita , Sunao Imada , Yoshito Abe , Hiromichi Itani , Tatsuaki Morokata , Hideo Tsutsumi
IPC分类号： C07D413/02 , C07D413/14 , C07D401/02 , C07D401/14 , A61K31/443
CPC分类号： C07D413/04 , C07D417/04 , C07D471/04
摘要： To provide a useful compound as an active ingredient for a preventing and/or treating agent for rejection in the transplantation of an organ, bone marrow, or a tissue, an autoimmune disease, or the like, which has an excellent S1P1 agonist activity.Since the compound of the invention has an S1P1 agonist activity, it is useful as an active ingredient for a treating or preventing agent for a disease caused by unfavorable lymphocytic infiltration, for example, an autoimmune disease such as graft rejection in the transplantation of an organ, bone marrow, or a tissue, a graft-versus-host disease, rheumatic arthritis, multiple sclerosis, systemic lupus erythematosus, a nephrotic syndrome, encephalomeningitis, myasthenia gravis, pancreatitis, hepatitis, nephritis, diabetes, pulmonary disorder, asthma, atopic dermatitis, inflammatory bowel disease, atherosclerosis, ischemia-reperfusion injury, or an inflammatory disease, and further, a disease caused by the abnormal growth or accumulation of cells such as cancer and leukemia.
摘要翻译：为了提供具有优异的S1P1激动剂活性的器官，骨髓或组织，自身免疫疾病等的移植中的预防和/或治疗剂的有效成分的有用化合物。由于本发明的化合物具有S1P1激动剂活性，因此可用作治疗或预防由不利淋巴细胞浸润引起的疾病的活性成分，例如自体免疫疾病例如器官移植中的移植排斥反应骨髓或组织，移植物抗宿主病，风湿性关节炎，多发性硬化症，系统性红斑狼疮，肾病综合征，脑炎，重症肌无力，胰腺炎，肝炎，肾炎，糖尿病，肺病，哮喘，特应性皮炎炎症性肠病，动脉粥样硬化，缺血再灌注损伤或炎性疾病，以及由细胞如癌症和白血病的异常生长或积累引起的疾病。

3. 发明授权

US07678820B2 Hetero compound 有权
标题翻译：杂环化合物
公开(公告)号：US07678820B2
公开(公告)日：2010-03-16
申请号：US12244102
申请日：2008-10-02
申请人： Hironori Harada , Kazuyuki Hattori , Kazuya Fujita , Masataka Morita , Sunao Imada , Yoshito Abe , Hiromichi Itani , Tatsuaki Morokata , Hideo Tsutsumi
发明人： Hironori Harada , Kazuyuki Hattori , Kazuya Fujita , Masataka Morita , Sunao Imada , Yoshito Abe , Hiromichi Itani , Tatsuaki Morokata , Hideo Tsutsumi
IPC分类号： A61K31/4245 , C07D271/06
CPC分类号： C07D413/04 , C07D417/04 , C07D471/04
摘要： To provide a useful compound as an active ingredient for a preventing and/or treating agent for rejection in the transplantation of an organ, bone marrow, or a tissue, an autoimmune disease, or the like, which has an excellent S1P1 agonist activity. Since the compound of the invention has an S1P1 agonist activity, it is useful as an active ingredient for a treating or preventing agent for a disease caused by unfavorable lymphocytic infiltration, for example, an autoimmune disease such as graft rejection in the transplantation of an organ, bone marrow, or a tissue, a graft-versus-host disease, rheumatic arthritis, multiple sclerosis, systemic lupus erythematosus, a nephrotic syndrome, encephalomeningitis, myasthenia gravis, pancreatitis, hepatitis, nephritis, diabetes, pulmonary disorder, asthma, atopic dermatitis, inflammatory bowel disease, atherosclerosis, ischemia-reperfusion injury, or an inflammatory disease, and further, a disease caused by the abnormal growth or accumulation of cells such as cancer and leukemia.
摘要翻译：为了提供具有优异的S1P1激动剂活性的器官，骨髓或组织，自身免疫疾病等的移植中的预防和/或治疗剂的有效成分的有用化合物。由于本发明的化合物具有S1P1激动剂活性，因此可用作治疗或预防由不利淋巴细胞浸润引起的疾病的活性成分，例如自体免疫疾病例如器官移植中的移植排斥反应骨髓或组织，移植物抗宿主病，风湿性关节炎，多发性硬化症，系统性红斑狼疮，肾病综合征，脑炎，重症肌无力，胰腺炎，肝炎，肾炎，糖尿病，肺病，哮喘，特应性皮炎炎症性肠病，动脉粥样硬化，缺血再灌注损伤或炎性疾病，以及由细胞如癌症和白血病的异常生长或积累引起的疾病。

