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1. 发明申请

US20130302821A1 Method For Evaluating Atherosclerotic Lesion, And Kit 审中-公开
标题翻译：评估动脉粥样硬化病变的方法和试剂盒
公开(公告)号：US20130302821A1
公开(公告)日：2013-11-14
申请号：US13885921
申请日：2011-11-17
申请人： Takeshi Sakamoto , Hiroko Hanzawa , Naomi Manri , Yuji Kuge
发明人： Takeshi Sakamoto , Hiroko Hanzawa , Naomi Manri , Yuji Kuge
IPC分类号： G01N33/68
CPC分类号： G01N33/6893 , A61B5/0071 , A61B5/02007 , A61B5/055 , A61B6/504 , A61B6/508 , A61B8/0891 , G01N2800/323 , G01N2800/52
摘要： The present invention provides a method and a means for evaluating atherosclerotic lesions by identifying a protein (marker protein) group, the expression level of which varies according to the progression of the atherosclerotic lesion, and using the proteins. Specifically, the present invention relates to a method for evaluating atherosclerotic lesions, comprising the steps of detecting a marker protein exhibiting an expression pattern (expression variation) characteristic at a specific disease stage of atherosclerotic lesions in a subject, and evaluating the atherosclerotic lesions in the subject based on the detection result.
摘要翻译：本发明提供了一种通过鉴定其表达水平根据动脉粥样硬化病变的进展以及使用蛋白质而变化的蛋白质（标记蛋白）组来评价动脉粥样硬化病变的方法和手段。具体而言，本发明涉及评价动脉粥样硬化病变的方法，其特征在于，包括以下步骤：检测在受试者的动脉粥样硬化病变的特定疾病阶段具有特征的表达模式（表达变异）的标记蛋白，并评价动脉粥样硬化病变主体根据检测结果。

2. 发明授权

US09175346B2 Evaluation method for arteriosclerosis 有权
标题翻译：动脉硬化评估方法
公开(公告)号：US09175346B2
公开(公告)日：2015-11-03
申请号：US13643590
申请日：2011-04-19
申请人： Hiroko Hanzawa , Takeshi Sakamoto , Naomi Manri , Yuji Kuge
发明人： Hiroko Hanzawa , Takeshi Sakamoto , Naomi Manri , Yuji Kuge
IPC分类号： G01N31/00 , G01N33/53 , C12Q1/68 , G01N33/564 , G01N33/86 , G01N33/18
CPC分类号： C12Q1/6883 , C12Q2600/112 , C12Q2600/158 , G01N33/18 , G01N33/1826 , G01N33/564 , G01N33/86 , G01N2333/4716 , G01N2800/323 , G01N2800/50 , G01N2800/52
摘要： Arteriosclerosis induces cerebral infarction and myocardial infarction. A multi-marker (a group of protein markers) that assesses the accurate pathogenesis of arteriosclerosis and enables the selection of an adequate treatment method for arteriosclerosis and prediction of the progression of arteriosclerosis, and an evaluation method for the diagnosis, prevention, and treatment of arteriosclerosis that uses said marker group as an indicator have been sought. The present invention relates to A method for evaluation of arteriosclerosis comprising the steps of (a) measuring the expression of von Willebrand factor and/or complement factor D in a sample derived from a subject, (b) measuring the expression of complement component C8 and/or vitamin K-dependent protein Z in the sample derived from the subject, and (c) evaluating arteriosclerosis in the subject on the basis of the results from (a) and (b).
摘要翻译：动脉硬化引起脑梗死和心肌梗死。评估动脉硬化的准确发病机理的多标记物（一组蛋白质标记物），能够选择适当的动脉硬化治疗方法和预测动脉硬化的进展，以及诊断，预防和治疗的评价方法已经寻求使用所述标记物组作为指标的动脉硬化。本发明涉及一种动脉硬化评估方法，其特征在于，包括以下步骤：（a）测定衍生自受试者的样品中血管性血友病因子和/或补体因子D的表达，（b）测量补体成分C8和 /或来自受试者的样品中的维生素K依赖性蛋白质Z，（c）基于（a）和（b）的结果评价受试者的动脉硬化。

