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1. 发明授权

US07714008B2 Heterocyclic GPR40 modulators 失效
标题翻译：杂环GPR40调节剂
公开(公告)号：US07714008B2
公开(公告)日：2010-05-11
申请号：US11900006
申请日：2007-09-06
申请人： Hilary Beck , Paul Dransfield , Zice Fu , Jonathan B. Houze , XianYun Jiao , Todd J. Kohn , SuJen Lai , Jinqian Liu , Jiwen Liu , Zhihua Ma , Julio C. Medina , Michael J. Schmitt , Rajiv Sharma , Wang Shen , Marc Vimolratana , Yingcai Wang , Zhongyu Wang
发明人： Hilary Beck , Paul Dransfield , Zice Fu , Jonathan B. Houze , XianYun Jiao , Todd J. Kohn , SuJen Lai , Jinqian Liu , Jiwen Liu , Zhihua Ma , Julio C. Medina , Michael J. Schmitt , Rajiv Sharma , Wang Shen , Marc Vimolratana , Yingcai Wang , Zhongyu Wang
IPC分类号： A61K31/192 , A61K31/422 , C07C59/11 , C07D261/06
CPC分类号： C07D261/08 , C07D409/12 , C07D413/06 , C07D413/12 , C07D417/12
摘要： The present invention provides compounds useful, for example, for treating metabolic disorders in a subject. Such compounds have the general formula I: where the definitions of the variables are provided herein. The present invention also provides compositions that include, and methods for using, the compounds in preparing medicaments and for treating metabolic disorders such as, for example, type II diabetes.
摘要翻译：本发明提供了可用于例如治疗受试者的代谢紊乱的化合物。这些化合物具有通式I：其中本文提供变量的定义。本发明还提供了组合物，其包括化合物在制备药物和用于治疗代谢性疾病例如II型糖尿病中的使用方法。

2. 发明授权

US08003648B2 Heterocyclic GPR40 modulators 失效
标题翻译：杂环GPR40调节剂
公开(公告)号：US08003648B2
公开(公告)日：2011-08-23
申请号：US12613418
申请日：2009-11-05
申请人： Hilary Beck , Paul Dransfield , Zice Fu , Jonathan B. Houze , XianYun Jiao , Todd J. Kohn , SuJen Lai , Jinqian Liu , Jiwen Liu , Zhihua Ma , Julio C. Medina , Michael J. Schmitt , Rajiv Sharma , Wang Shen , Marc Vimolratana , Yingcai Wang , Zhongyu Wang
发明人： Hilary Beck , Paul Dransfield , Zice Fu , Jonathan B. Houze , XianYun Jiao , Todd J. Kohn , SuJen Lai , Jinqian Liu , Jiwen Liu , Zhihua Ma , Julio C. Medina , Michael J. Schmitt , Rajiv Sharma , Wang Shen , Marc Vimolratana , Yingcai Wang , Zhongyu Wang
IPC分类号： A61K31/498 , A61K31/42 , A61K31/426 , A61K31/4245 , A61K31/443 , C07D261/06 , C07D277/22 , C07D271/06 , C07D413/02 , C07D241/36 , A61P3/10 , A61P9/00
CPC分类号： C07D261/08 , C07D409/12 , C07D413/06 , C07D413/12 , C07D417/12
摘要： The present invention provides compounds useful, for example, for treating metabolic disorders in a subject. Such compounds have the general formula I: where the definitions of the variables are provided herein. The present invention also provides compositions that include, and methods for using, the compounds in preparing medicaments and for treating metabolic disorders such as, for example, type II diabetes.
摘要翻译：本发明提供了可用于例如治疗受试者的代谢紊乱的化合物。这些化合物具有通式I：其中本文提供变量的定义。本发明还提供了组合物，其包括化合物在制备药物和用于治疗代谢性疾病例如II型糖尿病中的使用方法。

