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    • 4. 发明申请
    • Operation controller of culture tank
    • 培养罐操作控制器
    • US20070207538A1
    • 2007-09-06
    • US11526595
    • 2006-09-26
    • Ken Amano
    • Ken Amano
    • C12M3/00G06F19/00
    • C12M41/48
    • Provided is an operation controller of a culture tank which can more precisely control the internal state of the culture tank by specifying a relatively small number of internal state variables, thus constructing a mathematical model which describes intracellular conditions by using these internal state variables, and thereby incorporating observable external variables thereto. The operation controller includes: a culture tank in which a culture medium for culturing animal cells or microorganism is enclosed, a measuring device for measuring concentrations of nutrient components, concentrations of products, and the number density of cells in the culture medium; a supply device for replenishing the nutrient components and oxygen into the culture medium; and an arithmetic processing unit in which the measured values from the measuring device are inputted, and which thus controls the supply device. The arithmetic processing unit solves an equation derived from a circuit network of intracellular reaction rates stored in a storage device by using temporal rates of change of the concentrations of the nutrient components, of the concentrations of the products, and of the number density of the cells as input data, and thus calculates a desired intracellular reaction rate. Accordingly, the arithmetic processing unit controls the supply device based on the results of the calculation, whereby the arithmetic processing unit controls the concentrations of the components contained in the culture medium.
    • 提供了一种培养罐的操作控制器,其可以通过指定相对较少数量的内部状态变量来更精确地控制培养箱的内部状态,从而构建通过使用这些内部状态变量来描述细胞内条件的数学模型,从而 结合可观察的外部变量。 操作控制器包括:培养罐,其中封入有用于培养动物细胞或微生物的培养基,测量培养基中营养成分浓度,产物浓度和细胞数密度的测量装置; 供应装置,用于将营养成分和氧气补充到培养基中; 以及运算处理单元,其中来自测量装置的测量值被输入,从而控制供给装置。 算术处理单元通过使用营养成分浓度,产物浓度的时间变化率和细胞数密度的时间变化率来求解存储在存储装置中的电池网络中的细胞内反应速率的方程式 作为输入数据,从而计算所需的细胞内反应速率。 因此,算术处理单元基于计算结果来控制供给装置,由此算术处理单元控制培养基中所含的成分的浓度。
    • 5. 发明授权
    • Fast breeder reactor
    • 快速增殖反应堆
    • US4732729A
    • 1988-03-22
    • US703904
    • 1985-02-21
    • Ken AmanoKotaro Inoue
    • Ken AmanoKotaro Inoue
    • G21C15/02G21C1/02G21C1/03G21C5/06G21C15/00
    • G21C1/03G21C5/06Y02E30/34Y02E30/35
    • In the fast breeder reactor according to this invention, a medium-pressure plenum and a high-pressure plenum are disposed, in the mentioned order from above in a reactor core. Sodium is filled in the medium- and high-pressure plenums. The pressure in the medium-pressure plenum is lower than that in the high-pressure plenum. The lower ends of the entrance nozzles of a multiplicity of fuel assemblies loaded in the reactor core are supported by a supporting plate which forms a boundary between the medium- and high-pressure plenums. The entrance nozzles of control rod guide pipes disposed among the multiplicity of fuel assemblies are also supported by said supporting plate. The sodium in the medium-pressure plenum is supplied into each control rod guide pipe through a first opening provided in the lateral surface of the entrance nozzle of each control rod guide pipe. The sodium in the high-pressure plenum is supplied into each fuel assembly from the lower end of the entrance nozzle of each fuel assembly through a second opening provided piercing through the supporting plate. The sodium in the high-pressure plenum is supplied to the medium-pressure plenum through a pressure-reducing orifice.
