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1. 发明授权

US07119194B2 Nucleic acid-bondable magnetic carrier and method for isolating nucleic acid using the same 有权
标题翻译：核酸可键合磁性载体和使用其分离核酸的方法
公开(公告)号：US07119194B2
公开(公告)日：2006-10-10
申请号：US10202212
申请日：2002-07-22
申请人： Hiroaki Uematsu , Katsuya Daimon , Satoko Yoshiga
发明人： Hiroaki Uematsu , Katsuya Daimon , Satoko Yoshiga
IPC分类号： C07H21/00 , C07H21/02 , C07H21/04 , C07H1/06 , C07H1/08
CPC分类号： B82Y25/00 , B01D15/00 , B01D15/1807 , B01J20/103 , B01J20/28009 , B03C1/01 , C12N15/1013 , C12Q1/6806 , C12Q1/6844 , G01N33/54326 , H01F1/0054 , H01F1/0063 , H01F1/111 , C12Q2563/155 , C12Q2563/143
摘要： A nucleic acid-bondable magnetic carrier of the present invention is a magnetic silica particle comprising a superparamagnetic metal oxide, wherein the magnetic silica particle has a specific surface of about 100 to about 800 m2/g.
摘要翻译：本发明的可与核酸结合的磁性载体是包含超顺磁性金属氧化物的磁性二氧化硅颗粒，其中磁性二氧化硅颗粒的比表面积为约100至约800m 2 / g。

2. 发明授权

US5945525A Method for isolating nucleic acids using silica-coated magnetic particles 失效
标题翻译：使用二氧化硅涂覆的磁性颗粒分离核酸的方法
公开(公告)号：US5945525A
公开(公告)日：1999-08-31
申请号：US676982
申请日：1996-07-08
申请人： Hiroaki Uematsu , Katsuya Daimon , Satoko Yoshiga
发明人： Hiroaki Uematsu , Katsuya Daimon , Satoko Yoshiga
IPC分类号： G01N33/50 , B01D15/00 , B01J20/10 , B03C1/01 , B03C1/30 , C01B33/18 , C07H1/06 , C07H21/04 , C12N15/00 , C12N15/10 , C12Q1/68 , C12R1/445 , G01N33/543 , G01N33/552 , G01N33/553 , H01F1/00 , H01F1/11 , C12P19/34
CPC分类号： B82Y25/00 , B01D15/00 , B01D15/1807 , B01J20/103 , B01J20/28009 , B03C1/01 , C12N15/1013 , C12Q1/6806 , C12Q1/6844 , G01N33/54326 , H01F1/0063 , H01F1/111 , H01F1/0054
摘要： A nucleic acid-bondable magnetic carrier of the present invention is a magnetic silica particle comprising a superparamagnetic metal oxide, wherein the magnetic silica particle has a specific surface of about 100 to about 800 m.sup.2 /g.
摘要翻译：本发明的可与核酸结合的磁性载体是包含超顺磁金属氧化物的磁性二氧化硅颗粒，其中磁性二氧化硅颗粒具有约100至约800m 2 / g的比表面积。

3. 发明授权

US4551222A Flow through system liquid membrane type electrode 失效
标题翻译：流经系统液膜式电极
公开(公告)号：US4551222A
公开(公告)日：1985-11-05
申请号：US622262
申请日：1984-06-19
申请人： Hiroaki Uematsu , Junji Aoki
发明人： Hiroaki Uematsu , Junji Aoki
IPC分类号： G01N27/28 , G01N27/333 , G01N27/46
CPC分类号： G01N27/3335 , G01N27/28
摘要： A flow through system liquid membrane type electrode used for measuring a specific ion concentration in a flowing liquid sample. A cylindrical membrane holding member which is flat at one side surface, holds a sheet-like liquid membrane, the liquid membrane facing a liquid sample passage formed in a synthetic resin block, thereby to form a strong junction between the liquid membrane and the sample passage.
摘要翻译：用于测量流动液体样品中特定离子浓度的流通系统液膜型电极。在一个侧面平坦的圆筒状的膜保持部件保持片状的液膜，液膜面对形成在合成树脂块中的液体样品通道，从而在液体膜和样品通道之间形成强连接。