3. 发明申请

US20100075974A1 HETEROCYCLIC GPR40 MODULATORS 失效
标题翻译：杂环GPR40调制器
公开(公告)号：US20100075974A1
公开(公告)日：2010-03-25
申请号：US12613418
申请日：2009-11-05
申请人： Hilary Beck , Paul Dransfield , Zice Fu , Jonathan B. Houze , Xian Yun Jiao , Todd J. Kohn , SuJen Lai , Jinqian Liu , Jiwen Liu , Zhihua Ma , Julio C. Medina , Michael J. Schmitt , Rajiv Sharma , Wang Shen , Marc Vimolratana , Yingcai Wang , Zhongyu Wang
发明人： Hilary Beck , Paul Dransfield , Zice Fu , Jonathan B. Houze , Xian Yun Jiao , Todd J. Kohn , SuJen Lai , Jinqian Liu , Jiwen Liu , Zhihua Ma , Julio C. Medina , Michael J. Schmitt , Rajiv Sharma , Wang Shen , Marc Vimolratana , Yingcai Wang , Zhongyu Wang
IPC分类号： A61K31/498 , C07D261/06 , A61K31/42 , C07D277/22 , A61K31/426 , C07D271/06 , A61K31/4245 , C07D413/02 , A61K31/443 , C07D241/36 , A61P3/10 , A61P9/00
CPC分类号： C07D261/08 , C07D409/12 , C07D413/06 , C07D413/12 , C07D417/12
摘要： The present invention provides compounds useful, for example, for treating metabolic disorders in a subject. Such compounds have the general formula I: where the definitions of the variables are provided herein. The present invention also provides compositions that include, and methods for using, the compounds in preparing medicaments and for treating metabolic disorders such as, for example, type II diabetes.
摘要翻译：本发明提供了可用于例如治疗受试者的代谢紊乱的化合物。这些化合物具有通式I：其中本文提供变量的定义。本发明还提供了组合物，其包括化合物在制备药物和用于治疗代谢性疾病例如II型糖尿病中的使用方法。

4. 发明申请

US20080090840A1 Heterocyclic GPR40 Modulators 失效
标题翻译：杂环GPR40调制器
公开(公告)号：US20080090840A1
公开(公告)日：2008-04-17
申请号：US11900006
申请日：2007-09-06
申请人： Hilary Beck , Paul Dransfield , Zice Fu , Jonathan Houze , Xian Yun Jiao , Todd Kohn , SuJen Lai , Jinqian Liu , Jiwen Liu , Zhihua Ma , Michael Schmitt , Rajiv Sharma , Wang Shen , Marc Vimolratana , Yingcai Wang , Zhongyu Wang
发明人： Hilary Beck , Paul Dransfield , Zice Fu , Jonathan Houze , Xian Yun Jiao , Todd Kohn , SuJen Lai , Jinqian Liu , Jiwen Liu , Zhihua Ma , Michael Schmitt , Rajiv Sharma , Wang Shen , Marc Vimolratana , Yingcai Wang , Zhongyu Wang
IPC分类号： A61K31/41 , A61K31/42 , A61K31/44 , A61K31/4965 , A61P43/00 , C07D241/36 , C07D261/06 , C07D271/06 , C07D277/30 , C07D413/00
CPC分类号： C07D261/08 , C07D409/12 , C07D413/06 , C07D413/12 , C07D417/12
摘要： The present invention provides compounds useful, for example, for treating metabolic disorders in a subject. Such compounds have the general formula I: where the definitions of the variables are provided herein. The present invention also provides compositions that include, and methods for using, the compounds in preparing medicaments and for treating metabolic disorders such as, for example, type II diabetes.
摘要翻译：本发明提供了可用于例如治疗受试者的代谢紊乱的化合物。这些化合物具有通式I：其中本文提供变量的定义。本发明还提供了组合物，其包括化合物在制备药物和用于治疗代谢性疾病例如II型糖尿病中的使用方法。

5. 发明申请

US20110190330A1 SPIROCYCLIC GPR40 MODULATORS 有权
标题翻译：螺旋GPR40调制器
公开(公告)号：US20110190330A1
公开(公告)日：2011-08-04
申请号：US13119951
申请日：2009-10-13
申请人： Sean P. Brown , Paul Dransfield , Xiaohui Du , Zice Fu , Jonathan Houze , XianYun Jiao , Sujen Lai , An-Rong Li , Jiwen Liu , Zhihua Ma , Julio C. Medina , Vatee Pattaropong , Wang Shen , Marc Vimolratana , Yingcai Wang , Zhongyu Wang , Ming Yu , Liusheng Zhu
发明人： Sean P. Brown , Paul Dransfield , Xiaohui Du , Zice Fu , Jonathan Houze , XianYun Jiao , Sujen Lai , An-Rong Li , Jiwen Liu , Zhihua Ma , Julio C. Medina , Vatee Pattaropong , Wang Shen , Marc Vimolratana , Yingcai Wang , Zhongyu Wang , Ming Yu , Liusheng Zhu
IPC分类号： A61K31/4418 , C07C69/757 , C07C62/34 , C07D213/64 , C07D249/08 , C07D311/96 , C07D217/24 , C07D231/12 , A61K31/216 , A61K31/192 , A61K31/4196 , A61K31/352 , A61K31/415 , A61K31/426 , A61P3/10
CPC分类号： C07C62/34 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/10 , C07C2601/14 , C07D213/643 , C07D217/24 , C07D253/065 , C07D277/22 , C07D311/04 , C07D401/12
摘要： The present invention provides compounds useful, for example, for treating metabolic disorders in a subject. Such compounds have the general formula IA, IB, I′A or I′B: where the definitions of the variables are provided herein. The present invention also provides compositions that include, and methods for using, the compounds in preparing medicaments and for treating metabolic disorders such as, for example, type II diabetes.
摘要翻译：本发明提供了可用于例如治疗受试者的代谢紊乱的化合物。这些化合物具有通式IA，IB，I'A或I'B：其中本文提供变量的定义。本发明还提供了组合物，其包括化合物在制备药物和用于治疗代谢性疾病例如II型糖尿病中的使用方法。

