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1. 发明授权

US08952010B2 Amino group-containing pyrrolidinone derivative 有权
标题翻译：含氨基的吡咯烷酮衍生物
公开(公告)号：US08952010B2
公开(公告)日：2015-02-10
申请号：US13983540
申请日：2012-02-06
申请人： Hiroaki Inagaki , Tetsunori Fujisawa , Masao Itoh , Aki Yokomizo , Toshifumi Tsuda , Saito Higuchi , Biswajit Das , Rita Katoch , Dilip J. Upadhyay
发明人： Hiroaki Inagaki , Tetsunori Fujisawa , Masao Itoh , Aki Yokomizo , Toshifumi Tsuda , Saito Higuchi , Biswajit Das , Rita Katoch , Dilip J. Upadhyay
IPC分类号： A61K31/538 , A61K31/498 , C07D498/12 , C07D265/36 , C07D413/04 , C07D413/14 , C07D487/04 , C07D241/44 , A61K31/5383 , C07D471/04 , C07D519/00 , C07D498/04
CPC分类号： C07D487/04 , A61K31/5383 , C07D241/44 , C07D265/36 , C07D413/04 , C07D413/14 , C07D471/04 , C07D498/04 , C07D519/00 , Y02A50/475
摘要： A compound represented by the following formula (I) or a salt thereof: wherein R represents a hydrogen atom, a hydroxy group, or a halogen atom Ar1 represents a bicyclic heterocyclic group represented by the following formula: and Ar2 represents a bicyclic heterocyclic group represented by the following formulae:
摘要翻译：由下式（I）表示的化合物或其盐：其中R表示氢原子，羟基或卤素原子Ar1表示由下式表示的双环杂环基：Ar2表示双环杂环基，通过以下公式：

2. 发明申请

US20140187542A1 AMINO GROUP-CONTAINING PYRROLIDINONE DERIVATIVE 有权
标题翻译：氨基含有吡咯烷酮衍生物
公开(公告)号：US20140187542A1
公开(公告)日：2014-07-03
申请号：US13983540
申请日：2012-02-06
申请人： Hiroaki Inagaki , Tetsunori Fujisawa , Masao Itoh , Aki Yokomizo , Toshifumi Tsuda , Saito Higuchi , Biswajit Das , Rita Katoch , Dilip J. Upadhyay
发明人： Hiroaki Inagaki , Tetsunori Fujisawa , Masao Itoh , Aki Yokomizo , Toshifumi Tsuda , Saito Higuchi , Biswajit Das , Rita Katoch , Dilip J. Upadhyay
IPC分类号： C07D498/04 , C07D487/04 , C07D413/14
CPC分类号： C07D487/04 , A61K31/5383 , C07D241/44 , C07D265/36 , C07D413/04 , C07D413/14 , C07D471/04 , C07D498/04 , C07D519/00 , Y02A50/475
摘要： A compound represented by the following formula (I) or a salt thereof: wherein R represents a hydrogen atom, a hydroxy group, or a halogen atom Ar1 represents a bicyclic heterocyclic group represented by the following formula: and Ar2 represents a bicyclic heterocyclic group represented by the following formulae:
摘要翻译：由下式（I）表示的化合物或其盐：其中R表示氢原子，羟基或卤素原子Ar1表示由下式表示的双环杂环基：Ar2表示双环杂环基，通过以下公式：