4. 发明申请

US20090076070A1 HETERO COMPOUND 有权
标题翻译： HETERO化合物
公开(公告)号：US20090076070A1
公开(公告)日：2009-03-19
申请号：US12244102
申请日：2008-10-02
申请人： Hironori HARADA , Kazuyuki Hattori , Kazuya Fujita , Masataka Morita , Sunao Imada , Yoshito Abe , Hiromichi Itani , Tatsuaki Morokata , Hideo Tsutsumi
发明人： Hironori HARADA , Kazuyuki Hattori , Kazuya Fujita , Masataka Morita , Sunao Imada , Yoshito Abe , Hiromichi Itani , Tatsuaki Morokata , Hideo Tsutsumi
IPC分类号： A61K31/4245 , C07D413/14 , A61K31/437 , A61P35/02 , A61P19/02 , A61P1/00 , A61P9/10 , A61P37/06 , A61P35/00 , A61K31/4709
CPC分类号： C07D413/04 , C07D417/04 , C07D471/04
摘要： [Problems] To provide a useful compound as an active ingredient for a preventing and/or treating agent for rejection in the transplantation of an organ, bone marrow, or a tissue, an autoimmune disease, or the like, which has an excellent S1P1 agonist activity.[Means for Solving] Since the compound of the invention has an S1P1 agonist activity, it is useful as an active ingredient for a treating or preventing agent for a disease caused by unfavorable lymphocytic infiltration, for example, an autoimmune disease such as graft rejection in the transplantation of an organ, bone marrow, or a tissue, a graft-versus-host disease, rheumatic arthritis, multiple sclerosis, systemic lupus erythematosus, a nephrotic syndrome, encephalomeningitis, myasthenia gravis, pancreatitis, hepatitis, nephritis, diabetes, pulmonary disorder, asthma, atopic dermatitis, inflammatory bowel disease, atherosclerosis, ischemia-reperfusion injury, or an inflammatory disease, and further, a disease caused by the abnormal growth or accumulation of cells such as cancer and leukemia.
摘要翻译： [问题]提供一种有用的化合物作为活性成分，用于预防和/或治疗移植器官，骨髓或组织，自身免疫疾病等中的排斥反应，其具有优异的S1P1激动剂活动。 [解决手段]由于本发明的化合物具有S1P1激动剂活性，因此可用作由不利的淋巴细胞浸润引起的疾病的治疗或预防剂的活性成分，例如自身免疫性疾病例如移植排斥反应器官移植，骨髓或组织，移植物抗宿主病，风湿性关节炎，多发性硬化，系统性红斑狼疮，肾病综合征，脑炎，重症肌无力，胰腺炎，肝炎，肾炎，糖尿病，肺功能障碍哮喘，特应性皮炎，炎症性肠病，动脉粥样硬化，局部缺血再灌注损伤，炎症性疾病等疾病，以及癌症，白血病等细胞异常生长或积累引起的疾病。

