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1. 发明授权

US07666836B2 Method for the therapeutic management of endometriosis 失效
标题翻译：子宫内膜异位症治疗方法
公开(公告)号：US07666836B2
公开(公告)日：2010-02-23
申请号：US11311363
申请日：2005-12-20
申请人： Hilde Riethmuller-Winzen , Jurgen Engel , Ricardo Felberbaum , Klaus Diedrich , Kupker Wolfgang
发明人： Hilde Riethmuller-Winzen , Jurgen Engel , Ricardo Felberbaum , Klaus Diedrich , Kupker Wolfgang
IPC分类号： A61K38/00 , A61K31/497 , A61K31/519 , A61K31/505
CPC分类号： A61K38/08 , A61K45/06 , A61K2300/00
摘要： The present inventions provides a method for therapeutic management of extrauterine proliferation of endometrial tissue, chronic pelvic pain and fallopian tube obstruction by short term induction treatment with an LH-RH antagonist for 4 to 12 weeks. According to another aspect of the present invention, the short term LH-RH treatment is followed by the combined or separate administration of one or more active agents selected from the group consisting of a contraceptive, preferably an oral contraceptive, a non-steroidal anti-rheumatic agent, an analgetic, an androgen other than a 17-alpha-alkyl substituted testosterone or any combinations thereof. According to a further aspect of the present invention a pharmaceutical composition comprising an LHRH antagonist and one ore more active agents selected from the group consisting of a contraceptive, preferably an oral contraceptive, a non-steroidal anti-rheumatic agent, an analgetic, an androgen other than a 17-alpha-alkyl substituted testosterone or any combinations thereof are provided.
摘要翻译：本发明提供了一种通过LH-RH拮抗剂短期诱导治疗4至12周来治疗子宫内膜组织宫外增生，慢性盆腔疼痛和输卵管阻塞的方法。根据本发明的另一方面，短期LH-RH治疗之后是联合或分开施用一种或多种活性剂，所述活性剂选自避孕药，优选口服避孕药，非类固醇抗生素，风湿药，止痛剂，除17-α-烷基取代的睾酮以外的雄激素或其任何组合。根据本发明的另一方面，包含LHRH拮抗剂和一种或多种选自避孕药，优选口服避孕药，非甾体抗风湿药，止痛剂，雄激素的活性剂的药物组合物提供除17-α-烷基取代的睾酮或其任何组合以外的物质。

2. 发明申请

US20080255053A1 METHOD FOR THE THERAPEUTIC MANAGEMENT OF ENDOMETRIOSIS 审中-公开
标题翻译：内分泌治疗方法
公开(公告)号：US20080255053A1
公开(公告)日：2008-10-16
申请号：US12099091
申请日：2008-04-07
申请人： Hilde RIETHMULLER-WINZEN , Jurgen Engel , Ricardo Felberbaum , Klaus Diedrich , Kupker Wolfgang
发明人： Hilde RIETHMULLER-WINZEN , Jurgen Engel , Ricardo Felberbaum , Klaus Diedrich , Kupker Wolfgang
IPC分类号： A61K38/08
CPC分类号： A61K38/08 , A61K45/06 , A61K2300/00
摘要： The present inventions provides a method for therapeutic management of extrauterine proliferation of endometrial tissue, chronic pelvic pain and fallopian tube obstruction by short term induction treatment with an LH-RH antagonist for 4 to 12 weeks. According to another aspect of the present invention, the short term LH-RH treatment is followed by the combined or separate administration of one or more active agents selected from the group consisting of a contraceptive, preferably an oral contraceptive, a non-steroidal anti-rheumatic agent, an analgetic, an androgen other than a 17-alpha-alkyl substituted testosterone or any combinations thereof. According to a further aspect of the present invention a pharmaceutical composition comprising an LHRH antagonist and one ore more active agents selected from the group consisting of a contraceptive, preferably an oral contraceptive, a non-steroidal anti-rheumatic agent, an analgetic, an androgen other than a 17-alpha-alkyl substituted testosterone or any combinations thereof are provided.
摘要翻译：本发明提供了一种通过LH-RH拮抗剂短期诱导治疗4至12周来治疗子宫内膜组织宫外增生，慢性盆腔疼痛和输卵管阻塞的方法。根据本发明的另一方面，短期LH-RH治疗之后是联合或分开施用一种或多种活性剂，所述活性剂选自避孕药，优选口服避孕药，非类固醇抗生素，风湿药，止痛剂，除17-α-烷基取代的睾酮以外的雄激素或其任何组合。根据本发明的另一方面，包含LHRH拮抗剂和一种或多种选自避孕药，优选口服避孕药，非甾体抗风湿药，止痛剂，雄激素的活性剂的药物组合物提供除17-α-烷基取代的睾酮或其任何组合以外的物质。

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