3. 发明申请

US20100311966A1 IMIDAZOLE CARBONYL COMPOUND 有权
标题翻译：咪唑碳化合物
公开(公告)号：US20100311966A1
公开(公告)日：2010-12-09
申请号：US12811004
申请日：2008-12-26
申请人： Tsuyoshi Soneda , Hiroshi Takeshita , Yoshiko Kagoshima , Yuko Yamamoto , Takafumi Hosokawa , Toshiyuki Konosu , Nobuhisa Masuda , Takuya Uchida , Issei Achiwa , Junichi Kuroyanagi , Tetsunori Fujisawa , Aki Yokomizo , Tetsuji Noguchi
发明人： Tsuyoshi Soneda , Hiroshi Takeshita , Yoshiko Kagoshima , Yuko Yamamoto , Takafumi Hosokawa , Toshiyuki Konosu , Nobuhisa Masuda , Takuya Uchida , Issei Achiwa , Junichi Kuroyanagi , Tetsunori Fujisawa , Aki Yokomizo , Tetsuji Noguchi
IPC分类号： C07D498/04 , C07D277/56 , C07D513/04 , C07D233/90 , C07D403/12 , C07D495/04 , C07D495/16
CPC分类号： C07D487/04 , C07D233/66 , C07D233/90 , C07D401/12 , C07D401/14 , C07D403/12 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D487/06 , C07D487/12 , C07D495/04 , C07D495/16 , C07D498/04 , C07D513/04 , C07D519/00
摘要： An antibiotic compound having a novel mechanism of action, weak cytotoxicity, high solubility in water, effective in inhibiting both DNA gyrase GyrB and topoisomerase IV ParE subunits, and having antibacterial activity.
摘要翻译：具有新的作用机理，细胞毒性低，在水中溶解度高的抗生素化合物，有效抑制DNA促旋酶GyrB和拓扑异构酶IV ParE亚基，具有抗菌活性。

4. 发明授权

US08536197B2 Imidazole carbonyl compound 有权
标题翻译：咪唑羰基化合物
公开(公告)号：US08536197B2
公开(公告)日：2013-09-17
申请号：US12811004
申请日：2008-12-26
申请人： Tsuyoshi Soneda , Hiroshi Takeshita , Yoshiko Kagoshima , Yuko Yamamoto , Takafumi Hosokawa , Toshiyuki Konosu , Nobuhisa Masuda , Takuya Uchida , Issei Achiwa , Junichi Kuroyanagi , Tetsunori Fujisawa , Aki Yokomizo , Tetsuji Noguchi
发明人： Tsuyoshi Soneda , Hiroshi Takeshita , Yoshiko Kagoshima , Yuko Yamamoto , Takafumi Hosokawa , Toshiyuki Konosu , Nobuhisa Masuda , Takuya Uchida , Issei Achiwa , Junichi Kuroyanagi , Tetsunori Fujisawa , Aki Yokomizo , Tetsuji Noguchi
IPC分类号： C07D417/04 , C07D401/12 , A61K31/4164 , A61K31/4178
CPC分类号： C07D487/04 , C07D233/66 , C07D233/90 , C07D401/12 , C07D401/14 , C07D403/12 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D487/06 , C07D487/12 , C07D495/04 , C07D495/16 , C07D498/04 , C07D513/04 , C07D519/00
摘要： An antibiotic compound having a novel mechanism of action, weak cytotoxicity, high solubility in water, effective in inhibiting both DNA gyrase GyrB and topoisomerase IV ParE subunits, and having antibacterial activity.
摘要翻译：具有新的作用机理，细胞毒性低，在水中溶解度高的抗生素化合物，有效抑制DNA促旋酶GyrB和拓扑异构酶IV ParE亚基，具有抗菌活性。