    • 在根据本发明的快速增殖反应器中,按上述顺序在反应堆堆芯中设置中压增压室和高压增压室。 钠被填充在中高压气室中。 中压增压室的压力低于高压集气室的压力。 装载在反应堆堆芯中的多个燃料组件的入口喷嘴的下端由形成中压和高压集气室之间的边界的支撑板支撑。 设置在多个燃料组件中的控制杆引导管的入口喷嘴也由所述支撑板支撑。 通过设置在每个控制杆导管的入口喷嘴的侧表面上的第一开口将中压压力室中的钠供给到每个控制棒导管中。 高压增压室中的钠从每个燃料组件的入口喷嘴的下端通过穿过支撑板的第二开口供应到每个燃料组件中。 高压增压室中的钠通过减压孔供给中压增压室。
    • 6. 发明授权
    • Control device for fermenter
    • 发酵罐控制装置
    • US07771988B2
    • 2010-08-10
    • US11355954
    • 2006-02-17
    • Ken Amano
    • Ken Amano
    • C12M1/34
    • C12M41/48
    • The control device according to the present invention includes an input device for entering measured data from a measurement unit, which measures nutrient components, the concentrations of oxygen, carbon dioxide, and biomass in a culture medium; a processor for calculating nutrient components uptake rate, oxygen uptake rate and carbon dioxide exhaust rate per unit amount of biomass from the measured data entered in the aforementioned input device, as well as volumetric mass transfer coefficient kLa from turbulent energy k and a turbulent energy dissipation rate e, both of which are calculated by a transport equation, as well as a diffusion coefficient D, followed by calculating the concentrations of the nutrient components, dissolved oxygen and dissolved carbon dioxide in any area in the fermenter; and a display for displaying concentration distribution of the nutrient components, dissolved oxygen, and dissolved carbon dioxide in the fermenter.
    • 根据本发明的控制装置包括用于输入来自测量单元的测量数据的输入装置,其测量营养成分,培养基中的氧气,二氧化碳和生物量的浓度; 用于根据从上述输入装置输入的测量数据计算每单位量生物量的营养成分摄取速率,吸氧速率和二氧化碳排放率的处理器,以及来自湍流能量k的体积传质系数kLa和湍流能量耗散 速率e,它们都通过运输方程计算,以及扩散系数D,然后计算发酵罐中任何区域中的营养成分,溶解氧和溶解的二氧化碳的浓度; 以及显示器,用于显示发酵罐中的营养成分,溶解氧和溶解的二氧化碳的浓度分布。
    • 7. 发明申请
    • Control device for fermenter
    • 发酵罐控制装置
    • US20060216818A1
    • 2006-09-28
    • US11355954
    • 2006-02-17
    • Ken Amano
    • Ken Amano
    • C12M1/34
    • C12M41/48
    • The present invention allows biomass and/or biomass-produced components to be obtained at high yields by executing numeric simulation of flow to reasonably identify the running conditions suitable for a fermenter. The control device according to the present invention comprises an input means for entering measured data from a measurement means, which measures nutrient components, the concentrations of oxygen, carbon dioxide, and biomass in a culture medium; a computation means for calculating nutrient components uptake rate, oxygen uptake rate and carbon dioxide exhaust rate per unit amount of biomass from the measured data entered at the aforementioned input means, as well as volumetric mass transfer coefficient kLa from turbulent energy k and a turbulent energy dissipation rate e, both of which are calculated by a transport equation, as well as a diffusion coefficient D, followed by calculating the concentrations of the nutrient components, dissolved oxygen, and dissolved carbon dioxide in any area in the fermenter using an algorithm to numerically integrate a differential equation describing variations in medium components over time from the calculated nutrient components uptake rate, the calculated oxygen uptake rate, the calculated carbon dioxide exhaust rate, and the calculated volumetric mass transfer coefficient kLa; and a display means for displaying concentration distributions of the nutrient components, dissolved oxygen, and dissolved carbon dioxide in the fermenter based on the concentrations of the nutrient components, dissolved oxygen, and carbon dioxide in any area of the fermenter calculated at aforementioned computation means.
    • 本发明允许通过执行流动的数值模拟以高产率获得生物质和/或生物质产生的组分,以合理地识别适用于发酵罐的运行条件。 根据本发明的控制装置包括输入装置,用于输入来自测量装置的测量数据,该测量装置测量培养基中的营养成分,氧气,二氧化碳和生物质的浓度; 计算装置,用于根据从上述输入装置输入的测量数据计算营养成分摄取率,吸氧速率和每单位量生物量的二氧化碳排放率,以及来自湍流k的体积传质系数kLa和湍流能 耗散率e,它们都是通过运输方程式计算的,以及扩散系数D,然后使用数值算法计算发酵罐任何区域中营养成分,溶解氧和溶解二氧化碳的浓度 从计算的营养成分摄取速率,计算的氧气摄取速率,计算出的二氧化碳排出速率和计算的体积传质系数kLa中积分描述介质成分随时间变化的微分方程; 以及显示装置,用于基于在上述计算装置计算的发酵罐的任何区域中的营养成分,溶解氧和二氧化碳的浓度,显示发酵罐中的营养成分,溶解氧和溶解的二氧化碳的浓度分布。