4. 发明授权

US4877492A Method of measuring electrolyte in blood and urine by electrode method 失效
标题翻译：通过电极法测定血液和尿液中的电解质的方法
公开(公告)号：US4877492A
公开(公告)日：1989-10-31
申请号：US204994
申请日：1988-06-10
申请人： Hiroaki Uematsu , Shinji Imanishi
发明人： Hiroaki Uematsu , Shinji Imanishi
IPC分类号： G01N33/483 , G01N27/26 , G01N27/27 , G01N27/416 , G01N33/487 , G01N33/49
CPC分类号： G01N33/49 , G01N33/493 , Y10T436/19 , Y10T436/193333 , Y10T436/25625
摘要： Method of measuring electrolyte concentration in a urine sample, by preparing a calibrating solution containing ions of the electrolytes to be measured, preparing a diluent containing the same ions, diluting the urine sample with the diluent, measuring the electrolyte in the diluted urine with an electrode using the calibrating solution, and calculating the concentration of electrolyte based on the measured value. Additionally, the concentration of the same electrolytes in a blood sample can be measured without dilution, using the same calibrating solution.
摘要翻译：通过制备含有待测电解质的离子的校准溶液，制备含有相同离子的稀释剂，用稀释剂稀释尿样，用电极测量稀释尿液中的电解质，测定尿样中的电解质浓度的方法使用校准溶液，并根据测量值计算电解液的浓度。此外，使用相同的校准溶液，可以在不稀释的情况下测量血液样品中相同电解质的浓度。

5. 发明授权

US6146882A Incubator and analyzer including such incubator 失效
标题翻译：孵化器和分析仪包括这样的孵化器
公开(公告)号：US6146882A
公开(公告)日：2000-11-14
申请号：US242448
申请日：1999-03-30
申请人： Hiroaki Uematsu , Takashi Nakajima , Tatsuo Arai , Keiji Okumoto
发明人： Hiroaki Uematsu , Takashi Nakajima , Tatsuo Arai , Keiji Okumoto
IPC分类号： G01N35/00 , B01L7/00 , B01L7/04 , C12M1/00 , C12M1/04 , C12M1/34
CPC分类号： C12M41/14 , B01L7/52 , B01L9/523 , C12M23/12 , C12M23/48 , C12M23/50 , C12M41/48 , B01L2200/147 , B01L2300/0829 , B01L2300/1894 , B01L3/50855 , G01N2035/00366
摘要： An incubator comprises an incubating block (12) for incubating a sample at an any desired processing temperature by storing a well rack (14) held the sample such as specimens for instance, under that temperature, a cooling block (13) set to a cooling temperature, a dummy rack (15) which are cooled in the cooling block (13) during an incubating process, as well as first and second pushers (18a, 18b) and first and second carriages (19a, 19b) which together exchange the well rack (14) and the dummy rack (15) with each other.
摘要翻译： PCT No.PCT / JP98 / 02658 Sec。 371日期1999年3月30日 102（e）1999年3月30日PCT PCT日期1998年6月15日孵化器包括用于通过将保持样品的孔架（14）（例如样品）的任何所需加工温度孵育的培养箱（12）例如，在该温度下，设定为冷却温度的冷却块（13），在孵育过程中在冷却块（13）中冷却的虚拟齿条（15）以及第一和第二推动器（18a，18b））和第一和第二滑架（19a，19b），它们一起将井架（14）和虚设架（15）彼此交换。