5. 发明申请

US20110053933A1 HYDROXYQUINOXALINECARBOXAMIDE DERIVATIVE 审中-公开
标题翻译：羟基喹啉氧甲酰胺衍生物
公开(公告)号：US20110053933A1
公开(公告)日：2011-03-03
申请号：US12934506
申请日：2009-03-24
申请人： Kayoko Motoki , Kiichi Kawagoe , Shigeyuki Nishinaka , Sachie Masuda , Atsunobu Sakamoto , Satoru Kaneko , Tsuyoshi Arita , Aki Yokomizo
发明人： Kayoko Motoki , Kiichi Kawagoe , Shigeyuki Nishinaka , Sachie Masuda , Atsunobu Sakamoto , Satoru Kaneko , Tsuyoshi Arita , Aki Yokomizo
IPC分类号： A61K31/498 , C07D401/12 , C07D401/14 , A61K31/501 , C07D417/14 , A61K31/506 , C07D413/14 , A61K31/5377 , A61P7/02
CPC分类号： C07D401/12 , C07D401/14 , C07D417/14
摘要： The present invention provides a novel hydroxyquinoxaline carboxamide derivative that is useful for preventing and/or treating blood coagulation disorders. A compound represented by formula (i), or a pharmacologically acceptable salt thereof: wherein, each of R1 and R2 independently represents a group such as a hydrogen atom or a halogen atom; R3 represents a group such as a hydrogen atom; each of R4 and R5 independently represents a group such as a hydrogen atom, a halogen atom or a C1-4 alkyl group; each of R6 and R7 independently represents a hydrogen atom or a C1-4 alkyl group; X represents a group such as a C3-10 cycloalkyl group, C6-10 aryl group or a 5- to 10-membered heterocyclic group, which may be substituted with substituent(s) selected from substituent group α; Y represents a group such as —CO—, —O— or —NRa—, and Ra represents a group such as a hydrogen atom or a C1-4 alkyl group.
摘要翻译：本发明提供了可用于预防和/或治疗凝血障碍的新型羟基喹喔啉羧酰胺衍生物。式（i）表示的化合物或其药理学上可接受的盐：其中，R 1和R 2各自独立地表示氢原子或卤素原子等基团; R3表示氢原子等基团， R4和R5各自独立地表示氢原子，卤素原子或C1-4烷基等基团。 R6和R7各自独立地表示氢原子或C1-4烷基; X表示可以被选自取代基组α的取代基取代的C 10-10环烷基，C 6-10芳基或5〜10元杂环基等基团; Y表示-CO-，-O-或-NR a - ，R a表示氢原子或C 1-4烷基等基团。

6. 发明授权

US5919824A Aminophenol derivatives 失效
标题翻译：氨基苯酚衍生物
公开(公告)号：US5919824A
公开(公告)日：1999-07-06
申请号：US894799
申请日：1997-09-12
申请人： Shuichi Yokohama , Keiichi Kawagoe , Yasuyuki Takeda , Yoshihiro Yokomizo , Aki Yokomizo
发明人： Shuichi Yokohama , Keiichi Kawagoe , Yasuyuki Takeda , Yoshihiro Yokomizo , Aki Yokomizo
IPC分类号： C07C275/16 , C07C275/28 , A61K37/44 , C07C59/235
CPC分类号： C07C275/28 , C07C275/16 , Y10S514/925 , Y10S514/927
摘要： Aminophenol derivatives represented by the following formula (1): ##STR1## wherein X is O or S; A is alkylene, R.sup.1 is phenyl, etc., R.sup.2 and R.sup.3 are H or alkyl; R.sup.4 is substituted carbamoylalkyl, etc.; R.sup.5 is substituted amino, etc.; their salts, and optical isomers of the derivatives and salts. Also disclosed are gastrin receptor antagonists, cholecystokinin receptor antagonists, and medicines for digestive diseases. The compounds have strong binding inhibition against gastrin receptor or CCK-A receptor and also they have higher selectivity to either group of CCK-A receptor or gastrin receptor, and therefore, the compounds are useful for preventing and treating gastrointestinal diseases including peptic ulcers as well as central nervous system diseases.
摘要翻译： PCT No.PCT / JP96 / 00611 Sec。 371日期：1997年9月12日 102（e）1997年9月12日PCT PCT 1996年3月12日PCT公布。公开号WO96 / 28416 日期：1996年9月19日由下式（1）表示的苯酚衍生物：其中X为O或S; A是亚烷基，R 1是苯基等，R 2和R 3是H或烷基; R4是取代的氨基甲酰基烷基等; R5是取代氨基等。它们的盐和衍生物和盐的光学异构体。还公开了胃泌素受体拮抗剂，胆囊收缩素受体拮抗剂和用于消化疾病的药物。这些化合物对胃泌素受体或CCK-A受体具有强烈的结合抑制作用，并且对CCK-A受体或胃泌素受体组也具有较高的选择性，因此，该化合物也可用于预防和治疗胃肠疾病，包括消化性溃疡作为中枢神经系统疾病。

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