5. 发明授权

US06348474B1 Sulfonamide compounds and medicinal use thereof 失效
标题翻译：磺酰胺类化合物及其医药用途
公开(公告)号：US06348474B1
公开(公告)日：2002-02-19
申请号：US09446110
申请日：2000-02-14
申请人： Hiroshi Kayakiri , Yoshito Abe , Hitoshi Hamashima , Hitoshi Sawada , Tsuyoshi Mizutani , Teruo Oku , Noritsugu Yamasaki , Osamu Onomura , Masahiro Nishikawa , Takahiro Hiramura , Takafumi Imoto
发明人： Hiroshi Kayakiri , Yoshito Abe , Hitoshi Hamashima , Hitoshi Sawada , Tsuyoshi Mizutani , Teruo Oku , Noritsugu Yamasaki , Osamu Onomura , Masahiro Nishikawa , Takahiro Hiramura , Takafumi Imoto
IPC分类号： A61K31435
CPC分类号： C07D241/52 , C07D215/48 , C07D231/56 , C07D239/96 , C07D249/18 , C07D307/79 , C07D333/54 , C07D333/62 , C07D405/12 , C07D409/12 , C07D471/04 , C07D487/04 , C07D495/04
摘要： A sulfonamide compound of the formula (I): R1—SO2NHCO—A—R2 (I) wherein R1 is alkyl, alkenyl, alkynyl and the like; A is an optionally substituted heteropolycyclic group except benzimidazolyl, indolyl, 4,7-dihydrobenzimidazolyl and 2,3-dihydrobenzoxazinyl; X is alkylene, oxa, oxa(lower)alkylene and the like; and R2 is optionally substituted aryl, substituted biphenylyl and the like, a salt thereof and a pharmaceutical composition comprising the same. The sulfonamide compound is effective for the diseases treatable based on their blood sugar level-depressing activity, cGMP-PDE (especially PDE-V)-inhibiting activity, smooth muscle relaxing activity, bronchodilating activity, vasodilating activity, smooth muscle cell suppressing activity, and antiallergic activity.
摘要翻译：式（I）的磺酰胺化合物：其中R1是烷基，烯基，炔基等; A是任选取代的杂多环基团，除了苯并咪唑基，吲哚基，4,7-二氢苯并咪唑基和2,3-二氢苯并恶嗪基; X是亚烷基，氧杂，氧杂（低级）亚烷基等; 并且R 2是任选取代的芳基，取代的联苯基等，其盐和包含它们的药物组合物。磺胺类化合物可以基于其血糖降低活性，cGMP-PDE（特别是PDE-V）抑制活性，平滑肌松弛活性，支气管扩张活性，血管舒张活性，平滑肌细胞抑制活性，以及抗过敏活性。

6. 发明授权

US06242474B1 Aromatic ring derivatives 失效
标题翻译：芳香环衍生物
公开(公告)号：US06242474B1
公开(公告)日：2001-06-05
申请号：US09446619
申请日：2000-03-21
申请人： Noritsugu Yamasaki , Takafumi Imoto , Takahiro Hiramura , Osamu Onomura , Masahiro Nishikawa , Hiroshi Kayakiri , Yoshito Abe , Hitoshi Hamashima , Hitoshi Sawada
发明人： Noritsugu Yamasaki , Takafumi Imoto , Takahiro Hiramura , Osamu Onomura , Masahiro Nishikawa , Hiroshi Kayakiri , Yoshito Abe , Hitoshi Hamashima , Hitoshi Sawada
IPC分类号： A61K314164
CPC分类号： C07D213/78 , C07C311/51 , C07D213/81 , C07D233/64 , C07D233/68 , C07D409/06
摘要： Novel aromatic ring derivatives represented by formula (I) or their pharmaceutical acceptable salts are provided. wherein Nu represents a 5- or 6-membered aromatic ring; ch1 and ch2 each represents a cross-linking group; and A represents an aromatic ring. These compounds have blood sugar-depressing activity or PDE 5 inhibitory activity and are useful as medicines for treating impaired glucose tolerance, diabetes, diabetic complications, syndrome of insulin-resistance, polycystic ovary syndrome, hyperlipidemia, atherosclerosis, cardiovascular disorders, hyperglycemia, hypertension, stenocardia, pulmonary hypertension, congestive heart failure, glomerulopathy, tubulointerstitial disorders, renal failure, angiostenosis, distal angiopathy, cerebral apoplexy, chronic reversible obstructions, autoimmune diseases, allergic rhinitis, urticaria, glaucoma, diseases characterized by enteromotility disorders, impotence, nephritis, cachexia, pancreatitis, restenosis after PTCA, etc.
摘要翻译：提供由式（I）表示的新颖芳环衍生物或其药学上可接受的盐。其中Nu表示5-或6-元芳环; ch1和ch2各自表示交联基团; 并且A代表芳香环。这些化合物具有抑制血糖的活性或PDE 5抑制活性，可用作治疗糖耐量异常，糖尿病，糖尿病并发症，胰岛素抵抗综合征，多囊卵巢综合症，高脂血症，动脉粥样硬化，心血管疾病，高血糖症，高血压，心律失常，肺动脉高压，充血性心力衰竭，肾小球病，肾小管间质性疾病，肾衰竭，血管狭窄，远端血管病，脑中风，慢性可逆障碍，自身免疫性疾病，过敏性鼻炎，荨麻疹，青光眼，以肠蠕动为特征的疾病疾病，阳ence，肾炎，恶病质，胰腺炎，PTCA后再狭窄等。

