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1. 发明申请

US20070231385A1 Controlled Release Pharmaceutical Composition and a Process for Preparing the Same 审中-公开
标题翻译：控制释放药物组合物及其制备方法
公开(公告)号：US20070231385A1
公开(公告)日：2007-10-04
申请号：US10574320
申请日：2004-09-29
申请人： Himadri Sen , Suryakumar Jayanthi , Vineeth Raghavan , Ganga Arra
发明人： Himadri Sen , Suryakumar Jayanthi , Vineeth Raghavan , Ganga Arra
IPC分类号： A61K9/24 , A61K31/505 , A61K31/535 , A61K31/551 , A61K47/38
CPC分类号： A61K9/209
摘要： A three-drug antiretrovial pharmaceutical composition having a selective combination of a controlled release active formulation and an immediate release active formulation for once daily administration. The composition provides desired dosages of the actives lamivudine, zidovudine or pharmaceutically acceptable derivatives thereof, and the immediate release formulation including at least one selective Non-nucleoside Reverse Transcriptase Inhibitor (NNRTI), preferably nevirapine or a pharmaceutically acceptable derivative thereof along with pharmaceutically acceptable excipients. The once daily composition would favour patient compliance and effective treatment. A method of reducing the pill burden in a patient suffering from HIV infection and/or Acquired Immunodeffieciency Syndrome by administering a once daily dose of the three-drug antiretroviral pharmaceutical composition.
摘要翻译：一种三药抗逆转录药物组合物，其具有控释活性制剂和立即释放活性制剂的选择性组合，每日一次给药。所述组合物提供所需剂量的拉米夫定，齐多夫定或其药学上可接受的衍生物，并且立即释放制剂包括至少一种选择性非核苷逆转录酶抑制剂（NNRTI），优选奈韦拉平或其药学上可接受的衍生物以及药学上可接受的赋形剂。每天一次的组合将有利于患者的顺应性和有效的治疗。一种通过施用一日剂量的三药抗逆转录病毒药物组合物来减少患有HIV感染和/或获得性免疫缺陷综合征的患者的药丸负担的方法。

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