6. 发明授权

US5538849A Apparatus for automated assay of DNA probe and method for assaying nucleic acid in sample 失效
标题翻译：用于DNA探针自动化测定的装置和样品中核酸测定方法
公开(公告)号：US5538849A
公开(公告)日：1996-07-23
申请号：US174308
申请日：1993-12-29
申请人： Hiroaki Uematsu , Makoto Tsuruoka , Takashi Nakajima , Ken-ichi Chikanari , Misao Yoshimoto , Hiromichi Kobata
发明人： Hiroaki Uematsu , Makoto Tsuruoka , Takashi Nakajima , Ken-ichi Chikanari , Misao Yoshimoto , Hiromichi Kobata
IPC分类号： C12Q1/68 , G01N35/02 , C12N15/00 , G01N21/00 , G01N35/00
CPC分类号： G01N35/026 , C12Q1/6816 , Y10T436/11 , Y10T436/114165 , Y10T436/114998 , Y10T436/143333
摘要： An apparatus is presented for an automated assay of a DNA probe, which is performed by hybridizing a nucleic acid in a sample with a DNA probe marked with an enzyme and optically measuring a change that occurs in the substrate by catalysis of the enzyme which is bound with the DNA probe. The DNA probe hybridizes with the nucleic acid in the sample to assay the nucleic acid in the sample. Comprising (A) a sample-reagent unit, (B) a sample-reagent dispense unit, (C) a reaction vessel transport unit, (D) a hybridization unit, (E) a B/F separation unit, and (F) a light measurement unit; also presented is a method for assaying a nucleic acid in a sample by the apparatus of the present invention. According to the measurement apparatus of the present invention, a continuous and highly precise measurement is attainable. In particular, the light-shielding structure of the light measurement unit exhibits high levels of light-shielding effect and contributes to efficient light measurement and prevention of degradation of light receiving elements.
摘要翻译：提供了一种用于DNA探针的自动测定的装置，其通过将样品中的核酸与标记有酶的DNA探针杂交并通过催化结合的酶光学测量在底物中发生的变化来进行与DNA探针。 DNA探针与样品中的核酸杂交以测定样品中的核酸。包括（A）样品试剂单元，（B）样品试剂分配单元，（C）反应容器输送单元，（D）杂交单元，（E）B / F分离单元和（F）光测量单元; 还提出了通过本发明的装置测定样品中的核酸的方法。根据本发明的测量装置，可以获得连续高精度的测量。特别地，光测量单元的遮光结构具有高水平的遮光效果，并且有助于有效的光测量和防止光接收元件的劣化。

7. 发明授权

US4935117A Flow through type ion electrode 失效
标题翻译：流通型离子电极
公开(公告)号：US4935117A
公开(公告)日：1990-06-19
申请号：US370449
申请日：1989-06-23
申请人： Hiroaki Uematsu , Kunio Terada
发明人： Hiroaki Uematsu , Kunio Terada
IPC分类号： G01N27/28
CPC分类号： G01N27/28
摘要： A flow through type ion electrode apparatus including a number of interconnectable block structures. Each block structure includes recesses in respective faces thereof, which lead to a through hole extending between the faces. A membrane electrode is located within each block structure so as to communicate with the through hole. A spacer having a through hole therein is inserted in a recess of each of a pair of adjacent block structures to interconnect the adjacent block structures.
摘要翻译：一种流通式离子电极装置，包括多个可互连块结构。每个块结构包括在其各自的表面中的凹槽，其导致在两个面之间延伸的通孔。膜电极位于每个块结构内，以便与通孔连通。在其中具有通孔的间隔件插入在一对相邻块结构中的每一个的凹部中以互连相邻的块结构。

8. 发明授权

US4629744A Method for producing a response membrane for use in a chloride ion selective electrode 失效
标题翻译：用于生产用于氯离子选择性电极的响应膜的方法
公开(公告)号：US4629744A
公开(公告)日：1986-12-16
申请号：US714082
申请日：1985-03-20
申请人： Hiroaki Uematsu , Takeshi Kohno , Takeshi Miyazaki
发明人： Hiroaki Uematsu , Takeshi Kohno , Takeshi Miyazaki
IPC分类号： G01N27/333 , C08J9/28
CPC分类号： G01N27/3335
摘要： A composition for use in a chloride ion electrode is provided herein. This composition is made up of a mixture of an epoxy resin, a vinyl chloride resin, one or more solvents, a quaternary ammonium salt and hardening agents for setting said epoxy resin; wherein said epoxy resin and the vinyl chloride resin is used at a ratio of 8:1 to 1:2 by weight. The present invention also relates to a response membrane produced from said composition and a method for producing the response membrane by setting or hardening the aforementioned composition. When the response membrane is used in the chloride ion selective electrode, it is capable of measuring a sample containing blood or protein and by use of the response membrane, it is possible to selectively determine chloride ions in a sample with a high degree of accuracy.
摘要翻译：本文提供了一种用于氯离子电极的组合物。该组合物由环氧树脂，氯乙烯树脂，一种或多种溶剂，季铵盐和用于固化所述环氧树脂的硬化剂的混合物组成; 其中所述环氧树脂和氯乙烯树脂以8:1至1:2的比例使用。本发明还涉及由所述组合物制备的反应膜和通过凝固或硬化上述组合物来制备响应膜的方法。当在氯离子选择电极中使用响应膜时，其能够测量含有血液或蛋白质的样品，并且通过使用响应膜，可以以高精度选择性地确定样品中的氯离子。

