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1. 发明申请

US20100168380A1 PROCESS FOR SYNTHESIZING CYCLIC PEPTIDE COMPOUND 有权
标题翻译：合成环化合物的方法
公开(公告)号：US20100168380A1
公开(公告)日：2010-07-01
申请号：US12593221
申请日：2008-03-26
申请人： Hiroaki Suga , Hiroshi Murakami , Yuki Goto , Yusuke Yamagishi , Hiroshi Ashigai , Yusuke Sako
发明人： Hiroaki Suga , Hiroshi Murakami , Yuki Goto , Yusuke Yamagishi , Hiroshi Ashigai , Yusuke Sako
IPC分类号： C07K1/00 , C12P21/00
CPC分类号： C07K7/56 , C07K7/06 , C07K7/08 , C12N15/67 , C12P21/02
摘要： The objective is to provide a novel process for synthesizing a cyclic peptide compound. It is also an objective to provide a novel cyclic peptide compound. The novel process for synthesizing a cyclic peptide compound comprises the steps of: (1) translationally synthesizing a non-cyclic peptide compound having in a molecule a functional group 1 and a functional group 2, which are a pair of functional groups capable of reacting to form a bond, and (2) cyclizing the non-cyclic peptide compound by the reaction of the functional groups 1 and 2 to form a bond. The novel cyclic peptide compound can be synthesized by the process.
摘要翻译：目的是提供一种合成环肽化合物的新方法。提供新的环肽化合物也是目的。用于合成环肽化合物的新方法包括以下步骤：（1）在分子中转化合成具有官能团1和官能团2的能够对形成键，和（2）通过官能团1和2的反应使非环肽化合物环化以形成键。可以通过该方法合成新的环肽化合物。

2. 发明申请

US20130217599A1 NOVEL ARTIFICIAL TRANSLATION/SYNTHESIS SYSTEM 有权
标题翻译：新人工翻译/合成系统
公开(公告)号：US20130217599A1
公开(公告)日：2013-08-22
申请号：US13816911
申请日：2011-08-26
申请人： Hiroaki Suga , Hiroshi Murakami , Yuki Goto
发明人： Hiroaki Suga , Hiroshi Murakami , Yuki Goto
IPC分类号： C12P21/00
CPC分类号： C12P21/00 , C12N15/67 , C12P21/02
摘要： A new artificial translation-synthesis system of adding tRNAs binding special amino acids to the in vitro translation system and synthesizing peptides with special amino acids incorporated thereto according to a dual genetic code table and an artificial codon box division.
摘要翻译：一种新的人工翻译 - 合成系统，其将特异性氨基酸结合到体外翻译系统中并根据双重遗传密码表和人造密码子分组合成具有特异氨基酸的肽。

3. 发明申请

US20110275119A1 METHODS FOR RIBOSOMAL SYNTHESIS OF POLYPEPTIDES CONTAINING UNNATURAL N-TERMINAL GROUPS AND APPLICATIONS THEREOF 有权
标题翻译：含有未知N末端组的多肽的RIBOSOMAL合成方法及其应用
公开(公告)号：US20110275119A1
公开(公告)日：2011-11-10
申请号：US12515074
申请日：2007-11-13
申请人： Hiroaki Suga , Hiroshi Murakami , Yuki Goto , Atsushi Ohta
发明人： Hiroaki Suga , Hiroshi Murakami , Yuki Goto , Atsushi Ohta
IPC分类号： C12P21/00 , C12N9/10
CPC分类号： C12N15/67 , C12P21/02
摘要： The present invention aims to synthesize a polypeptide having an unnatural structure at the N-terminus via a biosynthetic process by translation of amino acid sequence information encoded by a nucleic acid. A polypeptide having any amino acid at the N-terminus is synthesized by using an ARS ribozyme that catalyzes the acylation of tRNA with any amino acid to attach any amino acid to an initiator tRNA, thereby initiating a translation with the initiator tRNA.
摘要翻译：本发明旨在通过生物合成方法通过翻译由核酸编码的氨基酸序列信息在N末端合成具有非天然结构的多肽。通过使用催化tRNA与任何氨基酸酰化以将任何氨基酸连接至引发剂tRNA的ARS核酶合成在N末端具有任何氨基酸的多肽，从而开始与引发剂tRNA的翻译。