3. 发明申请

US20130040851A1 Evaluation Method for Arteriosclerosis 有权
标题翻译：动脉硬化评估方法
公开(公告)号：US20130040851A1
公开(公告)日：2013-02-14
申请号：US13643590
申请日：2011-04-19
申请人： Hiroko Hanzawa , Takeshi Sakamoto , Naomi Manri , Yuji Kuge
发明人： Hiroko Hanzawa , Takeshi Sakamoto , Naomi Manri , Yuji Kuge
IPC分类号： G01N27/62 , C40B30/04 , C12Q1/68 , G01N33/566 , G01N21/64
CPC分类号： C12Q1/6883 , C12Q2600/112 , C12Q2600/158 , G01N33/18 , G01N33/1826 , G01N33/564 , G01N33/86 , G01N2333/4716 , G01N2800/323 , G01N2800/50 , G01N2800/52
摘要： Arteriosclerosis induces cerebral infarction and myocardial infarction. A multi-marker (a group of protein markers) that assesses the accurate pathogenesis of arteriosclerosis and enables the selection of an adequate treatment method for arteriosclerosis and prediction of the progression of arteriosclerosis, and an evaluation method for the diagnosis, prevention, and treatment of arteriosclerosis that uses said marker group as an indicator have been sought. The present invention relates to A method for evaluation of arteriosclerosis comprising the steps of (a) measuring the expression of von Willebrand factor and/or complement factor D in a sample derived from a subject, (b) measuring the expression of complement component C8 and/or vitamin K-dependent protein Z in the sample derived from the subject, and (c) evaluating arteriosclerosis in the subject on the basis of the results from (a) and (b).
摘要翻译：动脉硬化引起脑梗死和心肌梗死。评估动脉硬化的准确发病机理的多标记物（一组蛋白质标记物），能够选择适当的动脉硬化治疗方法和预测动脉硬化的进展，以及诊断，预防和治疗的评价方法已经寻求使用所述标记物组作为指标的动脉硬化。本发明涉及一种动脉硬化评估方法，其特征在于，包括以下步骤：（a）测定衍生自受试者的样品中血管性血友病因子和/或补体因子D的表达，（b）测量补体成分C8和 /或来自受试者的样品中的维生素K依赖性蛋白质Z，（c）基于（a）和（b）的结果评价受试者的动脉硬化。

4. 发明授权

US08603829B2 Atherosclerosis marker and use thereof 有权
标题翻译：动脉粥样硬化标记及其用途
公开(公告)号：US08603829B2
公开(公告)日：2013-12-10
申请号：US12805619
申请日：2010-08-10
申请人： Yuji Kuge , Hiroko Hanzawa , Takeshi Sakamoto , Naomi Manri
发明人： Yuji Kuge , Hiroko Hanzawa , Takeshi Sakamoto , Naomi Manri
IPC分类号： G01N33/50
CPC分类号： G01N33/6893 , G01N2800/323 , G01N2800/52
摘要： A method is provided for diagnosing or predicting atherosclerosis with the use of, as indicators, markers (factors) that allow early detection and progression prediction of the disease and a method for evaluating preventive or therapeutic effects. In one form, the present method includes detecting CD166 (ALCAM) level in a sample of a subject such as human. Another aspect of the present method includes evaluating preventive or therapeutic effects of a compound on atherosclerosis. A kit and an apparatus for carrying out such methods is also provided.
摘要翻译：提供了一种用于诊断或预测动脉粥样硬化的方法，其使用允许疾病的早期检测和进展预测的标志物（因子）作为指标，以及评估预防或治疗效果的方法。在一种形式中，本方法包括检测人类样本中的CD166（ALCAM）水平。本方法的另一方面包括评估化合物对动脉粥样硬化的预防或治疗作用。还提供了用于执行这种方法的套件和装置。