9. 发明授权

US4626512A Standard solution for simultaneously calibrating a plurality of ion electrodes 失效
标题翻译：用于同时校准多个离子电极的标准溶液
公开(公告)号：US4626512A
公开(公告)日：1986-12-02
申请号：US737036
申请日：1985-05-22
申请人： Narihiro Oku , Seiji Usui , Hiroaki Uematsu , Takeshi Kohno
发明人： Narihiro Oku , Seiji Usui , Hiroaki Uematsu , Takeshi Kohno
IPC分类号： G01N27/26 , G01N27/416 , G01N33/84 , G01N31/00
CPC分类号： G01N27/4165 , G01N33/84 , Y10T436/10 , Y10T436/108331
摘要： A standard solution for simultaneously calibrating a plurality of ion electrodes for determining a plurality of ion electrodes for determining a plurality of ions including at least potassium ions and calcium ions in blood, the improvement wherein the concentration of the standard solution for a potassium ion electrode and a calcium ion electrode is adjusted in accordance with the following equations: ##EQU1## As for potassium ion,C=C.sub.o .multidot.10.sup.-.DELTA.E/60As for calcium ion,C=C.sub.o .multidot.10.sup.-.DELTA.E/30As for potassium ion,A=-0.130 to -0.065As for calcium ion,A=-0.240 to -0.172whereinE: is the potential difference when an ionic strength of 150 mM is used as the standard;.mu.: is the ionic strength;C.sub.o : is the calibrated concentration;C: is the concentration of reagent added; andA: is the correction factor.
摘要翻译：一种用于同时校准多个离子电极以用于确定多个离子电极以用于确定血液中至少包含钾离子和钙离子的多个离子的标准溶液，其中所述改进是将钾离子电极的标准溶液和钙离子电极根据以下等式进行调整：对于钾离子，C = Co×10 -3 DELTA E / 60对于钙离子，C = Co×10 -3 DELTA E / 30对于钾离子，A = - 0.130〜-0.065对于钙离子，A = -0.240〜-0.172其中E：当以150mM的离子强度作为标准时的电位差; mu：离子强度; Co：是校准浓度; C：加入试剂的浓度; A：是校正因子。

10. 发明授权

US4519890A Flow system glass electrode 失效
标题翻译：流量系玻璃电极
公开(公告)号：US4519890A
公开(公告)日：1985-05-28
申请号：US614225
申请日：1984-05-24
申请人： Hiroaki Uematsu , Junji Aoki , Narihiro Oku
发明人： Hiroaki Uematsu , Junji Aoki , Narihiro Oku
IPC分类号： G01N27/28 , G01N27/36
CPC分类号： G01N27/28 , G01N27/36
摘要： A flow system glass electrode in use for pH measurement, which houses the glass electrode body in a resin block to improve an impact resistance, the glass electrode body being sealed by a packing to be small-sized and improve the degree of freedom in the direction of the use, sample flow tubes each being equal in an inner diameter to a response film and separate from the glass electrode body in order to eliminate stagnation of a sample liquid, enable the measurement of a minute sample, and facilitate manufacture and assembly of the electrode, the sample flow tubes being connected with a liquid inlet and a liquid outlet at the glass electrode body through couplings respectively.
摘要翻译：一种用于pH测量的流动系统玻璃电极，其将玻璃电极体容纳在树脂块中以提高耐冲击性，玻璃电极体被填料密封成小尺寸并提高了方向的自由度使用时，样品流管各自在内径相等于响应膜并与玻璃电极体分离，以消除样品液体的滞留，使得能够测量微小的样品，并且有助于制造和组装电极，样品流管分别通过耦合与玻璃电极体的液体入口和液体出口连接。

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