4. 发明授权

US07622248B2 Ribozymes with broad tRNA aminoacylation activity 有权
标题翻译：具有广泛tRNA氨基酰化活性的核酶
公开(公告)号：US07622248B2
公开(公告)日：2009-11-24
申请号：US10369036
申请日：2003-02-18
申请人： Hiroaki Suga , Hiroshi Murakami , Hirohide Saito
发明人： Hiroaki Suga , Hiroshi Murakami , Hirohide Saito
IPC分类号： C12Q1/68 , C12P19/34 , C07H21/00 , C07H21/02 , C07H21/04
CPC分类号： C12P21/00 , C12N15/113 , C12N2310/12
摘要： The present invention provides catalytic RNA molecules having cis or trans aminoacylation activity. The catalytic RNA molecules having cis aminoacylation activity comprise a catalytic domain and an aminoacylation domain. The catalytic RNA molecules having trans aminoacylation activity only have the catalytic domain. A method is provided for constructing and screening of these molecules. These molecules are suitable for aminoacylating with specific amino acids.
摘要翻译：本发明提供具有顺式或反式氨基酰化活性的催化RNA分子。具有顺式氨基酰化活性的催化RNA分子包含催化结构域和氨基酰化结构域。具有反氨基酰化活性的催化RNA分子仅具有催化结构域。提供了构建和筛选这些分子的方法。这些分子适合用特定氨基酸进行氨基酰化。

5. 发明授权

US09701993B2 Artificial translation/synthesis system 有权
公开(公告)号：US09701993B2
公开(公告)日：2017-07-11
申请号：US13816911
申请日：2011-08-26
申请人： Hiroaki Suga , Hiroshi Murakami , Yuki Goto
发明人： Hiroaki Suga , Hiroshi Murakami , Yuki Goto
IPC分类号： C12P21/00 , C12N15/67 , C12P21/02
CPC分类号： C12P21/00 , C12N15/67 , C12P21/02
摘要： A new artificial translation-synthesis system of adding tRNAs binding special amino acids to the in vitro translation system and synthesizing peptides with special amino acids incorporated thereto according to a dual genetic code table and an artificial codon box division.

6. 发明授权

US09090668B2 Process for synthesizing cyclic peptide compound 有权
标题翻译：环肽化合物的合成方法
公开(公告)号：US09090668B2
公开(公告)日：2015-07-28
申请号：US12593221
申请日：2008-03-26
申请人： Hiroaki Suga , Hiroshi Murakami , Yuki Goto , Yusuke Yamagishi , Hiroshi Ashigai , Yusuke Sako
发明人： Hiroaki Suga , Hiroshi Murakami , Yuki Goto , Yusuke Yamagishi , Hiroshi Ashigai , Yusuke Sako
IPC分类号： C07K7/56 , C07K7/06 , C07K7/08 , C12N15/67 , C12P21/02
CPC分类号： C07K7/56 , C07K7/06 , C07K7/08 , C12N15/67 , C12P21/02
摘要： The objective is to provide a novel process for synthesizing a cyclic peptide compound. It is also an objective to provide a novel cyclic peptide compound. The novel process for synthesizing a cyclic peptide compound comprises the steps of: (1) translationally synthesizing a non-cyclic peptide compound having in a molecule a functional group 1 and a functional group 2, which are a pair of functional groups capable of reacting to form a bond, and (2) cyclizing the non-cyclic peptide compound by the reaction of the functional groups 1 and 2 to form a bond. The novel cyclic peptide compound can be synthesized by the process.
摘要翻译：目的是提供一种合成环肽化合物的新方法。提供新的环肽化合物也是目的。用于合成环肽化合物的新方法包括以下步骤：（1）在分子中转化合成具有官能团1和官能团2的非环状肽化合物，所述官能团是能够使形成键，和（2）通过官能团1和2的反应使非环肽化合物环化以形成键。可以通过该方法合成新的环肽化合物。