5. 发明申请

US20110065199A1 Atherosclerosis marker and use thereof 有权
标题翻译：动脉粥样硬化标记及其用途
公开(公告)号：US20110065199A1
公开(公告)日：2011-03-17
申请号：US12805619
申请日：2010-08-10
申请人： Yuji Kuge , Hiroko Hanzawa , Takeshi Sakamoto , Naomi Manri
发明人： Yuji Kuge , Hiroko Hanzawa , Takeshi Sakamoto , Naomi Manri
IPC分类号： G01N33/50 , C07K16/00 , G01N30/00 , H01J49/00 , G01N1/00
CPC分类号： G01N33/6893 , G01N2800/323 , G01N2800/52
摘要： Since atherosclerosis induces cerebral infarction and myocardial infarction, a method for diagnosing or predicting atherosclerosis with the use of, as indicators, markers (factors) that allow early detection and progression prediction of the disease and a method for evaluating preventive or therapeutic effects have been awaited. This invention provides a method for diagnosing or predicting atherosclerosis which comprises detecting CD166 (ALCAM) level in a sample of a subject such as human, a method for evaluating preventive or therapeutic effects of a compound on atherosclerosis, and a kit and an apparatus for carrying out such methods.
摘要翻译：由于动脉粥样硬化引起脑梗死和心肌梗死，因此已经等待了使用可以使疾病早期检测和进展预测的标志物（因素）作为诊断或预测动脉粥样硬化的方法，以及评估预防或治疗效果的方法。本发明提供一种用于诊断或预测动脉粥样硬化的方法，其包括检测受试者例如人的样品中的CD166（ALCAM）水平，评估化合物对动脉粥样硬化的预防或治疗作用的方法，以及用于携带出这种方法。

6. 发明授权

US4904062A Collimating lens for use in optical memories 失效
标题翻译：用于光学存储器的准直透镜
公开(公告)号：US4904062A
公开(公告)日：1990-02-27
申请号：US321484
申请日：1989-03-08
申请人： Ichiro Morishita , Hiroko Hanzawa
发明人： Ichiro Morishita , Hiroko Hanzawa
IPC分类号： G02B13/00 , G02B3/00 , G02B13/18 , G02B13/24 , G11B7/125 , G11B7/135
CPC分类号： G11B7/1372 , G02B13/24 , G02B3/00
摘要： An improved collimating lens for use in optical memories is disclosed which comprises a first surface for receiving the incident beam which is concave, and a second surface for emitting the outgoing beam which is convex and non-spherical, characterized in that the said lens satisifies some particular conditions. If the collimating lens of the present invention is used, the beam passing through the periphery of the lens can be concentrated, and therefore, the actual number of openings of the objective lens is increased, and at the same time, the coupling efficiency can be improved. Accordingly it is possible to form very tiny spot on the disc, and the transmission rate can also be improved. Further, the appearance of the lens can be favorably shaped when manufacturing the lens, because the lens of the present invention is strong against the difference of the axes.
摘要翻译：公开了一种用于光学存储器的改进的准直透镜，其包括用于接收凹入的入射光束的第一表面和用于发射凸出和非球形的输出光束的第二表面，其特征在于，所述透镜满足一些特殊条件。如果使用本发明的准直透镜，则可以集中透过透镜周边的光束，因此物镜的实际开口数量增加，同时耦合效率可以改进。因此，可以在盘上形成非常微小的斑点，并且还可以提高透射率。此外，由于本发明的透镜相对于轴的差异强，所以在制造透镜时能够使透镜的外观成形。

7. 发明授权

US08043852B2 Monoclonal antibody specific to dentin-derived heparan sulfate 有权
标题翻译：牙本质硫酸乙酰肝素特异性单克隆抗体
公开(公告)号：US08043852B2
公开(公告)日：2011-10-25
申请号：US12222889
申请日：2008-08-19
申请人： Akiko Hisada , Ryosuke Takahashi , Hiroko Hanzawa
发明人： Akiko Hisada , Ryosuke Takahashi , Hiroko Hanzawa
IPC分类号： C12N5/12 , C12N5/00 , C07K16/00 , C07K16/18 , G01N33/53 , G01N33/577
CPC分类号： C07K16/18 , G01N2800/18
摘要： The present invention provides a monoclonal antibody displaying excellent specificity against heparan sulfate saccharide chains for the analysis of heparan sulfate saccharide chains specific to dentin. The invention also provides a method of evaluating reproductive dentin using the monoclonal antibody. The anti-heparan sulfate monoclonal antibody reacts against dentin-derived heparan sulfate and in particular the anti-heparan sulfate monoclonal antibody reacts strongly and specifically with uncalcified predentin regions. In the method of evaluating dentin, the antibody is reacted against an isolated dentin-derived sample and the reaction is used in order to evaluate the development of dentin.
摘要翻译：本发明提供了对硫酸乙酰肝糖链具有优异特异性的单克隆抗体，用于分析牙本质特异性的硫酸乙酰肝糖链。本发明还提供了使用单克隆抗体评估生殖牙本质的方法。抗硫酸乙酰肝素单克隆抗体与牙本质来源的硫酸乙酰肝素反应，特别是抗硫酸乙酰肝素单克隆抗体强烈而特异地与未煅烧的前体蛋白区域反应。在评估牙本质的方法中，抗体与分离的牙本质衍生的样品反应，并且使用反应来评估牙本质的发育。