6. 发明授权

US08748462B2 Spirocyclic GPR40 modulators 有权
标题翻译：螺环GPR40调节剂
公开(公告)号：US08748462B2
公开(公告)日：2014-06-10
申请号：US13119951
申请日：2009-10-13
申请人： Sean P. Brown , Paul Dransfield , Xiaohui Du , Zice Fu , Jonathan Houze , XianYun Jiao , Sujen Lai , An-Rong Li , Jiwen Liu , Zhihua Ma , Julio C. Medina , Vatee Pattaropong , Wang Shen , Marc Vimolratana , Yingcai Wang , Zhongyu Wang , Ming Yu , Liusheng Zhu
发明人： Sean P. Brown , Paul Dransfield , Xiaohui Du , Zice Fu , Jonathan Houze , XianYun Jiao , Sujen Lai , An-Rong Li , Jiwen Liu , Zhihua Ma , Julio C. Medina , Vatee Pattaropong , Wang Shen , Marc Vimolratana , Yingcai Wang , Zhongyu Wang , Ming Yu , Liusheng Zhu
IPC分类号： A61K31/19 , C07C69/76 , C07D211/72 , C07D211/84 , C07D213/62 , A61K31/44
CPC分类号： C07C62/34 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/10 , C07C2601/14 , C07D213/643 , C07D217/24 , C07D253/065 , C07D277/22 , C07D311/04 , C07D401/12
摘要： The present invention provides compounds useful, for example, for treating metabolic disorders in a subject. Such compounds have the general formula IA, IB, I′A or I′B: where the definitions of the variables are provided herein. The present invention also provides compositions that include, and methods for using, the compounds in preparing medicaments and for treating metabolic disorders such as, for example, type II diabetes.
摘要翻译：本发明提供了可用于例如治疗受试者的代谢紊乱的化合物。这些化合物具有通式IA，IB，I'A或I'B：其中本文提供变量的定义。本发明还提供了组合物，其包括化合物在制备药物和用于治疗代谢性疾病例如II型糖尿病中的使用方法。

7. 发明申请

US20070244155A1 Bicyclic carboxylic acid derivatives useful for treating metabolic disorders 审中-公开
标题翻译：用于治疗代谢紊乱的双环羧酸衍生物
公开(公告)号：US20070244155A1
公开(公告)日：2007-10-18
申请号：US11717945
申请日：2007-03-13
申请人： Rajiv Sharma , Michelle Akerman , Mario Cardozo , Jonathan Houze , An-Rong Li , Jinquian Liu , Jiwen Liu , Zhihua Ma , Julio Medina , Michael Schmitt , Ying Sun , Yingcai Wang , Zhongyu Wang , Liusheng Zhu
发明人： Rajiv Sharma , Michelle Akerman , Mario Cardozo , Jonathan Houze , An-Rong Li , Jinquian Liu , Jiwen Liu , Zhihua Ma , Julio Medina , Michael Schmitt , Ying Sun , Yingcai Wang , Zhongyu Wang , Liusheng Zhu
IPC分类号： A61K31/4704 , A61K31/405 , A61K31/366 , A61K31/353 , A61K31/192
CPC分类号： C07C57/62 , C07C59/64 , C07C59/72 , C07D209/08 , C07D209/46 , C07D215/20 , C07D215/227 , C07D277/24 , C07D311/58 , C07D311/74 , C07D311/76 , C07D313/08 , C07D417/12 , C07D498/04
摘要： Compounds having the general formula I and/or the general formula II are useful, for example, for treating metabolic disorders in a subject where the variables are provided herein. Compositions and methods for using the compounds for preparing medicaments and for treating metabolic disorders such as, for instance, type II diabetes are disclosed.
摘要翻译：具有通式I和/或通式II的化合物可用于例如在本文提供变量的受试者中治疗代谢紊乱。公开了用于制备药物和用于治疗代谢性疾病例如II型糖尿病的化合物的组合物和方法。