7. 发明授权

US08188260B2 Versatile acylation catalytic RNAs and uses thereof 有权
标题翻译：多功能酰化催化RNA及其用途
公开(公告)号：US08188260B2
公开(公告)日：2012-05-29
申请号：US12086125
申请日：2006-12-05
申请人： Hiroaki Suga , Hiroshi Murakami
发明人： Hiroaki Suga , Hiroshi Murakami
IPC分类号： C07H21/04 , C07H21/02 , C12N15/85
CPC分类号： C12N15/67 , C12N9/93 , C12P19/34
摘要： An object of the present invention is to provide novel ribozyme systems capable of catalyzing tRNA acetylation using various carboxylic acids as acyl donors and uses thereof. Disclosed is a ribozyme catalyzing tRNA acetylation having a structure consisting of the RNA sequence represented by: (formula 1) P1-Z1Z2Z3Z4(N1)1(N1)2 . . . (N1)p-P2-(N2)1(N2)2 . . . (N2)q Y1Y2Y3-(N3)1(N3)2-N4GGN wherein (N1)1-(N1)p each independently represent any monoribonucleotide of U, C, A, and G; p represents 3 or 4; (N2)1-(N2)q each independently represent any monoribonucleotide of U, C, A, and G; q represents 5 or 6; (N3)1-(N3)2 each independently represent any monoribonucleotide of U, C, A, and G; N4 represents any monoribonucleotide of U, C, A, and G; Z1-Z4 each independently represent C or G; Y1-Y3 each independently represent C or G; N represents a monoribonucleotide complementary to A or G; and P1 and P2 represent a domain consisting of any RNA sequence capable of having a stem-loop structure.
摘要翻译：本发明的目的是提供能够使用各种羧酸作为酰基供体催化tRNA乙酰化的新型核酶系统及其用途。公开了一种催化tRNA乙酰化的核酶，其结构由以下所示的RNA序列组成：（式1）P1-Z1Z2Z3Z4（N1）1（N1）2。。。（N1）p-P2-（N2）1（N2）2。。。（N 2）q Y1Y2Y3-（N3）1（N3）2-N4GGN其中（N1）1-（N1）p各自独立地表示U，C，A和G的任何单核糖核苷酸; p表示3或4; （N 2）1-（N 2）q各自独立地表示U，C，A和G的任何单核糖核苷酸; q表示5或6; （N3）1-（N3）2各自独立地表示U，C，A和G的任何单核糖核苷酸; N4代表U，C，A和G的任何单核糖核苷酸; Z1-Z4各自独立地表示C或G; Y1-Y3各自独立地表示C或G; N表示与A或G互补的单核糖核苷酸; P1和P2表示由能够具有茎 - 环结构的任何RNA序列组成的结构域。

8. 发明申请

US20090281280A1 Versatile tRNA Acylation Catalytic RNAs and Uses Thereof 有权
标题翻译：多功能tRNA酰化催化RNA及其用途
公开(公告)号：US20090281280A1
公开(公告)日：2009-11-12
申请号：US12086125
申请日：2006-12-05
申请人： Hiroaki Suga , Hiroshi Murakami
发明人： Hiroaki Suga , Hiroshi Murakami
IPC分类号： C07K1/107 , C07H21/02 , C07H21/04 , C07D209/20
CPC分类号： C12N15/67 , C12N9/93 , C12P19/34
摘要： An object of the present invention is to provide novel ribozyme systems capable of catalyzing tRNA acylation using various carboxylic acids as acyl donors and uses thereof.Disclosed is a ribozyme catalyzing tRNA acylation having a structure consisting of the RNA sequence represented by (formula 1): P1-Z1Z2Z3Z4(N1)1(N1)2 . . . (N1)p—P2-(N2)1(N2)2 . . . (N2)qY1Y2Y3(N3)1(N3)2N4GGN wherein (N1)1-(N1)p each independently represent any monoribonucleotide of U, C, A and G; p represents 3 or 4; (N2)1-(N2)q each independently represent any monoribonucleotide of U, C, A and G; q represents 5 or 6; (N3)1-(N3)2 each independently represent any monoribonucleotide of U, C, A and G; N4 represents any monoribonucleotide of U, C, A and G; Z1-Z4 each independently represent C or G; Y1-Y3 each independently represent C or G; N represents a monoribonucleotide complementary to A or G; and P1 and P2 represent a domain consisting of any RNA sequence capable of having a stem-loop structure.
摘要翻译：本发明的目的是提供能够使用各种羧酸作为酰基供体催化tRNA酰化的新型核酶体系及其用途。公开了催化tRNA酰化的核酶，其具有由（式1）表示的RNA序列组成的结构：P1-Z1Z2Z3Z4（N1）1（N1）2。。。（N1）p-P2-（N2）1（N2）2。。。（N2）qY1Y2Y3（N3）1（N3）2N4GGN其中（N1）1-（N1）p各自独立地表示U，C，A和G的任何单核糖核苷酸; p表示3或4; （N2）1-（N2）q各自独立地表示U，C，A和G的任何单核糖核苷酸; q表示5或6; （N3）1-（N3）2各自独立地表示U，C，A和G的任何单核糖核苷酸; N4代表U，C，A和G的任何单核糖核苷酸; Z1-Z4各自独立地表示C或G; Y1-Y3各自独立地表示C或G; N表示与A或G互补的单核糖核苷酸; P1和P2表示由能够具有茎 - 环结构的任何RNA序列组成的结构域。