8. 发明授权

US4925283A Objective lens for optical memory device 失效
标题翻译：物镜用于光学存储器件
公开(公告)号：US4925283A
公开(公告)日：1990-05-15
申请号：US388797
申请日：1989-08-02
申请人： Ichiro Morishita , Hiroko Hanzawa
发明人： Ichiro Morishita , Hiroko Hanzawa
IPC分类号： G02B9/00 , G02B13/18 , G02B13/24 , G11B7/135
CPC分类号： G02B13/24
摘要： An objective lens for an optical memory device comprising a plane surface on one side thereof for emitting a luminous flux oppositely to a disk, and an aspherical surface on the other of the side thereof for receiving a luminous flux reversely to the disk in such a manner that the following conditions (1) and (2) are satisfied:1.69.ltoreq.n.ltoreq.1.74 (1)n-1.gtoreq.(n.sub.C -n.sub.A')/0.00056 (2)where n is a refractive index of a lens medium for the wavelength of an incident light, n.sub.A' is a refractive index of a lens medium for A' beam (768.2 nm of wavelength) of a reference light beam, and n.sub.C is a refractive index of a lens medium for a C beam (656.3 nm of wavelength). Thus, the lens can sufficiently obtain the thickness of the periphery thereof, has a plenty of utility in light weight, and can follow a variation in a laser wavelength due to the switching of the emitting light power of a semiconductor laser.
摘要翻译：一种用于光学存储器件的物镜，包括一侧的平面，用于发射与盘相反的光通量，另一侧的非球面用于以这种方式接收与光盘反向的光通量满足以下条件（1）和（2）：1.69 / =（nC-nA'）/ 0.00056（2）其中n是用于入射光波长的透镜介质，nA'是参考光束的A'光束（768.2nm波长）的透镜介质的折射率，n C是用于C的透镜介质的折射率光束（波长为656.3nm）。因此，透镜可以充分获得其周边的厚度，具有很大的实用性，重量轻，并且可以跟随由于半导体激光器的发光功率的切换而导致的激光波长的变化。

9. 发明申请

US20090081809A1 Monoclonal antibody specific to dentin-derived heparan sulfate 有权
标题翻译：牙本质硫酸乙酰肝素特异性单克隆抗体
公开(公告)号：US20090081809A1
公开(公告)日：2009-03-26
申请号：US12222889
申请日：2008-08-19
申请人： Akiko Hisada , Ryossuke Takahashi , Hiroko Hanzawa
发明人： Akiko Hisada , Ryossuke Takahashi , Hiroko Hanzawa
IPC分类号： G01N33/566 , C07K16/18 , C12N5/06
CPC分类号： C07K16/18 , G01N2800/18
摘要： The present invention provides a monoclonal antibody displaying excellent specificity against heparan sulfate saccharide chains for the analysis of heparan sulfate saccharide chains specific to dentin. The invention also provides a method of evaluating reproductive dentin using the monoclonal antibody. The anti-heparan sulfate monoclonal antibody reacts against dentin-derived heparan sulfate and in particular the anti-heparan sulfate monoclonal antibody reacts strongly and specifically with uncalcified predentin regions. In the method of evaluating dentin, the antibody is reacted against an isolated dentin-derived sample and the reaction is used in order to evaluate the development of dentin.
摘要翻译：本发明提供了对硫酸乙酰肝糖链具有优异特异性的单克隆抗体，用于分析牙本质特异性的硫酸乙酰肝糖链。本发明还提供了使用单克隆抗体评估生殖牙本质的方法。抗硫酸乙酰肝素单克隆抗体与牙本质来源的硫酸乙酰肝素反应，特别是抗硫酸乙酰肝素单克隆抗体强烈而特异地与未煅烧的前体蛋白区域反应。在评估牙本质的方法中，抗体与分离的牙本质衍生的样品反应，并且使用反应来评估牙本质的发育。

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