7. 发明授权

US5994368A Pyridopyrimidones, quinolines and fused N-heterocycles as bradykinin antagonists 失效
标题翻译：吡啶并嘧啶酮，喹啉和稠合的N-杂环作为缓激肽拮抗剂
公开(公告)号：US5994368A
公开(公告)日：1999-11-30
申请号：US809416
申请日：1997-04-25
申请人： Teruo Oku , Hiroshi Kayakiri , Shigeki Satoh , Yoshito Abe , Yuki Sawada , Takayuki Inoue , Hirokazu Tanaka
发明人： Teruo Oku , Hiroshi Kayakiri , Shigeki Satoh , Yoshito Abe , Yuki Sawada , Takayuki Inoue , Hirokazu Tanaka
IPC分类号： C07D237/28 , A61K31/47 , A61K31/495 , A61K31/505 , A61K31/517 , A61K31/535 , A61P29/00 , A61P37/00 , A61P37/02 , A61P37/08 , A61P43/00 , C07D215/26 , C07D215/38 , C07D215/40 , C07D215/42 , C07D215/48 , C07D237/30 , C07D239/74 , C07D241/38 , C07D241/40 , C07D401/12 , C07D401/14 , C07D403/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D471/04 , A01N43/42 , C07D215/16
CPC分类号： C07D401/12 , C07D215/26 , C07D215/40 , C07D215/42 , C07D215/48 , C07D241/40 , C07D401/14 , C07D403/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D471/04
摘要： This invention relates to a compound of the formula: ##STR1## wherein Z is a group of the formula: ##STR2## in which X.sup.1 is N or C--R.sup.1,X.sup.2 is N or C--R.sup.9,X.sup.3 is N or C--R.sup.2,R.sup.1 is lower alkyl,R.sup.2 is hydrogen, lower alkyl, etc.,R.sup.9 is hydrogen or lower alkyl,R.sup.3 is halogen, etc.,R.sup.4 is halogen, etc.,R.sup.5 is a group of the formula: ##STR3## A is lower alkylene, and Y is O, etc.,and pharmaceutically acceptable salts thereof, to processes for preparation thereof, to a pharmaceutical composition comprising the same, and to methods to using the same therapeutically in the prevention and/or the treatment of bradykinin or its analogues mediated diseases in human being or animals.
摘要翻译：本发明涉及下式化合物：其中Z为下式基团：其中X1为N或C-R1，X2为N或C-R9，X3为N或C-R2，R1为低级烷基， R2是氢，低级烷基等，R9是氢或低级烷基，R3是卤素等，R4是卤素等，R5是下式的基团：A是低级亚烷基，Y是O等及其药学上可接受的盐，其制备方法，涉及包含其的药物组合物，以及在预防和/或治疗缓激肽或其类似物介导的人或动物疾病中的治疗方法。