9. 发明授权

US08557542B2 Methods for ribosomal synthesis of polypeptides containing unnatural N-terminal groups and applications thereof 有权
标题翻译：含有非天然N端基的多肽的核糖体合成方法及其应用
公开(公告)号：US08557542B2
公开(公告)日：2013-10-15
申请号：US12515074
申请日：2007-11-13
申请人： Hiroaki Suga , Hiroshi Murakami , Yuki Goto , Atsushi Ohta
发明人： Hiroaki Suga , Hiroshi Murakami , Yuki Goto , Atsushi Ohta
IPC分类号： C12P21/06
CPC分类号： C12N15/67 , C12P21/02
摘要： The present invention aims to synthesize a polypeptide having an unnatural structure at the N-terminus via a biosynthetic process by translation of amino acid sequence information encoded by a nucleic acid. A polypeptide having any amino acid at the N-terminus is synthesized by using an ARS ribozyme that catalyzes the acylation of tRNA with any amino acid to attach any amino acid to an initiator tRNA, thereby initiating a translation with the initiator tRNA.
摘要翻译：本发明旨在通过生物合成方法通过翻译由核酸编码的氨基酸序列信息在N末端合成具有非天然结构的多肽。通过使用催化tRNA与任何氨基酸酰化以将任何氨基酸连接至引发剂tRNA的ARS核酶合成在N末端具有任何氨基酸的多肽，从而开始与引发剂tRNA的翻译。

10. 发明授权

US09046145B2 Shock absorber 有权
标题翻译：减震器
公开(公告)号：US09046145B2
公开(公告)日：2015-06-02
申请号：US13479821
申请日：2012-05-24
申请人： Hiroshi Murakami , Osamu Yuno , Tomohiko Fujioka , Takashi Nezu , Shunsuke Mori
发明人： Hiroshi Murakami , Osamu Yuno , Tomohiko Fujioka , Takashi Nezu , Shunsuke Mori
IPC分类号： F16F9/34 , F16F9/46 , F16F9/32
CPC分类号： F16F9/464 , F16F9/325 , F16F2226/04
摘要： A shock absorber in which a flow of hydraulic oil caused by sliding movement of a piston in a cylinder is controlled by a pilot type main valve and a pilot valve to generate damping force. The valve-opening operation of the main valve is controlled by adjusting the pressure in a pilot chamber with the pilot valve. A valve block and a solenoid block are connected together into one unit and inserted into a casing before being secured with a nut. At this time, an actuating rod of the solenoid block is engaged with a pilot valve member retained by a pilot spring and a fail-safe spring in a cylindrical portion of a pilot body of the valve block.
摘要翻译：一种减振器，其中由气缸中的活塞的滑动运动引起的液压油流由先导式主阀和先导阀控制，以产生阻尼力。通过用先导阀调节先导室中的压力来控制主阀的开阀操作。在用螺母固定之前，将阀块和螺线管块连接在一起，并插入到壳体中。此时，螺线管块的致动杆与由先导弹簧保持的先导阀构件和阀块的先导体的圆筒部中的故障保护弹簧接合。

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