8. 发明授权

US09219360B2 Safe quick disconnect leakage protector 有权
标题翻译：安全快速断开漏电保护器
公开(公告)号：US09219360B2
公开(公告)日：2015-12-22
申请号：US14235798
申请日：2011-08-09
申请人： Zhongyu Wang
发明人： Zhongyu Wang
IPC分类号： H02H3/00 , H02H3/16 , H02H3/05 , H02H3/33 , H02H5/10 , H02H1/06
CPC分类号： H02H3/162 , H02H1/066 , H02H3/05 , H02H3/16 , H02H3/334 , H02H5/105
摘要： The present disclosure provides a safe quick disconnect leakage protector, including a power supply circuit, a sampling circuit, a couple of single-pole single-throws, an on and off control circuit, and a testing circuit. The sampling circuit collects the leakage current signal between the live wire and the neutral wire and outputting the leakage current signal; the main control circuit receives the leakage current signal outputted from the sampling circuit, amplifies the leakage current signal, and outputs a grounding failure control signal when the leakage current reaches the predetermined value; the on and off control circuit receives the grounding failure control signal outputted from the main control circuit and controls the single-pole single-throw switches to disconnect the load from the external power supply according to the grounding failure control signal, thereby protecting the load and improves the safety of the leakage protection of an electrical appliance.
摘要翻译：本公开提供了一种安全的快速断开泄漏保护器，包括电源电路，采样电路，一对单极单掷，开关控制电路和测试电路。采样电路收集有线和中线之间的漏电流信号，并输出漏电流信号; 主控电路接收从采样电路输出的泄漏电流信号，放大漏电流信号，并在泄漏电流达到预定值时输出接地故障控制信号; 接通和断开控制电路接收从主控电路输出的接地故障控制信号，并控制单刀单掷开关根据接地故障控制信号从外部电源断开负载，从而保护负载和提高电器的漏电保护的安全性。

9. 发明申请

US20130237566A1 HETEROCYCLIC COMPOUNDS AS S1P1 AGONISTS FOR THE TREATMENT OF AUTOIMMUNE AND VASCULAR DISEASES 有权
标题翻译：作为S1P1治疗自身免疫性疾病和血管疾病的药物的异种化合物
公开(公告)号：US20130237566A1
公开(公告)日：2013-09-12
申请号：US13883358
申请日：2011-11-02
申请人： Robert J. Cherney , Zhongyu Wang
发明人： Robert J. Cherney , Zhongyu Wang
IPC分类号： C07D413/14 , C07D413/04
CPC分类号： C07D413/14 , C07D413/04
摘要： Disclosed are compounds of Formula (I) or stereoisomers, salts, or prodrugs thereof, wherein: W is CH2 or O; Q is Formula (II), Formula (III) or Formula (IV); and R1, R2, R3, R4, n, and G are defined herein. Also disclosed are methods of using such compounds as selective agonists for G protein-coupled receptor S1P1, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating, preventing, or slowing the progression of diseases or disorders in a variety of therapeutic areas, such as autoimmune diseases and vascular disease.
摘要翻译：公开了式（I）的化合物或其立体异构体，盐或前药，其中：W是CH 2或O; Q是式（II），式（III）或式（IV）; 并且R1，R2，R3，R4，n和G如本文所定义。还公开了使用这种化合物作为G蛋白偶联受体S1P1的选择性激动剂的方法，以及包含这些化合物的药物组合物。这些化合物可用于治疗，预防或减缓各种治疗领域（例如自身免疫疾病和血管疾病）中的疾病或病症的进展。

10. 发明申请

US20120149733A1 PIPERIDINYL COMPOUND AS A MODULATOR OF CHEMOKINE RECEPTOR ACTIVITY 有权
标题翻译：作为化合物受体活性的调节剂的哌啶化合物
公开(公告)号：US20120149733A1
公开(公告)日：2012-06-14
申请号：US13160944
申请日：2011-06-15
申请人： Robert J. Cherney , John V. Duncia , Daniel S. Gardner , Joseph B. Santella , Zhongyu Wang
发明人： Robert J. Cherney , John V. Duncia , Daniel S. Gardner , Joseph B. Santella , Zhongyu Wang
IPC分类号： A61K31/451 , A61P19/02 , A61P7/00 , A61P29/00 , A61P9/00 , A61P1/00 , A61P9/04 , A61P37/00 , A61P31/18 , A61P25/28 , A61P17/06 , A61P9/10 , A61P25/00 , A61P1/04 , A61P19/04 , A61P1/16 , A61P11/06 , A61P37/06 , A61P35/00 , C07D211/52
CPC分类号： C07D211/52 , A61K31/451
摘要： The present application describes the compound of formula (I): or stereoisomers or pharmaceutically acceptable salts thereof. In addition, methods of treating and preventing inflammatory diseases such as asthma and allergic diseases, as well as autoimmune pathologies such as rheumatoid arthritis and arthrosclerosis using the compound of the invention are disclosed.
摘要翻译：本申请描述了式（I）化合物或其立体异构体或其药学上可接受的盐。此外，公开了使用本发明的化合物治疗和预防炎症性疾病如哮喘和过敏性疾病以及自身免疫病态如类风湿性关节炎和关节病的方法。

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