8. 发明授权

US5750699A Method of preparing certain 3-halo-imidazopyridines 失效
标题翻译：制备某些3-卤代 - 咪唑并吡啶的方法
公开(公告)号：US5750699A
公开(公告)日：1998-05-12
申请号：US662198
申请日：1996-06-12
申请人： Teruo Oku , Hiroshi Kayakiri , Shigeki Satoh , Yoshito Abe , Yuki Sawada , Hirokazu Tanaka
发明人： Teruo Oku , Hiroshi Kayakiri , Shigeki Satoh , Yoshito Abe , Yuki Sawada , Hirokazu Tanaka
IPC分类号： C07D471/04 , C07D471/02
CPC分类号： C07D471/04
摘要： The invention relates to bradykinin antagonists of the formula: ##STR1## wherein R.sup.1 is halogen, R.sup.2 and R.sup.3 are each hydrogen, lower alkyl, halo(lower)alkyl or acyl, R.sup.4 is aryl having suitable substituent(s), or a heterocyclic group optionally having suitable substituent(s), Q is O or N--R.sup.11, in which R.sup.11 is hydrogen or acyl, and A is lower alkylene, and pharmaceutically acceptable salts thereof.
摘要翻译：本发明涉及下式的缓激肽拮抗剂：其中R 1为卤素，R 2和R 3各自为氢，低级烷基，卤代（低级）烷基或酰基，R 4为具有合适取代基的芳基或杂环基任选具有合适的取代基，Q是O或N-R 11，其中R 11是氢或酰基，A是低级亚烷基，及其药学上可接受的盐。

9. 发明授权

US5708173A Heterocyclic compounds 失效
标题翻译：杂环化合物
公开(公告)号：US5708173A
公开(公告)日：1998-01-13
申请号：US660393
申请日：1996-06-07
申请人： Teruo Oku , Hiroshi Kayakiri , Shigeki Satoh , Yoshito Abe , Yuki Sawada , Takayuki Inoue , Hirokazu Tanaka
发明人： Teruo Oku , Hiroshi Kayakiri , Shigeki Satoh , Yoshito Abe , Yuki Sawada , Takayuki Inoue , Hirokazu Tanaka
IPC分类号： A61K31/47 , A61K31/495 , A61K31/498 , A61K31/50 , A61K31/502 , A61K31/505 , A61K31/517 , A61K31/53 , A61P35/00 , A61P37/08 , A61P43/00 , C07D215/24 , C07D215/26 , C07D215/40 , C07D237/10 , C07D237/28 , C07D239/74 , C07D241/42 , C07D241/44 , C07D401/12 , C07D401/14 , C07D403/12 , C07D409/12 , C07D413/12 , C07F7/18 , C07D215/20 , C07D215/36
CPC分类号： C07D401/12 , C07D215/26 , C07D237/28 , C07D239/74 , C07D241/42 , C07D401/14 , C07D403/12 , C07D409/12 , C07D413/12 , C07F7/1856
摘要： A compound of the formula: ##STR1## or its salt is prepared by reacting a compound of the formula: ##STR2## with a compound of the formula: ##STR3## Wherein the variables are all defined in claim 1.
摘要翻译：通过使下式化合物与下式化合物反应制备下式的化合物：其中所有的变量都被定义在权利要求1中。

10. 发明授权

US08026962B2 Image synthesizing apparatus and image pickup apparatus with a brightness adjusting processing 有权
标题翻译：具有亮度调整处理的图像合成装置和图像拾取装置
公开(公告)号：US08026962B2
公开(公告)日：2011-09-27
申请号：US12397726
申请日：2009-03-04
申请人： Yoshito Abe , Kazunori Kita
发明人： Yoshito Abe , Kazunori Kita
IPC分类号： H04N5/217
CPC分类号： H04N5/243 , G06T5/002 , G06T5/009 , G06T5/40 , G06T5/50 , G06T2207/10016 , G06T2207/20221
摘要： Disclosed is an image synthesizer including an image frames memory which memorizes a plurality of image frames which are produced by continuously taking pictures of a subject, an image synthesizer which synthesizes a plurality of image frames to a summation image, an image brightness adjuster which adjusts brightness of the summation image by synthesizing the image frames with the image synthesizer, and a display which displays the summation image which is being synthesized by the image synthesizing means in the image brightness adjusting processing.
摘要翻译：公开了一种图像合成器，包括存储多个图像帧的图像帧存储器，所述图像帧存储器通过连续拍摄被摄体的图像，合成多个图像帧的图像合成器到和图像，调整亮度的图像亮度调节器通过与图像合成器合成图像帧，以及在图像亮度调整处理中显示由图像合成装置合成的求和图像的显示。

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